Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9APB9_LEIMU

TriTrypDb:

LmxM.13.0950

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0005884	actin filament	6	1
GO:0005930	axoneme	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1

Expansion

Sequence features

E9APB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APB9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0005200	structural constituent of cytoskeleton	2	1
GO:0098918	structural constituent of synapse	2	1
GO:0098973	structural constituent of postsynaptic actin cytoskeleton	3	1
GO:0099186	structural constituent of postsynapse	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.363
CLV_NRD_NRD_1	256	258	PF00675	0.345
CLV_NRD_NRD_1	466	468	PF00675	0.341
CLV_PCSK_KEX2_1	256	258	PF00082	0.341
CLV_PCSK_SKI1_1	159	163	PF00082	0.328
CLV_PCSK_SKI1_1	175	179	PF00082	0.210
DEG_MDM2_SWIB_1	77	84	PF02201	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.665
DEG_SCF_TRCP1_1	156	162	PF00400	0.470
DEG_SCF_TRCP1_1	299	305	PF00400	0.363
DEG_SPOP_SBC_1	269	273	PF00917	0.363
DOC_CKS1_1	111	116	PF01111	0.443
DOC_CKS1_1	235	240	PF01111	0.541
DOC_MAPK_MEF2A_6	118	126	PF00069	0.470
DOC_PP1_RVXF_1	372	379	PF00149	0.538
DOC_PP2B_LxvP_1	31	34	PF13499	0.488
DOC_PP4_FxxP_1	314	317	PF00568	0.470
DOC_USP7_MATH_1	249	253	PF00917	0.554
DOC_USP7_MATH_1	283	287	PF00917	0.578
DOC_USP7_MATH_1	402	406	PF00917	0.532
DOC_WW_Pin1_4	110	115	PF00397	0.443
DOC_WW_Pin1_4	177	182	PF00397	0.555
DOC_WW_Pin1_4	234	239	PF00397	0.508
DOC_WW_Pin1_4	240	245	PF00397	0.549
DOC_WW_Pin1_4	287	292	PF00397	0.548
DOC_WW_Pin1_4	96	101	PF00397	0.488
LIG_14-3-3_CanoR_1	175	182	PF00244	0.488
LIG_14-3-3_CanoR_1	256	265	PF00244	0.515
LIG_14-3-3_CanoR_1	321	329	PF00244	0.492
LIG_14-3-3_CanoR_1	443	449	PF00244	0.569
LIG_Actin_WH2_2	84	99	PF00022	0.510
LIG_BRCT_BRCA1_1	404	408	PF00533	0.510
LIG_BRCT_BRCA1_1	88	92	PF00533	0.531
LIG_Clathr_ClatBox_1	295	299	PF01394	0.363
LIG_deltaCOP1_diTrp_1	80	88	PF00928	0.498
LIG_eIF4E_1	338	344	PF01652	0.571
LIG_FHA_1	106	112	PF00498	0.510
LIG_FHA_1	119	125	PF00498	0.352
LIG_FHA_1	136	142	PF00498	0.517
LIG_FHA_1	148	154	PF00498	0.463
LIG_FHA_1	160	166	PF00498	0.462
LIG_FHA_1	186	192	PF00498	0.488
LIG_FHA_1	260	266	PF00498	0.515
LIG_FHA_1	329	335	PF00498	0.472
LIG_FHA_1	5	11	PF00498	0.422
LIG_FHA_2	202	208	PF00498	0.456
LIG_FHA_2	280	286	PF00498	0.560
LIG_LIR_Apic_2	311	317	PF02991	0.470
LIG_LIR_Gen_1	169	177	PF02991	0.581
LIG_LIR_Gen_1	457	465	PF02991	0.541
LIG_LIR_Gen_1	85	96	PF02991	0.458
LIG_LIR_LC3C_4	150	155	PF02991	0.541
LIG_LIR_Nem_3	169	174	PF02991	0.581
LIG_LIR_Nem_3	377	381	PF02991	0.470
LIG_LIR_Nem_3	405	411	PF02991	0.529
LIG_LIR_Nem_3	457	463	PF02991	0.470
LIG_LIR_Nem_3	80	84	PF02991	0.476
LIG_LIR_Nem_3	85	91	PF02991	0.446
LIG_MYND_1	244	248	PF01753	0.363
LIG_NRBOX	190	196	PF00104	0.488
LIG_PCNA_PIPBox_1	456	465	PF02747	0.541
LIG_Pex14_1	88	92	PF04695	0.531
LIG_Pex14_2	368	372	PF04695	0.470
LIG_Pex14_2	77	81	PF04695	0.541
LIG_SH2_CRK	171	175	PF00017	0.515
LIG_SH2_CRK	338	342	PF00017	0.571
LIG_SH2_GRB2like	396	399	PF00017	0.541
LIG_SH2_NCK_1	236	240	PF00017	0.531
LIG_SH2_STAP1	396	400	PF00017	0.510
LIG_SH2_STAP1	445	449	PF00017	0.470
LIG_SH2_STAT5	135	138	PF00017	0.541
LIG_SH2_STAT5	190	193	PF00017	0.470
LIG_SH2_STAT5	220	223	PF00017	0.453
LIG_SH2_STAT5	236	239	PF00017	0.515
LIG_SH3_3	108	114	PF00018	0.477
LIG_SH3_3	34	40	PF00018	0.488
LIG_SH3_3	66	72	PF00018	0.488
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.470
LIG_SUMO_SIM_anti_2	339	346	PF11976	0.546
LIG_SUMO_SIM_par_1	138	146	PF11976	0.511
LIG_SUMO_SIM_par_1	293	300	PF11976	0.363
LIG_SUMO_SIM_par_1	339	346	PF11976	0.524
LIG_TRAF2_1	206	209	PF00917	0.534
LIG_TYR_ITIM	478	483	PF00017	0.541
LIG_WRC_WIRS_1	126	131	PF05994	0.470
MOD_CDK_SPxxK_3	287	294	PF00069	0.363
MOD_CK1_1	143	149	PF00069	0.510
MOD_CK1_1	16	22	PF00069	0.536
MOD_CK1_1	252	258	PF00069	0.574
MOD_CK1_1	268	274	PF00069	0.469
MOD_CK1_1	339	345	PF00069	0.401
MOD_CK1_1	346	352	PF00069	0.393
MOD_CK1_1	426	432	PF00069	0.541
MOD_CK1_1	99	105	PF00069	0.538
MOD_CK2_1	201	207	PF00069	0.470
MOD_CK2_1	279	285	PF00069	0.560
MOD_CK2_1	287	293	PF00069	0.577
MOD_CK2_1	349	355	PF00069	0.550
MOD_CK2_1	463	469	PF00069	0.470
MOD_GlcNHglycan	156	159	PF01048	0.256
MOD_GlcNHglycan	223	226	PF01048	0.253
MOD_GlcNHglycan	251	254	PF01048	0.359
MOD_GlcNHglycan	267	270	PF01048	0.275
MOD_GlcNHglycan	273	276	PF01048	0.353
MOD_GlcNHglycan	299	302	PF01048	0.316
MOD_GlcNHglycan	304	307	PF01048	0.300
MOD_GSK3_1	136	143	PF00069	0.456
MOD_GSK3_1	230	237	PF00069	0.422
MOD_GSK3_1	240	247	PF00069	0.515
MOD_GSK3_1	252	259	PF00069	0.554
MOD_GSK3_1	265	272	PF00069	0.508
MOD_GSK3_1	275	282	PF00069	0.570
MOD_GSK3_1	283	290	PF00069	0.404
MOD_GSK3_1	339	346	PF00069	0.401
MOD_N-GLC_1	287	292	PF02516	0.332
MOD_N-GLC_1	3	8	PF02516	0.598
MOD_N-GLC_1	336	341	PF02516	0.341
MOD_N-GLC_1	346	351	PF02516	0.341
MOD_N-GLC_2	385	387	PF02516	0.270
MOD_NEK2_1	105	110	PF00069	0.571
MOD_NEK2_1	125	130	PF00069	0.468
MOD_NEK2_1	136	141	PF00069	0.411
MOD_NEK2_1	336	341	PF00069	0.510
MOD_NEK2_1	343	348	PF00069	0.510
MOD_NEK2_1	449	454	PF00069	0.477
MOD_NEK2_1	463	468	PF00069	0.470
MOD_PIKK_1	105	111	PF00454	0.557
MOD_PIKK_1	136	142	PF00454	0.456
MOD_PIKK_1	175	181	PF00454	0.513
MOD_PIKK_1	256	262	PF00454	0.566
MOD_PK_1	41	47	PF00069	0.571
MOD_PKA_1	256	262	PF00069	0.571
MOD_PKA_2	255	261	PF00069	0.568
MOD_PKA_2	368	374	PF00069	0.554
MOD_PKA_2	423	429	PF00069	0.463
MOD_Plk_1	118	124	PF00069	0.470
MOD_Plk_1	336	342	PF00069	0.510
MOD_Plk_1	349	355	PF00069	0.510
MOD_Plk_2-3	350	356	PF00069	0.515
MOD_Plk_4	130	136	PF00069	0.470
MOD_Plk_4	140	146	PF00069	0.470
MOD_Plk_4	32	38	PF00069	0.541
MOD_Plk_4	336	342	PF00069	0.571
MOD_Plk_4	444	450	PF00069	0.475
MOD_ProDKin_1	110	116	PF00069	0.443
MOD_ProDKin_1	177	183	PF00069	0.555
MOD_ProDKin_1	234	240	PF00069	0.508
MOD_ProDKin_1	244	250	PF00069	0.563
MOD_ProDKin_1	287	293	PF00069	0.548
MOD_ProDKin_1	96	102	PF00069	0.488
TRG_DiLeu_BaEn_1	169	174	PF01217	0.515
TRG_DiLeu_BaEn_2	100	106	PF01217	0.470
TRG_ENDOCYTIC_2	171	174	PF00928	0.515
TRG_ENDOCYTIC_2	338	341	PF00928	0.546
TRG_ENDOCYTIC_2	396	399	PF00928	0.510
TRG_ENDOCYTIC_2	480	483	PF00928	0.610
TRG_ER_diArg_1	40	43	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P696	Leptomonas seymouri	26%	100%
A0A0N0P8M2	Leptomonas seymouri	74%	100%
A0A0N1IM09	Leptomonas seymouri	25%	100%
A0A1X0NU35	Trypanosomatidae	27%	100%
A0A3Q8I9L1	Leishmania donovani	94%	100%
A0A3Q8IJ53	Leishmania donovani	27%	93%
A0A422NGD7	Trypanosoma rangeli	54%	100%
A0A422NI92	Trypanosoma rangeli	26%	100%
A0A422NRB8	Trypanosoma rangeli	26%	100%
A2WNB0	Oryza sativa subsp. indica	27%	100%
A4FUX8	Bos taurus	26%	100%
A4H783	Leishmania braziliensis	82%	100%
A4HMB0	Leishmania braziliensis	25%	93%
A4HVM3	Leishmania infantum	94%	100%
A4IAX6	Leishmania infantum	27%	93%
C9ZXR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A6N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AQC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
E9ATB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B5V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	93%
O94805	Homo sapiens	26%	100%
O96019	Homo sapiens	26%	100%
P45890	Drosophila melanogaster	20%	100%
P86173	Rattus norvegicus	26%	100%
Q09849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4FX37	Leishmania major	26%	95%
Q4P2E8	Ustilago maydis (strain 521 / FGSC 9021)	23%	90%
Q4QG59	Leishmania major	94%	100%
Q4R333	Macaca fascicularis	26%	100%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q4WHA3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q5AW89	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	100%
Q5NBI2	Oryza sativa subsp. japonica	27%	100%
Q6BXN0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	98%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q84M92	Arabidopsis thaliana	27%	100%
Q8LGE3	Arabidopsis thaliana	29%	100%
Q99MR0	Mus musculus	26%	100%
Q9D864	Mus musculus	24%	100%
Q9DEE9	Gallus gallus	23%	100%
Q9GZN1	Homo sapiens	24%	100%
Q9Z2N8	Mus musculus	26%	100%
V5AVP6	Trypanosoma cruzi	50%	100%
V5DJL3	Trypanosoma cruzi	27%	100%