Nucleoside-diphosphate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APC9_LEIMU

TriTrypDb:

LmxM.13.1050

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APC9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.418
CLV_C14_Caspase3-7	3	7	PF00656	0.617
CLV_C14_Caspase3-7	81	85	PF00656	0.501
CLV_NRD_NRD_1	148	150	PF00675	0.565
CLV_NRD_NRD_1	32	34	PF00675	0.407
CLV_PCSK_KEX2_1	32	34	PF00082	0.443
CLV_PCSK_SKI1_1	193	197	PF00082	0.229
CLV_PCSK_SKI1_1	21	25	PF00082	0.282
CLV_PCSK_SKI1_1	218	222	PF00082	0.138
DEG_APCC_DBOX_1	52	60	PF00400	0.531
DEG_SPOP_SBC_1	86	90	PF00917	0.488
DOC_CKS1_1	25	30	PF01111	0.371
DOC_CYCLIN_RxL_1	144	156	PF00134	0.525
DOC_CYCLIN_RxL_1	18	27	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.482
DOC_MAPK_gen_1	163	170	PF00069	0.398
DOC_MAPK_MEF2A_6	163	170	PF00069	0.357
DOC_PP2B_LxvP_1	75	78	PF13499	0.668
DOC_USP7_MATH_1	162	166	PF00917	0.455
DOC_USP7_MATH_1	4	8	PF00917	0.585
DOC_USP7_MATH_1	86	90	PF00917	0.516
DOC_WW_Pin1_4	229	234	PF00397	0.576
DOC_WW_Pin1_4	24	29	PF00397	0.433
LIG_14-3-3_CanoR_1	87	93	PF00244	0.456
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_BIR_III_3	1	5	PF00653	0.673
LIG_BRCT_BRCA1_1	88	92	PF00533	0.612
LIG_FHA_1	104	110	PF00498	0.476
LIG_FHA_1	178	184	PF00498	0.609
LIG_FHA_2	79	85	PF00498	0.654
LIG_LIR_Gen_1	106	113	PF02991	0.348
LIG_LIR_Gen_1	46	56	PF02991	0.332
LIG_LIR_Nem_3	106	111	PF02991	0.349
LIG_LIR_Nem_3	35	39	PF02991	0.372
LIG_LIR_Nem_3	46	52	PF02991	0.266
LIG_SH2_PTP2	108	111	PF00017	0.299
LIG_SH2_STAT5	108	111	PF00017	0.250
LIG_SH2_STAT5	187	190	PF00017	0.413
LIG_SH2_STAT5	39	42	PF00017	0.408
LIG_SH3_1	205	211	PF00018	0.424
LIG_SH3_2	208	213	PF14604	0.424
LIG_SH3_3	205	211	PF00018	0.453
LIG_SH3_3	71	77	PF00018	0.604
LIG_SUMO_SIM_anti_2	165	170	PF11976	0.461
LIG_SUMO_SIM_par_1	22	27	PF11976	0.400
LIG_TYR_ITSM	104	111	PF00017	0.413
LIG_WRC_WIRS_1	121	126	PF05994	0.402
MOD_CK1_1	181	187	PF00069	0.556
MOD_CK2_1	120	126	PF00069	0.289
MOD_Cter_Amidation	147	150	PF01082	0.465
MOD_GlcNHglycan	180	183	PF01048	0.550
MOD_GlcNHglycan	2	5	PF01048	0.618
MOD_GSK3_1	120	127	PF00069	0.494
MOD_GSK3_1	177	184	PF00069	0.497
MOD_N-GLC_1	221	226	PF02516	0.421
MOD_NEK2_1	103	108	PF00069	0.428
MOD_NEK2_1	112	117	PF00069	0.427
MOD_NEK2_1	120	125	PF00069	0.402
MOD_NEK2_1	15	20	PF00069	0.498
MOD_NEK2_1	153	158	PF00069	0.475
MOD_PIKK_1	124	130	PF00454	0.477
MOD_PIKK_1	221	227	PF00454	0.600
MOD_PKA_2	86	92	PF00069	0.383
MOD_Plk_4	120	126	PF00069	0.412
MOD_Plk_4	92	98	PF00069	0.520
MOD_ProDKin_1	24	30	PF00069	0.433
TRG_DiLeu_BaEn_1	54	59	PF01217	0.458
TRG_DiLeu_BaEn_4	54	60	PF01217	0.411
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.344
TRG_DiLeu_LyEn_5	54	59	PF01217	0.458
TRG_ENDOCYTIC_2	108	111	PF00928	0.250
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P894	Leptomonas seymouri	62%	95%
A0A0S4JTH8	Bodo saltans	35%	100%
A0A1X0NPH5	Trypanosomatidae	36%	80%
A0A3S7WSM5	Leishmania donovani	91%	98%
A0A422NGD0	Trypanosoma rangeli	39%	90%
A4H793	Leishmania braziliensis	79%	100%
A4HVN3	Leishmania infantum	91%	98%
D0A6L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	89%
P56597	Homo sapiens	24%	100%
Q4QG49	Leishmania major	89%	100%
V5DBS4	Trypanosoma cruzi	40%	90%