Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APB4_LEIMU

TriTrypDb:

LmxM.13.0900

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.657
CLV_NRD_NRD_1	114	116	PF00675	0.581
CLV_NRD_NRD_1	128	130	PF00675	0.575
CLV_NRD_NRD_1	167	169	PF00675	0.569
CLV_NRD_NRD_1	171	173	PF00675	0.545
CLV_NRD_NRD_1	183	185	PF00675	0.568
CLV_NRD_NRD_1	222	224	PF00675	0.579
CLV_NRD_NRD_1	253	255	PF00675	0.595
CLV_NRD_NRD_1	368	370	PF00675	0.809
CLV_NRD_NRD_1	503	505	PF00675	0.710
CLV_NRD_NRD_1	520	522	PF00675	0.809
CLV_NRD_NRD_1	523	525	PF00675	0.856
CLV_NRD_NRD_1	566	568	PF00675	0.593
CLV_PCSK_FUR_1	521	525	PF00082	0.747
CLV_PCSK_KEX2_1	114	116	PF00082	0.581
CLV_PCSK_KEX2_1	128	130	PF00082	0.575
CLV_PCSK_KEX2_1	13	15	PF00082	0.675
CLV_PCSK_KEX2_1	133	135	PF00082	0.581
CLV_PCSK_KEX2_1	171	173	PF00082	0.545
CLV_PCSK_KEX2_1	222	224	PF00082	0.586
CLV_PCSK_KEX2_1	248	250	PF00082	0.541
CLV_PCSK_KEX2_1	252	254	PF00082	0.553
CLV_PCSK_KEX2_1	263	265	PF00082	0.500
CLV_PCSK_KEX2_1	30	32	PF00082	0.495
CLV_PCSK_KEX2_1	43	45	PF00082	0.585
CLV_PCSK_KEX2_1	505	507	PF00082	0.710
CLV_PCSK_KEX2_1	519	521	PF00082	0.784
CLV_PCSK_KEX2_1	523	525	PF00082	0.846
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.675
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.581
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.598
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.567
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.495
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.585
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.659
CLV_PCSK_PC7_1	129	135	PF00082	0.572
CLV_PCSK_PC7_1	249	255	PF00082	0.551
CLV_PCSK_PC7_1	519	525	PF00082	0.767
CLV_PCSK_SKI1_1	172	176	PF00082	0.553
CLV_PCSK_SKI1_1	191	195	PF00082	0.610
CLV_PCSK_SKI1_1	227	231	PF00082	0.529
CLV_PCSK_SKI1_1	264	268	PF00082	0.566
CLV_PCSK_SKI1_1	423	427	PF00082	0.647
CLV_PCSK_SKI1_1	556	560	PF00082	0.729
DEG_SPOP_SBC_1	489	493	PF00917	0.587
DEG_SPOP_SBC_1	70	74	PF00917	0.759
DOC_CKS1_1	478	483	PF01111	0.636
DOC_CYCLIN_RxL_1	260	269	PF00134	0.586
DOC_MAPK_gen_1	139	145	PF00069	0.676
DOC_MAPK_gen_1	168	179	PF00069	0.556
DOC_MAPK_gen_1	222	234	PF00069	0.577
DOC_MAPK_gen_1	248	259	PF00069	0.601
DOC_MAPK_gen_1	434	442	PF00069	0.603
DOC_MAPK_gen_1	502	509	PF00069	0.768
DOC_MAPK_MEF2A_6	171	179	PF00069	0.550
DOC_MAPK_MEF2A_6	252	261	PF00069	0.607
DOC_MAPK_NFAT4_5	172	180	PF00069	0.555
DOC_PP1_RVXF_1	200	206	PF00149	0.595
DOC_PP1_RVXF_1	261	268	PF00149	0.580
DOC_PP2B_LxvP_1	296	299	PF13499	0.600
DOC_PP4_FxxP_1	108	111	PF00568	0.570
DOC_USP7_MATH_1	2	6	PF00917	0.625
DOC_USP7_MATH_1	241	245	PF00917	0.608
DOC_USP7_MATH_1	331	335	PF00917	0.721
DOC_USP7_MATH_1	378	382	PF00917	0.801
DOC_USP7_MATH_1	474	478	PF00917	0.682
DOC_USP7_MATH_1	488	492	PF00917	0.671
DOC_USP7_MATH_1	530	534	PF00917	0.794
DOC_USP7_MATH_1	535	539	PF00917	0.708
DOC_USP7_MATH_1	542	546	PF00917	0.603
DOC_USP7_MATH_1	551	555	PF00917	0.541
DOC_USP7_MATH_1	566	570	PF00917	0.601
DOC_USP7_MATH_1	69	73	PF00917	0.718
DOC_USP7_MATH_1	79	83	PF00917	0.681
DOC_USP7_MATH_1	97	101	PF00917	0.635
DOC_USP7_UBL2_3	224	228	PF12436	0.574
DOC_WW_Pin1_4	107	112	PF00397	0.571
DOC_WW_Pin1_4	386	391	PF00397	0.833
DOC_WW_Pin1_4	477	482	PF00397	0.797
DOC_WW_Pin1_4	540	545	PF00397	0.746
DOC_WW_Pin1_4	71	76	PF00397	0.667
LIG_14-3-3_CanoR_1	423	429	PF00244	0.672
LIG_14-3-3_CanoR_1	436	442	PF00244	0.514
LIG_14-3-3_CanoR_1	556	566	PF00244	0.548
LIG_Actin_WH2_2	33	48	PF00022	0.616
LIG_APCC_ABBAyCdc20_2	263	269	PF00400	0.570
LIG_BIR_III_2	466	470	PF00653	0.721
LIG_BRCT_BRCA1_1	104	108	PF00533	0.644
LIG_BRCT_BRCA1_1	189	193	PF00533	0.608
LIG_deltaCOP1_diTrp_1	25	36	PF00928	0.607
LIG_DLG_GKlike_1	253	261	PF00625	0.709
LIG_FHA_1	282	288	PF00498	0.616
LIG_FHA_1	295	301	PF00498	0.587
LIG_FHA_1	424	430	PF00498	0.725
LIG_FHA_1	435	441	PF00498	0.545
LIG_FHA_1	447	453	PF00498	0.510
LIG_FHA_1	47	53	PF00498	0.636
LIG_FHA_1	553	559	PF00498	0.695
LIG_FHA_2	165	171	PF00498	0.614
LIG_FHA_2	176	182	PF00498	0.502
LIG_FHA_2	270	276	PF00498	0.663
LIG_FHA_2	281	287	PF00498	0.490
LIG_FHA_2	343	349	PF00498	0.660
LIG_FHA_2	392	398	PF00498	0.697
LIG_Integrin_RGD_1	362	364	PF01839	0.754
LIG_LIR_Apic_2	105	111	PF02991	0.628
LIG_LIR_Gen_1	103	112	PF02991	0.613
LIG_LIR_Gen_1	173	182	PF02991	0.562
LIG_LIR_Gen_1	32	40	PF02991	0.607
LIG_LIR_Nem_3	103	107	PF02991	0.627
LIG_LIR_Nem_3	173	177	PF02991	0.549
LIG_LIR_Nem_3	32	36	PF02991	0.551
LIG_MYND_1	460	464	PF01753	0.669
LIG_Pex14_2	104	108	PF04695	0.618
LIG_SH2_CRK	18	22	PF00017	0.684
LIG_SH2_CRK	236	240	PF00017	0.616
LIG_SH2_STAP1	18	22	PF00017	0.786
LIG_SH2_STAP1	84	88	PF00017	0.488
LIG_SH2_STAT5	106	109	PF00017	0.609
LIG_SH2_STAT5	238	241	PF00017	0.608
LIG_SH3_3	286	292	PF00018	0.553
LIG_SH3_3	407	413	PF00018	0.710
LIG_SH3_3	454	460	PF00018	0.645
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.572
LIG_SUMO_SIM_anti_2	414	420	PF11976	0.780
LIG_SUMO_SIM_par_1	141	147	PF11976	0.572
LIG_SUMO_SIM_par_1	414	420	PF11976	0.780
LIG_TRAF2_1	345	348	PF00917	0.742
LIG_TYR_ITIM	234	239	PF00017	0.612
LIG_UBA3_1	257	263	PF00899	0.604
MOD_CDC14_SPxK_1	389	392	PF00782	0.750
MOD_CDK_SPxK_1	386	392	PF00069	0.750
MOD_CDK_SPxxK_3	107	114	PF00069	0.568
MOD_CDK_SPxxK_3	540	547	PF00069	0.776
MOD_CK1_1	100	106	PF00069	0.725
MOD_CK1_1	144	150	PF00069	0.577
MOD_CK1_1	35	41	PF00069	0.585
MOD_CK1_1	374	380	PF00069	0.769
MOD_CK1_1	477	483	PF00069	0.686
MOD_CK1_1	5	11	PF00069	0.662
MOD_CK1_1	554	560	PF00069	0.608
MOD_CK2_1	107	113	PF00069	0.592
MOD_CK2_1	164	170	PF00069	0.625
MOD_CK2_1	175	181	PF00069	0.492
MOD_CK2_1	280	286	PF00069	0.462
MOD_CK2_1	342	348	PF00069	0.536
MOD_CK2_1	391	397	PF00069	0.699
MOD_CK2_1	540	546	PF00069	0.648
MOD_Cter_Amidation	11	14	PF01082	0.736
MOD_Cter_Amidation	261	264	PF01082	0.606
MOD_Cter_Amidation	502	505	PF01082	0.651
MOD_DYRK1A_RPxSP_1	386	390	PF00069	0.534
MOD_GlcNHglycan	311	314	PF01048	0.768
MOD_GlcNHglycan	334	337	PF01048	0.703
MOD_GlcNHglycan	37	40	PF01048	0.610
MOD_GlcNHglycan	373	376	PF01048	0.796
MOD_GlcNHglycan	380	383	PF01048	0.734
MOD_GlcNHglycan	386	389	PF01048	0.646
MOD_GlcNHglycan	394	397	PF01048	0.607
MOD_GlcNHglycan	452	455	PF01048	0.701
MOD_GlcNHglycan	49	52	PF01048	0.630
MOD_GlcNHglycan	492	495	PF01048	0.628
MOD_GlcNHglycan	559	562	PF01048	0.620
MOD_GlcNHglycan	56	59	PF01048	0.634
MOD_GlcNHglycan	7	10	PF01048	0.713
MOD_GlcNHglycan	81	84	PF01048	0.757
MOD_GSK3_1	102	109	PF00069	0.642
MOD_GSK3_1	265	272	PF00069	0.631
MOD_GSK3_1	277	284	PF00069	0.622
MOD_GSK3_1	294	301	PF00069	0.670
MOD_GSK3_1	31	38	PF00069	0.592
MOD_GSK3_1	373	380	PF00069	0.741
MOD_GSK3_1	419	426	PF00069	0.652
MOD_GSK3_1	446	453	PF00069	0.579
MOD_GSK3_1	490	497	PF00069	0.781
MOD_GSK3_1	526	533	PF00069	0.797
MOD_N-GLC_1	3	8	PF02516	0.634
MOD_N-GLC_1	445	450	PF02516	0.573
MOD_NEK2_1	175	180	PF00069	0.554
MOD_PIKK_1	530	536	PF00454	0.764
MOD_PKA_1	253	259	PF00069	0.704
MOD_PKA_2	2	8	PF00069	0.718
MOD_PKA_2	253	259	PF00069	0.704
MOD_PKA_2	269	275	PF00069	0.469
MOD_PKA_2	435	441	PF00069	0.604
MOD_PKA_2	446	452	PF00069	0.636
MOD_PKA_2	566	572	PF00069	0.535
MOD_PKB_1	44	52	PF00069	0.621
MOD_Plk_1	277	283	PF00069	0.733
MOD_Plk_1	31	37	PF00069	0.547
MOD_Plk_4	141	147	PF00069	0.568
MOD_Plk_4	241	247	PF00069	0.609
MOD_Plk_4	253	259	PF00069	0.602
MOD_Plk_4	32	38	PF00069	0.585
MOD_Plk_4	424	430	PF00069	0.617
MOD_ProDKin_1	107	113	PF00069	0.570
MOD_ProDKin_1	386	392	PF00069	0.836
MOD_ProDKin_1	477	483	PF00069	0.798
MOD_ProDKin_1	540	546	PF00069	0.747
MOD_ProDKin_1	71	77	PF00069	0.670
MOD_SUMO_rev_2	187	195	PF00179	0.644
MOD_SUMO_rev_2	197	204	PF00179	0.524
TRG_DiLeu_BaEn_1	302	307	PF01217	0.615
TRG_DiLeu_BaEn_2	169	175	PF01217	0.650
TRG_DiLeu_BaEn_2	31	37	PF01217	0.606
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.611
TRG_DiLeu_LyEn_5	302	307	PF01217	0.615
TRG_ENDOCYTIC_2	18	21	PF00928	0.690
TRG_ENDOCYTIC_2	236	239	PF00928	0.576
TRG_ER_diArg_1	221	223	PF00400	0.589
TRG_ER_diArg_1	252	254	PF00400	0.614
TRG_ER_diArg_1	504	507	PF00400	0.767
TRG_ER_diArg_1	519	521	PF00400	0.647
TRG_ER_diLys_1	568	573	PF00400	0.681
TRG_NLS_MonoExtC_3	503	508	PF00514	0.555
TRG_NLS_MonoExtN_4	502	509	PF00514	0.585
TRG_NLS_MonoExtN_4	566	571	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I995	Leptomonas seymouri	59%	100%
A0A3Q8II04	Leishmania donovani	84%	91%
A4H778	Leishmania braziliensis	75%	100%
A4HVL8	Leishmania infantum	85%	93%
Q4QG64	Leishmania major	83%	100%