Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APB3_LEIMU

TriTrypDb:

LmxM.13.0890

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.581
CLV_NRD_NRD_1	103	105	PF00675	0.566
CLV_NRD_NRD_1	141	143	PF00675	0.590
CLV_NRD_NRD_1	236	238	PF00675	0.493
CLV_NRD_NRD_1	257	259	PF00675	0.512
CLV_NRD_NRD_1	51	53	PF00675	0.630
CLV_NRD_NRD_1	75	77	PF00675	0.575
CLV_PCSK_FUR_1	234	238	PF00082	0.487
CLV_PCSK_KEX2_1	140	142	PF00082	0.625
CLV_PCSK_KEX2_1	236	238	PF00082	0.475
CLV_PCSK_KEX2_1	257	259	PF00082	0.529
CLV_PCSK_KEX2_1	53	55	PF00082	0.559
CLV_PCSK_KEX2_1	75	77	PF00082	0.575
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.519
CLV_PCSK_SKI1_1	304	308	PF00082	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.617
DOC_MAPK_MEF2A_6	276	284	PF00069	0.486
DOC_PP4_MxPP_1	88	91	PF00568	0.470
DOC_USP7_MATH_1	22	26	PF00917	0.719
DOC_USP7_MATH_1	48	52	PF00917	0.658
DOC_WW_Pin1_4	321	326	PF00397	0.621
DOC_WW_Pin1_4	36	41	PF00397	0.608
LIG_14-3-3_CanoR_1	104	112	PF00244	0.349
LIG_14-3-3_CanoR_1	63	68	PF00244	0.537
LIG_APCC_ABBAyCdc20_2	65	71	PF00400	0.448
LIG_BIR_III_2	146	150	PF00653	0.521
LIG_BRCT_BRCA1_1	312	316	PF00533	0.564
LIG_FHA_1	209	215	PF00498	0.434
LIG_FHA_2	149	155	PF00498	0.739
LIG_LIR_Gen_1	131	139	PF02991	0.522
LIG_LIR_Gen_1	190	198	PF02991	0.459
LIG_LIR_Gen_1	202	208	PF02991	0.391
LIG_LIR_Gen_1	313	321	PF02991	0.668
LIG_LIR_Nem_3	131	137	PF02991	0.528
LIG_LIR_Nem_3	190	194	PF02991	0.457
LIG_LIR_Nem_3	197	201	PF02991	0.401
LIG_LIR_Nem_3	202	206	PF02991	0.402
LIG_LIR_Nem_3	313	319	PF02991	0.665
LIG_LIR_Nem_3	62	67	PF02991	0.445
LIG_LIR_Nem_3	71	77	PF02991	0.454
LIG_SH2_STAP1	229	233	PF00017	0.495
LIG_SH2_STAT3	229	232	PF00017	0.538
LIG_SH2_STAT5	191	194	PF00017	0.450
LIG_SH3_3	154	160	PF00018	0.764
LIG_SH3_3	201	207	PF00018	0.444
LIG_TRAF2_1	253	256	PF00917	0.606
LIG_TRAF2_1	324	327	PF00917	0.563
LIG_TRAF2_1	335	338	PF00917	0.443
MOD_CK1_1	36	42	PF00069	0.580
MOD_CK2_1	148	154	PF00069	0.727
MOD_CK2_1	295	301	PF00069	0.721
MOD_CK2_1	321	327	PF00069	0.571
MOD_GlcNHglycan	113	116	PF01048	0.608
MOD_GlcNHglycan	16	20	PF01048	0.643
MOD_GlcNHglycan	24	27	PF01048	0.681
MOD_GlcNHglycan	271	274	PF01048	0.473
MOD_GlcNHglycan	295	300	PF01048	0.704
MOD_GlcNHglycan	35	38	PF01048	0.446
MOD_GSK3_1	103	110	PF00069	0.596
MOD_GSK3_1	11	18	PF00069	0.693
MOD_GSK3_1	166	173	PF00069	0.648
MOD_GSK3_1	306	313	PF00069	0.704
MOD_NEK2_1	208	213	PF00069	0.443
MOD_NEK2_1	307	312	PF00069	0.624
MOD_PIKK_1	107	113	PF00454	0.472
MOD_PIKK_1	228	234	PF00454	0.538
MOD_PKA_1	236	242	PF00069	0.542
MOD_PKA_2	103	109	PF00069	0.656
MOD_PKA_2	236	242	PF00069	0.452
MOD_PKB_1	140	148	PF00069	0.564
MOD_PKB_1	234	242	PF00069	0.540
MOD_Plk_1	208	214	PF00069	0.505
MOD_Plk_4	187	193	PF00069	0.424
MOD_Plk_4	199	205	PF00069	0.345
MOD_ProDKin_1	321	327	PF00069	0.621
MOD_ProDKin_1	36	42	PF00069	0.610
MOD_SUMO_for_1	289	292	PF00179	0.567
MOD_SUMO_rev_2	296	306	PF00179	0.748
TRG_AP2beta_CARGO_1	131	141	PF09066	0.589
TRG_DiLeu_BaEn_1	265	270	PF01217	0.517
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.452
TRG_ENDOCYTIC_2	191	194	PF00928	0.454
TRG_ER_diArg_1	140	142	PF00400	0.486
TRG_ER_diArg_1	233	236	PF00400	0.529
TRG_ER_diArg_1	257	259	PF00400	0.533
TRG_ER_diArg_1	74	76	PF00400	0.581
TRG_ER_diArg_1	98	101	PF00400	0.495
TRG_NLS_MonoExtC_3	51	56	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K8	Leptomonas seymouri	57%	90%
A0A0S4IK25	Bodo saltans	31%	83%
A0A1X0NN31	Trypanosomatidae	42%	100%
A0A3S7WSI8	Leishmania donovani	90%	100%
A4H777	Leishmania braziliensis	75%	99%
A4HVL7	Leishmania infantum	90%	100%
D0A6N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QG65	Leishmania major	89%	100%
V5BK51	Trypanosoma cruzi	42%	100%