Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APF0_LEIMU

TriTrypDb:

LmxM.13.1260

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9APF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.666
CLV_NRD_NRD_1	139	141	PF00675	0.516
CLV_PCSK_FUR_1	137	141	PF00082	0.389
CLV_PCSK_KEX2_1	139	141	PF00082	0.472
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.483
CLV_PCSK_SKI1_1	60	64	PF00082	0.442
CLV_PCSK_SKI1_1	65	69	PF00082	0.398
DEG_APCC_DBOX_1	59	67	PF00400	0.534
DOC_MAPK_gen_1	99	109	PF00069	0.341
DOC_MAPK_MEF2A_6	102	110	PF00069	0.406
DOC_PP2B_LxvP_1	33	36	PF13499	0.759
DOC_USP7_MATH_1	23	27	PF00917	0.729
DOC_USP7_MATH_1	93	97	PF00917	0.355
LIG_14-3-3_CanoR_1	140	150	PF00244	0.608
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_deltaCOP1_diTrp_1	95	103	PF00928	0.520
LIG_EH1_1	115	123	PF00400	0.385
LIG_FHA_2	140	146	PF00498	0.606
LIG_LIR_LC3C_4	30	35	PF02991	0.652
LIG_LIR_Nem_3	174	180	PF02991	0.685
LIG_PDZ_Class_3	191	196	PF00595	0.757
LIG_Pex14_1	97	101	PF04695	0.517
LIG_SH2_CRK	69	73	PF00017	0.422
LIG_SH2_GRB2like	177	180	PF00017	0.614
LIG_SH2_STAT3	61	64	PF00017	0.653
LIG_SH3_3	15	21	PF00018	0.781
LIG_SH3_3	31	37	PF00018	0.580
LIG_SH3_3	41	47	PF00018	0.584
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.716
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.675
LIG_SUMO_SIM_par_1	105	112	PF11976	0.509
LIG_TRAF2_1	168	171	PF00917	0.758
LIG_Vh1_VBS_1	107	125	PF01044	0.330
MOD_CK2_1	149	155	PF00069	0.779
MOD_CK2_1	189	195	PF00069	0.718
MOD_GlcNHglycan	27	30	PF01048	0.514
MOD_GSK3_1	139	146	PF00069	0.697
MOD_N-GLC_1	189	194	PF02516	0.485
MOD_NEK2_1	86	91	PF00069	0.457
MOD_PKA_1	139	145	PF00069	0.721
MOD_PKA_2	139	145	PF00069	0.734
MOD_Plk_1	172	178	PF00069	0.806
MOD_Plk_1	50	56	PF00069	0.678
MOD_Plk_2-3	173	179	PF00069	0.747
MOD_Plk_4	109	115	PF00069	0.404
MOD_Plk_4	50	56	PF00069	0.609
TRG_NLS_MonoExtN_4	137	143	PF00514	0.738
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM79	Leptomonas seymouri	37%	100%
A0A3Q8II27	Leishmania donovani	83%	100%
A4H7A9	Leishmania braziliensis	55%	100%
A4HVQ4	Leishmania infantum	82%	100%
Q4QG28	Leishmania major	81%	100%