Protein Smaug

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein Smaug

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APB5_LEIMU

TriTrypDb:

LmxM.13.0910

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

E9APB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.616
CLV_C14_Caspase3-7	691	695	PF00656	0.535
CLV_NRD_NRD_1	300	302	PF00675	0.737
CLV_NRD_NRD_1	327	329	PF00675	0.797
CLV_NRD_NRD_1	44	46	PF00675	0.711
CLV_NRD_NRD_1	443	445	PF00675	0.586
CLV_NRD_NRD_1	817	819	PF00675	0.826
CLV_PCSK_KEX2_1	191	193	PF00082	0.687
CLV_PCSK_KEX2_1	300	302	PF00082	0.737
CLV_PCSK_KEX2_1	326	328	PF00082	0.810
CLV_PCSK_KEX2_1	36	38	PF00082	0.750
CLV_PCSK_KEX2_1	426	428	PF00082	0.725
CLV_PCSK_KEX2_1	43	45	PF00082	0.651
CLV_PCSK_KEX2_1	645	647	PF00082	0.378
CLV_PCSK_KEX2_1	791	793	PF00082	0.735
CLV_PCSK_KEX2_1	817	819	PF00082	0.800
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.607
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.750
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.725
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.378
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.735
CLV_PCSK_SKI1_1	177	181	PF00082	0.658
CLV_PCSK_SKI1_1	184	188	PF00082	0.577
CLV_PCSK_SKI1_1	191	195	PF00082	0.507
CLV_PCSK_SKI1_1	587	591	PF00082	0.641
CLV_PCSK_SKI1_1	749	753	PF00082	0.522
DEG_SCF_FBW7_1	247	254	PF00400	0.522
DEG_SCF_FBW7_1	48	53	PF00400	0.752
DEG_SPOP_SBC_1	239	243	PF00917	0.653
DEG_SPOP_SBC_1	370	374	PF00917	0.730
DEG_SPOP_SBC_1	511	515	PF00917	0.698
DOC_ANK_TNKS_1	403	410	PF00023	0.656
DOC_CKS1_1	486	491	PF01111	0.728
DOC_CYCLIN_RxL_1	181	190	PF00134	0.678
DOC_MAPK_DCC_7	730	740	PF00069	0.483
DOC_MAPK_gen_1	649	658	PF00069	0.452
DOC_MAPK_gen_1	678	687	PF00069	0.542
DOC_MAPK_MEF2A_6	147	155	PF00069	0.712
DOC_MAPK_MEF2A_6	157	164	PF00069	0.533
DOC_MAPK_MEF2A_6	782	790	PF00069	0.693
DOC_MAPK_NFAT4_5	157	165	PF00069	0.574
DOC_PP1_RVXF_1	679	685	PF00149	0.484
DOC_PP2B_LxvP_1	60	63	PF13499	0.697
DOC_PP4_FxxP_1	51	54	PF00568	0.763
DOC_PP4_FxxP_1	537	540	PF00568	0.700
DOC_PP4_FxxP_1	810	813	PF00568	0.545
DOC_USP7_MATH_1	101	105	PF00917	0.714
DOC_USP7_MATH_1	213	217	PF00917	0.602
DOC_USP7_MATH_1	238	242	PF00917	0.761
DOC_USP7_MATH_1	251	255	PF00917	0.708
DOC_USP7_MATH_1	279	283	PF00917	0.729
DOC_USP7_MATH_1	292	296	PF00917	0.627
DOC_USP7_MATH_1	369	373	PF00917	0.789
DOC_USP7_MATH_1	478	482	PF00917	0.627
DOC_USP7_MATH_1	620	624	PF00917	0.558
DOC_USP7_MATH_1	794	798	PF00917	0.658
DOC_USP7_MATH_1	92	96	PF00917	0.708
DOC_USP7_UBL2_3	445	449	PF12436	0.633
DOC_USP7_UBL2_3	645	649	PF12436	0.483
DOC_WW_Pin1_4	199	204	PF00397	0.619
DOC_WW_Pin1_4	247	252	PF00397	0.583
DOC_WW_Pin1_4	338	343	PF00397	0.746
DOC_WW_Pin1_4	384	389	PF00397	0.751
DOC_WW_Pin1_4	46	51	PF00397	0.737
DOC_WW_Pin1_4	480	485	PF00397	0.771
DOC_WW_Pin1_4	97	102	PF00397	0.776
LIG_14-3-3_CanoR_1	43	51	PF00244	0.727
LIG_14-3-3_CanoR_1	499	506	PF00244	0.536
LIG_14-3-3_CanoR_1	622	626	PF00244	0.616
LIG_14-3-3_CanoR_1	635	641	PF00244	0.407
LIG_14-3-3_CanoR_1	717	727	PF00244	0.451
LIG_14-3-3_CanoR_1	730	736	PF00244	0.409
LIG_14-3-3_CanoR_1	737	741	PF00244	0.316
LIG_14-3-3_CanoR_1	782	787	PF00244	0.685
LIG_Actin_WH2_2	608	624	PF00022	0.559
LIG_Actin_WH2_2	668	685	PF00022	0.299
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BIR_III_4	568	572	PF00653	0.664
LIG_BRCT_BRCA1_1	103	107	PF00533	0.745
LIG_BRCT_BRCA1_1	241	245	PF00533	0.602
LIG_BRCT_BRCA1_1	372	376	PF00533	0.723
LIG_EVH1_1	800	804	PF00568	0.695
LIG_FHA_1	480	486	PF00498	0.805
LIG_FHA_1	653	659	PF00498	0.569
LIG_FHA_2	205	211	PF00498	0.504
LIG_FHA_2	452	458	PF00498	0.561
LIG_FHA_2	517	523	PF00498	0.509
LIG_FHA_2	637	643	PF00498	0.504
LIG_GBD_Chelix_1	124	132	PF00786	0.635
LIG_Integrin_isoDGR_2	258	260	PF01839	0.711
LIG_LIR_Apic_2	49	54	PF02991	0.756
LIG_LIR_Apic_2	535	540	PF02991	0.698
LIG_LIR_Gen_1	343	352	PF02991	0.773
LIG_LIR_Nem_3	343	349	PF02991	0.776
LIG_LIR_Nem_3	373	379	PF02991	0.776
LIG_LIR_Nem_3	551	557	PF02991	0.691
LIG_MYND_1	466	470	PF01753	0.727
LIG_NRBOX	148	154	PF00104	0.649
LIG_NRBOX	182	188	PF00104	0.537
LIG_NRBOX	737	743	PF00104	0.543
LIG_NRP_CendR_1	817	820	PF00754	0.716
LIG_SH2_CRK	138	142	PF00017	0.713
LIG_SH2_CRK	299	303	PF00017	0.674
LIG_SH2_STAP1	501	505	PF00017	0.708
LIG_SH2_STAT5	122	125	PF00017	0.635
LIG_SH2_STAT5	246	249	PF00017	0.530
LIG_SH2_STAT5	338	341	PF00017	0.695
LIG_SH2_STAT5	346	349	PF00017	0.763
LIG_SH2_STAT5	625	628	PF00017	0.516
LIG_SH3_1	327	333	PF00018	0.782
LIG_SH3_3	327	333	PF00018	0.833
LIG_SH3_3	392	398	PF00018	0.724
LIG_SH3_3	427	433	PF00018	0.541
LIG_SH3_3	483	489	PF00018	0.734
LIG_SH3_3	490	496	PF00018	0.659
LIG_SH3_3	51	57	PF00018	0.763
LIG_SH3_3	798	804	PF00018	0.762
LIG_SUMO_SIM_anti_2	739	745	PF11976	0.496
LIG_SUMO_SIM_par_1	739	745	PF11976	0.496
LIG_TYR_ITIM	136	141	PF00017	0.706
LIG_UBA3_1	30	36	PF00899	0.674
MOD_CDK_SPK_2	199	204	PF00069	0.619
MOD_CDK_SPK_2	97	102	PF00069	0.766
MOD_CK1_1	214	220	PF00069	0.687
MOD_CK1_1	226	232	PF00069	0.680
MOD_CK1_1	254	260	PF00069	0.647
MOD_CK1_1	26	32	PF00069	0.689
MOD_CK1_1	309	315	PF00069	0.751
MOD_CK1_1	372	378	PF00069	0.718
MOD_CK1_1	435	441	PF00069	0.720
MOD_CK1_1	451	457	PF00069	0.568
MOD_CK1_1	607	613	PF00069	0.675
MOD_CK1_1	652	658	PF00069	0.576
MOD_CK1_1	76	82	PF00069	0.749
MOD_CK1_1	784	790	PF00069	0.634
MOD_CK2_1	204	210	PF00069	0.507
MOD_CK2_1	414	420	PF00069	0.777
MOD_CK2_1	451	457	PF00069	0.558
MOD_CK2_1	692	698	PF00069	0.546
MOD_CK2_1	97	103	PF00069	0.779
MOD_GlcNHglycan	164	167	PF01048	0.423
MOD_GlcNHglycan	213	216	PF01048	0.688
MOD_GlcNHglycan	221	224	PF01048	0.710
MOD_GlcNHglycan	264	267	PF01048	0.777
MOD_GlcNHglycan	281	284	PF01048	0.695
MOD_GlcNHglycan	294	297	PF01048	0.667
MOD_GlcNHglycan	303	306	PF01048	0.732
MOD_GlcNHglycan	318	321	PF01048	0.539
MOD_GlcNHglycan	380	383	PF01048	0.758
MOD_GlcNHglycan	410	413	PF01048	0.648
MOD_GlcNHglycan	427	430	PF01048	0.643
MOD_GlcNHglycan	437	440	PF01048	0.659
MOD_GlcNHglycan	446	449	PF01048	0.558
MOD_GlcNHglycan	454	457	PF01048	0.565
MOD_GlcNHglycan	514	517	PF01048	0.690
MOD_GlcNHglycan	694	697	PF01048	0.448
MOD_GlcNHglycan	722	725	PF01048	0.450
MOD_GlcNHglycan	75	78	PF01048	0.746
MOD_GlcNHglycan	762	765	PF01048	0.618
MOD_GlcNHglycan	804	807	PF01048	0.718
MOD_GlcNHglycan	86	89	PF01048	0.656
MOD_GSK3_1	19	26	PF00069	0.752
MOD_GSK3_1	213	220	PF00069	0.674
MOD_GSK3_1	229	236	PF00069	0.593
MOD_GSK3_1	247	254	PF00069	0.646
MOD_GSK3_1	279	286	PF00069	0.538
MOD_GSK3_1	421	428	PF00069	0.685
MOD_GSK3_1	440	447	PF00069	0.626
MOD_GSK3_1	448	455	PF00069	0.706
MOD_GSK3_1	46	53	PF00069	0.775
MOD_GSK3_1	476	483	PF00069	0.787
MOD_GSK3_1	512	519	PF00069	0.560
MOD_GSK3_1	621	628	PF00069	0.559
MOD_GSK3_1	69	76	PF00069	0.777
MOD_GSK3_1	774	781	PF00069	0.670
MOD_GSK3_1	97	104	PF00069	0.775
MOD_LATS_1	633	639	PF00433	0.432
MOD_N-GLC_1	199	204	PF02516	0.619
MOD_N-GLC_1	218	223	PF02516	0.675
MOD_N-GLC_1	251	256	PF02516	0.607
MOD_N-GLC_1	279	284	PF02516	0.772
MOD_N-GLC_1	533	538	PF02516	0.700
MOD_N-GLC_1	636	641	PF02516	0.495
MOD_N-GLC_1	713	718	PF02516	0.533
MOD_N-GLC_2	287	289	PF02516	0.561
MOD_NEK2_1	187	192	PF00069	0.517
MOD_NEK2_1	261	266	PF00069	0.603
MOD_NEK2_1	621	626	PF00069	0.602
MOD_NEK2_1	671	676	PF00069	0.525
MOD_NEK2_1	69	74	PF00069	0.745
MOD_NEK2_1	700	705	PF00069	0.453
MOD_NEK2_1	713	718	PF00069	0.358
MOD_NEK2_1	720	725	PF00069	0.241
MOD_NEK2_1	742	747	PF00069	0.568
MOD_NEK2_2	267	272	PF00069	0.753
MOD_PIKK_1	516	522	PF00454	0.509
MOD_PIKK_1	794	800	PF00454	0.528
MOD_PIKK_1	92	98	PF00454	0.714
MOD_PK_1	449	455	PF00069	0.553
MOD_PK_1	649	655	PF00069	0.469
MOD_PK_1	782	788	PF00069	0.758
MOD_PKA_1	43	49	PF00069	0.717
MOD_PKA_1	444	450	PF00069	0.540
MOD_PKA_2	259	265	PF00069	0.787
MOD_PKA_2	43	49	PF00069	0.717
MOD_PKA_2	621	627	PF00069	0.504
MOD_PKA_2	736	742	PF00069	0.555
MOD_PKA_2	781	787	PF00069	0.685
MOD_Plk_1	251	257	PF00069	0.611
MOD_Plk_1	533	539	PF00069	0.621
MOD_Plk_1	636	642	PF00069	0.525
MOD_Plk_1	649	655	PF00069	0.478
MOD_Plk_1	70	76	PF00069	0.582
MOD_Plk_2-3	414	420	PF00069	0.539
MOD_Plk_4	101	107	PF00069	0.771
MOD_Plk_4	151	157	PF00069	0.663
MOD_Plk_4	175	181	PF00069	0.564
MOD_Plk_4	204	210	PF00069	0.548
MOD_Plk_4	251	257	PF00069	0.671
MOD_Plk_4	26	32	PF00069	0.689
MOD_Plk_4	267	273	PF00069	0.754
MOD_Plk_4	432	438	PF00069	0.734
MOD_Plk_4	621	627	PF00069	0.624
MOD_Plk_4	636	642	PF00069	0.379
MOD_Plk_4	64	70	PF00069	0.604
MOD_Plk_4	671	677	PF00069	0.474
MOD_Plk_4	736	742	PF00069	0.491
MOD_ProDKin_1	199	205	PF00069	0.616
MOD_ProDKin_1	247	253	PF00069	0.583
MOD_ProDKin_1	338	344	PF00069	0.746
MOD_ProDKin_1	384	390	PF00069	0.753
MOD_ProDKin_1	46	52	PF00069	0.739
MOD_ProDKin_1	480	486	PF00069	0.767
MOD_ProDKin_1	97	103	PF00069	0.779
MOD_SUMO_rev_2	638	647	PF00179	0.504
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.642
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.545
TRG_ENDOCYTIC_2	138	141	PF00928	0.712
TRG_ENDOCYTIC_2	346	349	PF00928	0.776
TRG_ENDOCYTIC_2	554	557	PF00928	0.692
TRG_ER_diArg_1	299	301	PF00400	0.751
TRG_ER_diArg_1	326	328	PF00400	0.810
TRG_ER_diArg_1	43	45	PF00400	0.708
TRG_ER_diArg_1	680	683	PF00400	0.565
TRG_ER_diArg_1	773	776	PF00400	0.529
TRG_ER_diArg_1	817	820	PF00400	0.840
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSJ0	Leishmania donovani	82%	100%
A4H779	Leishmania braziliensis	61%	100%
A4HVL9	Leishmania infantum	82%	100%
Q4QG63	Leishmania major	83%	100%