Outer arm dynein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain Tctex-type, putative

Species:

Leishmania mexicana

UniProt:

E9APE2_LEIMU

TriTrypDb:

LmxM.13.1180

Length:

118

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9APE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APE2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CYCLIN_yCln2_LP_2	61	67	PF00134	0.326
DOC_MAPK_MEF2A_6	76	85	PF00069	0.459
DOC_MAPK_MEF2A_6	93	101	PF00069	0.353
DOC_USP7_MATH_1	15	19	PF00917	0.365
DOC_USP7_MATH_2	100	106	PF00917	0.379
DOC_USP7_UBL2_3	62	66	PF12436	0.326
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BRCT_BRCA1_1	81	85	PF00533	0.307
LIG_GBD_Chelix_1	50	58	PF00786	0.405
LIG_LIR_Gen_1	104	114	PF02991	0.361
LIG_LIR_Gen_1	82	90	PF02991	0.326
LIG_LIR_Nem_3	104	109	PF02991	0.371
LIG_LIR_Nem_3	82	88	PF02991	0.307
LIG_PCNA_yPIPBox_3	22	32	PF02747	0.326
LIG_Pex14_2	85	89	PF04695	0.307
LIG_PTB_Apo_2	100	107	PF02174	0.451
LIG_SH2_CRK	65	69	PF00017	0.418
LIG_SH2_STAT5	113	116	PF00017	0.429
LIG_SH2_STAT5	67	70	PF00017	0.370
LIG_SH3_3	94	100	PF00018	0.307
LIG_TRAF2_1	20	23	PF00917	0.523
LIG_UBA3_1	54	63	PF00899	0.418
MOD_CK1_1	14	20	PF00069	0.544
MOD_CK1_1	53	59	PF00069	0.448
MOD_CK2_1	17	23	PF00069	0.543
MOD_GlcNHglycan	13	16	PF01048	0.360
MOD_GSK3_1	11	18	PF00069	0.585
MOD_N-GLC_1	102	107	PF02516	0.307
MOD_NEK2_1	28	33	PF00069	0.451
MOD_NEK2_1	74	79	PF00069	0.325
MOD_NEK2_2	108	113	PF00069	0.326
MOD_Plk_1	102	108	PF00069	0.348
MOD_Plk_4	108	114	PF00069	0.307
MOD_Plk_4	50	56	PF00069	0.362
MOD_SUMO_rev_2	57	64	PF00179	0.412
TRG_ENDOCYTIC_2	65	68	PF00928	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I984	Leptomonas seymouri	84%	100%
A0A0S4JBN6	Bodo saltans	56%	100%
A0A1X0NMX7	Trypanosomatidae	61%	100%
A0A3R7MI20	Trypanosoma rangeli	61%	100%
A0A3S7WP25	Leishmania donovani	30%	100%
A0A3S7WSJ3	Leishmania donovani	99%	100%
A4H7A2	Leishmania braziliensis	95%	100%
A4HVP6	Leishmania infantum	99%	100%
D0A4G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A6J9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
P51807	Mus musculus	29%	100%
P51808	Homo sapiens	32%	100%
P56387	Mus musculus	31%	100%
P63171	Bos taurus	31%	100%
P63172	Homo sapiens	31%	100%
Q4QG36	Leishmania major	98%	100%
Q4QJG0	Leishmania major	31%	100%
Q54PG1	Dictyostelium discoideum	33%	100%
Q5NVF5	Pongo abelii	32%	100%
Q6XXL8	Ovis aries	32%	100%
Q8SPS9	Canis lupus familiaris	39%	100%
Q94524	Drosophila melanogaster	33%	100%
Q9Z336	Rattus norvegicus	34%	100%