Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APG4_LEIMU

TriTrypDb:

LmxM.13.1400

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.469
CLV_NRD_NRD_1	133	135	PF00675	0.562
CLV_NRD_NRD_1	448	450	PF00675	0.521
CLV_NRD_NRD_1	532	534	PF00675	0.534
CLV_NRD_NRD_1	62	64	PF00675	0.625
CLV_NRD_NRD_1	653	655	PF00675	0.470
CLV_PCSK_KEX2_1	133	135	PF00082	0.562
CLV_PCSK_KEX2_1	29	31	PF00082	0.627
CLV_PCSK_KEX2_1	448	450	PF00082	0.438
CLV_PCSK_KEX2_1	532	534	PF00082	0.525
CLV_PCSK_KEX2_1	62	64	PF00082	0.627
CLV_PCSK_KEX2_1	653	655	PF00082	0.470
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.627
CLV_PCSK_SKI1_1	449	453	PF00082	0.380
CLV_PCSK_SKI1_1	532	536	PF00082	0.560
CLV_PCSK_SKI1_1	62	66	PF00082	0.641
CLV_Separin_Metazoa	626	630	PF03568	0.638
DEG_APCC_DBOX_1	414	422	PF00400	0.518
DEG_SCF_FBW7_1	536	541	PF00400	0.621
DOC_ANK_TNKS_1	46	53	PF00023	0.666
DOC_CKS1_1	431	436	PF01111	0.497
DOC_CKS1_1	499	504	PF01111	0.579
DOC_CKS1_1	560	565	PF01111	0.460
DOC_CYCLIN_yCln2_LP_2	3	6	PF00134	0.606
DOC_MAPK_DCC_7	395	405	PF00069	0.475
DOC_MAPK_gen_1	67	76	PF00069	0.611
DOC_MAPK_MEF2A_6	411	418	PF00069	0.558
DOC_PP2B_LxvP_1	3	6	PF13499	0.574
DOC_PP2B_LxvP_1	414	417	PF13499	0.490
DOC_USP7_MATH_1	111	115	PF00917	0.514
DOC_USP7_MATH_1	129	133	PF00917	0.538
DOC_USP7_MATH_1	305	309	PF00917	0.693
DOC_USP7_MATH_1	359	363	PF00917	0.606
DOC_USP7_MATH_1	383	387	PF00917	0.672
DOC_USP7_MATH_1	538	542	PF00917	0.610
DOC_USP7_MATH_1	556	560	PF00917	0.552
DOC_USP7_MATH_1	609	613	PF00917	0.669
DOC_USP7_MATH_1	87	91	PF00917	0.545
DOC_WW_Pin1_4	127	132	PF00397	0.656
DOC_WW_Pin1_4	139	144	PF00397	0.696
DOC_WW_Pin1_4	200	205	PF00397	0.450
DOC_WW_Pin1_4	258	263	PF00397	0.595
DOC_WW_Pin1_4	430	435	PF00397	0.487
DOC_WW_Pin1_4	498	503	PF00397	0.446
DOC_WW_Pin1_4	534	539	PF00397	0.567
DOC_WW_Pin1_4	559	564	PF00397	0.691
LIG_14-3-3_CanoR_1	184	189	PF00244	0.494
LIG_14-3-3_CanoR_1	346	354	PF00244	0.593
LIG_14-3-3_CanoR_1	395	403	PF00244	0.502
LIG_14-3-3_CanoR_1	415	425	PF00244	0.184
LIG_14-3-3_CanoR_1	449	459	PF00244	0.501
LIG_14-3-3_CanoR_1	532	537	PF00244	0.507
LIG_FHA_1	197	203	PF00498	0.526
LIG_FHA_1	375	381	PF00498	0.527
LIG_FHA_1	395	401	PF00498	0.519
LIG_FHA_1	499	505	PF00498	0.501
LIG_FHA_1	563	569	PF00498	0.774
LIG_FHA_1	614	620	PF00498	0.513
LIG_FHA_1	636	642	PF00498	0.533
LIG_FHA_2	134	140	PF00498	0.478
LIG_FHA_2	165	171	PF00498	0.345
LIG_FHA_2	18	24	PF00498	0.619
LIG_FHA_2	308	314	PF00498	0.536
LIG_FHA_2	389	395	PF00498	0.505
LIG_FHA_2	483	489	PF00498	0.667
LIG_FHA_2	73	79	PF00498	0.581
LIG_Integrin_RGD_1	40	42	PF01839	0.574
LIG_LIR_Nem_3	517	521	PF02991	0.406
LIG_LIR_Nem_3	98	103	PF02991	0.536
LIG_MYND_1	2	6	PF01753	0.659
LIG_Pex14_2	601	605	PF04695	0.467
LIG_SH2_CRK	633	637	PF00017	0.538
LIG_SH2_NCK_1	521	525	PF00017	0.468
LIG_SH2_SRC	510	513	PF00017	0.505
LIG_SH2_SRC	521	524	PF00017	0.304
LIG_SH2_STAP1	290	294	PF00017	0.567
LIG_SH2_STAT3	186	189	PF00017	0.488
LIG_SH2_STAT3	477	480	PF00017	0.567
LIG_SH2_STAT5	164	167	PF00017	0.380
LIG_SH2_STAT5	186	189	PF00017	0.389
LIG_SH2_STAT5	247	250	PF00017	0.478
LIG_SH2_STAT5	477	480	PF00017	0.468
LIG_SH2_STAT5	631	634	PF00017	0.546
LIG_SH3_3	201	207	PF00018	0.540
LIG_SH3_3	560	566	PF00018	0.462
LIG_SH3_3	636	642	PF00018	0.572
LIG_SH3_3	658	664	PF00018	0.466
LIG_SUMO_SIM_anti_2	71	78	PF11976	0.612
LIG_SUMO_SIM_par_1	376	381	PF11976	0.396
LIG_SUMO_SIM_par_1	71	78	PF11976	0.643
LIG_TRAF2_1	485	488	PF00917	0.663
LIG_TRAF2_1	69	72	PF00917	0.714
LIG_TRFH_1	534	538	PF08558	0.594
LIG_WW_3	626	630	PF00397	0.638
MOD_CDC14_SPxK_1	130	133	PF00782	0.600
MOD_CDK_SPK_2	559	564	PF00069	0.454
MOD_CDK_SPxK_1	127	133	PF00069	0.669
MOD_CDK_SPxxK_3	127	134	PF00069	0.404
MOD_CDK_SPxxK_3	203	210	PF00069	0.563
MOD_CK1_1	125	131	PF00069	0.643
MOD_CK1_1	132	138	PF00069	0.654
MOD_CK1_1	203	209	PF00069	0.528
MOD_CK1_1	309	315	PF00069	0.630
MOD_CK1_1	541	547	PF00069	0.598
MOD_CK1_1	559	565	PF00069	0.646
MOD_CK1_1	86	92	PF00069	0.459
MOD_CK2_1	133	139	PF00069	0.555
MOD_CK2_1	17	23	PF00069	0.658
MOD_CK2_1	307	313	PF00069	0.502
MOD_CK2_1	482	488	PF00069	0.665
MOD_CK2_1	615	621	PF00069	0.569
MOD_Cter_Amidation	60	63	PF01082	0.678
MOD_DYRK1A_RPxSP_1	660	664	PF00069	0.465
MOD_GlcNHglycan	113	116	PF01048	0.583
MOD_GlcNHglycan	123	127	PF01048	0.547
MOD_GlcNHglycan	194	197	PF01048	0.482
MOD_GlcNHglycan	262	265	PF01048	0.610
MOD_GlcNHglycan	349	352	PF01048	0.658
MOD_GlcNHglycan	380	383	PF01048	0.557
MOD_GlcNHglycan	385	388	PF01048	0.648
MOD_GlcNHglycan	542	546	PF01048	0.578
MOD_GlcNHglycan	576	581	PF01048	0.790
MOD_GlcNHglycan	85	88	PF01048	0.458
MOD_GlcNHglycan	89	92	PF01048	0.544
MOD_GSK3_1	111	118	PF00069	0.564
MOD_GSK3_1	125	132	PF00069	0.575
MOD_GSK3_1	133	140	PF00069	0.723
MOD_GSK3_1	192	199	PF00069	0.559
MOD_GSK3_1	256	263	PF00069	0.427
MOD_GSK3_1	295	302	PF00069	0.682
MOD_GSK3_1	303	310	PF00069	0.673
MOD_GSK3_1	331	338	PF00069	0.522
MOD_GSK3_1	374	381	PF00069	0.586
MOD_GSK3_1	534	541	PF00069	0.532
MOD_GSK3_1	609	616	PF00069	0.574
MOD_GSK3_1	641	648	PF00069	0.457
MOD_GSK3_1	79	86	PF00069	0.532
MOD_GSK3_1	87	94	PF00069	0.529
MOD_N-GLC_1	196	201	PF02516	0.588
MOD_NEK2_1	105	110	PF00069	0.431
MOD_NEK2_1	192	197	PF00069	0.441
MOD_NEK2_1	396	401	PF00069	0.452
MOD_NEK2_1	450	455	PF00069	0.535
MOD_NEK2_1	481	486	PF00069	0.549
MOD_NEK2_1	645	650	PF00069	0.440
MOD_NEK2_1	83	88	PF00069	0.484
MOD_NEK2_2	290	295	PF00069	0.522
MOD_NEK2_2	556	561	PF00069	0.554
MOD_PK_1	564	570	PF00069	0.481
MOD_PKA_1	133	139	PF00069	0.481
MOD_PKA_1	29	35	PF00069	0.625
MOD_PKA_1	532	538	PF00069	0.513
MOD_PKA_2	116	122	PF00069	0.480
MOD_PKA_2	132	138	PF00069	0.611
MOD_PKA_2	256	262	PF00069	0.316
MOD_PKA_2	29	35	PF00069	0.625
MOD_PKA_2	318	324	PF00069	0.560
MOD_PKA_2	394	400	PF00069	0.481
MOD_PKA_2	532	538	PF00069	0.513
MOD_Plk_1	17	23	PF00069	0.656
MOD_Plk_1	290	296	PF00069	0.619
MOD_Plk_1	91	97	PF00069	0.591
MOD_Plk_2-3	72	78	PF00069	0.611
MOD_Plk_4	331	337	PF00069	0.482
MOD_Plk_4	396	402	PF00069	0.433
MOD_Plk_4	473	479	PF00069	0.599
MOD_Plk_4	523	529	PF00069	0.322
MOD_Plk_4	609	615	PF00069	0.626
MOD_Plk_4	72	78	PF00069	0.593
MOD_Plk_4	79	85	PF00069	0.533
MOD_Plk_4	95	101	PF00069	0.333
MOD_ProDKin_1	127	133	PF00069	0.668
MOD_ProDKin_1	139	145	PF00069	0.686
MOD_ProDKin_1	200	206	PF00069	0.453
MOD_ProDKin_1	258	264	PF00069	0.588
MOD_ProDKin_1	430	436	PF00069	0.495
MOD_ProDKin_1	498	504	PF00069	0.441
MOD_ProDKin_1	534	540	PF00069	0.577
MOD_ProDKin_1	559	565	PF00069	0.694
TRG_DiLeu_BaEn_1	523	528	PF01217	0.496
TRG_ENDOCYTIC_2	598	601	PF00928	0.530
TRG_ER_diArg_1	448	450	PF00400	0.520
TRG_ER_diArg_1	532	534	PF00400	0.534
TRG_ER_diArg_1	62	64	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.750

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM77	Leptomonas seymouri	57%	81%
A0A1X0NK49	Trypanosomatidae	34%	94%
A0A3Q8II43	Leishmania donovani	92%	100%
A4H7C2	Leishmania braziliensis	81%	100%
A4HVR8	Leishmania infantum	92%	100%
D0A6H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	91%
Q4QG14	Leishmania major	92%	100%
V5BHJ9	Trypanosoma cruzi	37%	99%