Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APC3_LEIMU

TriTrypDb:

LmxM.13.0990

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.638
CLV_C14_Caspase3-7	440	444	PF00656	0.610
CLV_NRD_NRD_1	187	189	PF00675	0.457
CLV_NRD_NRD_1	191	193	PF00675	0.456
CLV_NRD_NRD_1	197	199	PF00675	0.474
CLV_NRD_NRD_1	226	228	PF00675	0.653
CLV_NRD_NRD_1	253	255	PF00675	0.536
CLV_NRD_NRD_1	281	283	PF00675	0.792
CLV_NRD_NRD_1	289	291	PF00675	0.693
CLV_NRD_NRD_1	293	295	PF00675	0.781
CLV_NRD_NRD_1	3	5	PF00675	0.573
CLV_NRD_NRD_1	324	326	PF00675	0.577
CLV_NRD_NRD_1	352	354	PF00675	0.635
CLV_NRD_NRD_1	471	473	PF00675	0.498
CLV_NRD_NRD_1	476	478	PF00675	0.535
CLV_NRD_NRD_1	72	74	PF00675	0.538
CLV_PCSK_FUR_1	290	294	PF00082	0.668
CLV_PCSK_FUR_1	468	472	PF00082	0.486
CLV_PCSK_KEX2_1	16	18	PF00082	0.553
CLV_PCSK_KEX2_1	191	193	PF00082	0.483
CLV_PCSK_KEX2_1	197	199	PF00082	0.441
CLV_PCSK_KEX2_1	224	226	PF00082	0.567
CLV_PCSK_KEX2_1	281	283	PF00082	0.646
CLV_PCSK_KEX2_1	291	293	PF00082	0.676
CLV_PCSK_KEX2_1	3	5	PF00082	0.573
CLV_PCSK_KEX2_1	31	33	PF00082	0.508
CLV_PCSK_KEX2_1	326	328	PF00082	0.564
CLV_PCSK_KEX2_1	348	350	PF00082	0.628
CLV_PCSK_KEX2_1	425	427	PF00082	0.425
CLV_PCSK_KEX2_1	470	472	PF00082	0.530
CLV_PCSK_KEX2_1	65	67	PF00082	0.462
CLV_PCSK_KEX2_1	72	74	PF00082	0.458
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.601
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.474
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.549
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.699
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.464
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.557
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.628
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.541
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.481
CLV_PCSK_PC7_1	68	74	PF00082	0.495
CLV_PCSK_SKI1_1	19	23	PF00082	0.652
CLV_PCSK_SKI1_1	214	218	PF00082	0.625
CLV_PCSK_SKI1_1	257	261	PF00082	0.473
CLV_PCSK_SKI1_1	293	297	PF00082	0.751
CLV_PCSK_SKI1_1	31	35	PF00082	0.616
CLV_PCSK_SKI1_1	326	330	PF00082	0.504
CLV_PCSK_SKI1_1	389	393	PF00082	0.394
CLV_PCSK_SKI1_1	56	60	PF00082	0.602
CLV_PCSK_SKI1_1	73	77	PF00082	0.591
DEG_SCF_FBW7_1	120	126	PF00400	0.611
DOC_CKS1_1	120	125	PF01111	0.821
DOC_MAPK_gen_1	245	252	PF00069	0.490
DOC_MAPK_gen_1	323	330	PF00069	0.586
DOC_MAPK_gen_1	425	432	PF00069	0.437
DOC_MAPK_MEF2A_6	245	252	PF00069	0.476
DOC_MAPK_RevD_3	171	186	PF00069	0.380
DOC_PP1_RVXF_1	324	331	PF00149	0.580
DOC_PP2B_LxvP_1	152	155	PF13499	0.795
DOC_USP7_MATH_1	123	127	PF00917	0.757
DOC_USP7_MATH_1	267	271	PF00917	0.668
DOC_USP7_MATH_1	341	345	PF00917	0.711
DOC_USP7_MATH_1	385	389	PF00917	0.549
DOC_USP7_MATH_1	447	451	PF00917	0.538
DOC_USP7_MATH_1	91	95	PF00917	0.635
DOC_USP7_UBL2_3	129	133	PF12436	0.614
DOC_USP7_UBL2_3	185	189	PF12436	0.454
DOC_USP7_UBL2_3	224	228	PF12436	0.595
DOC_WW_Pin1_4	119	124	PF00397	0.822
DOC_WW_Pin1_4	21	26	PF00397	0.511
LIG_14-3-3_CanoR_1	254	260	PF00244	0.623
LIG_14-3-3_CanoR_1	325	331	PF00244	0.623
LIG_14-3-3_CanoR_1	461	467	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_4	303	307	PF00653	0.562
LIG_FHA_2	164	170	PF00498	0.625
LIG_FHA_2	269	275	PF00498	0.477
LIG_FHA_2	438	444	PF00498	0.715
LIG_LIR_Gen_1	136	144	PF02991	0.549
LIG_LIR_Gen_1	357	367	PF02991	0.510
LIG_LIR_Nem_3	136	140	PF02991	0.630
LIG_LIR_Nem_3	357	362	PF02991	0.504
LIG_LIR_Nem_3	452	458	PF02991	0.446
LIG_LIR_Nem_3	485	489	PF02991	0.634
LIG_PDZ_Class_2	485	490	PF00595	0.524
LIG_SH2_NCK_1	359	363	PF00017	0.604
LIG_SH2_STAP1	215	219	PF00017	0.554
LIG_SH2_STAT5	61	64	PF00017	0.484
LIG_SH3_2	128	133	PF14604	0.605
LIG_SH3_3	117	123	PF00018	0.716
LIG_SH3_3	125	131	PF00018	0.720
LIG_SH3_3	148	154	PF00018	0.754
LIG_SH3_3	368	374	PF00018	0.506
LIG_SUMO_SIM_anti_2	360	366	PF11976	0.504
LIG_TRAF2_1	100	103	PF00917	0.508
LIG_TRAF2_1	177	180	PF00917	0.575
LIG_TRAF2_1	207	210	PF00917	0.457
LIG_TRAF2_1	450	453	PF00917	0.399
LIG_UBA3_1	181	189	PF00899	0.349
LIG_UBA3_1	58	65	PF00899	0.529
MOD_CDK_SPK_2	124	129	PF00069	0.499
MOD_CDK_SPxK_1	124	130	PF00069	0.498
MOD_CDK_SPxxK_3	21	28	PF00069	0.501
MOD_CK1_1	147	153	PF00069	0.578
MOD_CK1_1	268	274	PF00069	0.471
MOD_CK1_1	47	53	PF00069	0.639
MOD_CK1_1	93	99	PF00069	0.806
MOD_CK2_1	136	142	PF00069	0.633
MOD_CK2_1	174	180	PF00069	0.637
MOD_CK2_1	268	274	PF00069	0.471
MOD_CK2_1	341	347	PF00069	0.771
MOD_CK2_1	447	453	PF00069	0.426
MOD_CK2_1	97	103	PF00069	0.571
MOD_Cter_Amidation	222	225	PF01082	0.567
MOD_GlcNHglycan	142	147	PF01048	0.584
MOD_GlcNHglycan	283	286	PF01048	0.800
MOD_GlcNHglycan	93	96	PF01048	0.748
MOD_GSK3_1	111	118	PF00069	0.659
MOD_GSK3_1	119	126	PF00069	0.708
MOD_GSK3_1	163	170	PF00069	0.666
MOD_GSK3_1	47	54	PF00069	0.645
MOD_GSK3_1	87	94	PF00069	0.718
MOD_NEK2_1	144	149	PF00069	0.588
MOD_PIKK_1	265	271	PF00454	0.513
MOD_PIKK_1	434	440	PF00454	0.404
MOD_PIKK_1	51	57	PF00454	0.509
MOD_PKA_1	281	287	PF00069	0.548
MOD_PKA_1	293	299	PF00069	0.606
MOD_PKA_1	326	332	PF00069	0.553
MOD_PKA_2	160	166	PF00069	0.739
MOD_PKA_2	281	287	PF00069	0.581
MOD_PKA_2	293	299	PF00069	0.574
MOD_PKA_2	326	332	PF00069	0.632
MOD_PKA_2	447	453	PF00069	0.550
MOD_PKB_1	292	300	PF00069	0.704
MOD_Plk_2-3	136	142	PF00069	0.555
MOD_Plk_2-3	169	175	PF00069	0.568
MOD_Plk_2-3	347	353	PF00069	0.457
MOD_Plk_4	147	153	PF00069	0.757
MOD_ProDKin_1	119	125	PF00069	0.822
MOD_ProDKin_1	21	27	PF00069	0.506
MOD_SUMO_for_1	184	187	PF00179	0.347
MOD_SUMO_for_1	482	485	PF00179	0.522
MOD_SUMO_rev_2	24	33	PF00179	0.606
MOD_SUMO_rev_2	258	268	PF00179	0.467
MOD_SUMO_rev_2	347	355	PF00179	0.447
MOD_SUMO_rev_2	450	458	PF00179	0.471
MOD_SUMO_rev_2	473	480	PF00179	0.549
TRG_DiLeu_BaEn_1	410	415	PF01217	0.536
TRG_DiLeu_BaEn_4	179	185	PF01217	0.349
TRG_DiLeu_BaEn_4	453	459	PF01217	0.378
TRG_DiLeu_LyEn_5	410	415	PF01217	0.571
TRG_ENDOCYTIC_2	359	362	PF00928	0.599
TRG_ER_diArg_1	197	200	PF00400	0.623
TRG_ER_diArg_1	280	282	PF00400	0.611
TRG_ER_diArg_1	290	293	PF00400	0.626
TRG_ER_diArg_1	325	328	PF00400	0.585
TRG_ER_diArg_1	411	414	PF00400	0.528
TRG_ER_diArg_1	468	471	PF00400	0.539
TRG_NLS_Bipartite_1	281	295	PF00514	0.534
TRG_NLS_Bipartite_1	3	20	PF00514	0.604
TRG_NLS_MonoCore_2	128	133	PF00514	0.605
TRG_NLS_MonoCore_2	289	294	PF00514	0.666
TRG_NLS_MonoExtC_3	128	133	PF00514	0.688
TRG_NLS_MonoExtC_3	223	228	PF00514	0.554
TRG_NLS_MonoExtC_3	289	294	PF00514	0.710
TRG_NLS_MonoExtN_4	128	133	PF00514	0.680
TRG_NLS_MonoExtN_4	224	231	PF00514	0.575
TRG_NLS_MonoExtN_4	28	35	PF00514	0.545
TRG_NLS_MonoExtN_4	290	295	PF00514	0.623
TRG_NLS_MonoExtN_4	323	329	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE43	Leptomonas seymouri	57%	97%
A0A3S7WSJ6	Leishmania donovani	86%	100%
A0A422NGB0	Trypanosoma rangeli	37%	100%
A4H787	Leishmania braziliensis	72%	99%
A4HVM7	Leishmania infantum	86%	100%
D0A6M7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QG55	Leishmania major	85%	100%
V5AVQ1	Trypanosoma cruzi	35%	100%