RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APF7_LEIMU

TriTrypDb:

LmxM.13.1330

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9APF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	420	422	PF00675	0.515
CLV_PCSK_FUR_1	417	421	PF00082	0.510
CLV_PCSK_KEX2_1	416	418	PF00082	0.543
CLV_PCSK_KEX2_1	419	421	PF00082	0.516
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.555
CLV_PCSK_SKI1_1	192	196	PF00082	0.453
CLV_PCSK_SKI1_1	236	240	PF00082	0.657
CLV_PCSK_SKI1_1	33	37	PF00082	0.658
DEG_APCC_DBOX_1	67	75	PF00400	0.645
DEG_SCF_FBW7_1	409	415	PF00400	0.792
DEG_SPOP_SBC_1	193	197	PF00917	0.453
DEG_SPOP_SBC_1	397	401	PF00917	0.659
DOC_CKS1_1	409	414	PF01111	0.791
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.380
DOC_MAPK_gen_1	66	74	PF00069	0.645
DOC_MAPK_RevD_3	405	418	PF00069	0.749
DOC_PP4_FxxP_1	221	224	PF00568	0.453
DOC_PP4_FxxP_1	295	298	PF00568	0.757
DOC_USP7_MATH_1	13	17	PF00917	0.435
DOC_USP7_MATH_1	130	134	PF00917	0.695
DOC_USP7_MATH_1	194	198	PF00917	0.453
DOC_USP7_MATH_1	241	245	PF00917	0.506
DOC_USP7_MATH_1	257	261	PF00917	0.451
DOC_USP7_MATH_1	315	319	PF00917	0.680
DOC_USP7_MATH_1	393	397	PF00917	0.754
DOC_USP7_MATH_1	486	490	PF00917	0.512
DOC_USP7_UBL2_3	108	112	PF12436	0.726
DOC_WW_Pin1_4	154	159	PF00397	0.610
DOC_WW_Pin1_4	231	236	PF00397	0.546
DOC_WW_Pin1_4	252	257	PF00397	0.476
DOC_WW_Pin1_4	311	316	PF00397	0.712
DOC_WW_Pin1_4	328	333	PF00397	0.644
DOC_WW_Pin1_4	369	374	PF00397	0.696
DOC_WW_Pin1_4	408	413	PF00397	0.791
DOC_WW_Pin1_4	456	461	PF00397	0.506
DOC_WW_Pin1_4	50	55	PF00397	0.306
LIG_14-3-3_CanoR_1	131	140	PF00244	0.812
LIG_14-3-3_CanoR_1	192	202	PF00244	0.402
LIG_14-3-3_CanoR_1	357	367	PF00244	0.682
LIG_Actin_WH2_1	333	349	PF00022	0.557
LIG_Actin_WH2_2	334	349	PF00022	0.557
LIG_BRCT_BRCA1_1	275	279	PF00533	0.714
LIG_CaM_NSCaTE_8	483	490	PF13499	0.385
LIG_EH1_1	334	342	PF00400	0.646
LIG_eIF4E_1	335	341	PF01652	0.644
LIG_FHA_1	194	200	PF00498	0.326
LIG_FHA_1	259	265	PF00498	0.252
LIG_FHA_1	294	300	PF00498	0.725
LIG_FHA_1	409	415	PF00498	0.792
LIG_FHA_1	422	428	PF00498	0.648
LIG_FHA_1	488	494	PF00498	0.515
LIG_FHA_1	51	57	PF00498	0.486
LIG_FHA_2	474	480	PF00498	0.479
LIG_LIR_Apic_2	216	220	PF02991	0.484
LIG_LIR_Gen_1	204	210	PF02991	0.428
LIG_LIR_Gen_1	287	295	PF02991	0.728
LIG_LIR_Gen_1	324	335	PF02991	0.651
LIG_LIR_Nem_3	204	208	PF02991	0.428
LIG_LIR_Nem_3	260	265	PF02991	0.424
LIG_LIR_Nem_3	276	282	PF02991	0.570
LIG_LIR_Nem_3	287	292	PF02991	0.680
LIG_LIR_Nem_3	324	330	PF02991	0.652
LIG_LIR_Nem_3	441	447	PF02991	0.335
LIG_LIR_Nem_3	464	470	PF02991	0.524
LIG_LIR_Nem_3	476	481	PF02991	0.434
LIG_PDZ_Class_2	491	496	PF00595	0.523
LIG_Pex14_1	275	279	PF04695	0.667
LIG_SH2_CRK	161	165	PF00017	0.702
LIG_SH2_CRK	186	190	PF00017	0.492
LIG_SH2_CRK	217	221	PF00017	0.427
LIG_SH2_NCK_1	217	221	PF00017	0.427
LIG_SH2_STAT5	335	338	PF00017	0.649
LIG_SH2_STAT5	481	484	PF00017	0.520
LIG_SH3_2	342	347	PF14604	0.688
LIG_SH3_3	152	158	PF00018	0.613
LIG_SH3_3	250	256	PF00018	0.491
LIG_SH3_3	339	345	PF00018	0.726
LIG_SH3_3	389	395	PF00018	0.695
LIG_SH3_3	406	412	PF00018	0.749
LIG_SUMO_SIM_anti_2	489	495	PF11976	0.429
LIG_SUMO_SIM_par_1	195	204	PF11976	0.294
LIG_SUMO_SIM_par_1	467	473	PF11976	0.496
LIG_TRAF2_1	97	100	PF00917	0.748
LIG_WRC_WIRS_1	202	207	PF05994	0.389
LIG_WRC_WIRS_1	264	269	PF05994	0.453
LIG_WW_2	392	395	PF00397	0.614
MOD_CDK_SPK_2	231	236	PF00069	0.501
MOD_CDK_SPK_2	328	333	PF00069	0.644
MOD_CK1_1	106	112	PF00069	0.657
MOD_CK1_1	132	138	PF00069	0.694
MOD_CK1_1	201	207	PF00069	0.387
MOD_CK1_1	234	240	PF00069	0.525
MOD_CK1_1	246	252	PF00069	0.451
MOD_CK1_1	314	320	PF00069	0.627
MOD_CK1_1	396	402	PF00069	0.813
MOD_CK1_1	453	459	PF00069	0.440
MOD_CK1_1	461	467	PF00069	0.467
MOD_CK1_1	489	495	PF00069	0.515
MOD_CK2_1	357	363	PF00069	0.554
MOD_GlcNHglycan	15	18	PF01048	0.576
MOD_GlcNHglycan	19	23	PF01048	0.569
MOD_GlcNHglycan	239	242	PF01048	0.721
MOD_GlcNHglycan	269	272	PF01048	0.324
MOD_GlcNHglycan	306	309	PF01048	0.571
MOD_GlcNHglycan	395	398	PF01048	0.574
MOD_GlcNHglycan	401	404	PF01048	0.546
MOD_GlcNHglycan	456	459	PF01048	0.699
MOD_GSK3_1	129	136	PF00069	0.692
MOD_GSK3_1	150	157	PF00069	0.693
MOD_GSK3_1	194	201	PF00069	0.373
MOD_GSK3_1	237	244	PF00069	0.521
MOD_GSK3_1	263	270	PF00069	0.324
MOD_GSK3_1	306	313	PF00069	0.755
MOD_GSK3_1	322	329	PF00069	0.740
MOD_GSK3_1	357	364	PF00069	0.657
MOD_GSK3_1	369	376	PF00069	0.667
MOD_GSK3_1	377	384	PF00069	0.691
MOD_GSK3_1	393	400	PF00069	0.731
MOD_GSK3_1	408	415	PF00069	0.734
MOD_GSK3_1	449	456	PF00069	0.545
MOD_N-GLC_1	258	263	PF02516	0.596
MOD_N-GLC_1	304	309	PF02516	0.415
MOD_NEK2_1	174	179	PF00069	0.641
MOD_NEK2_1	18	23	PF00069	0.414
MOD_NEK2_1	247	252	PF00069	0.552
MOD_NEK2_1	267	272	PF00069	0.335
MOD_NEK2_1	322	327	PF00069	0.733
MOD_NEK2_1	336	341	PF00069	0.580
MOD_NEK2_1	426	431	PF00069	0.588
MOD_NEK2_1	449	454	PF00069	0.537
MOD_NEK2_2	243	248	PF00069	0.522
MOD_PIKK_1	134	140	PF00454	0.714
MOD_PIKK_1	293	299	PF00454	0.693
MOD_PIKK_1	315	321	PF00454	0.757
MOD_PKA_2	130	136	PF00069	0.738
MOD_PKA_2	356	362	PF00069	0.724
MOD_PKB_1	419	427	PF00069	0.737
MOD_Plk_1	258	264	PF00069	0.376
MOD_Plk_1	440	446	PF00069	0.389
MOD_Plk_4	139	145	PF00069	0.684
MOD_Plk_4	150	156	PF00069	0.660
MOD_Plk_4	201	207	PF00069	0.364
MOD_Plk_4	243	249	PF00069	0.511
MOD_Plk_4	26	32	PF00069	0.458
MOD_Plk_4	284	290	PF00069	0.637
MOD_Plk_4	322	328	PF00069	0.729
MOD_Plk_4	336	342	PF00069	0.593
MOD_Plk_4	489	495	PF00069	0.429
MOD_ProDKin_1	154	160	PF00069	0.606
MOD_ProDKin_1	231	237	PF00069	0.542
MOD_ProDKin_1	252	258	PF00069	0.473
MOD_ProDKin_1	311	317	PF00069	0.711
MOD_ProDKin_1	328	334	PF00069	0.644
MOD_ProDKin_1	369	375	PF00069	0.697
MOD_ProDKin_1	408	414	PF00069	0.791
MOD_ProDKin_1	456	462	PF00069	0.508
MOD_ProDKin_1	50	56	PF00069	0.306
MOD_SUMO_rev_2	29	38	PF00179	0.528
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.775
TRG_ENDOCYTIC_2	161	164	PF00928	0.758
TRG_ENDOCYTIC_2	186	189	PF00928	0.630
TRG_ENDOCYTIC_2	335	338	PF00928	0.649
TRG_ER_diArg_1	417	420	PF00400	0.723
TRG_NLS_MonoCore_2	415	420	PF00514	0.753
TRG_NLS_MonoExtC_3	415	420	PF00514	0.753

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I976	Leptomonas seymouri	43%	96%
A0A3Q8ICY4	Leishmania donovani	88%	100%
A4H7B6	Leishmania braziliensis	70%	100%
A4HVR1	Leishmania infantum	87%	100%
Q4QG21	Leishmania major	86%	99%