TPK_B1_binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thiamin pyrophosphokinase, vitamin B1 binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APE8_LEIMU

TriTrypDb:

LmxM.13.1240

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APE8

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006766	vitamin metabolic process	3	11
GO:0006767	water-soluble vitamin metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009110	vitamin biosynthetic process	4	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004788	thiamine diphosphokinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016778	diphosphotransferase activity	4	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.568
CLV_C14_Caspase3-7	205	209	PF00656	0.300
CLV_NRD_NRD_1	18	20	PF00675	0.454
CLV_NRD_NRD_1	187	189	PF00675	0.731
CLV_NRD_NRD_1	221	223	PF00675	0.555
CLV_NRD_NRD_1	330	332	PF00675	0.597
CLV_PCSK_FUR_1	219	223	PF00082	0.559
CLV_PCSK_FUR_1	328	332	PF00082	0.421
CLV_PCSK_KEX2_1	117	119	PF00082	0.487
CLV_PCSK_KEX2_1	187	189	PF00082	0.720

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFZ8	Leptomonas seymouri	44%	100%
A0A1X0NMY7	Trypanosomatidae	30%	100%
A0A3Q8IBS6	Leishmania donovani	86%	99%
A0A422N0R9	Trypanosoma rangeli	27%	100%
A4H7A7	Leishmania braziliensis	70%	100%
A4HVQ2	Leishmania infantum	87%	100%
D0A6I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4QG30	Leishmania major	85%	100%
V5ARR9	Trypanosoma cruzi	27%	100%

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