Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9APE9_LEIMU

TriTrypDb:

LmxM.13.1250

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9APE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.838
CLV_PCSK_FUR_1	134	138	PF00082	0.766
CLV_PCSK_KEX2_1	105	107	PF00082	0.839
CLV_PCSK_KEX2_1	136	138	PF00082	0.744
CLV_PCSK_KEX2_1	175	177	PF00082	0.604
CLV_PCSK_KEX2_1	256	258	PF00082	0.657
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.839
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.756
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.604
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.657
CLV_PCSK_PC7_1	171	177	PF00082	0.586
CLV_PCSK_SKI1_1	105	109	PF00082	0.798
CLV_PCSK_SKI1_1	175	179	PF00082	0.613
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DEG_SCF_FBW7_1	36	43	PF00400	0.515
DOC_CKS1_1	118	123	PF01111	0.587
DOC_CKS1_1	170	175	PF01111	0.775
DOC_CKS1_1	37	42	PF01111	0.514
DOC_CKS1_1	49	54	PF01111	0.551
DOC_CYCLIN_RxL_1	171	180	PF00134	0.797
DOC_USP7_MATH_1	107	111	PF00917	0.630
DOC_USP7_MATH_1	20	24	PF00917	0.530
DOC_USP7_MATH_1	54	58	PF00917	0.637
DOC_USP7_UBL2_3	175	179	PF12436	0.730
DOC_WW_Pin1_4	117	122	PF00397	0.592
DOC_WW_Pin1_4	16	21	PF00397	0.494
DOC_WW_Pin1_4	169	174	PF00397	0.765
DOC_WW_Pin1_4	205	210	PF00397	0.750
DOC_WW_Pin1_4	23	28	PF00397	0.493
DOC_WW_Pin1_4	36	41	PF00397	0.466
DOC_WW_Pin1_4	48	53	PF00397	0.629
DOC_WW_Pin1_4	82	87	PF00397	0.600
LIG_14-3-3_CanoR_1	197	202	PF00244	0.708
LIG_14-3-3_CanoR_1	55	59	PF00244	0.558
LIG_BRCT_BRCA1_1	190	194	PF00533	0.826
LIG_Clathr_ClatBox_1	147	151	PF01394	0.549
LIG_FHA_1	124	130	PF00498	0.576
LIG_FHA_1	37	43	PF00498	0.517
LIG_FHA_1	60	66	PF00498	0.549
LIG_LIR_Apic_2	43	49	PF02991	0.539
LIG_LIR_Gen_1	26	36	PF02991	0.446
LIG_LIR_Nem_3	17	21	PF02991	0.492
LIG_LIR_Nem_3	26	31	PF02991	0.517
LIG_SH2_NCK_1	212	216	PF00017	0.754
LIG_SH2_STAP1	190	194	PF00017	0.826
LIG_SH2_STAT5	166	169	PF00017	0.549
LIG_SH2_STAT5	35	38	PF00017	0.441
LIG_SH3_1	46	52	PF00018	0.550
LIG_SH3_3	119	125	PF00018	0.473
LIG_SH3_3	167	173	PF00018	0.692
LIG_SH3_3	46	52	PF00018	0.633
LIG_SUMO_SIM_par_1	146	151	PF11976	0.549
LIG_TYR_ITIM	163	168	PF00017	0.433
MOD_CDK_SPK_2	50	55	PF00069	0.697
MOD_CDK_SPxK_1	169	175	PF00069	0.720
MOD_CDK_SPxK_1	82	88	PF00069	0.723
MOD_CDK_SPxxK_3	169	176	PF00069	0.726
MOD_CDK_SPxxK_3	48	55	PF00069	0.694
MOD_CK1_1	14	20	PF00069	0.662
MOD_CK1_1	188	194	PF00069	0.789
MOD_CK1_1	196	202	PF00069	0.490
MOD_CK1_1	213	219	PF00069	0.506
MOD_CK1_1	23	29	PF00069	0.481
MOD_CK1_1	234	240	PF00069	0.814
MOD_CK1_1	249	255	PF00069	0.554
MOD_CK1_1	44	50	PF00069	0.680
MOD_CK1_1	53	59	PF00069	0.786
MOD_CK2_1	107	113	PF00069	0.656
MOD_CK2_1	196	202	PF00069	0.668
MOD_CK2_1	234	240	PF00069	0.831
MOD_Cter_Amidation	103	106	PF01082	0.822
MOD_Cter_Amidation	173	176	PF01082	0.748
MOD_GlcNHglycan	13	16	PF01048	0.651
MOD_GlcNHglycan	22	25	PF01048	0.502
MOD_GlcNHglycan	89	92	PF01048	0.671
MOD_GSK3_1	10	17	PF00069	0.659
MOD_GSK3_1	185	192	PF00069	0.748
MOD_GSK3_1	193	200	PF00069	0.645
MOD_GSK3_1	204	211	PF00069	0.698
MOD_GSK3_1	225	232	PF00069	0.714
MOD_GSK3_1	246	253	PF00069	0.719
MOD_GSK3_1	36	43	PF00069	0.640
MOD_GSK3_1	44	51	PF00069	0.589
MOD_GSK3_1	59	66	PF00069	0.732
MOD_LATS_1	248	254	PF00433	0.719
MOD_N-GLC_1	222	227	PF02516	0.698
MOD_NEK2_1	203	208	PF00069	0.811
MOD_NEK2_1	42	47	PF00069	0.666
MOD_NEK2_1	63	68	PF00069	0.717
MOD_NEK2_2	54	59	PF00069	0.697
MOD_PK_1	197	203	PF00069	0.691
MOD_PKA_2	196	202	PF00069	0.668
MOD_PKA_2	203	209	PF00069	0.599
MOD_PKA_2	54	60	PF00069	0.696
MOD_PKA_2	87	93	PF00069	0.671
MOD_Plk_4	30	36	PF00069	0.617
MOD_ProDKin_1	117	123	PF00069	0.746
MOD_ProDKin_1	16	22	PF00069	0.611
MOD_ProDKin_1	169	175	PF00069	0.720
MOD_ProDKin_1	205	211	PF00069	0.691
MOD_ProDKin_1	23	29	PF00069	0.606
MOD_ProDKin_1	36	42	PF00069	0.574
MOD_ProDKin_1	48	54	PF00069	0.797
MOD_ProDKin_1	82	88	PF00069	0.765
MOD_SUMO_rev_2	110	117	PF00179	0.774
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.757
TRG_ENDOCYTIC_2	165	168	PF00928	0.549
TRG_NLS_MonoExtN_4	102	109	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.773

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4QG29	Leishmania major	79%	100%