Leucyl-tRNA synthetase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APC1_LEIMU

TriTrypDb:

LmxM.13.0970

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.652
CLV_C14_Caspase3-7	207	211	PF00656	0.458
CLV_C14_Caspase3-7	329	333	PF00656	0.816
CLV_C14_Caspase3-7	392	396	PF00656	0.752
CLV_NRD_NRD_1	27	29	PF00675	0.732
CLV_NRD_NRD_1	306	308	PF00675	0.697
CLV_NRD_NRD_1	417	419	PF00675	0.610
CLV_NRD_NRD_1	571	573	PF00675	0.504
CLV_PCSK_KEX2_1	27	29	PF00082	0.732
CLV_PCSK_KEX2_1	504	506	PF00082	0.490
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.490
CLV_PCSK_SKI1_1	184	188	PF00082	0.677
CLV_PCSK_SKI1_1	217	221	PF00082	0.504
CLV_PCSK_SKI1_1	539	543	PF00082	0.480
CLV_PCSK_SKI1_1	584	588	PF00082	0.454
CLV_Separin_Metazoa	117	121	PF03568	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DEG_SCF_FBW7_1	564	571	PF00400	0.539
DEG_SPOP_SBC_1	211	215	PF00917	0.536
DEG_SPOP_SBC_1	51	55	PF00917	0.801
DOC_CYCLIN_yClb1_LxF_4	531	537	PF00134	0.325
DOC_MAPK_gen_1	280	288	PF00069	0.595
DOC_PP1_RVXF_1	272	279	PF00149	0.492
DOC_PP1_RVXF_1	542	549	PF00149	0.487
DOC_PP2B_LxvP_1	15	18	PF13499	0.718
DOC_PP4_MxPP_1	470	473	PF00568	0.661
DOC_USP7_MATH_1	100	104	PF00917	0.700
DOC_USP7_MATH_1	121	125	PF00917	0.412
DOC_USP7_MATH_1	196	200	PF00917	0.708
DOC_USP7_MATH_1	211	215	PF00917	0.470
DOC_USP7_MATH_1	31	35	PF00917	0.708
DOC_USP7_MATH_1	376	380	PF00917	0.680
DOC_USP7_MATH_1	393	397	PF00917	0.711
DOC_USP7_MATH_1	449	453	PF00917	0.708
DOC_USP7_MATH_1	50	54	PF00917	0.810
DOC_USP7_MATH_1	7	11	PF00917	0.723
DOC_USP7_MATH_1	80	84	PF00917	0.711
DOC_USP7_UBL2_3	180	184	PF12436	0.642
DOC_WW_Pin1_4	262	267	PF00397	0.515
DOC_WW_Pin1_4	420	425	PF00397	0.556
DOC_WW_Pin1_4	52	57	PF00397	0.789
DOC_WW_Pin1_4	523	528	PF00397	0.550
DOC_WW_Pin1_4	564	569	PF00397	0.521
LIG_14-3-3_CanoR_1	120	126	PF00244	0.413
LIG_14-3-3_CanoR_1	226	236	PF00244	0.471
LIG_14-3-3_CanoR_1	337	345	PF00244	0.732
LIG_14-3-3_CanoR_1	418	424	PF00244	0.752
LIG_AP2alpha_1	533	537	PF02296	0.543
LIG_APCC_ABBA_1	325	330	PF00400	0.823
LIG_APCC_ABBA_1	575	580	PF00400	0.454
LIG_BRCT_BRCA1_1	412	416	PF00533	0.499
LIG_Clathr_ClatBox_1	483	487	PF01394	0.478
LIG_EVH1_1	471	475	PF00568	0.537
LIG_FHA_1	100	106	PF00498	0.706
LIG_FHA_1	167	173	PF00498	0.582
LIG_FHA_1	320	326	PF00498	0.823
LIG_FHA_1	342	348	PF00498	0.681
LIG_FHA_1	349	355	PF00498	0.649
LIG_FHA_1	421	427	PF00498	0.727
LIG_FHA_1	483	489	PF00498	0.496
LIG_FHA_1	569	575	PF00498	0.494
LIG_FHA_1	7	13	PF00498	0.679
LIG_FHA_2	111	117	PF00498	0.724
LIG_FHA_2	131	137	PF00498	0.280
LIG_FHA_2	327	333	PF00498	0.817
LIG_FHA_2	337	343	PF00498	0.649
LIG_GBD_Chelix_1	530	538	PF00786	0.620
LIG_LIR_Gen_1	461	471	PF02991	0.593
LIG_LIR_Gen_1	510	521	PF02991	0.517
LIG_LIR_Gen_1	535	545	PF02991	0.498
LIG_LIR_Nem_3	461	466	PF02991	0.584
LIG_LIR_Nem_3	500	506	PF02991	0.489
LIG_LIR_Nem_3	510	516	PF02991	0.434
LIG_LIR_Nem_3	580	586	PF02991	0.427
LIG_Pex14_2	533	537	PF04695	0.543
LIG_REV1ctd_RIR_1	534	543	PF16727	0.542
LIG_SH2_CRK	503	507	PF00017	0.492
LIG_SH2_GRB2like	287	290	PF00017	0.641
LIG_SH2_GRB2like	509	512	PF00017	0.530
LIG_SH2_NCK_1	513	517	PF00017	0.508
LIG_SH2_PTP2	463	466	PF00017	0.683
LIG_SH2_STAP1	146	150	PF00017	0.476
LIG_SH2_STAP1	495	499	PF00017	0.449
LIG_SH2_STAP1	509	513	PF00017	0.523
LIG_SH2_STAT3	578	581	PF00017	0.575
LIG_SH2_STAT5	269	272	PF00017	0.515
LIG_SH2_STAT5	287	290	PF00017	0.641
LIG_SH2_STAT5	305	308	PF00017	0.699
LIG_SH2_STAT5	463	466	PF00017	0.586
LIG_SH2_STAT5	66	69	PF00017	0.764
LIG_SH3_3	353	359	PF00018	0.571
LIG_SH3_3	469	475	PF00018	0.560
LIG_SH3_3	485	491	PF00018	0.478
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.462
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.594
LIG_SUMO_SIM_anti_2	485	490	PF11976	0.482
LIG_SUMO_SIM_par_1	482	487	PF11976	0.477
LIG_SxIP_EBH_1	229	240	PF03271	0.483
LIG_TRAF2_1	133	136	PF00917	0.518
LIG_TRAF2_1	339	342	PF00917	0.741
LIG_TRAF2_1	34	37	PF00917	0.824
LIG_TRAF2_1	448	451	PF00917	0.649
LIG_TRAF2_1	452	455	PF00917	0.754
LIG_TYR_ITAM	500	516	PF00017	0.509
LIG_UBA3_1	246	254	PF00899	0.456
LIG_UBA3_1	277	283	PF00899	0.527
LIG_WRC_WIRS_1	122	127	PF05994	0.409
MOD_CDK_SPK_2	523	528	PF00069	0.550
MOD_CK1_1	168	174	PF00069	0.352
MOD_CK1_1	199	205	PF00069	0.689
MOD_CK1_1	212	218	PF00069	0.558
MOD_CK1_1	227	233	PF00069	0.379
MOD_CK1_1	262	268	PF00069	0.509
MOD_CK1_1	396	402	PF00069	0.818
MOD_CK1_1	417	423	PF00069	0.644
MOD_CK1_1	5	11	PF00069	0.766
MOD_CK1_1	57	63	PF00069	0.471
MOD_CK1_1	91	97	PF00069	0.679
MOD_CK2_1	130	136	PF00069	0.524
MOD_CK2_1	199	205	PF00069	0.776
MOD_CK2_1	31	37	PF00069	0.723
MOD_CK2_1	336	342	PF00069	0.803
MOD_CK2_1	369	375	PF00069	0.625
MOD_CK2_1	449	455	PF00069	0.817
MOD_GlcNHglycan	102	105	PF01048	0.621
MOD_GlcNHglycan	152	155	PF01048	0.455
MOD_GlcNHglycan	33	36	PF01048	0.825
MOD_GlcNHglycan	371	374	PF01048	0.722
MOD_GlcNHglycan	378	381	PF01048	0.638
MOD_GlcNHglycan	382	385	PF01048	0.621
MOD_GlcNHglycan	391	394	PF01048	0.672
MOD_GlcNHglycan	395	398	PF01048	0.538
MOD_GlcNHglycan	399	402	PF01048	0.673
MOD_GlcNHglycan	419	422	PF01048	0.595
MOD_GlcNHglycan	476	479	PF01048	0.637
MOD_GlcNHglycan	9	12	PF01048	0.594
MOD_GlcNHglycan	90	93	PF01048	0.783
MOD_GSK3_1	100	107	PF00069	0.698
MOD_GSK3_1	121	128	PF00069	0.337
MOD_GSK3_1	2	9	PF00069	0.635
MOD_GSK3_1	209	216	PF00069	0.637
MOD_GSK3_1	220	227	PF00069	0.629
MOD_GSK3_1	258	265	PF00069	0.501
MOD_GSK3_1	350	357	PF00069	0.699
MOD_GSK3_1	376	383	PF00069	0.790
MOD_GSK3_1	389	396	PF00069	0.541
MOD_GSK3_1	397	404	PF00069	0.680
MOD_GSK3_1	406	413	PF00069	0.564
MOD_GSK3_1	422	429	PF00069	0.642
MOD_GSK3_1	50	57	PF00069	0.718
MOD_GSK3_1	564	571	PF00069	0.497
MOD_N-GLC_1	258	263	PF02516	0.510
MOD_N-GLC_2	130	132	PF02516	0.532
MOD_NEK2_1	125	130	PF00069	0.505
MOD_NEK2_1	220	225	PF00069	0.518
MOD_NEK2_1	242	247	PF00069	0.454
MOD_NEK2_1	306	311	PF00069	0.511
MOD_NEK2_1	548	553	PF00069	0.532
MOD_NEK2_1	579	584	PF00069	0.450
MOD_NEK2_2	11	16	PF00069	0.541
MOD_NEK2_2	19	24	PF00069	0.531
MOD_PIKK_1	130	136	PF00454	0.502
MOD_PIKK_1	562	568	PF00454	0.571
MOD_PKA_2	306	312	PF00069	0.511
MOD_PKA_2	336	342	PF00069	0.740
MOD_PKA_2	417	423	PF00069	0.615
MOD_Plk_1	258	264	PF00069	0.505
MOD_Plk_1	297	303	PF00069	0.662
MOD_Plk_1	341	347	PF00069	0.687
MOD_Plk_1	579	585	PF00069	0.450
MOD_Plk_4	220	226	PF00069	0.527
MOD_Plk_4	228	234	PF00069	0.481
MOD_Plk_4	242	248	PF00069	0.429
MOD_Plk_4	341	347	PF00069	0.698
MOD_Plk_4	458	464	PF00069	0.618
MOD_ProDKin_1	262	268	PF00069	0.509
MOD_ProDKin_1	420	426	PF00069	0.559
MOD_ProDKin_1	52	58	PF00069	0.784
MOD_ProDKin_1	523	529	PF00069	0.551
MOD_ProDKin_1	564	570	PF00069	0.513
MOD_SUMO_for_1	186	189	PF00179	0.606
MOD_SUMO_for_1	411	414	PF00179	0.727
MOD_SUMO_rev_2	183	188	PF00179	0.550
MOD_SUMO_rev_2	202	211	PF00179	0.454
MOD_SUMO_rev_2	268	276	PF00179	0.497
TRG_DiLeu_BaEn_1	114	119	PF01217	0.574
TRG_DiLeu_BaEn_1	177	182	PF01217	0.518
TRG_DiLeu_BaEn_2	340	346	PF01217	0.645
TRG_ENDOCYTIC_2	145	148	PF00928	0.461
TRG_ENDOCYTIC_2	463	466	PF00928	0.683
TRG_ENDOCYTIC_2	503	506	PF00928	0.490
TRG_ENDOCYTIC_2	513	516	PF00928	0.508
TRG_ENDOCYTIC_2	583	586	PF00928	0.439
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM83	Leptomonas seymouri	59%	94%
A0A3S7WSI1	Leishmania donovani	86%	94%
A4H785	Leishmania braziliensis	76%	100%
A4HVM5	Leishmania infantum	86%	94%
Q4QG57	Leishmania major	85%	100%