Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9APG2_LEIMU

TriTrypDb:

LmxM.13.1380

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9APG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APG2

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	418	420	PF00675	0.216
CLV_NRD_NRD_1	421	423	PF00675	0.213
CLV_NRD_NRD_1	440	442	PF00675	0.305
CLV_PCSK_KEX2_1	418	420	PF00082	0.234
CLV_PCSK_KEX2_1	423	425	PF00082	0.265
CLV_PCSK_KEX2_1	99	101	PF00082	0.445
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.240
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.445
CLV_PCSK_PC7_1	414	420	PF00082	0.228
CLV_PCSK_PC7_1	95	101	PF00082	0.383
CLV_PCSK_SKI1_1	140	144	PF00082	0.344
CLV_PCSK_SKI1_1	414	418	PF00082	0.224
CLV_PCSK_SKI1_1	447	451	PF00082	0.403
DEG_MDM2_SWIB_1	469	477	PF02201	0.249
DOC_AGCK_PIF_1	462	467	PF00069	0.259
DOC_CYCLIN_RxL_1	441	453	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.237
DOC_MAPK_gen_1	235	244	PF00069	0.344
DOC_MAPK_MEF2A_6	389	397	PF00069	0.312
DOC_PP2B_LxvP_1	360	363	PF13499	0.237
DOC_PP2B_PxIxI_1	456	462	PF00149	0.382
DOC_PP4_FxxP_1	271	274	PF00568	0.510
DOC_PP4_FxxP_1	342	345	PF00568	0.471
DOC_SPAK_OSR1_1	251	255	PF12202	0.344
DOC_USP7_MATH_1	21	25	PF00917	0.466
DOC_USP7_MATH_1	496	500	PF00917	0.379
DOC_WW_Pin1_4	165	170	PF00397	0.310
LIG_14-3-3_CanoR_1	204	212	PF00244	0.307
LIG_14-3-3_CanoR_1	307	311	PF00244	0.271
LIG_14-3-3_CanoR_1	418	426	PF00244	0.488
LIG_APCC_ABBA_1	459	464	PF00400	0.382
LIG_BRCT_BRCA1_1	182	186	PF00533	0.215
LIG_BRCT_BRCA1_1	197	201	PF00533	0.215
LIG_BRCT_BRCA1_1	452	456	PF00533	0.206
LIG_BRCT_BRCA1_1	465	469	PF00533	0.265
LIG_BRCT_BRCA1_1	517	521	PF00533	0.285
LIG_BRCT_BRCA1_1	553	557	PF00533	0.224
LIG_EH1_1	251	259	PF00400	0.344
LIG_eIF4E_1	555	561	PF01652	0.150
LIG_FHA_1	147	153	PF00498	0.324
LIG_FHA_1	179	185	PF00498	0.233
LIG_FHA_1	201	207	PF00498	0.335
LIG_FHA_1	216	222	PF00498	0.331
LIG_FHA_1	227	233	PF00498	0.323
LIG_FHA_1	293	299	PF00498	0.376
LIG_FHA_1	314	320	PF00498	0.344
LIG_FHA_1	323	329	PF00498	0.222
LIG_FHA_1	356	362	PF00498	0.269
LIG_FHA_1	366	372	PF00498	0.290
LIG_FHA_1	458	464	PF00498	0.202
LIG_FHA_1	485	491	PF00498	0.224
LIG_FHA_1	493	499	PF00498	0.300
LIG_FHA_1	501	507	PF00498	0.249
LIG_FHA_2	121	127	PF00498	0.230
LIG_FHA_2	58	64	PF00498	0.332
LIG_FHA_2	67	73	PF00498	0.307
LIG_IBAR_NPY_1	46	48	PF08397	0.234
LIG_IRF3_LxIS_1	12	19	PF10401	0.303
LIG_LIR_Apic_2	269	274	PF02991	0.471
LIG_LIR_Gen_1	141	151	PF02991	0.172
LIG_LIR_Gen_1	179	188	PF02991	0.252
LIG_LIR_Gen_1	210	220	PF02991	0.212
LIG_LIR_Gen_1	265	274	PF02991	0.460
LIG_LIR_Gen_1	277	288	PF02991	0.463
LIG_LIR_Gen_1	316	324	PF02991	0.459
LIG_LIR_Gen_1	333	343	PF02991	0.227
LIG_LIR_Gen_1	358	367	PF02991	0.245
LIG_LIR_Gen_1	460	469	PF02991	0.327
LIG_LIR_Gen_1	488	498	PF02991	0.201
LIG_LIR_Gen_1	49	57	PF02991	0.226
LIG_LIR_Gen_1	503	510	PF02991	0.260
LIG_LIR_Gen_1	554	565	PF02991	0.246
LIG_LIR_Nem_3	101	105	PF02991	0.300
LIG_LIR_Nem_3	107	113	PF02991	0.257
LIG_LIR_Nem_3	141	146	PF02991	0.318
LIG_LIR_Nem_3	149	154	PF02991	0.300
LIG_LIR_Nem_3	179	185	PF02991	0.232
LIG_LIR_Nem_3	210	215	PF02991	0.330
LIG_LIR_Nem_3	260	266	PF02991	0.422
LIG_LIR_Nem_3	277	283	PF02991	0.411
LIG_LIR_Nem_3	316	320	PF02991	0.346
LIG_LIR_Nem_3	358	362	PF02991	0.370
LIG_LIR_Nem_3	453	459	PF02991	0.229
LIG_LIR_Nem_3	460	465	PF02991	0.322
LIG_LIR_Nem_3	466	472	PF02991	0.292
LIG_LIR_Nem_3	474	478	PF02991	0.195
LIG_LIR_Nem_3	488	494	PF02991	0.254
LIG_LIR_Nem_3	49	54	PF02991	0.223
LIG_LIR_Nem_3	503	507	PF02991	0.257
LIG_LIR_Nem_3	554	560	PF02991	0.287
LIG_MAD2	35	43	PF02301	0.199
LIG_MYND_1	433	437	PF01753	0.400
LIG_NRBOX	2	8	PF00104	0.441
LIG_NRBOX	219	225	PF00104	0.366
LIG_NRBOX	69	75	PF00104	0.296
LIG_OCRL_FandH_1	142	154	PF00620	0.144
LIG_Pex14_1	263	267	PF04695	0.428
LIG_Pex14_1	351	355	PF04695	0.510
LIG_Pex14_2	197	201	PF04695	0.209
LIG_Pex14_2	320	324	PF04695	0.194
LIG_Pex14_2	355	359	PF04695	0.382
LIG_Pex14_2	458	462	PF04695	0.366
LIG_Pex14_2	465	469	PF04695	0.303
LIG_Pex14_2	535	539	PF04695	0.346
LIG_SH2_CRK	182	186	PF00017	0.271
LIG_SH2_CRK	276	280	PF00017	0.366
LIG_SH2_CRK	481	485	PF00017	0.228
LIG_SH2_CRK	528	532	PF00017	0.150
LIG_SH2_GRB2like	193	196	PF00017	0.310
LIG_SH2_NCK_1	182	186	PF00017	0.271
LIG_SH2_NCK_1	267	271	PF00017	0.510
LIG_SH2_NCK_1	366	370	PF00017	0.300
LIG_SH2_PTP2	151	154	PF00017	0.296
LIG_SH2_PTP2	491	494	PF00017	0.325
LIG_SH2_SRC	267	270	PF00017	0.449
LIG_SH2_SRC	51	54	PF00017	0.175
LIG_SH2_STAP1	105	109	PF00017	0.271
LIG_SH2_STAP1	120	124	PF00017	0.177
LIG_SH2_STAP1	178	182	PF00017	0.222
LIG_SH2_STAP1	193	197	PF00017	0.194
LIG_SH2_STAP1	267	271	PF00017	0.486
LIG_SH2_STAP1	366	370	PF00017	0.300
LIG_SH2_STAP1	528	532	PF00017	0.277
LIG_SH2_STAP1	553	557	PF00017	0.234
LIG_SH2_STAT5	151	154	PF00017	0.229
LIG_SH2_STAT5	178	181	PF00017	0.263
LIG_SH2_STAT5	276	279	PF00017	0.503
LIG_SH2_STAT5	28	31	PF00017	0.306
LIG_SH2_STAT5	322	325	PF00017	0.346
LIG_SH2_STAT5	380	383	PF00017	0.261
LIG_SH2_STAT5	387	390	PF00017	0.279
LIG_SH2_STAT5	415	418	PF00017	0.477
LIG_SH2_STAT5	443	446	PF00017	0.498
LIG_SH2_STAT5	448	451	PF00017	0.359
LIG_SH2_STAT5	491	494	PF00017	0.307
LIG_SH2_STAT5	53	56	PF00017	0.222
LIG_SH2_STAT5	537	540	PF00017	0.260
LIG_SH2_STAT5	555	558	PF00017	0.147
LIG_SH2_STAT5	572	575	PF00017	0.382
LIG_SH2_STAT5	577	580	PF00017	0.492
LIG_SH3_1	434	440	PF00018	0.415
LIG_SH3_2	437	442	PF14604	0.471
LIG_SH3_3	398	404	PF00018	0.264
LIG_SH3_3	434	440	PF00018	0.432
LIG_SUMO_SIM_anti_2	218	224	PF11976	0.389
LIG_SUMO_SIM_par_1	221	227	PF11976	0.327
LIG_SUMO_SIM_par_1	289	295	PF11976	0.306
LIG_SUMO_SIM_par_1	448	453	PF11976	0.330
LIG_SUMO_SIM_par_1	65	72	PF11976	0.205
LIG_TRAF2_1	60	63	PF00917	0.265
LIG_TRFH_1	359	363	PF08558	0.314
LIG_TYR_ITIM	526	531	PF00017	0.150
LIG_TYR_ITSM	147	154	PF00017	0.363
LIG_UBA3_1	534	540	PF00899	0.150
LIG_WRC_WIRS_1	177	182	PF05994	0.259
LIG_WRC_WIRS_1	314	319	PF05994	0.440
LIG_WRC_WIRS_1	472	477	PF05994	0.248
LIG_WRC_WIRS_1	501	506	PF05994	0.314
LIG_WW_3	438	442	PF00397	0.382
MOD_CDC14_SPxK_1	168	171	PF00782	0.382
MOD_CDK_SPxK_1	165	171	PF00069	0.382
MOD_CK1_1	19	25	PF00069	0.542
MOD_CK1_1	207	213	PF00069	0.259
MOD_CK1_1	301	307	PF00069	0.411
MOD_CK1_1	471	477	PF00069	0.314
MOD_CK2_1	135	141	PF00069	0.208
MOD_CK2_1	186	192	PF00069	0.422
MOD_CK2_1	57	63	PF00069	0.413
MOD_CK2_1	66	72	PF00069	0.378
MOD_GlcNHglycan	18	21	PF01048	0.430
MOD_GlcNHglycan	197	200	PF01048	0.208
MOD_GlcNHglycan	259	263	PF01048	0.328
MOD_GlcNHglycan	325	328	PF01048	0.322
MOD_GlcNHglycan	332	335	PF01048	0.294
MOD_GlcNHglycan	373	376	PF01048	0.218
MOD_GlcNHglycan	452	455	PF01048	0.400
MOD_GlcNHglycan	8	11	PF01048	0.399
MOD_GlcNHglycan	92	95	PF01048	0.150
MOD_GSK3_1	160	167	PF00069	0.314
MOD_GSK3_1	176	183	PF00069	0.250
MOD_GSK3_1	2	9	PF00069	0.577
MOD_GSK3_1	200	207	PF00069	0.401
MOD_GSK3_1	211	218	PF00069	0.312
MOD_GSK3_1	258	265	PF00069	0.150
MOD_GSK3_1	463	470	PF00069	0.376
MOD_GSK3_1	482	489	PF00069	0.254
MOD_GSK3_1	492	499	PF00069	0.248
MOD_GSK3_1	77	84	PF00069	0.358
MOD_N-GLC_1	160	165	PF02516	0.269
MOD_N-GLC_1	90	95	PF02516	0.252
MOD_NEK2_1	146	151	PF00069	0.334
MOD_NEK2_1	16	21	PF00069	0.376
MOD_NEK2_1	164	169	PF00069	0.323
MOD_NEK2_1	180	185	PF00069	0.277
MOD_NEK2_1	186	191	PF00069	0.299
MOD_NEK2_1	215	220	PF00069	0.365
MOD_NEK2_1	224	229	PF00069	0.292
MOD_NEK2_1	231	236	PF00069	0.212
MOD_NEK2_1	291	296	PF00069	0.368
MOD_NEK2_1	355	360	PF00069	0.246
MOD_NEK2_1	378	383	PF00069	0.239
MOD_NEK2_1	450	455	PF00069	0.298
MOD_NEK2_1	467	472	PF00069	0.314
MOD_NEK2_1	484	489	PF00069	0.168
MOD_NEK2_1	521	526	PF00069	0.249
MOD_NEK2_1	538	543	PF00069	0.249
MOD_NEK2_1	551	556	PF00069	0.259
MOD_NEK2_1	573	578	PF00069	0.402
MOD_NEK2_1	6	11	PF00069	0.361
MOD_NEK2_2	21	26	PF00069	0.315
MOD_NEK2_2	262	267	PF00069	0.150
MOD_NEK2_2	457	462	PF00069	0.297
MOD_PIKK_1	380	386	PF00454	0.194
MOD_PK_1	515	521	PF00069	0.363
MOD_PKA_2	195	201	PF00069	0.399
MOD_PKA_2	274	280	PF00069	0.377
MOD_PKA_2	306	312	PF00069	0.332
MOD_PKA_2	417	423	PF00069	0.349
MOD_PKB_1	209	217	PF00069	0.328
MOD_Plk_1	120	126	PF00069	0.393
MOD_Plk_1	160	166	PF00069	0.269
MOD_Plk_1	186	192	PF00069	0.289
MOD_Plk_1	463	469	PF00069	0.297
MOD_Plk_2-3	135	141	PF00069	0.216
MOD_Plk_2-3	187	193	PF00069	0.314
MOD_Plk_4	146	152	PF00069	0.334
MOD_Plk_4	173	179	PF00069	0.308
MOD_Plk_4	180	186	PF00069	0.258
MOD_Plk_4	211	217	PF00069	0.186
MOD_Plk_4	24	30	PF00069	0.551
MOD_Plk_4	298	304	PF00069	0.398
MOD_Plk_4	355	361	PF00069	0.428
MOD_Plk_4	468	474	PF00069	0.288
MOD_Plk_4	486	492	PF00069	0.208
MOD_Plk_4	496	502	PF00069	0.320
MOD_Plk_4	568	574	PF00069	0.248
MOD_ProDKin_1	165	171	PF00069	0.382
MOD_SUMO_for_1	170	173	PF00179	0.314
MOD_SUMO_for_1	242	245	PF00179	0.314
MOD_SUMO_rev_2	32	37	PF00179	0.288
TRG_DiLeu_BaEn_2	140	146	PF01217	0.216
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.256
TRG_ENDOCYTIC_2	151	154	PF00928	0.363
TRG_ENDOCYTIC_2	182	185	PF00928	0.328
TRG_ENDOCYTIC_2	267	270	PF00928	0.260
TRG_ENDOCYTIC_2	276	279	PF00928	0.268
TRG_ENDOCYTIC_2	335	338	PF00928	0.293
TRG_ENDOCYTIC_2	448	451	PF00928	0.393
TRG_ENDOCYTIC_2	481	484	PF00928	0.254
TRG_ENDOCYTIC_2	491	494	PF00928	0.260
TRG_ENDOCYTIC_2	51	54	PF00928	0.262
TRG_ENDOCYTIC_2	528	531	PF00928	0.240
TRG_ENDOCYTIC_2	532	535	PF00928	0.265
TRG_ER_diArg_1	209	212	PF00400	0.295
TRG_ER_diArg_1	417	419	PF00400	0.259
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	26%	88%
A0A0N1I2B1	Leptomonas seymouri	24%	93%
A0A0N1I6Y7	Leptomonas seymouri	22%	95%
A0A0N1IME8	Leptomonas seymouri	59%	100%
A0A0S4IV41	Bodo saltans	24%	92%
A0A0S4J9X2	Bodo saltans	21%	91%
A0A0S4JBB1	Bodo saltans	29%	92%
A0A0S4JCH7	Bodo saltans	24%	86%
A0A0S4JIF4	Bodo saltans	27%	92%
A0A0S4JWZ9	Bodo saltans	26%	96%
A0A0S4JZ31	Bodo saltans	29%	100%
A0A1X0NJN3	Trypanosomatidae	37%	99%
A0A1X0NK64	Trypanosomatidae	23%	94%
A0A1X0NLM6	Trypanosomatidae	27%	100%
A0A1X0NZX5	Trypanosomatidae	26%	91%
A0A1X0P2G3	Trypanosomatidae	23%	93%
A0A1X0P6M4	Trypanosomatidae	24%	77%
A0A1X0PA12	Trypanosomatidae	27%	93%
A0A3Q8IBT4	Leishmania donovani	80%	100%
A0A3Q8IFM1	Leishmania donovani	23%	92%
A0A3Q8IHT3	Leishmania donovani	22%	92%
A0A3R7MBZ3	Trypanosoma rangeli	24%	94%
A0A3S7X2L7	Leishmania donovani	24%	86%
A0A422NED2	Trypanosoma rangeli	24%	91%
A0A422NMS9	Trypanosoma rangeli	25%	90%
A0A422P482	Trypanosoma rangeli	36%	98%
A4H7C1	Leishmania braziliensis	71%	100%
A4HB85	Leishmania braziliensis	21%	100%
A4HHH4	Leishmania braziliensis	24%	87%
A4HHY3	Leishmania braziliensis	24%	100%
A4HVR6	Leishmania infantum	80%	100%
A4I4M3	Leishmania infantum	24%	87%
A4I563	Leishmania infantum	23%	92%
A4IAD3	Leishmania infantum	22%	92%
A4IFE9	Bos taurus	28%	97%
A5D7E2	Bos taurus	30%	92%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	81%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	93%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AE21	Leishmania major	21%	87%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	87%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	90%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	92%
F4HW17	Arabidopsis thaliana	28%	100%
F4JRE0	Arabidopsis thaliana	28%	90%
F4KIB2	Arabidopsis thaliana	24%	91%
O15321	Homo sapiens	28%	97%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	88%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	83%
P58021	Mus musculus	24%	89%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	88%
Q4KLL4	Rattus norvegicus	30%	92%
Q4Q2H8	Leishmania major	21%	98%
Q4Q7S3	Leishmania major	23%	100%
Q4QG16	Leishmania major	77%	100%
Q54ZW0	Dictyostelium discoideum	27%	100%
Q55FP0	Dictyostelium discoideum	27%	92%
Q5R8F1	Pongo abelii	28%	97%
Q5R8Y6	Pongo abelii	24%	89%
Q5RDY2	Pongo abelii	30%	92%
Q66HF2	Rattus norvegicus	28%	100%
Q66HG5	Rattus norvegicus	24%	89%
Q7YTA6	Dictyostelium discoideum	23%	90%
Q8BH24	Mus musculus	30%	92%
Q8RWW1	Arabidopsis thaliana	24%	92%
Q92544	Homo sapiens	30%	92%
Q940G0	Arabidopsis thaliana	32%	100%
Q940S0	Arabidopsis thaliana	27%	99%
Q99805	Homo sapiens	24%	89%
Q9C5N2	Arabidopsis thaliana	24%	91%
Q9C720	Arabidopsis thaliana	25%	92%
Q9DBU0	Mus musculus	29%	97%
Q9ET30	Mus musculus	30%	100%
Q9FHT4	Arabidopsis thaliana	27%	99%
Q9FYQ8	Arabidopsis thaliana	29%	90%
Q9HD45	Homo sapiens	30%	100%
Q9LIC2	Arabidopsis thaliana	25%	92%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	94%
Q9ZPS7	Arabidopsis thaliana	28%	99%
V5BCD5	Trypanosoma cruzi	23%	93%
V5BHS7	Trypanosoma cruzi	25%	100%
V5D9U0	Trypanosoma cruzi	27%	91%
V5DII3	Trypanosoma cruzi	35%	98%