TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APD5_LEIMU

TriTrypDb:

LmxM.13.1110

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.575
CLV_C14_Caspase3-7	395	399	PF00656	0.799
CLV_C14_Caspase3-7	94	98	PF00656	0.596
CLV_NRD_NRD_1	12	14	PF00675	0.553
CLV_NRD_NRD_1	151	153	PF00675	0.548
CLV_NRD_NRD_1	217	219	PF00675	0.488
CLV_NRD_NRD_1	227	229	PF00675	0.534
CLV_NRD_NRD_1	249	251	PF00675	0.625
CLV_NRD_NRD_1	315	317	PF00675	0.554
CLV_NRD_NRD_1	403	405	PF00675	0.654
CLV_NRD_NRD_1	428	430	PF00675	0.596
CLV_NRD_NRD_1	445	447	PF00675	0.383
CLV_NRD_NRD_1	468	470	PF00675	0.505
CLV_NRD_NRD_1	474	476	PF00675	0.529
CLV_NRD_NRD_1	509	511	PF00675	0.592
CLV_NRD_NRD_1	58	60	PF00675	0.586
CLV_NRD_NRD_1	6	8	PF00675	0.592
CLV_NRD_NRD_1	66	68	PF00675	0.501
CLV_PCSK_KEX2_1	12	14	PF00082	0.605
CLV_PCSK_KEX2_1	163	165	PF00082	0.472
CLV_PCSK_KEX2_1	217	219	PF00082	0.543
CLV_PCSK_KEX2_1	249	251	PF00082	0.652
CLV_PCSK_KEX2_1	299	301	PF00082	0.523
CLV_PCSK_KEX2_1	403	405	PF00082	0.674
CLV_PCSK_KEX2_1	428	430	PF00082	0.589
CLV_PCSK_KEX2_1	445	447	PF00082	0.370
CLV_PCSK_KEX2_1	463	465	PF00082	0.518
CLV_PCSK_KEX2_1	468	470	PF00082	0.502
CLV_PCSK_KEX2_1	474	476	PF00082	0.483
CLV_PCSK_KEX2_1	65	67	PF00082	0.545
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.494
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.537
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.645
CLV_PCSK_PC7_1	464	470	PF00082	0.595
CLV_PCSK_SKI1_1	159	163	PF00082	0.599
CLV_PCSK_SKI1_1	191	195	PF00082	0.557
CLV_PCSK_SKI1_1	265	269	PF00082	0.697
CLV_PCSK_SKI1_1	510	514	PF00082	0.522
DEG_APCC_DBOX_1	123	131	PF00400	0.620
DOC_CYCLIN_yClb5_NLxxxL_5	203	211	PF00134	0.546
DOC_MAPK_gen_1	445	452	PF00069	0.634
DOC_PP1_RVXF_1	33	40	PF00149	0.614
DOC_USP7_MATH_1	19	23	PF00917	0.435
DOC_USP7_MATH_1	397	401	PF00917	0.773
DOC_USP7_UBL2_3	159	163	PF12436	0.475
DOC_USP7_UBL2_3	359	363	PF12436	0.632
DOC_USP7_UBL2_3	417	421	PF12436	0.594
LIG_14-3-3_CanoR_1	137	143	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_CaM_IQ_9	455	471	PF13499	0.520
LIG_FHA_1	336	342	PF00498	0.630
LIG_FHA_1	76	82	PF00498	0.643
LIG_FHA_2	267	273	PF00498	0.621
LIG_Integrin_RGD_1	387	389	PF01839	0.794
LIG_LIR_Nem_3	489	495	PF02991	0.474
LIG_PCNA_PIPBox_1	103	112	PF02747	0.578
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.543
LIG_PCNA_yPIPBox_3	96	110	PF02747	0.585
LIG_PTB_Apo_2	253	260	PF02174	0.653
LIG_PTB_Phospho_1	253	259	PF10480	0.684
LIG_REV1ctd_RIR_1	37	46	PF16727	0.628
LIG_SH2_SRC	495	498	PF00017	0.480
LIG_SH2_STAP1	110	114	PF00017	0.573
LIG_SH2_STAP1	354	358	PF00017	0.598
LIG_SH2_STAP1	423	427	PF00017	0.625
LIG_SH2_STAT3	110	113	PF00017	0.573
LIG_SH2_STAT3	336	339	PF00017	0.722
LIG_SH2_STAT3	430	433	PF00017	0.661
LIG_SH2_STAT5	324	327	PF00017	0.653
LIG_SH2_STAT5	45	48	PF00017	0.619
LIG_SH2_STAT5	495	498	PF00017	0.440
LIG_TRAF2_1	123	126	PF00917	0.598
LIG_TRAF2_1	235	238	PF00917	0.528
LIG_TRAF2_1	290	293	PF00917	0.537
LIG_TRAF2_1	312	315	PF00917	0.649
LIG_TRAF2_1	328	331	PF00917	0.458
LIG_TRAF2_1	483	486	PF00917	0.583
MOD_CK2_1	266	272	PF00069	0.680
MOD_CK2_1	30	36	PF00069	0.556
MOD_GlcNHglycan	21	24	PF01048	0.586
MOD_GlcNHglycan	392	395	PF01048	0.793
MOD_GSK3_1	67	74	PF00069	0.456
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	24	29	PF00069	0.650
MOD_NEK2_1	43	48	PF00069	0.612
MOD_NEK2_1	69	74	PF00069	0.580
MOD_PIKK_1	335	341	PF00454	0.613
MOD_PIKK_1	45	51	PF00454	0.689
MOD_PIKK_1	510	516	PF00454	0.640
MOD_PK_1	294	300	PF00069	0.568
MOD_PKA_1	510	516	PF00069	0.632
MOD_PKB_1	65	73	PF00069	0.538
MOD_Plk_1	24	30	PF00069	0.650
MOD_Plk_4	206	212	PF00069	0.545
MOD_Plk_4	345	351	PF00069	0.588
MOD_Plk_4	495	501	PF00069	0.560
MOD_SUMO_for_1	162	165	PF00179	0.523
MOD_SUMO_for_1	328	331	PF00179	0.645
MOD_SUMO_rev_2	115	121	PF00179	0.563
MOD_SUMO_rev_2	291	295	PF00179	0.564
MOD_SUMO_rev_2	314	319	PF00179	0.656
MOD_SUMO_rev_2	377	384	PF00179	0.689
TRG_ENDOCYTIC_2	158	161	PF00928	0.631
TRG_ER_diArg_1	11	13	PF00400	0.612
TRG_ER_diArg_1	134	137	PF00400	0.546
TRG_ER_diArg_1	249	252	PF00400	0.678
TRG_ER_diArg_1	427	429	PF00400	0.620
TRG_ER_diArg_1	65	67	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD47	Leptomonas seymouri	64%	97%
A0A1X0NPL9	Trypanosomatidae	38%	100%
A0A3R7MPR3	Trypanosoma rangeli	37%	100%
A0A3S5H6P4	Leishmania donovani	95%	100%
A4H797	Leishmania braziliensis	84%	100%
A4HVN9	Leishmania infantum	95%	100%
D0A6K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QG43	Leishmania major	94%	100%
V5BBN8	Trypanosoma cruzi	38%	100%