Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APG3_LEIMU

TriTrypDb:

LmxM.13.1390

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.476
CLV_NRD_NRD_1	377	379	PF00675	0.576
CLV_PCSK_KEX2_1	142	144	PF00082	0.476
CLV_PCSK_KEX2_1	15	17	PF00082	0.603
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.637
CLV_PCSK_SKI1_1	293	297	PF00082	0.345
CLV_PCSK_SKI1_1	31	35	PF00082	0.488
CLV_PCSK_SKI1_1	378	382	PF00082	0.560
CLV_PCSK_SKI1_1	51	55	PF00082	0.294
DEG_SPOP_SBC_1	39	43	PF00917	0.574
DOC_AGCK_PIF_3	399	402	PF00069	0.426
DOC_CYCLIN_RxL_1	28	42	PF00134	0.513
DOC_MAPK_FxFP_2	11	14	PF00069	0.739
DOC_MAPK_gen_1	28	38	PF00069	0.489
DOC_PP1_RVXF_1	101	107	PF00149	0.429
DOC_PP4_FxxP_1	11	14	PF00568	0.642
DOC_PP4_FxxP_1	137	140	PF00568	0.379
DOC_PP4_FxxP_1	186	189	PF00568	0.379
DOC_USP7_MATH_1	138	142	PF00917	0.415
DOC_USP7_MATH_1	18	22	PF00917	0.734
DOC_USP7_MATH_1	202	206	PF00917	0.476
DOC_USP7_MATH_1	304	308	PF00917	0.322
DOC_USP7_MATH_1	39	43	PF00917	0.574
DOC_USP7_MATH_1	64	68	PF00917	0.304
DOC_USP7_MATH_1	90	94	PF00917	0.652
DOC_USP7_UBL2_3	171	175	PF12436	0.476
DOC_WW_Pin1_4	130	135	PF00397	0.379
DOC_WW_Pin1_4	222	227	PF00397	0.379
DOC_WW_Pin1_4	325	330	PF00397	0.379
LIG_14-3-3_CanoR_1	51	61	PF00244	0.349
LIG_14-3-3_CanoR_1	89	99	PF00244	0.660
LIG_APCC_ABBA_1	344	349	PF00400	0.379
LIG_BIR_III_4	69	73	PF00653	0.559
LIG_BRCT_BRCA1_1	140	144	PF00533	0.452
LIG_CtBP_PxDLS_1	316	320	PF00389	0.379
LIG_deltaCOP1_diTrp_1	240	250	PF00928	0.379
LIG_FHA_1	360	366	PF00498	0.424
LIG_FHA_2	205	211	PF00498	0.379
LIG_LIR_Apic_2	10	14	PF02991	0.593
LIG_LIR_Apic_2	136	140	PF02991	0.379
LIG_LIR_Apic_2	183	189	PF02991	0.379
LIG_LIR_Apic_2	198	202	PF02991	0.378
LIG_LIR_Gen_1	308	319	PF02991	0.379
LIG_LIR_Gen_1	388	399	PF02991	0.397
LIG_LIR_Gen_1	67	76	PF02991	0.278
LIG_LIR_Nem_3	287	291	PF02991	0.448
LIG_LIR_Nem_3	308	314	PF02991	0.357
LIG_LIR_Nem_3	388	394	PF02991	0.404
LIG_LIR_Nem_3	67	71	PF02991	0.456
LIG_PDZ_Class_2	397	402	PF00595	0.426
LIG_Pex14_2	124	128	PF04695	0.354
LIG_Pex14_2	195	199	PF04695	0.483
LIG_Pex14_2	71	75	PF04695	0.448
LIG_Rb_pABgroove_1	118	126	PF01858	0.379
LIG_SH2_STAT5	294	297	PF00017	0.329
LIG_SH3_3	58	64	PF00018	0.611
LIG_SUMO_SIM_par_1	157	162	PF11976	0.379
LIG_UBA3_1	393	398	PF00899	0.513
MOD_CDK_SPK_2	325	330	PF00069	0.379
MOD_CK1_1	133	139	PF00069	0.320
MOD_CK1_1	21	27	PF00069	0.514
MOD_CK1_1	4	10	PF00069	0.629
MOD_CK1_1	40	46	PF00069	0.581
MOD_CK1_1	91	97	PF00069	0.397
MOD_CK2_1	258	264	PF00069	0.739
MOD_CK2_1	269	275	PF00069	0.454
MOD_CK2_1	382	388	PF00069	0.573
MOD_CK2_1	90	96	PF00069	0.609
MOD_CMANNOS	243	246	PF00535	0.379
MOD_GlcNHglycan	233	236	PF01048	0.410
MOD_GlcNHglycan	269	272	PF01048	0.618
MOD_GlcNHglycan	42	45	PF01048	0.655
MOD_GSK3_1	126	133	PF00069	0.334
MOD_GSK3_1	267	274	PF00069	0.584
MOD_GSK3_1	38	45	PF00069	0.548
MOD_GSK3_1	382	389	PF00069	0.448
MOD_NEK2_1	1	6	PF00069	0.604
MOD_NEK2_1	114	119	PF00069	0.460
MOD_NEK2_1	38	43	PF00069	0.595
MOD_NEK2_1	54	59	PF00069	0.613
MOD_NEK2_1	81	86	PF00069	0.487
MOD_PIKK_1	108	114	PF00454	0.380
MOD_PIKK_1	126	132	PF00454	0.439
MOD_PK_1	382	388	PF00069	0.573
MOD_PKA_2	88	94	PF00069	0.530
MOD_Plk_1	382	388	PF00069	0.493
MOD_Plk_4	18	24	PF00069	0.592
MOD_Plk_4	264	270	PF00069	0.757
MOD_Plk_4	306	312	PF00069	0.342
MOD_ProDKin_1	130	136	PF00069	0.379
MOD_ProDKin_1	222	228	PF00069	0.379
MOD_ProDKin_1	325	331	PF00069	0.379
MOD_SUMO_rev_2	210	220	PF00179	0.476
MOD_SUMO_rev_2	24	33	PF00179	0.508
TRG_DiLeu_BaEn_1	264	269	PF01217	0.756
TRG_ENDOCYTIC_2	166	169	PF00928	0.439
TRG_ENDOCYTIC_2	311	314	PF00928	0.331
TRG_ENDOCYTIC_2	68	71	PF00928	0.456
TRG_ER_diArg_1	142	144	PF00400	0.476
TRG_NES_CRM1_1	112	125	PF08389	0.358
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW4	Leptomonas seymouri	64%	99%
A0A0S4IRF8	Bodo saltans	32%	87%
A0A179HLJ8	Purpureocillium lilacinum	31%	100%
A0A3S5H6P9	Leishmania donovani	93%	100%
A4HVR7	Leishmania infantum	93%	100%
P64760	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	35%	100%
P9WKP2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	100%
P9WKP3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	100%
Q02883	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	86%
Q4QG15	Leishmania major	94%	100%
Q58CN9	Bos taurus	38%	100%
Q5RCU3	Pongo abelii	38%	100%
Q6IQ20	Homo sapiens	38%	100%
Q769K2	Rattus norvegicus	39%	100%
Q8BH82	Mus musculus	34%	100%
Q965X7	Caenorhabditis elegans	31%	100%
Q965X9	Caenorhabditis elegans	31%	100%