LeishMANIAdb
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Protein Skeletor

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein Skeletor
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9APF6_LEIMU
TriTrypDb:
LmxM.13.1320
Length:
465

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 4
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Expansion

Sequence features

E9APF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APF6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 300 306 PF00089 0.414
CLV_NRD_NRD_1 342 344 PF00675 0.518
CLV_NRD_NRD_1 375 377 PF00675 0.455
CLV_NRD_NRD_1 432 434 PF00675 0.569
CLV_NRD_NRD_1 436 438 PF00675 0.558
CLV_PCSK_KEX2_1 342 344 PF00082 0.519
CLV_PCSK_KEX2_1 375 377 PF00082 0.439
CLV_PCSK_KEX2_1 432 434 PF00082 0.568
CLV_PCSK_KEX2_1 436 438 PF00082 0.557
CLV_PCSK_PC7_1 432 438 PF00082 0.557
CLV_PCSK_SKI1_1 251 255 PF00082 0.668
DEG_Nend_UBRbox_3 1 3 PF02207 0.418
DOC_ANK_TNKS_1 375 382 PF00023 0.628
DOC_MAPK_RevD_3 362 376 PF00069 0.575
DOC_PP1_RVXF_1 249 256 PF00149 0.482
DOC_USP7_MATH_1 105 109 PF00917 0.387
DOC_USP7_MATH_1 6 10 PF00917 0.381
DOC_WW_Pin1_4 325 330 PF00397 0.611
DOC_WW_Pin1_4 332 337 PF00397 0.772
LIG_14-3-3_CanoR_1 157 166 PF00244 0.176
LIG_14-3-3_CanoR_1 234 244 PF00244 0.428
LIG_14-3-3_CanoR_1 441 450 PF00244 0.829
LIG_14-3-3_CanoR_1 47 56 PF00244 0.262
LIG_BIR_III_4 67 71 PF00653 0.251
LIG_BRCT_BRCA1_1 443 447 PF00533 0.756
LIG_Clathr_ClatBox_1 202 206 PF01394 0.290
LIG_CtBP_PxDLS_1 359 363 PF00389 0.587
LIG_FHA_1 197 203 PF00498 0.383
LIG_FHA_1 59 65 PF00498 0.256
LIG_FHA_2 380 386 PF00498 0.669
LIG_FHA_2 419 425 PF00498 0.652
LIG_FHA_2 444 450 PF00498 0.695
LIG_FHA_2 58 64 PF00498 0.247
LIG_LIR_Apic_2 419 425 PF02991 0.677
LIG_LIR_Gen_1 194 203 PF02991 0.362
LIG_LIR_Gen_1 219 230 PF02991 0.331
LIG_LIR_Gen_1 258 269 PF02991 0.332
LIG_LIR_Gen_1 3 12 PF02991 0.367
LIG_LIR_Nem_3 149 155 PF02991 0.309
LIG_LIR_Nem_3 194 198 PF02991 0.394
LIG_LIR_Nem_3 219 225 PF02991 0.354
LIG_LIR_Nem_3 227 231 PF02991 0.403
LIG_LIR_Nem_3 258 264 PF02991 0.358
LIG_LIR_Nem_3 3 7 PF02991 0.455
LIG_LIR_Nem_3 444 450 PF02991 0.750
LIG_MYND_1 325 329 PF01753 0.635
LIG_NRBOX 11 17 PF00104 0.451
LIG_PDZ_Class_2 460 465 PF00595 0.701
LIG_Pex14_1 133 137 PF04695 0.323
LIG_Pex14_1 152 156 PF04695 0.323
LIG_Pex14_1 260 264 PF04695 0.359
LIG_Pex14_2 246 250 PF04695 0.486
LIG_PTB_Apo_2 197 204 PF02174 0.257
LIG_SH2_CRK 195 199 PF00017 0.411
LIG_SH2_CRK 222 226 PF00017 0.320
LIG_SH2_CRK 322 326 PF00017 0.666
LIG_SH2_NCK_1 195 199 PF00017 0.316
LIG_SH2_NCK_1 322 326 PF00017 0.666
LIG_SH2_SRC 378 381 PF00017 0.645
LIG_SH2_SRC 422 425 PF00017 0.675
LIG_SH2_STAT5 100 103 PF00017 0.379
LIG_SH2_STAT5 281 284 PF00017 0.436
LIG_SH2_STAT5 308 311 PF00017 0.700
LIG_SH2_STAT5 58 61 PF00017 0.338
LIG_SH3_3 104 110 PF00018 0.324
LIG_SH3_3 173 179 PF00018 0.273
LIG_SH3_3 205 211 PF00018 0.320
LIG_SH3_3 229 235 PF00018 0.524
LIG_SH3_3 350 356 PF00018 0.649
LIG_SH3_3 402 408 PF00018 0.680
LIG_SH3_3 447 453 PF00018 0.738
LIG_SUMO_SIM_par_1 11 17 PF11976 0.546
LIG_TRAF2_1 289 292 PF00917 0.674
LIG_TRAF2_1 336 339 PF00917 0.759
LIG_TRAF2_1 421 424 PF00917 0.695
LIG_TRAF2_1 60 63 PF00917 0.231
LIG_TRAF2_2 353 358 PF00917 0.655
LIG_TRFH_1 228 232 PF08558 0.339
LIG_UBA3_1 33 39 PF00899 0.445
LIG_WRC_WIRS_1 1 6 PF05994 0.389
MOD_CK1_1 194 200 PF00069 0.418
MOD_CK1_1 435 441 PF00069 0.781
MOD_CK1_1 48 54 PF00069 0.361
MOD_CK2_1 368 374 PF00069 0.625
MOD_CK2_1 379 385 PF00069 0.659
MOD_CK2_1 407 413 PF00069 0.680
MOD_CK2_1 418 424 PF00069 0.641
MOD_CK2_1 49 55 PF00069 0.434
MOD_CK2_1 57 63 PF00069 0.288
MOD_GlcNHglycan 103 106 PF01048 0.570
MOD_GlcNHglycan 18 21 PF01048 0.686
MOD_GlcNHglycan 424 428 PF01048 0.637
MOD_GlcNHglycan 51 54 PF01048 0.539
MOD_GlcNHglycan 8 11 PF01048 0.637
MOD_GSK3_1 105 112 PF00069 0.322
MOD_GSK3_1 119 126 PF00069 0.357
MOD_GSK3_1 251 258 PF00069 0.438
MOD_GSK3_1 423 430 PF00069 0.776
MOD_GSK3_1 431 438 PF00069 0.791
MOD_GSK3_1 439 446 PF00069 0.734
MOD_GSK3_1 45 52 PF00069 0.307
MOD_GSK3_1 54 61 PF00069 0.197
MOD_GSK3_1 71 78 PF00069 0.271
MOD_GSK3_1 94 101 PF00069 0.324
MOD_NEK2_1 16 21 PF00069 0.484
MOD_NEK2_1 398 403 PF00069 0.646
MOD_NEK2_1 49 54 PF00069 0.392
MOD_NEK2_2 283 288 PF00069 0.521
MOD_PIKK_1 160 166 PF00454 0.323
MOD_PIKK_1 315 321 PF00454 0.743
MOD_PIKK_1 441 447 PF00454 0.756
MOD_PK_1 439 445 PF00069 0.813
MOD_PKA_1 432 438 PF00069 0.759
MOD_PKA_2 431 437 PF00069 0.788
MOD_PKA_2 94 100 PF00069 0.203
MOD_PKB_1 437 445 PF00069 0.757
MOD_Plk_1 160 166 PF00069 0.183
MOD_Plk_1 399 405 PF00069 0.810
MOD_Plk_1 54 60 PF00069 0.318
MOD_Plk_1 95 101 PF00069 0.296
MOD_Plk_4 399 405 PF00069 0.617
MOD_Plk_4 54 60 PF00069 0.334
MOD_Plk_4 75 81 PF00069 0.289
MOD_Plk_4 95 101 PF00069 0.243
MOD_ProDKin_1 325 331 PF00069 0.610
MOD_ProDKin_1 332 338 PF00069 0.770
MOD_SUMO_for_1 289 292 PF00179 0.674
MOD_SUMO_rev_2 451 461 PF00179 0.554
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.291
TRG_ENDOCYTIC_2 195 198 PF00928 0.395
TRG_ENDOCYTIC_2 222 225 PF00928 0.355
TRG_ER_diArg_1 436 439 PF00400 0.755
TRG_Pf-PMV_PEXEL_1 441 445 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 46% 99%
A0A1X0NJM3 Trypanosomatidae 25% 100%
A0A1X0NK39 Trypanosomatidae 22% 100%
A0A1X0NN75 Trypanosomatidae 23% 100%
A0A1X0NVE8 Trypanosomatidae 26% 100%
A0A3S7WSM6 Leishmania donovani 89% 100%
A0A3S7X9E7 Leishmania donovani 36% 100%
A4H7B5 Leishmania braziliensis 67% 100%
A4HMU5 Leishmania braziliensis 34% 100%
A4HVR0 Leishmania infantum 89% 100%
E9AFA3 Leishmania major 36% 100%
E9AHW4 Leishmania infantum 36% 100%
E9B6F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
Q4QG22 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS