LeishMANIAdb
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Katanin p60 ATPase-containing subunit A-like 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A-like 2
Gene product:
serine peptidase, Clan SJ, family S16, putative
Species:
Leishmania mexicana
UniProt:
E9APC0_LEIMU
TriTrypDb:
LmxM.13.0960
Length:
557

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 11
GO:0005737 cytoplasm 2 11
GO:0005874 microtubule 6 11
GO:0099080 supramolecular complex 2 11
GO:0099081 supramolecular polymer 3 11
GO:0099512 supramolecular fiber 4 11
GO:0099513 polymeric cytoskeletal fiber 5 11
GO:0110165 cellular anatomical entity 1 11
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

E9APC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APC0

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 11
GO:0006996 organelle organization 4 11
GO:0007010 cytoskeleton organization 5 11
GO:0007017 microtubule-based process 2 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0051013 microtubule severing 4 11
GO:0071840 cellular component organization or biogenesis 2 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0005524 ATP binding 5 11
GO:0008017 microtubule binding 5 11
GO:0008092 cytoskeletal protein binding 3 11
GO:0008568 microtubule severing ATPase activity 2 11
GO:0015631 tubulin binding 4 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016853 isomerase activity 2 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0140657 ATP-dependent activity 1 11
GO:0140776 protein-containing complex destabilizing activity 1 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.688
CLV_C14_Caspase3-7 222 226 PF00656 0.504
CLV_C14_Caspase3-7 370 374 PF00656 0.254
CLV_C14_Caspase3-7 397 401 PF00656 0.383
CLV_C14_Caspase3-7 75 79 PF00656 0.542
CLV_NRD_NRD_1 132 134 PF00675 0.627
CLV_NRD_NRD_1 213 215 PF00675 0.693
CLV_NRD_NRD_1 236 238 PF00675 0.589
CLV_NRD_NRD_1 38 40 PF00675 0.489
CLV_NRD_NRD_1 389 391 PF00675 0.280
CLV_NRD_NRD_1 405 407 PF00675 0.280
CLV_NRD_NRD_1 429 431 PF00675 0.254
CLV_NRD_NRD_1 450 452 PF00675 0.471
CLV_NRD_NRD_1 490 492 PF00675 0.383
CLV_PCSK_FUR_1 36 40 PF00082 0.416
CLV_PCSK_KEX2_1 131 133 PF00082 0.552
CLV_PCSK_KEX2_1 179 181 PF00082 0.715
CLV_PCSK_KEX2_1 213 215 PF00082 0.693
CLV_PCSK_KEX2_1 236 238 PF00082 0.539
CLV_PCSK_KEX2_1 38 40 PF00082 0.410
CLV_PCSK_KEX2_1 389 391 PF00082 0.274
CLV_PCSK_KEX2_1 404 406 PF00082 0.254
CLV_PCSK_KEX2_1 429 431 PF00082 0.254
CLV_PCSK_KEX2_1 433 435 PF00082 0.254
CLV_PCSK_KEX2_1 450 452 PF00082 0.457
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.594
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.273
CLV_PCSK_PC1ET2_1 433 435 PF00082 0.254
CLV_PCSK_PC7_1 127 133 PF00082 0.533
CLV_PCSK_PC7_1 429 435 PF00082 0.254
CLV_PCSK_SKI1_1 236 240 PF00082 0.455
CLV_PCSK_SKI1_1 259 263 PF00082 0.371
CLV_PCSK_SKI1_1 280 284 PF00082 0.328
CLV_PCSK_SKI1_1 305 309 PF00082 0.266
CLV_PCSK_SKI1_1 317 321 PF00082 0.228
CLV_PCSK_SKI1_1 353 357 PF00082 0.254
CLV_PCSK_SKI1_1 38 42 PF00082 0.416
CLV_PCSK_SKI1_1 389 393 PF00082 0.254
CLV_PCSK_SKI1_1 433 437 PF00082 0.254
CLV_PCSK_SKI1_1 450 454 PF00082 0.362
DEG_APCC_DBOX_1 235 243 PF00400 0.503
DEG_Kelch_Keap1_1 121 126 PF01344 0.459
DEG_Nend_UBRbox_1 1 4 PF02207 0.635
DEG_SPOP_SBC_1 141 145 PF00917 0.671
DOC_CYCLIN_RxL_1 350 357 PF00134 0.254
DOC_CYCLIN_RxL_1 445 456 PF00134 0.432
DOC_CYCLIN_yClb5_NLxxxL_5 161 170 PF00134 0.691
DOC_MAPK_gen_1 302 310 PF00069 0.315
DOC_MAPK_gen_1 350 360 PF00069 0.273
DOC_MAPK_gen_1 36 46 PF00069 0.380
DOC_MAPK_gen_1 404 413 PF00069 0.333
DOC_MAPK_gen_1 429 439 PF00069 0.254
DOC_MAPK_HePTP_8 35 47 PF00069 0.460
DOC_MAPK_MEF2A_6 38 47 PF00069 0.390
DOC_MAPK_MEF2A_6 430 439 PF00069 0.254
DOC_MAPK_RevD_3 435 451 PF00069 0.453
DOC_PP1_RVXF_1 443 450 PF00149 0.402
DOC_PP1_SILK_1 298 303 PF00149 0.455
DOC_PP4_FxxP_1 310 313 PF00568 0.254
DOC_USP7_MATH_1 142 146 PF00917 0.742
DOC_USP7_MATH_1 15 19 PF00917 0.464
DOC_USP7_MATH_1 201 205 PF00917 0.715
DOC_USP7_MATH_1 336 340 PF00917 0.294
DOC_USP7_MATH_1 378 382 PF00917 0.350
DOC_WW_Pin1_4 144 149 PF00397 0.711
LIG_14-3-3_CanoR_1 107 117 PF00244 0.608
LIG_14-3-3_CanoR_1 133 139 PF00244 0.666
LIG_14-3-3_CanoR_1 329 333 PF00244 0.273
LIG_14-3-3_CanoR_1 389 399 PF00244 0.254
LIG_14-3-3_CanoR_1 434 440 PF00244 0.365
LIG_14-3-3_CanoR_1 533 537 PF00244 0.436
LIG_14-3-3_CanoR_1 68 72 PF00244 0.494
LIG_Actin_WH2_2 147 164 PF00022 0.674
LIG_Actin_WH2_2 246 261 PF00022 0.506
LIG_AP2alpha_2 229 231 PF02296 0.460
LIG_BIR_III_4 113 117 PF00653 0.668
LIG_BRCT_BRCA1_1 364 368 PF00533 0.254
LIG_CaM_IQ_9 21 36 PF13499 0.331
LIG_CaM_IQ_9 60 75 PF13499 0.580
LIG_CtBP_PxDLS_1 148 152 PF00389 0.595
LIG_EVH1_1 242 246 PF00568 0.462
LIG_FHA_1 22 28 PF00498 0.384
LIG_FHA_1 245 251 PF00498 0.479
LIG_FHA_1 364 370 PF00498 0.254
LIG_FHA_1 391 397 PF00498 0.254
LIG_FHA_1 423 429 PF00498 0.301
LIG_FHA_2 173 179 PF00498 0.513
LIG_FHA_2 395 401 PF00498 0.447
LIG_FHA_2 466 472 PF00498 0.177
LIG_FHA_2 519 525 PF00498 0.387
LIG_Integrin_isoDGR_2 502 504 PF01839 0.383
LIG_Integrin_RGD_1 345 347 PF01839 0.254
LIG_LIR_Gen_1 90 100 PF02991 0.451
LIG_LIR_Nem_3 228 234 PF02991 0.677
LIG_LIR_Nem_3 267 273 PF02991 0.490
LIG_LIR_Nem_3 295 300 PF02991 0.370
LIG_LIR_Nem_3 330 335 PF02991 0.254
LIG_LIR_Nem_3 88 92 PF02991 0.415
LIG_LYPXL_yS_3 293 296 PF13949 0.404
LIG_MYND_1 159 163 PF01753 0.674
LIG_Rb_pABgroove_1 350 358 PF01858 0.298
LIG_SH2_SRC 362 365 PF00017 0.273
LIG_SH2_STAP1 463 467 PF00017 0.383
LIG_SH2_STAP1 544 548 PF00017 0.297
LIG_SH3_1 240 246 PF00018 0.450
LIG_SH3_2 511 516 PF14604 0.661
LIG_SH3_3 151 157 PF00018 0.627
LIG_SH3_3 227 233 PF00018 0.543
LIG_SH3_3 235 241 PF00018 0.469
LIG_SH3_3 284 290 PF00018 0.353
LIG_SH3_3 434 440 PF00018 0.270
LIG_SH3_3 508 514 PF00018 0.621
LIG_SUMO_SIM_anti_2 17 24 PF11976 0.327
LIG_SUMO_SIM_anti_2 477 482 PF11976 0.254
LIG_SUMO_SIM_anti_2 81 88 PF11976 0.433
LIG_SUMO_SIM_par_1 42 48 PF11976 0.335
LIG_SUMO_SIM_par_1 435 441 PF11976 0.383
LIG_TRAF2_1 28 31 PF00917 0.465
LIG_TYR_ITIM 291 296 PF00017 0.367
LIG_UBA3_1 296 305 PF00899 0.365
LIG_UBA3_1 395 404 PF00899 0.273
LIG_UBA3_1 427 433 PF00899 0.254
MOD_CK1_1 137 143 PF00069 0.576
MOD_CK1_1 144 150 PF00069 0.709
MOD_CK1_1 339 345 PF00069 0.265
MOD_CK1_1 374 380 PF00069 0.264
MOD_CK1_1 438 444 PF00069 0.522
MOD_CK1_1 456 462 PF00069 0.484
MOD_CK1_1 67 73 PF00069 0.416
MOD_CK2_1 149 155 PF00069 0.762
MOD_CK2_1 202 208 PF00069 0.679
MOD_CK2_1 378 384 PF00069 0.345
MOD_CK2_1 465 471 PF00069 0.177
MOD_CK2_1 492 498 PF00069 0.392
MOD_Cter_Amidation 211 214 PF01082 0.692
MOD_GlcNHglycan 123 126 PF01048 0.621
MOD_GlcNHglycan 136 139 PF01048 0.621
MOD_GlcNHglycan 187 191 PF01048 0.663
MOD_GlcNHglycan 198 201 PF01048 0.758
MOD_GlcNHglycan 204 207 PF01048 0.591
MOD_GlcNHglycan 277 280 PF01048 0.472
MOD_GlcNHglycan 376 379 PF01048 0.292
MOD_GlcNHglycan 473 476 PF01048 0.296
MOD_GlcNHglycan 552 555 PF01048 0.409
MOD_GlcNHglycan 74 77 PF01048 0.598
MOD_GSK3_1 137 144 PF00069 0.681
MOD_GSK3_1 168 175 PF00069 0.665
MOD_GSK3_1 323 330 PF00069 0.254
MOD_GSK3_1 335 342 PF00069 0.254
MOD_GSK3_1 374 381 PF00069 0.271
MOD_GSK3_1 390 397 PF00069 0.262
MOD_GSK3_1 467 474 PF00069 0.283
MOD_GSK3_1 505 512 PF00069 0.453
MOD_GSK3_1 525 532 PF00069 0.358
MOD_GSK3_1 550 557 PF00069 0.454
MOD_LATS_1 507 513 PF00433 0.647
MOD_NEK2_1 191 196 PF00069 0.770
MOD_NEK2_1 21 26 PF00069 0.323
MOD_NEK2_1 253 258 PF00069 0.348
MOD_NEK2_1 414 419 PF00069 0.254
MOD_NEK2_1 7 12 PF00069 0.646
MOD_NEK2_2 328 333 PF00069 0.254
MOD_PIKK_1 21 27 PF00454 0.495
MOD_PIKK_1 394 400 PF00454 0.387
MOD_PIKK_1 492 498 PF00454 0.294
MOD_PKA_2 161 167 PF00069 0.713
MOD_PKA_2 328 334 PF00069 0.295
MOD_PKA_2 378 384 PF00069 0.333
MOD_PKA_2 532 538 PF00069 0.489
MOD_PKA_2 67 73 PF00069 0.494
MOD_PKB_1 105 113 PF00069 0.581
MOD_Plk_4 253 259 PF00069 0.454
MOD_Plk_4 315 321 PF00069 0.264
MOD_Plk_4 328 334 PF00069 0.254
MOD_Plk_4 336 342 PF00069 0.254
MOD_Plk_4 363 369 PF00069 0.254
MOD_Plk_4 371 377 PF00069 0.254
MOD_Plk_4 81 87 PF00069 0.405
MOD_ProDKin_1 144 150 PF00069 0.713
MOD_SUMO_for_1 391 394 PF00179 0.254
MOD_SUMO_rev_2 30 35 PF00179 0.506
TRG_DiLeu_BaEn_1 371 376 PF01217 0.254
TRG_DiLeu_BaEn_1 432 437 PF01217 0.254
TRG_DiLeu_BaEn_4 30 36 PF01217 0.513
TRG_DiLeu_BaLyEn_6 448 453 PF01217 0.417
TRG_ENDOCYTIC_2 293 296 PF00928 0.404
TRG_ENDOCYTIC_2 92 95 PF00928 0.401
TRG_ER_diArg_1 104 107 PF00400 0.584
TRG_ER_diArg_1 131 133 PF00400 0.600
TRG_ER_diArg_1 236 238 PF00400 0.539
TRG_ER_diArg_1 35 38 PF00400 0.445
TRG_ER_diArg_1 389 391 PF00400 0.279
TRG_ER_diArg_1 428 430 PF00400 0.254
TRG_ER_diArg_1 449 451 PF00400 0.476
TRG_NLS_Bipartite_1 389 408 PF00514 0.273
TRG_NLS_MonoExtC_3 403 409 PF00514 0.273
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.366
TRG_Pf-PMV_PEXEL_1 353 357 PF00026 0.254
TRG_Pf-PMV_PEXEL_1 491 496 PF00026 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P897 Leptomonas seymouri 68% 97%
A0A0S4IR32 Bodo saltans 54% 100%
A0A1X0NPJ1 Trypanosomatidae 59% 97%
A0A3Q8I9I1 Leishmania donovani 91% 99%
A0JMA9 Xenopus tropicalis 44% 100%
A4H784 Leishmania braziliensis 80% 100%
A4HVM4 Leishmania infantum 91% 99%
C9ZK16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 68%
D0A6N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 98%
Q3B8D5 Xenopus laevis 38% 100%
Q4QG58 Leishmania major 91% 100%
Q5XIK7 Rattus norvegicus 43% 100%
Q6AZT2 Xenopus laevis 37% 93%
Q8IYT4 Homo sapiens 41% 100%
Q9D3R6 Mus musculus 41% 100%
V5DBR1 Trypanosoma cruzi 57% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS