Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APC4_LEIMU

TriTrypDb:

LmxM.13.1000

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.635
CLV_C14_Caspase3-7	267	271	PF00656	0.591
CLV_C14_Caspase3-7	294	298	PF00656	0.557
CLV_NRD_NRD_1	114	116	PF00675	0.648
CLV_NRD_NRD_1	158	160	PF00675	0.735
CLV_NRD_NRD_1	230	232	PF00675	0.442
CLV_NRD_NRD_1	347	349	PF00675	0.644
CLV_NRD_NRD_1	366	368	PF00675	0.625
CLV_PCSK_FUR_1	287	291	PF00082	0.683
CLV_PCSK_KEX2_1	114	116	PF00082	0.648
CLV_PCSK_KEX2_1	158	160	PF00082	0.689
CLV_PCSK_KEX2_1	289	291	PF00082	0.646
CLV_PCSK_KEX2_1	347	349	PF00082	0.622
CLV_PCSK_KEX2_1	35	37	PF00082	0.731
CLV_PCSK_KEX2_1	366	368	PF00082	0.462
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.684
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.654
CLV_PCSK_SKI1_1	350	354	PF00082	0.690
CLV_PCSK_SKI1_1	356	360	PF00082	0.531
CLV_PCSK_SKI1_1	409	413	PF00082	0.356
CLV_PCSK_SKI1_1	422	426	PF00082	0.384
DEG_APCC_DBOX_1	380	388	PF00400	0.461
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DEG_SCF_FBW7_1	9	16	PF00400	0.606
DOC_CKS1_1	160	165	PF01111	0.756
DOC_CYCLIN_RxL_1	419	429	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.532
DOC_MAPK_gen_1	231	238	PF00069	0.447
DOC_MAPK_gen_1	61	71	PF00069	0.404
DOC_MAPK_MEF2A_6	231	240	PF00069	0.548
DOC_PP1_RVXF_1	407	413	PF00149	0.355
DOC_PP4_FxxP_1	440	443	PF00568	0.486
DOC_USP7_MATH_1	13	17	PF00917	0.715
DOC_USP7_MATH_1	173	177	PF00917	0.567
DOC_USP7_MATH_1	198	202	PF00917	0.427
DOC_USP7_MATH_1	24	28	PF00917	0.601
DOC_USP7_MATH_1	342	346	PF00917	0.527
DOC_USP7_MATH_1	377	381	PF00917	0.437
DOC_USP7_MATH_2	189	195	PF00917	0.702
DOC_WW_Pin1_4	159	164	PF00397	0.723
DOC_WW_Pin1_4	276	281	PF00397	0.691
DOC_WW_Pin1_4	9	14	PF00397	0.665
LIG_14-3-3_CanoR_1	121	126	PF00244	0.530
LIG_14-3-3_CanoR_1	330	338	PF00244	0.660
LIG_14-3-3_CanoR_1	435	439	PF00244	0.379
LIG_Actin_WH2_2	395	411	PF00022	0.268
LIG_BIR_III_4	265	269	PF00653	0.554
LIG_BRCT_BRCA1_1	436	440	PF00533	0.448
LIG_Clathr_ClatBox_1	237	241	PF01394	0.535
LIG_FHA_1	48	54	PF00498	0.546
LIG_FHA_1	64	70	PF00498	0.487
LIG_FHA_1	97	103	PF00498	0.581
LIG_FHA_2	324	330	PF00498	0.645
LIG_FHA_2	445	451	PF00498	0.439
LIG_FHA_2	58	64	PF00498	0.532
LIG_FHA_2	70	76	PF00498	0.486
LIG_LIR_Apic_2	437	443	PF02991	0.475
LIG_LIR_Gen_1	66	74	PF02991	0.312
LIG_LIR_Nem_3	399	404	PF02991	0.378
LIG_LIR_Nem_3	66	70	PF02991	0.430
LIG_LIR_Nem_3	75	81	PF02991	0.456
LIG_Pex14_2	397	401	PF04695	0.381
LIG_SH2_CRK	67	71	PF00017	0.380
LIG_SH2_CRK	89	93	PF00017	0.476
LIG_SH2_STAP1	404	408	PF00017	0.391
LIG_SH2_STAP1	67	71	PF00017	0.380
LIG_SH2_STAP1	96	100	PF00017	0.539
LIG_SH2_STAT5	217	220	PF00017	0.508
LIG_SH2_STAT5	451	454	PF00017	0.460
LIG_SH2_STAT5	67	70	PF00017	0.418
LIG_SH2_STAT5	89	92	PF00017	0.510
LIG_SH3_3	154	160	PF00018	0.743
LIG_SH3_3	223	229	PF00018	0.467
LIG_SH3_3	278	284	PF00018	0.531
LIG_SH3_3	34	40	PF00018	0.643
LIG_SUMO_SIM_par_1	66	72	PF11976	0.488
LIG_SUMO_SIM_par_1	97	103	PF11976	0.566
LIG_TRFH_1	428	432	PF08558	0.488
LIG_TYR_ITIM	65	70	PF00017	0.396
MOD_CK1_1	194	200	PF00069	0.619
MOD_CK1_1	244	250	PF00069	0.574
MOD_CK1_1	276	282	PF00069	0.717
MOD_CK1_1	4	10	PF00069	0.705
MOD_CK2_1	323	329	PF00069	0.724
MOD_CK2_1	444	450	PF00069	0.462
MOD_CK2_1	456	462	PF00069	0.438
MOD_CK2_1	69	75	PF00069	0.497
MOD_CK2_1	91	97	PF00069	0.574
MOD_Cter_Amidation	229	232	PF01082	0.487
MOD_Cter_Amidation	33	36	PF01082	0.616
MOD_Cter_Amidation	345	348	PF01082	0.655
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.688
MOD_GlcNHglycan	134	137	PF01048	0.557
MOD_GlcNHglycan	177	180	PF01048	0.729
MOD_GlcNHglycan	185	189	PF01048	0.596
MOD_GlcNHglycan	243	246	PF01048	0.667
MOD_GlcNHglycan	26	29	PF01048	0.719
MOD_GlcNHglycan	275	278	PF01048	0.723
MOD_GlcNHglycan	3	6	PF01048	0.708
MOD_GlcNHglycan	344	347	PF01048	0.621
MOD_GlcNHglycan	356	359	PF01048	0.533
MOD_GSK3_1	128	135	PF00069	0.436
MOD_GSK3_1	167	174	PF00069	0.725
MOD_GSK3_1	194	201	PF00069	0.474
MOD_GSK3_1	252	259	PF00069	0.664
MOD_GSK3_1	279	286	PF00069	0.665
MOD_GSK3_1	342	349	PF00069	0.668
MOD_GSK3_1	350	357	PF00069	0.575
MOD_GSK3_1	434	441	PF00069	0.378
MOD_GSK3_1	59	66	PF00069	0.564
MOD_GSK3_1	9	16	PF00069	0.667
MOD_LATS_1	328	334	PF00433	0.658
MOD_LATS_1	45	51	PF00433	0.599
MOD_N-GLC_1	24	29	PF02516	0.716
MOD_N-GLC_1	342	347	PF02516	0.565
MOD_N-GLC_1	456	461	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	151	156	PF00069	0.632
MOD_NEK2_1	352	357	PF00069	0.651
MOD_NEK2_1	434	439	PF00069	0.374
MOD_NEK2_1	444	449	PF00069	0.533
MOD_NEK2_2	136	141	PF00069	0.412
MOD_PIKK_1	359	365	PF00454	0.392
MOD_PKA_1	158	164	PF00069	0.641
MOD_PKA_2	158	164	PF00069	0.641
MOD_PKA_2	329	335	PF00069	0.592
MOD_PKA_2	346	352	PF00069	0.700
MOD_PKA_2	434	440	PF00069	0.392
MOD_PKB_1	128	136	PF00069	0.425
MOD_PKB_1	348	356	PF00069	0.627
MOD_Plk_1	136	142	PF00069	0.415
MOD_Plk_1	194	200	PF00069	0.619
MOD_Plk_1	456	462	PF00069	0.532
MOD_Plk_1	96	102	PF00069	0.538
MOD_Plk_2-3	456	462	PF00069	0.532
MOD_Plk_4	356	362	PF00069	0.564
MOD_Plk_4	414	420	PF00069	0.368
MOD_Plk_4	434	440	PF00069	0.373
MOD_Plk_4	65	71	PF00069	0.502
MOD_ProDKin_1	159	165	PF00069	0.725
MOD_ProDKin_1	276	282	PF00069	0.692
MOD_ProDKin_1	9	15	PF00069	0.667
MOD_SUMO_for_1	257	260	PF00179	0.715
MOD_SUMO_for_1	308	311	PF00179	0.736
MOD_SUMO_rev_2	161	170	PF00179	0.659
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.557
TRG_ENDOCYTIC_2	67	70	PF00928	0.381
TRG_ENDOCYTIC_2	89	92	PF00928	0.472
TRG_ER_diArg_1	114	116	PF00400	0.650
TRG_ER_diArg_1	127	130	PF00400	0.367
TRG_ER_diArg_1	157	159	PF00400	0.683
TRG_ER_diArg_1	210	213	PF00400	0.461
TRG_ER_diArg_1	290	293	PF00400	0.729
TRG_ER_diArg_1	347	350	PF00400	0.631
TRG_ER_diArg_1	365	367	PF00400	0.584
TRG_ER_diArg_1	387	390	PF00400	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7S2	Leptomonas seymouri	50%	100%
A0A3S5H6P2	Leishmania donovani	87%	100%
A4H788	Leishmania braziliensis	71%	100%
A4HVM8	Leishmania infantum	87%	100%
Q4QG54	Leishmania major	87%	100%