Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APE1_LEIMU

TriTrypDb:

LmxM.13.1170

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9APE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.461
CLV_C14_Caspase3-7	191	195	PF00656	0.610
CLV_C14_Caspase3-7	261	265	PF00656	0.647
CLV_C14_Caspase3-7	51	55	PF00656	0.793
CLV_NRD_NRD_1	118	120	PF00675	0.568
CLV_NRD_NRD_1	187	189	PF00675	0.715
CLV_NRD_NRD_1	232	234	PF00675	0.549
CLV_NRD_NRD_1	265	267	PF00675	0.649
CLV_NRD_NRD_1	273	275	PF00675	0.674
CLV_NRD_NRD_1	28	30	PF00675	0.673
CLV_NRD_NRD_1	316	318	PF00675	0.354
CLV_NRD_NRD_1	399	401	PF00675	0.463
CLV_NRD_NRD_1	413	415	PF00675	0.584
CLV_NRD_NRD_1	420	422	PF00675	0.667
CLV_PCSK_KEX2_1	117	119	PF00082	0.515
CLV_PCSK_KEX2_1	187	189	PF00082	0.711
CLV_PCSK_KEX2_1	224	226	PF00082	0.643
CLV_PCSK_KEX2_1	232	234	PF00082	0.575
CLV_PCSK_KEX2_1	272	274	PF00082	0.646
CLV_PCSK_KEX2_1	28	30	PF00082	0.673
CLV_PCSK_KEX2_1	399	401	PF00082	0.457
CLV_PCSK_KEX2_1	413	415	PF00082	0.595
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.652
CLV_PCSK_PC7_1	183	189	PF00082	0.586
CLV_PCSK_SKI1_1	111	115	PF00082	0.563
CLV_PCSK_SKI1_1	118	122	PF00082	0.511
CLV_PCSK_SKI1_1	141	145	PF00082	0.443
CLV_PCSK_SKI1_1	221	225	PF00082	0.676
CLV_PCSK_SKI1_1	322	326	PF00082	0.529
CLV_PCSK_SKI1_1	352	356	PF00082	0.445
CLV_PCSK_SKI1_1	462	466	PF00082	0.409
CLV_PCSK_SKI1_1	493	497	PF00082	0.329
CLV_Separin_Metazoa	396	400	PF03568	0.386
DEG_SPOP_SBC_1	423	427	PF00917	0.652
DEG_SPOP_SBC_1	452	456	PF00917	0.490
DEG_SPOP_SBC_1	83	87	PF00917	0.695
DOC_CKS1_1	444	449	PF01111	0.583
DOC_CYCLIN_RxL_1	115	125	PF00134	0.524
DOC_CYCLIN_RxL_1	290	298	PF00134	0.465
DOC_CYCLIN_RxL_1	365	374	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.519
DOC_MAPK_gen_1	278	288	PF00069	0.384
DOC_MAPK_gen_1	399	407	PF00069	0.591
DOC_MAPK_MEF2A_6	281	288	PF00069	0.359
DOC_MAPK_MEF2A_6	389	397	PF00069	0.478
DOC_PP1_RVXF_1	366	373	PF00149	0.385
DOC_PP2B_LxvP_1	288	291	PF13499	0.436
DOC_PP2B_LxvP_1	3	6	PF13499	0.523
DOC_PP4_FxxP_1	407	410	PF00568	0.740
DOC_PP4_FxxP_1	437	440	PF00568	0.682
DOC_SPAK_OSR1_1	311	315	PF12202	0.412
DOC_USP7_MATH_1	291	295	PF00917	0.514
DOC_USP7_MATH_1	328	332	PF00917	0.601
DOC_USP7_MATH_1	452	456	PF00917	0.444
DOC_USP7_MATH_1	84	88	PF00917	0.620
DOC_USP7_UBL2_3	318	322	PF12436	0.480
DOC_WW_Pin1_4	192	197	PF00397	0.722
DOC_WW_Pin1_4	254	259	PF00397	0.765
DOC_WW_Pin1_4	331	336	PF00397	0.650
DOC_WW_Pin1_4	429	434	PF00397	0.658
DOC_WW_Pin1_4	440	445	PF00397	0.591
DOC_WW_Pin1_4	92	97	PF00397	0.608
LIG_14-3-3_CanoR_1	159	169	PF00244	0.430
LIG_14-3-3_CanoR_1	205	210	PF00244	0.504
LIG_14-3-3_CanoR_1	278	288	PF00244	0.473
LIG_14-3-3_CanoR_1	366	371	PF00244	0.380
LIG_14-3-3_CanoR_1	414	420	PF00244	0.623
LIG_14-3-3_CanoR_1	453	459	PF00244	0.507
LIG_BIR_III_2	81	85	PF00653	0.598
LIG_BRCT_BRCA1_1	165	169	PF00533	0.358
LIG_BRCT_BRCA1_1	368	372	PF00533	0.468
LIG_BRCT_BRCA1_1	454	458	PF00533	0.347
LIG_BRCT_BRCA1_1	86	90	PF00533	0.774
LIG_CaM_IQ_9	128	143	PF13499	0.441
LIG_deltaCOP1_diTrp_1	308	312	PF00928	0.304
LIG_deltaCOP1_diTrp_1	346	355	PF00928	0.477
LIG_FHA_1	423	429	PF00498	0.635
LIG_FHA_1	505	511	PF00498	0.521
LIG_FHA_2	308	314	PF00498	0.399
LIG_FHA_2	337	343	PF00498	0.602
LIG_GBD_Chelix_1	536	544	PF00786	0.479
LIG_KLC1_Yacidic_2	391	396	PF13176	0.395
LIG_LIR_Apic_2	406	410	PF02991	0.647
LIG_LIR_Apic_2	77	83	PF02991	0.606
LIG_LIR_Gen_1	308	316	PF02991	0.303
LIG_LIR_Gen_1	391	402	PF02991	0.382
LIG_LIR_Gen_1	471	481	PF02991	0.411
LIG_LIR_Gen_1	497	506	PF02991	0.531
LIG_LIR_Nem_3	156	161	PF02991	0.475
LIG_LIR_Nem_3	287	292	PF02991	0.314
LIG_LIR_Nem_3	308	312	PF02991	0.304
LIG_MLH1_MIPbox_1	165	169	PF16413	0.358
LIG_MYND_1	151	155	PF01753	0.405
LIG_RPA_C_Fungi	269	281	PF08784	0.370
LIG_SH2_CRK	206	210	PF00017	0.458
LIG_SH2_CRK	480	484	PF00017	0.274
LIG_SH2_GRB2like	360	363	PF00017	0.373
LIG_SH2_NCK_1	243	247	PF00017	0.606
LIG_SH2_SRC	179	182	PF00017	0.508
LIG_SH2_SRC	360	363	PF00017	0.373
LIG_SH2_STAP1	474	478	PF00017	0.285
LIG_SH2_STAT3	513	516	PF00017	0.274
LIG_SH2_STAT5	168	171	PF00017	0.328
LIG_SH2_STAT5	179	182	PF00017	0.445
LIG_SH2_STAT5	243	246	PF00017	0.604
LIG_SH2_STAT5	360	363	PF00017	0.443
LIG_SH2_STAT5	394	397	PF00017	0.438
LIG_SH2_STAT5	484	487	PF00017	0.255
LIG_SH2_STAT5	499	502	PF00017	0.265
LIG_SH2_STAT5	513	516	PF00017	0.259
LIG_SH2_STAT5	526	529	PF00017	0.239
LIG_SH3_3	149	155	PF00018	0.430
LIG_SH3_3	441	447	PF00018	0.720
LIG_SH3_3	95	101	PF00018	0.581
LIG_TRAF2_1	380	383	PF00917	0.367
LIG_WW_3	218	222	PF00397	0.589
MOD_CK1_1	103	109	PF00069	0.619
MOD_CK1_1	167	173	PF00069	0.500
MOD_CK1_1	253	259	PF00069	0.506
MOD_CK1_1	32	38	PF00069	0.612
MOD_CK1_1	331	337	PF00069	0.627
MOD_CK1_1	429	435	PF00069	0.688
MOD_CK1_1	457	463	PF00069	0.452
MOD_CK1_1	8	14	PF00069	0.662
MOD_CK2_1	336	342	PF00069	0.458
MOD_CK2_1	414	420	PF00069	0.737
MOD_CK2_1	72	78	PF00069	0.576
MOD_GlcNHglycan	155	158	PF01048	0.468
MOD_GlcNHglycan	18	21	PF01048	0.521
MOD_GlcNHglycan	221	224	PF01048	0.764
MOD_GlcNHglycan	31	34	PF01048	0.672
MOD_GlcNHglycan	428	431	PF01048	0.759
MOD_GlcNHglycan	459	462	PF01048	0.419
MOD_GlcNHglycan	469	473	PF01048	0.241
MOD_GlcNHglycan	7	10	PF01048	0.604
MOD_GlcNHglycan	90	93	PF01048	0.621
MOD_GSK3_1	11	18	PF00069	0.712
MOD_GSK3_1	160	167	PF00069	0.534
MOD_GSK3_1	179	186	PF00069	0.552
MOD_GSK3_1	250	257	PF00069	0.507
MOD_GSK3_1	28	35	PF00069	0.662
MOD_GSK3_1	291	298	PF00069	0.411
MOD_GSK3_1	422	429	PF00069	0.491
MOD_GSK3_1	453	460	PF00069	0.543
MOD_GSK3_1	536	543	PF00069	0.395
MOD_GSK3_1	84	91	PF00069	0.617
MOD_NEK2_1	161	166	PF00069	0.426
MOD_NEK2_1	169	174	PF00069	0.298
MOD_NEK2_1	284	289	PF00069	0.471
MOD_NEK2_1	295	300	PF00069	0.370
MOD_NEK2_1	336	341	PF00069	0.444
MOD_NEK2_1	536	541	PF00069	0.466
MOD_NEK2_1	90	95	PF00069	0.722
MOD_NEK2_2	66	71	PF00069	0.547
MOD_PIKK_1	250	256	PF00454	0.519
MOD_PIKK_1	408	414	PF00454	0.600
MOD_PIKK_1	463	469	PF00454	0.448
MOD_PIKK_1	72	78	PF00454	0.619
MOD_PK_1	205	211	PF00069	0.463
MOD_PKA_1	28	34	PF00069	0.592
MOD_PKA_2	241	247	PF00069	0.682
MOD_PKA_2	28	34	PF00069	0.682
MOD_PKA_2	452	458	PF00069	0.508
MOD_PKA_2	47	53	PF00069	0.713
MOD_PKA_2	66	72	PF00069	0.651
MOD_Plk_1	295	301	PF00069	0.385
MOD_Plk_1	307	313	PF00069	0.259
MOD_Plk_4	164	170	PF00069	0.557
MOD_Plk_4	295	301	PF00069	0.401
MOD_ProDKin_1	192	198	PF00069	0.718
MOD_ProDKin_1	254	260	PF00069	0.765
MOD_ProDKin_1	331	337	PF00069	0.653
MOD_ProDKin_1	429	435	PF00069	0.652
MOD_ProDKin_1	440	446	PF00069	0.589
MOD_ProDKin_1	92	98	PF00069	0.605
MOD_SUMO_rev_2	417	423	PF00179	0.731
MOD_SUMO_rev_2	50	58	PF00179	0.736
TRG_DiLeu_BaEn_1	126	131	PF01217	0.299
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.548
TRG_ENDOCYTIC_2	168	171	PF00928	0.328
TRG_ENDOCYTIC_2	206	209	PF00928	0.454
TRG_ENDOCYTIC_2	394	397	PF00928	0.465
TRG_ENDOCYTIC_2	474	477	PF00928	0.236
TRG_ENDOCYTIC_2	499	502	PF00928	0.422
TRG_ER_diArg_1	117	119	PF00400	0.547
TRG_ER_diArg_1	240	243	PF00400	0.602
TRG_ER_diArg_1	27	29	PF00400	0.679
TRG_ER_diArg_1	272	274	PF00400	0.674
TRG_ER_diArg_1	365	368	PF00400	0.320
TRG_ER_diArg_1	398	400	PF00400	0.447
TRG_NES_CRM1_1	494	509	PF08389	0.318
TRG_NLS_MonoExtN_4	173	179	PF00514	0.296
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	462	467	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J1	Leptomonas seymouri	50%	100%
A0A0S4J8B7	Bodo saltans	28%	100%
A0A1X0NMY2	Trypanosomatidae	34%	100%
A0A3R7KEA8	Trypanosoma rangeli	34%	100%
A0A3S7WSK1	Leishmania donovani	92%	100%
A4HVP5	Leishmania infantum	92%	100%
D0A6K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QG37	Leishmania major	91%	99%
V5D7N8	Trypanosoma cruzi	36%	100%