AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9APD8_LEIMU

TriTrypDb:

LmxM.13.1140

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APD8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.375
CLV_C14_Caspase3-7	258	262	PF00656	0.323
CLV_C14_Caspase3-7	387	391	PF00656	0.343
CLV_NRD_NRD_1	133	135	PF00675	0.326
CLV_NRD_NRD_1	165	167	PF00675	0.414
CLV_NRD_NRD_1	61	63	PF00675	0.274
CLV_PCSK_KEX2_1	133	135	PF00082	0.324
CLV_PCSK_KEX2_1	165	167	PF00082	0.389
CLV_PCSK_KEX2_1	61	63	PF00082	0.274
CLV_PCSK_SKI1_1	139	143	PF00082	0.211
CLV_PCSK_SKI1_1	242	246	PF00082	0.279
CLV_PCSK_SKI1_1	386	390	PF00082	0.457
CLV_PCSK_SKI1_1	8	12	PF00082	0.564
CLV_Separin_Metazoa	265	269	PF03568	0.169
DEG_APCC_DBOX_1	297	305	PF00400	0.181
DEG_Nend_UBRbox_3	1	3	PF02207	0.669
DEG_SCF_TRCP1_1	204	209	PF00400	0.197
DOC_MAPK_DCC_7	3	12	PF00069	0.385
DOC_MAPK_gen_1	57	66	PF00069	0.411
DOC_MAPK_HePTP_8	213	225	PF00069	0.246
DOC_MAPK_HePTP_8	56	68	PF00069	0.274
DOC_MAPK_MEF2A_6	216	225	PF00069	0.305
DOC_MAPK_MEF2A_6	336	344	PF00069	0.286
DOC_MAPK_MEF2A_6	59	68	PF00069	0.289
DOC_PP4_FxxP_1	104	107	PF00568	0.411
DOC_USP7_MATH_1	44	48	PF00917	0.365
DOC_USP7_MATH_1	75	79	PF00917	0.402
DOC_USP7_MATH_1	84	88	PF00917	0.402
DOC_USP7_UBL2_3	11	15	PF12436	0.391
DOC_USP7_UBL2_3	289	293	PF12436	0.425
DOC_WW_Pin1_4	197	202	PF00397	0.387
DOC_WW_Pin1_4	223	228	PF00397	0.286
DOC_WW_Pin1_4	347	352	PF00397	0.296
LIG_14-3-3_CanoR_1	139	145	PF00244	0.326
LIG_14-3-3_CanoR_1	195	201	PF00244	0.397
LIG_14-3-3_CanoR_1	247	253	PF00244	0.312
LIG_14-3-3_CanoR_1	336	341	PF00244	0.361
LIG_Actin_WH2_2	118	135	PF00022	0.321
LIG_BRCT_BRCA1_1	177	181	PF00533	0.203
LIG_BRCT_BRCA1_1	361	365	PF00533	0.274
LIG_CtBP_PxDLS_1	65	69	PF00389	0.169
LIG_eIF4E_1	31	37	PF01652	0.274
LIG_FHA_1	226	232	PF00498	0.298
LIG_FHA_1	280	286	PF00498	0.307
LIG_FHA_1	337	343	PF00498	0.375
LIG_FHA_1	387	393	PF00498	0.428
LIG_FHA_2	101	107	PF00498	0.197
LIG_FHA_2	367	373	PF00498	0.298
LIG_LIR_Apic_2	103	107	PF02991	0.222
LIG_LIR_Apic_2	350	355	PF02991	0.305
LIG_LIR_Nem_3	306	311	PF02991	0.336
LIG_MLH1_MIPbox_1	361	365	PF16413	0.274
LIG_SH2_NCK_1	352	356	PF00017	0.275
LIG_SH2_STAT5	31	34	PF00017	0.274
LIG_SH3_3	48	54	PF00018	0.335
LIG_SUMO_SIM_par_1	221	226	PF11976	0.305
LIG_TRAF2_1	272	275	PF00917	0.412
LIG_WRC_WIRS_1	308	313	PF05994	0.411
MOD_CDK_SPxxK_3	223	230	PF00069	0.357
MOD_CK1_1	109	115	PF00069	0.461
MOD_CK1_1	153	159	PF00069	0.456
MOD_CK1_1	18	24	PF00069	0.545
MOD_CK1_1	199	205	PF00069	0.387
MOD_CK1_1	314	320	PF00069	0.378
MOD_CK1_1	321	327	PF00069	0.374
MOD_CK1_1	366	372	PF00069	0.300
MOD_CK1_1	74	80	PF00069	0.344
MOD_CK2_1	366	372	PF00069	0.249
MOD_CK2_1	84	90	PF00069	0.296
MOD_GlcNHglycan	152	155	PF01048	0.339
MOD_GlcNHglycan	17	20	PF01048	0.508
MOD_GlcNHglycan	204	207	PF01048	0.423
MOD_GlcNHglycan	235	238	PF01048	0.313
MOD_GlcNHglycan	321	324	PF01048	0.383
MOD_GlcNHglycan	330	333	PF01048	0.439
MOD_GlcNHglycan	73	76	PF01048	0.211
MOD_GSK3_1	18	25	PF00069	0.384
MOD_GSK3_1	195	202	PF00069	0.357
MOD_GSK3_1	285	292	PF00069	0.264
MOD_GSK3_1	303	310	PF00069	0.401
MOD_GSK3_1	313	320	PF00069	0.305
MOD_GSK3_1	323	330	PF00069	0.287
MOD_GSK3_1	359	366	PF00069	0.407
MOD_GSK3_1	38	45	PF00069	0.237
MOD_GSK3_1	70	77	PF00069	0.335
MOD_N-GLC_1	175	180	PF02516	0.203
MOD_N-GLC_1	206	211	PF02516	0.270
MOD_N-GLC_1	366	371	PF02516	0.357
MOD_N-GLC_1	38	43	PF02516	0.203
MOD_NEK2_1	100	105	PF00069	0.341
MOD_NEK2_1	140	145	PF00069	0.415
MOD_NEK2_1	181	186	PF00069	0.374
MOD_NEK2_1	279	284	PF00069	0.308
MOD_NEK2_1	319	324	PF00069	0.361
MOD_NEK2_1	37	42	PF00069	0.320
MOD_NEK2_1	395	400	PF00069	0.439
MOD_PIKK_1	181	187	PF00454	0.370
MOD_PIKK_1	246	252	PF00454	0.448
MOD_PIKK_1	25	31	PF00454	0.442
MOD_PIKK_1	366	372	PF00454	0.296
MOD_PKA_2	246	252	PF00069	0.378
MOD_PKA_2	359	365	PF00069	0.243
MOD_Plk_1	175	181	PF00069	0.240
MOD_Plk_1	206	212	PF00069	0.246
MOD_Plk_1	366	372	PF00069	0.411
MOD_Plk_2-3	255	261	PF00069	0.370
MOD_Plk_4	314	320	PF00069	0.451
MOD_Plk_4	395	401	PF00069	0.510
MOD_ProDKin_1	197	203	PF00069	0.373
MOD_ProDKin_1	223	229	PF00069	0.286
MOD_ProDKin_1	347	353	PF00069	0.296
TRG_DiLeu_BaEn_2	274	280	PF01217	0.211
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.351
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.246
TRG_ENDOCYTIC_2	308	311	PF00928	0.278
TRG_ER_diArg_1	132	134	PF00400	0.326
TRG_ER_diArg_1	358	361	PF00400	0.189
TRG_ER_diArg_1	60	62	PF00400	0.428
TRG_NES_CRM1_1	243	255	PF08389	0.302
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L5	Leptomonas seymouri	65%	100%
A0A0N1I6V6	Leptomonas seymouri	23%	100%
A0A0S4J886	Bodo saltans	32%	97%
A0A0S4JJG1	Bodo saltans	26%	100%
A0A1X0NNK2	Trypanosomatidae	41%	100%
A0A3Q8I9M0	Leishmania donovani	91%	100%
A0A3Q8IDU3	Leishmania donovani	23%	100%
A0A3R7LZE9	Trypanosoma rangeli	45%	100%
A4H7A0	Leishmania braziliensis	78%	100%
A4HF07	Leishmania braziliensis	24%	100%
A4HVP2	Leishmania infantum	91%	100%
A4I286	Leishmania infantum	23%	100%
D0A6K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AYD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q942	Leishmania major	24%	100%
Q4QG40	Leishmania major	89%	100%
V5ARR6	Trypanosoma cruzi	45%	94%