Putative 40S ribosomal protein S4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S4, putative

Species:

Leishmania mexicana

UniProt:

E9APE6_LEIMU

TriTrypDb:

LmxM.13.1220

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9APE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APE6

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003735	structural constituent of ribosome	2	2
GO:0005198	structural molecule activity	1	2
GO:0005488	binding	1	2
GO:0019843	rRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.835
CLV_NRD_NRD_1	231	233	PF00675	0.449
CLV_NRD_NRD_1	416	418	PF00675	0.709
CLV_NRD_NRD_1	425	427	PF00675	0.686
CLV_NRD_NRD_1	428	430	PF00675	0.634
CLV_NRD_NRD_1	56	58	PF00675	0.814
CLV_PCSK_KEX2_1	14	16	PF00082	0.838
CLV_PCSK_KEX2_1	164	166	PF00082	0.449
CLV_PCSK_KEX2_1	231	233	PF00082	0.449
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.838
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.449
CLV_PCSK_SKI1_1	157	161	PF00082	0.714
CLV_PCSK_SKI1_1	207	211	PF00082	0.449
CLV_PCSK_SKI1_1	262	266	PF00082	0.449
CLV_PCSK_SKI1_1	276	280	PF00082	0.274
DEG_APCC_DBOX_1	192	200	PF00400	0.650
DEG_APCC_DBOX_1	219	227	PF00400	0.650
DEG_APCC_DBOX_1	261	269	PF00400	0.650
DEG_Nend_UBRbox_4	1	3	PF02207	0.796
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.779
DOC_CYCLIN_yCln2_LP_2	149	152	PF00134	0.774
DOC_MAPK_DCC_7	191	201	PF00069	0.650
DOC_MAPK_gen_1	191	200	PF00069	0.650
DOC_MAPK_gen_1	260	268	PF00069	0.650
DOC_MAPK_gen_1	319	326	PF00069	0.722
DOC_MAPK_gen_1	328	337	PF00069	0.469
DOC_MAPK_gen_1	343	352	PF00069	0.357
DOC_MAPK_gen_1	35	45	PF00069	0.815
DOC_MAPK_HePTP_8	381	393	PF00069	0.650
DOC_MAPK_MEF2A_6	123	130	PF00069	0.779
DOC_MAPK_MEF2A_6	191	200	PF00069	0.650
DOC_MAPK_MEF2A_6	384	393	PF00069	0.650
DOC_MAPK_NFAT4_5	193	201	PF00069	0.549
DOC_PP2B_LxvP_1	124	127	PF13499	0.768
DOC_PP2B_LxvP_1	149	152	PF13499	0.774
DOC_PP2B_LxvP_1	166	169	PF13499	0.437
DOC_PP4_FxxP_1	71	74	PF00568	0.778
DOC_PP4_FxxP_1	92	95	PF00568	0.782
DOC_USP7_MATH_1	306	310	PF00917	0.650
DOC_USP7_MATH_1	96	100	PF00917	0.786
DOC_USP7_UBL2_3	157	161	PF12436	0.714
DOC_WW_Pin1_4	128	133	PF00397	0.783
DOC_WW_Pin1_4	77	82	PF00397	0.768
DOC_WW_Pin1_4	91	96	PF00397	0.537
LIG_14-3-3_CanoR_1	144	148	PF00244	0.795
LIG_14-3-3_CanoR_1	38	44	PF00244	0.813
LIG_Actin_WH2_2	194	209	PF00022	0.549
LIG_BIR_III_4	366	370	PF00653	0.650
LIG_BRCT_BRCA1_1	79	83	PF00533	0.769
LIG_Clathr_ClatBox_1	223	227	PF01394	0.650
LIG_EVH1_2	126	130	PF00568	0.774
LIG_FHA_1	285	291	PF00498	0.650
LIG_FHA_1	40	46	PF00498	0.813
LIG_FHA_2	143	149	PF00498	0.795
LIG_FHA_2	5	11	PF00498	0.802
LIG_LIR_Nem_3	106	110	PF02991	0.782
LIG_LIR_Nem_3	122	128	PF02991	0.494
LIG_LYPXL_yS_3	107	110	PF13949	0.783
LIG_Pex14_2	83	87	PF04695	0.786
LIG_SH2_STAP1	208	212	PF00017	0.650
LIG_SH2_STAT5	284	287	PF00017	0.650
LIG_SH3_2	152	157	PF14604	0.767
LIG_SH3_3	147	153	PF00018	0.779
LIG_SH3_3	177	183	PF00018	0.650
LIG_SH3_3	241	247	PF00018	0.650
LIG_SH3_3	388	394	PF00018	0.650
LIG_SH3_3	73	79	PF00018	0.772
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.785
LIG_SUMO_SIM_anti_2	41	48	PF11976	0.816
LIG_SUMO_SIM_par_1	290	295	PF11976	0.650
LIG_UBA3_1	198	207	PF00899	0.650
LIG_UBA3_1	379	384	PF00899	0.650
MOD_CDC14_SPxK_1	94	97	PF00782	0.780
MOD_CDK_SPxK_1	91	97	PF00069	0.784
MOD_CK1_1	119	125	PF00069	0.430
MOD_CK1_1	175	181	PF00069	0.650
MOD_CK1_1	99	105	PF00069	0.788
MOD_CK2_1	142	148	PF00069	0.792
MOD_CK2_1	266	272	PF00069	0.650
MOD_CK2_1	365	371	PF00069	0.549
MOD_CK2_1	4	10	PF00069	0.797
MOD_Cter_Amidation	55	58	PF01082	0.819
MOD_GlcNHglycan	132	135	PF01048	0.776
MOD_GlcNHglycan	19	22	PF01048	0.527
MOD_GlcNHglycan	2	5	PF01048	0.791
MOD_GlcNHglycan	366	370	PF01048	0.449
MOD_GlcNHglycan	59	62	PF01048	0.794
MOD_GSK3_1	25	32	PF00069	0.830
MOD_GSK3_1	306	313	PF00069	0.650
MOD_GSK3_1	34	41	PF00069	0.659
MOD_GSK3_1	99	106	PF00069	0.786
MOD_LATS_1	363	369	PF00433	0.549
MOD_N-GLC_1	266	271	PF02516	0.449
MOD_NEK2_1	135	140	PF00069	0.785
MOD_NEK2_1	389	394	PF00069	0.650
MOD_PIKK_1	30	36	PF00454	0.825
MOD_PKA_1	57	63	PF00069	0.799
MOD_PKA_2	143	149	PF00069	0.795
MOD_PKA_2	96	102	PF00069	0.786
MOD_PKB_1	15	23	PF00069	0.832
MOD_Plk_4	310	316	PF00069	0.650
MOD_Plk_4	39	45	PF00069	0.811
MOD_Plk_4	72	78	PF00069	0.776
MOD_ProDKin_1	128	134	PF00069	0.782
MOD_ProDKin_1	77	83	PF00069	0.770
MOD_ProDKin_1	91	97	PF00069	0.539
MOD_SUMO_for_1	350	353	PF00179	0.645
MOD_SUMO_rev_2	227	237	PF00179	0.650
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.775
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.650
TRG_DiLeu_LyEn_5	194	199	PF01217	0.581
TRG_ENDOCYTIC_2	107	110	PF00928	0.783
TRG_ER_diArg_1	15	17	PF00400	0.838
TRG_ER_diArg_1	183	186	PF00400	0.650
TRG_ER_diArg_1	202	205	PF00400	0.412
TRG_ER_diArg_1	230	232	PF00400	0.650
TRG_ER_diArg_1	300	303	PF00400	0.650
TRG_ER_diArg_1	343	346	PF00400	0.599
TRG_NLS_MonoCore_2	13	18	PF00514	0.834
TRG_NLS_MonoExtC_3	425	430	PF00514	0.843
TRG_NLS_MonoExtN_4	423	430	PF00514	0.837

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1D8PCI6	CANAL	51%	100%
A1RS06	PYRIL	37%	100%
A2BMD1	HYPBU	33%	100%
A3DNB9	STAMF	35%	100%
A3MWZ7	PYRCJ	35%	100%
A4FWA9	METM5	35%	100%
A4WLL4	PYRAR	35%	100%
A4YCX8	METS5	29%	100%
A5UL76	METS3	34%	100%
A6UQ56	METVS	32%	100%
A6UWV0	META3	33%	100%
A6VGZ7	METM7	35%	100%
A8ACD4	IGNH4	33%	100%
A8MB20	CALMQ	30%	100%
A9A9Q2	METM6	34%	100%
B0R668	HALS3	28%	100%
B1L778	KORCO	32%	100%
B1Y9S4	PYRNV	36%	100%
B8D5V8	DESA1	32%	100%
B9LSR5	HALLT	29%	100%
C3MQ71	SULIL	29%	100%
C3MVJ0	SULIM	29%	100%
C3N5T9	SULIA	29%	100%
C3NEF5	SULIY	29%	100%
C3NH97	SULIN	29%	100%
C4KHG8	SULIK	29%	100%
O05634	SULAC	30%	100%
O22424	MAIZE	51%	100%
O26123	METTH	38%	100%
O28366	ARCFU	33%	100%
O59430	PYRHO	38%	100%
O59950	YARLI	49%	100%
O62738	MONDO	52%	100%
O62739	MONDO	53%	100%
O81363	PRUAR	48%	100%
P0C233	TETTH	47%	100%
P0CX35	YEAST	51%	100%
P0CX36	YEAST	51%	100%
P14023	METVA	32%	100%
P22090	HUMAN	51%	100%
P22510	HALMA	28%	100%
P41042	DROME	52%	100%
P46299	GOSHI	52%	100%
P46300	SOLTU	51%	100%
P47836	CHICK	52%	100%
P47837	CANAX	49%	100%
P47961	CRIGR	52%	100%
P49204	ARATH	51%	100%
P49398	ORYSJ	52%	100%
P49401	XENLA	52%	100%
P51405	DICDI	48%	100%
P54039	METJA	36%	100%
P55832	HORSE	54%	100%
P62428	METMP	33%	100%
P62429	NANEQ	31%	100%
P62701	HUMAN	52%	100%
P62702	MOUSE	52%	100%
P62703	RAT	52%	100%
P62704	MESAU	52%	100%
P62705	FELCA	52%	100%
P79103	BOVIN	52%	100%
P79183	MACFU	51%	100%
P87158	SCHPO	51%	100%
Q0W1X6	METAR	31%	100%
Q2FT37	METHJ	30%	100%
Q2NFW9	METST	34%	100%
Q3IMX6	NATPD	27%	100%
Q40941	BIGNA	22%	100%
Q46GA7	METBF	33%	100%
Q4GXU6	CARGR	50%	100%
Q4PMB3	IXOSC	52%	100%
Q56230	THEAC	33%	100%
Q56FH2	LYSTE	52%	100%
Q5JJG0	THEKO	37%	100%
Q5UAP0	BOMMO	51%	100%
Q642H9	DANRE	52%	100%
Q6GVM7	PANTR	50%	100%
Q6L1B5	PICTO	28%	100%
Q6PBC4	XENTR	52%	100%
Q76MY1	MACFU	52%	100%
Q76N24	CHLAE	52%	100%
Q861U7	PONPY	50%	100%
Q861U8	GORGO	51%	100%
Q861U9	PANTR	51%	100%
Q861V0	PANPA	51%	100%
Q8PV38	METMA	32%	100%
Q8SRB9	ENCCU	35%	100%
Q8TD47	HUMAN	49%	100%
Q8TRT5	METAC	33%	100%
Q8TW18	METKA	36%	100%
Q8U011	PYRFU	37%	100%
Q8VYK6	ARATH	51%	100%
Q8ZTD3	PYRAE	34%	100%
Q90YS0	ICTPU	52%	100%
Q93VH9	ARATH	52%	100%
Q95V34	SPOFR	51%	100%
Q975J2	SULTO	29%	100%
Q97BW4	THEVO	33%	100%
Q9HPC2	HALSA	28%	100%
Q9N3X2	CAEEL	52%	100%
Q9P4W9	SCHPO	51%	100%
Q9USW5	SCHPO	51%	100%
Q9UX94	SACS2	29%	100%
Q9V1U8	PYRAB	37%	100%
Q9YF85	AERPE	37%	100%