LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania mexicana
UniProt:
E9APE5_LEIMU
TriTrypDb:
LmxM.13.1210
Length:
500

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

E9APE5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APE5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 316 320 PF00656 0.542
CLV_NRD_NRD_1 288 290 PF00675 0.544
CLV_NRD_NRD_1 86 88 PF00675 0.330
CLV_PCSK_KEX2_1 230 232 PF00082 0.292
CLV_PCSK_KEX2_1 288 290 PF00082 0.391
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.251
CLV_PCSK_SKI1_1 227 231 PF00082 0.282
CLV_PCSK_SKI1_1 233 237 PF00082 0.299
CLV_PCSK_SKI1_1 325 329 PF00082 0.401
CLV_PCSK_SKI1_1 406 410 PF00082 0.281
CLV_PCSK_SKI1_1 415 419 PF00082 0.331
CLV_PCSK_SKI1_1 43 47 PF00082 0.503
DEG_Nend_Nbox_1 1 3 PF02207 0.639
DEG_SPOP_SBC_1 168 172 PF00917 0.339
DOC_ANK_TNKS_1 287 294 PF00023 0.615
DOC_CDC14_PxL_1 360 368 PF14671 0.463
DOC_CKS1_1 81 86 PF01111 0.375
DOC_MAPK_gen_1 372 382 PF00069 0.381
DOC_MAPK_gen_1 87 93 PF00069 0.541
DOC_MAPK_HePTP_8 91 103 PF00069 0.514
DOC_MAPK_MEF2A_6 375 384 PF00069 0.398
DOC_MAPK_MEF2A_6 415 423 PF00069 0.355
DOC_MAPK_MEF2A_6 94 103 PF00069 0.342
DOC_MAPK_NFAT4_5 94 102 PF00069 0.438
DOC_PP1_RVXF_1 397 403 PF00149 0.552
DOC_PP1_RVXF_1 404 410 PF00149 0.548
DOC_PP2B_LxvP_1 110 113 PF13499 0.331
DOC_PP2B_LxvP_1 361 364 PF13499 0.336
DOC_PP2B_LxvP_1 366 369 PF13499 0.295
DOC_PP4_FxxP_1 344 347 PF00568 0.606
DOC_USP7_MATH_1 294 298 PF00917 0.806
DOC_USP7_MATH_1 30 34 PF00917 0.378
DOC_USP7_MATH_1 483 487 PF00917 0.383
DOC_USP7_UBL2_3 178 182 PF12436 0.197
DOC_USP7_UBL2_3 233 237 PF12436 0.380
DOC_WW_Pin1_4 52 57 PF00397 0.464
DOC_WW_Pin1_4 80 85 PF00397 0.414
LIG_14-3-3_CanoR_1 214 219 PF00244 0.512
LIG_14-3-3_CanoR_1 325 333 PF00244 0.585
LIG_14-3-3_CanoR_1 393 399 PF00244 0.336
LIG_14-3-3_CanoR_1 463 472 PF00244 0.531
LIG_14-3-3_CanoR_1 87 92 PF00244 0.504
LIG_BIR_III_2 50 54 PF00653 0.297
LIG_BIR_III_4 389 393 PF00653 0.304
LIG_BRCT_BRCA1_1 198 202 PF00533 0.409
LIG_BRCT_BRCA1_1 211 215 PF00533 0.473
LIG_BRCT_BRCA1_1 54 58 PF00533 0.435
LIG_BRCT_BRCA1_1 89 93 PF00533 0.531
LIG_Clathr_ClatBox_1 101 105 PF01394 0.379
LIG_EH1_1 355 363 PF00400 0.429
LIG_eIF4E_1 14 20 PF01652 0.345
LIG_eIF4E_1 437 443 PF01652 0.350
LIG_FHA_1 112 118 PF00498 0.318
LIG_FHA_1 14 20 PF00498 0.339
LIG_FHA_1 234 240 PF00498 0.508
LIG_FHA_1 377 383 PF00498 0.360
LIG_FHA_1 71 77 PF00498 0.341
LIG_FHA_2 314 320 PF00498 0.501
LIG_FHA_2 326 332 PF00498 0.512
LIG_LIR_Gen_1 105 113 PF02991 0.352
LIG_LIR_Gen_1 143 153 PF02991 0.493
LIG_LIR_Gen_1 183 193 PF02991 0.304
LIG_LIR_Gen_1 199 210 PF02991 0.444
LIG_LIR_Gen_1 212 223 PF02991 0.408
LIG_LIR_Gen_1 374 385 PF02991 0.351
LIG_LIR_Gen_1 422 431 PF02991 0.399
LIG_LIR_Nem_3 105 110 PF02991 0.290
LIG_LIR_Nem_3 143 148 PF02991 0.503
LIG_LIR_Nem_3 183 188 PF02991 0.311
LIG_LIR_Nem_3 199 205 PF02991 0.342
LIG_LIR_Nem_3 212 218 PF02991 0.376
LIG_LIR_Nem_3 225 229 PF02991 0.412
LIG_LIR_Nem_3 274 279 PF02991 0.774
LIG_LIR_Nem_3 374 380 PF02991 0.308
LIG_LIR_Nem_3 40 44 PF02991 0.336
LIG_LIR_Nem_3 422 426 PF02991 0.374
LIG_LIR_Nem_3 64 68 PF02991 0.296
LIG_LIR_Nem_3 90 96 PF02991 0.527
LIG_LYPXL_SIV_4 11 19 PF13949 0.182
LIG_Pex14_1 59 63 PF04695 0.237
LIG_Pex14_2 161 165 PF04695 0.346
LIG_Pex14_2 353 357 PF04695 0.287
LIG_PTB_Apo_2 444 451 PF02174 0.333
LIG_PTB_Apo_2 57 64 PF02174 0.271
LIG_SH2_CRK 145 149 PF00017 0.489
LIG_SH2_CRK 427 431 PF00017 0.299
LIG_SH2_NCK_1 145 149 PF00017 0.527
LIG_SH2_NCK_1 66 70 PF00017 0.404
LIG_SH2_SRC 12 15 PF00017 0.434
LIG_SH2_SRC 139 142 PF00017 0.388
LIG_SH2_SRC 429 432 PF00017 0.327
LIG_SH2_STAP1 14 18 PF00017 0.355
LIG_SH2_STAP1 185 189 PF00017 0.289
LIG_SH2_STAT5 12 15 PF00017 0.339
LIG_SH2_STAT5 139 142 PF00017 0.364
LIG_SH2_STAT5 193 196 PF00017 0.301
LIG_SH2_STAT5 429 432 PF00017 0.304
LIG_SH2_STAT5 437 440 PF00017 0.344
LIG_SH3_1 428 434 PF00018 0.193
LIG_SH3_3 29 35 PF00018 0.413
LIG_SH3_3 428 434 PF00018 0.297
LIG_SH3_3 453 459 PF00018 0.408
LIG_SH3_3 494 500 PF00018 0.515
LIG_SH3_3 50 56 PF00018 0.323
LIG_SH3_3 78 84 PF00018 0.346
LIG_SUMO_SIM_anti_2 359 365 PF11976 0.463
LIG_SUMO_SIM_anti_2 379 384 PF11976 0.319
LIG_SUMO_SIM_par_1 108 114 PF11976 0.289
LIG_SUMO_SIM_par_1 359 365 PF11976 0.385
LIG_TYR_ITSM 141 148 PF00017 0.485
LIG_WRC_WIRS_1 215 220 PF05994 0.530
LIG_WRC_WIRS_1 62 67 PF05994 0.286
MOD_CDK_SPxxK_3 80 87 PF00069 0.409
MOD_CK1_1 70 76 PF00069 0.325
MOD_CK2_1 135 141 PF00069 0.393
MOD_CK2_1 298 304 PF00069 0.522
MOD_CK2_1 325 331 PF00069 0.529
MOD_CK2_1 4 10 PF00069 0.545
MOD_GlcNHglycan 156 159 PF01048 0.312
MOD_GlcNHglycan 165 168 PF01048 0.333
MOD_GlcNHglycan 32 35 PF01048 0.559
MOD_GSK3_1 111 118 PF00069 0.338
MOD_GSK3_1 163 170 PF00069 0.316
MOD_GSK3_1 177 184 PF00069 0.293
MOD_GSK3_1 294 301 PF00069 0.803
MOD_GSK3_1 313 320 PF00069 0.466
MOD_N-GLC_1 244 249 PF02516 0.336
MOD_N-GLC_1 252 257 PF02516 0.411
MOD_N-GLC_1 3 8 PF02516 0.303
MOD_N-GLC_1 325 330 PF02516 0.299
MOD_NEK2_1 127 132 PF00069 0.387
MOD_NEK2_1 140 145 PF00069 0.487
MOD_NEK2_1 147 152 PF00069 0.470
MOD_NEK2_1 194 199 PF00069 0.350
MOD_NEK2_1 20 25 PF00069 0.319
MOD_NEK2_1 209 214 PF00069 0.246
MOD_NEK2_1 3 8 PF00069 0.562
MOD_NEK2_1 333 338 PF00069 0.506
MOD_NEK2_1 356 361 PF00069 0.367
MOD_NEK2_1 408 413 PF00069 0.321
MOD_NEK2_1 443 448 PF00069 0.405
MOD_NEK2_1 477 482 PF00069 0.345
MOD_NEK2_1 89 94 PF00069 0.513
MOD_NEK2_1 97 102 PF00069 0.301
MOD_NEK2_2 394 399 PF00069 0.233
MOD_PIKK_1 115 121 PF00454 0.379
MOD_PIKK_1 70 76 PF00454 0.274
MOD_PKA_1 87 93 PF00069 0.505
MOD_Plk_1 140 146 PF00069 0.511
MOD_Plk_1 3 9 PF00069 0.670
MOD_Plk_2-3 298 304 PF00069 0.561
MOD_Plk_4 135 141 PF00069 0.385
MOD_Plk_4 184 190 PF00069 0.289
MOD_Plk_4 20 26 PF00069 0.346
MOD_Plk_4 356 362 PF00069 0.309
MOD_Plk_4 419 425 PF00069 0.331
MOD_Plk_4 477 483 PF00069 0.339
MOD_Plk_4 67 73 PF00069 0.349
MOD_Plk_4 77 83 PF00069 0.308
MOD_Plk_4 97 103 PF00069 0.247
MOD_ProDKin_1 52 58 PF00069 0.458
MOD_ProDKin_1 80 86 PF00069 0.408
MOD_SUMO_rev_2 278 284 PF00179 0.606
TRG_ENDOCYTIC_2 145 148 PF00928 0.498
TRG_ENDOCYTIC_2 185 188 PF00928 0.312
TRG_ENDOCYTIC_2 193 196 PF00928 0.290
TRG_ENDOCYTIC_2 276 279 PF00928 0.777
TRG_ENDOCYTIC_2 427 430 PF00928 0.335
TRG_ENDOCYTIC_2 437 440 PF00928 0.376
TRG_ER_diArg_1 462 465 PF00400 0.380

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 35% 100%
A0A0N0P6Z5 Leptomonas seymouri 31% 100%
A0A0N1I1J0 Leptomonas seymouri 33% 100%
A0A0N1I8E8 Leptomonas seymouri 26% 100%
A0A0N1PBQ1 Leptomonas seymouri 66% 99%
A0A0S4JBS4 Bodo saltans 31% 100%
A0A1X0NN91 Trypanosomatidae 53% 100%
A0A1X0NPL0 Trypanosomatidae 55% 100%
A0A1X0NV38 Trypanosomatidae 34% 100%
A0A1X0NWJ5 Trypanosomatidae 36% 100%
A0A3Q8ICX7 Leishmania donovani 87% 100%
A0A3R7NQR3 Trypanosoma rangeli 55% 100%
A0A3S7WTL0 Leishmania donovani 34% 100%
A0A3S7XAS5 Leishmania donovani 33% 100%
A0A422MQ08 Trypanosoma rangeli 34% 100%
A0A422N8M2 Trypanosoma rangeli 31% 100%
A0A422NHH9 Trypanosoma rangeli 31% 100%
A0A422NR81 Trypanosoma rangeli 34% 100%
A1L272 Danio rerio 24% 97%
A4H6I0 Leishmania braziliensis 34% 100%
A4H7A5 Leishmania braziliensis 77% 100%
A4HG96 Leishmania braziliensis 26% 97%
A4HP60 Leishmania braziliensis 32% 99%
A4HUW2 Leishmania infantum 36% 91%
A4HVP9 Leishmania infantum 87% 100%
A4HWK9 Leishmania infantum 34% 100%
A4IDG6 Leishmania infantum 33% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AGM5 Leishmania infantum 34% 100%
E9AGM6 Leishmania infantum 34% 100%
E9AGM7 Leishmania infantum 34% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
O76343 Leishmania donovani 34% 100%
Q4Q1M9 Leishmania major 32% 98%
Q4QF58 Leishmania major 34% 100%
Q4QF59 Leishmania major 34% 100%
Q4QG33 Leishmania major 86% 100%
Q4QH25 Leishmania major 35% 99%
Q7RTT9 Homo sapiens 22% 94%
Q8R139 Mus musculus 22% 95%
V5BGB1 Trypanosoma cruzi 56% 100%
V5BRM5 Trypanosoma cruzi 35% 100%
V5DSF4 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS