LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9APF5_LEIMU
TriTrypDb:
LmxM.13.1310
Length:
415

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 5
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9APF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APF5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.450
CLV_C14_Caspase3-7 359 363 PF00656 0.708
CLV_NRD_NRD_1 407 409 PF00675 0.454
CLV_PCSK_SKI1_1 408 412 PF00082 0.451
DEG_Nend_UBRbox_3 1 3 PF02207 0.598
DOC_CDC14_PxL_1 43 51 PF14671 0.304
DOC_MAPK_gen_1 16 25 PF00069 0.572
DOC_MAPK_MEF2A_6 16 25 PF00069 0.572
DOC_MAPK_MEF2A_6 172 180 PF00069 0.197
DOC_PP4_FxxP_1 170 173 PF00568 0.301
DOC_PP4_FxxP_1 389 392 PF00568 0.675
DOC_PP4_FxxP_1 52 55 PF00568 0.434
DOC_USP7_MATH_1 176 180 PF00917 0.275
DOC_USP7_MATH_1 196 200 PF00917 0.259
DOC_USP7_MATH_1 410 414 PF00917 0.608
DOC_USP7_MATH_1 55 59 PF00917 0.422
DOC_USP7_MATH_1 6 10 PF00917 0.507
DOC_WW_Pin1_4 172 177 PF00397 0.302
DOC_WW_Pin1_4 388 393 PF00397 0.642
LIG_14-3-3_CanoR_1 143 151 PF00244 0.361
LIG_14-3-3_CanoR_1 197 201 PF00244 0.254
LIG_14-3-3_CanoR_1 202 207 PF00244 0.402
LIG_14-3-3_CanoR_1 253 260 PF00244 0.313
LIG_14-3-3_CanoR_1 334 339 PF00244 0.702
LIG_ActinCP_TwfCPI_2 52 61 PF01115 0.377
LIG_BRCT_BRCA1_1 203 207 PF00533 0.437
LIG_BRCT_BRCA1_1 254 258 PF00533 0.400
LIG_FHA_1 119 125 PF00498 0.335
LIG_FHA_1 161 167 PF00498 0.344
LIG_FHA_1 83 89 PF00498 0.312
LIG_FHA_2 110 116 PF00498 0.197
LIG_FHA_2 143 149 PF00498 0.329
LIG_FHA_2 219 225 PF00498 0.449
LIG_FHA_2 350 356 PF00498 0.639
LIG_GBD_Chelix_1 25 33 PF00786 0.570
LIG_IRF3_LxIS_1 151 158 PF10401 0.301
LIG_LIR_Apic_2 51 55 PF02991 0.433
LIG_LIR_Gen_1 98 106 PF02991 0.329
LIG_LIR_Nem_3 132 136 PF02991 0.328
LIG_LIR_Nem_3 232 236 PF02991 0.436
LIG_LIR_Nem_3 98 104 PF02991 0.295
LIG_NRBOX 28 34 PF00104 0.516
LIG_Pex14_1 286 290 PF04695 0.387
LIG_Pex14_2 133 137 PF04695 0.301
LIG_Pex14_2 187 191 PF04695 0.329
LIG_PTB_Apo_2 398 405 PF02174 0.617
LIG_PTB_Phospho_1 398 404 PF10480 0.618
LIG_SH2_CRK 101 105 PF00017 0.331
LIG_SH2_STAT3 181 184 PF00017 0.324
LIG_SH2_STAT3 273 276 PF00017 0.416
LIG_SH2_STAT5 103 106 PF00017 0.301
LIG_SH2_STAT5 165 168 PF00017 0.288
LIG_SH2_STAT5 169 172 PF00017 0.265
LIG_SH3_3 148 154 PF00018 0.301
LIG_SH3_3 170 176 PF00018 0.307
LIG_SUMO_SIM_anti_2 24 29 PF11976 0.586
LIG_SUMO_SIM_anti_2 292 298 PF11976 0.400
LIG_SUMO_SIM_par_1 19 24 PF11976 0.604
LIG_SUMO_SIM_par_1 28 34 PF11976 0.492
LIG_TRAF2_1 325 328 PF00917 0.710
LIG_WRC_WIRS_1 49 54 PF05994 0.371
MOD_CK1_1 220 226 PF00069 0.460
MOD_CK1_1 337 343 PF00069 0.716
MOD_CK2_1 142 148 PF00069 0.228
MOD_GlcNHglycan 126 129 PF01048 0.531
MOD_GlcNHglycan 227 230 PF01048 0.627
MOD_GlcNHglycan 352 355 PF01048 0.522
MOD_GlcNHglycan 404 407 PF01048 0.460
MOD_GlcNHglycan 56 60 PF01048 0.614
MOD_GSK3_1 104 111 PF00069 0.303
MOD_GSK3_1 172 179 PF00069 0.290
MOD_GSK3_1 216 223 PF00069 0.464
MOD_GSK3_1 225 232 PF00069 0.373
MOD_GSK3_1 248 255 PF00069 0.357
MOD_GSK3_1 262 269 PF00069 0.397
MOD_GSK3_1 330 337 PF00069 0.736
MOD_GSK3_1 346 353 PF00069 0.763
MOD_GSK3_1 366 373 PF00069 0.644
MOD_N-GLC_1 191 196 PF02516 0.501
MOD_N-GLC_1 242 247 PF02516 0.665
MOD_NEK2_1 131 136 PF00069 0.405
MOD_NEK2_1 155 160 PF00069 0.301
MOD_NEK2_1 191 196 PF00069 0.273
MOD_NEK2_1 236 241 PF00069 0.425
MOD_NEK2_1 302 307 PF00069 0.309
MOD_NEK2_1 338 343 PF00069 0.717
MOD_NEK2_1 360 365 PF00069 0.655
MOD_NEK2_2 176 181 PF00069 0.231
MOD_PIKK_1 248 254 PF00454 0.419
MOD_PIKK_1 262 268 PF00454 0.484
MOD_PIKK_1 346 352 PF00454 0.775
MOD_PKA_1 408 414 PF00069 0.686
MOD_PKA_2 142 148 PF00069 0.361
MOD_PKA_2 196 202 PF00069 0.275
MOD_PKA_2 225 231 PF00069 0.325
MOD_PKA_2 252 258 PF00069 0.365
MOD_PKB_1 246 254 PF00069 0.308
MOD_Plk_1 217 223 PF00069 0.442
MOD_Plk_1 242 248 PF00069 0.396
MOD_Plk_2-3 218 224 PF00069 0.416
MOD_Plk_4 160 166 PF00069 0.354
MOD_Plk_4 176 182 PF00069 0.255
MOD_Plk_4 186 192 PF00069 0.275
MOD_Plk_4 196 202 PF00069 0.261
MOD_Plk_4 237 243 PF00069 0.446
MOD_Plk_4 334 340 PF00069 0.720
MOD_Plk_4 370 376 PF00069 0.654
MOD_ProDKin_1 172 178 PF00069 0.302
MOD_ProDKin_1 388 394 PF00069 0.643
MOD_SUMO_for_1 395 398 PF00179 0.608
MOD_SUMO_rev_2 405 411 PF00179 0.634
TRG_ENDOCYTIC_2 101 104 PF00928 0.329
TRG_ENDOCYTIC_2 233 236 PF00928 0.450
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY91 Leptomonas seymouri 36% 100%
A0A0N1PG18 Leptomonas seymouri 52% 93%
A0A3S5H587 Leishmania donovani 34% 100%
A0A3S5H6P8 Leishmania donovani 86% 99%
A4H3U3 Leishmania braziliensis 34% 100%
A4H7B4 Leishmania braziliensis 67% 100%
A4HS17 Leishmania infantum 34% 100%
A4HVQ9 Leishmania infantum 86% 99%
E9AK04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
Q4QG23 Leishmania major 83% 100%
Q9XZY2 Leishmania major 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS