Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APG6_LEIMU

TriTrypDb:

LmxM.13.1420

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.406
CLV_NRD_NRD_1	54	56	PF00675	0.491
CLV_PCSK_KEX2_1	112	114	PF00082	0.406
CLV_PCSK_KEX2_1	238	240	PF00082	0.661
CLV_PCSK_KEX2_1	54	56	PF00082	0.491
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.661
CLV_PCSK_SKI1_1	164	168	PF00082	0.489
CLV_PCSK_SKI1_1	2	6	PF00082	0.468
CLV_PCSK_SKI1_1	203	207	PF00082	0.362
CLV_PCSK_SKI1_1	216	220	PF00082	0.408
DEG_Nend_UBRbox_1	1	4	PF02207	0.512
DOC_CKS1_1	44	49	PF01111	0.471
DOC_MAPK_gen_1	197	206	PF00069	0.442
DOC_MAPK_MEF2A_6	147	156	PF00069	0.445
DOC_MAPK_RevD_3	98	113	PF00069	0.390
DOC_PP4_FxxP_1	149	152	PF00568	0.553
DOC_USP7_MATH_1	30	34	PF00917	0.660
DOC_USP7_MATH_1	77	81	PF00917	0.569
DOC_USP7_UBL2_3	226	230	PF12436	0.491
DOC_WW_Pin1_4	135	140	PF00397	0.608
DOC_WW_Pin1_4	26	31	PF00397	0.639
DOC_WW_Pin1_4	43	48	PF00397	0.485
DOC_WW_Pin1_4	59	64	PF00397	0.460
LIG_14-3-3_CanoR_1	147	152	PF00244	0.651
LIG_14-3-3_CanoR_1	216	223	PF00244	0.363
LIG_14-3-3_CanoR_1	239	246	PF00244	0.562
LIG_14-3-3_CanoR_1	54	58	PF00244	0.570
LIG_Actin_WH2_2	6	24	PF00022	0.440
LIG_BIR_III_2	60	64	PF00653	0.462
LIG_CtBP_PxDLS_1	160	164	PF00389	0.383
LIG_FHA_1	120	126	PF00498	0.485
LIG_FHA_1	5	11	PF00498	0.454
LIG_FHA_1	69	75	PF00498	0.712
LIG_FHA_2	125	131	PF00498	0.475
LIG_FHA_2	44	50	PF00498	0.537
LIG_FHA_2	83	89	PF00498	0.346
LIG_LIR_Gen_1	48	57	PF02991	0.492
LIG_LIR_Nem_3	48	53	PF02991	0.478
LIG_MYND_1	140	144	PF01753	0.558
LIG_NRBOX	162	168	PF00104	0.383
LIG_Rb_LxCxE_1	219	237	PF01857	0.410
LIG_SH2_STAP1	114	118	PF00017	0.446
LIG_SH2_STAT5	92	95	PF00017	0.505
LIG_SH3_3	33	39	PF00018	0.550
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.483
LIG_SUMO_SIM_par_1	203	209	PF11976	0.426
LIG_TRAF2_1	168	171	PF00917	0.565
MOD_CK1_1	43	49	PF00069	0.509
MOD_CK2_1	124	130	PF00069	0.467
MOD_CK2_1	53	59	PF00069	0.567
MOD_CK2_1	82	88	PF00069	0.371
MOD_GlcNHglycan	2	5	PF01048	0.553
MOD_GlcNHglycan	33	36	PF01048	0.703
MOD_GlcNHglycan	48	53	PF01048	0.559
MOD_GlcNHglycan	75	78	PF01048	0.671
MOD_GSK3_1	126	133	PF00069	0.477
MOD_GSK3_1	26	33	PF00069	0.595
MOD_GSK3_1	73	80	PF00069	0.668
MOD_PKA_2	53	59	PF00069	0.567
MOD_Plk_1	48	54	PF00069	0.524
MOD_Plk_2-3	124	130	PF00069	0.496
MOD_Plk_4	130	136	PF00069	0.458
MOD_Plk_4	40	46	PF00069	0.537
MOD_ProDKin_1	135	141	PF00069	0.612
MOD_ProDKin_1	26	32	PF00069	0.646
MOD_ProDKin_1	43	49	PF00069	0.477
MOD_ProDKin_1	59	65	PF00069	0.467
MOD_SUMO_rev_2	193	198	PF00179	0.459
TRG_DiLeu_BaEn_1	130	135	PF01217	0.531
TRG_ENDOCYTIC_2	114	117	PF00928	0.448
TRG_ENDOCYTIC_2	92	95	PF00928	0.462
TRG_ER_diArg_1	111	113	PF00400	0.403
TRG_ER_diArg_1	17	20	PF00400	0.485
TRG_ER_diArg_1	53	55	PF00400	0.482
TRG_NLS_MonoCore_2	237	242	PF00514	0.700
TRG_NLS_MonoExtC_3	237	243	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Q3	Leptomonas seymouri	49%	100%
A0A3S7WSS0	Leishmania donovani	88%	100%
A0A422P490	Trypanosoma rangeli	31%	100%
A4H7C4	Leishmania braziliensis	77%	100%
A4HVS9	Leishmania infantum	87%	100%
Q4QG12	Leishmania major	86%	97%