Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APC5_LEIMU

TriTrypDb:

LmxM.13.1010

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9APC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.632
CLV_NRD_NRD_1	130	132	PF00675	0.671
CLV_NRD_NRD_1	140	142	PF00675	0.668
CLV_NRD_NRD_1	181	183	PF00675	0.413
CLV_NRD_NRD_1	200	202	PF00675	0.600
CLV_NRD_NRD_1	225	227	PF00675	0.437
CLV_PCSK_KEX2_1	140	142	PF00082	0.652
CLV_PCSK_KEX2_1	181	183	PF00082	0.413
CLV_PCSK_KEX2_1	200	202	PF00082	0.541
CLV_PCSK_KEX2_1	224	226	PF00082	0.447
CLV_PCSK_PC7_1	221	227	PF00082	0.456
CLV_PCSK_SKI1_1	181	185	PF00082	0.439
CLV_PCSK_SKI1_1	225	229	PF00082	0.503
CLV_PCSK_SKI1_1	305	309	PF00082	0.383
DEG_APCC_DBOX_1	310	318	PF00400	0.686
DEG_Nend_UBRbox_1	1	4	PF02207	0.733
DEG_SPOP_SBC_1	26	30	PF00917	0.646
DEG_SPOP_SBC_1	82	86	PF00917	0.357
DOC_MAPK_gen_1	140	148	PF00069	0.562
DOC_MAPK_gen_1	181	187	PF00069	0.633
DOC_MAPK_gen_1	224	235	PF00069	0.687
DOC_MAPK_HePTP_8	223	235	PF00069	0.697
DOC_MAPK_MEF2A_6	226	235	PF00069	0.680
DOC_PP2B_LxvP_1	108	111	PF13499	0.508
DOC_PP2B_LxvP_1	269	272	PF13499	0.511
DOC_USP7_MATH_1	83	87	PF00917	0.501
DOC_USP7_MATH_2	203	209	PF00917	0.690
DOC_WW_Pin1_4	95	100	PF00397	0.517
LIG_14-3-3_CanoR_1	140	148	PF00244	0.506
LIG_14-3-3_CanoR_1	181	186	PF00244	0.644
LIG_14-3-3_CanoR_1	206	213	PF00244	0.603
LIG_14-3-3_CanoR_1	256	264	PF00244	0.431
LIG_Actin_WH2_2	36	53	PF00022	0.600
LIG_EH1_1	163	171	PF00400	0.411
LIG_EH1_1	247	255	PF00400	0.513
LIG_eIF4E_1	164	170	PF01652	0.411
LIG_FHA_1	101	107	PF00498	0.547
LIG_FHA_1	140	146	PF00498	0.388
LIG_FHA_1	182	188	PF00498	0.653
LIG_FHA_1	191	197	PF00498	0.588
LIG_FHA_1	249	255	PF00498	0.397
LIG_FHA_1	63	69	PF00498	0.520
LIG_FHA_1	82	88	PF00498	0.366
LIG_FHA_2	189	195	PF00498	0.686
LIG_FHA_2	9	15	PF00498	0.718
LIG_PCNA_PIPBox_1	32	41	PF02747	0.606
LIG_PCNA_yPIPBox_3	32	44	PF02747	0.612
LIG_PDZ_Class_3	322	327	PF00595	0.672
LIG_Pex14_1	292	296	PF04695	0.411
LIG_RPA_C_Fungi	251	263	PF08784	0.409
LIG_SH2_CRK	64	68	PF00017	0.513
LIG_SH2_GRB2like	137	140	PF00017	0.664
LIG_SH2_NCK_1	236	240	PF00017	0.389
LIG_SH2_STAP1	164	168	PF00017	0.411
LIG_SH2_STAP1	174	178	PF00017	0.466
LIG_SH2_STAP1	236	240	PF00017	0.389
LIG_SH2_STAP1	64	68	PF00017	0.416
LIG_SH2_STAT5	133	136	PF00017	0.594
LIG_SH2_STAT5	177	180	PF00017	0.534
LIG_SH2_STAT5	287	290	PF00017	0.411
LIG_SH2_STAT5	38	41	PF00017	0.437
LIG_SH2_STAT5	64	67	PF00017	0.383
LIG_SH3_2	213	218	PF14604	0.452
LIG_SH3_3	210	216	PF00018	0.545
LIG_SH3_3	288	294	PF00018	0.513
LIG_SUMO_SIM_anti_2	165	170	PF11976	0.374
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.416
LIG_SUMO_SIM_par_1	158	165	PF11976	0.410
LIG_SUMO_SIM_par_1	312	318	PF11976	0.509
LIG_SUMO_SIM_par_1	64	70	PF11976	0.411
LIG_SUMO_SIM_par_1	72	78	PF11976	0.544
LIG_TRAF2_1	30	33	PF00917	0.610
LIG_TYR_ITIM	62	67	PF00017	0.411
MOD_CK1_1	273	279	PF00069	0.534
MOD_CK2_1	188	194	PF00069	0.599
MOD_CK2_1	25	31	PF00069	0.530
MOD_GlcNHglycan	149	152	PF01048	0.628
MOD_GlcNHglycan	157	160	PF01048	0.480
MOD_GlcNHglycan	45	48	PF01048	0.462
MOD_GlcNHglycan	69	72	PF01048	0.375
MOD_GSK3_1	303	310	PF00069	0.421
MOD_GSK3_1	39	46	PF00069	0.471
MOD_NEK2_1	106	111	PF00069	0.682
MOD_NEK2_1	248	253	PF00069	0.397
MOD_NEK2_1	303	308	PF00069	0.415
MOD_NEK2_1	39	44	PF00069	0.495
MOD_NEK2_1	62	67	PF00069	0.428
MOD_NEK2_1	69	74	PF00069	0.394
MOD_NEK2_1	81	86	PF00069	0.474
MOD_NEK2_2	172	177	PF00069	0.558
MOD_NEK2_2	216	221	PF00069	0.470
MOD_NEK2_2	243	248	PF00069	0.222
MOD_PIKK_1	109	115	PF00454	0.639
MOD_PIKK_1	257	263	PF00454	0.616
MOD_PKA_1	181	187	PF00069	0.455
MOD_PKA_2	139	145	PF00069	0.575
MOD_PKA_2	181	187	PF00069	0.455
MOD_PKA_2	205	211	PF00069	0.497
MOD_PKA_2	257	263	PF00069	0.616
MOD_PKA_2	43	49	PF00069	0.511
MOD_Plk_1	75	81	PF00069	0.619
MOD_Plk_4	152	158	PF00069	0.444
MOD_Plk_4	243	249	PF00069	0.411
MOD_Plk_4	270	276	PF00069	0.557
MOD_Plk_4	62	68	PF00069	0.436
MOD_Plk_4	69	75	PF00069	0.388
MOD_Plk_4	83	89	PF00069	0.535
MOD_ProDKin_1	95	101	PF00069	0.654
TRG_ENDOCYTIC_2	264	267	PF00928	0.649
TRG_ENDOCYTIC_2	64	67	PF00928	0.411
TRG_ER_diArg_1	181	183	PF00400	0.506
TRG_ER_diArg_1	200	202	PF00400	0.782
TRG_ER_diArg_1	223	226	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT7	Leptomonas seymouri	52%	94%
A0A3S7WSJ9	Leishmania donovani	91%	100%
A4H789	Leishmania braziliensis	77%	100%
A4HVM9	Leishmania infantum	91%	100%
Q4QG53	Leishmania major	89%	100%