C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APB2_LEIMU

TriTrypDb:

LmxM.13.0880

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APB2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	643	647	PF00656	0.838
CLV_C14_Caspase3-7	650	654	PF00656	0.735
CLV_NRD_NRD_1	225	227	PF00675	0.807
CLV_NRD_NRD_1	291	293	PF00675	0.792
CLV_NRD_NRD_1	313	315	PF00675	0.784
CLV_NRD_NRD_1	503	505	PF00675	0.663
CLV_NRD_NRD_1	81	83	PF00675	0.586
CLV_PCSK_KEX2_1	225	227	PF00082	0.807
CLV_PCSK_KEX2_1	291	293	PF00082	0.792
CLV_PCSK_KEX2_1	313	315	PF00082	0.784
CLV_PCSK_KEX2_1	492	494	PF00082	0.662
CLV_PCSK_KEX2_1	503	505	PF00082	0.663
CLV_PCSK_KEX2_1	682	684	PF00082	0.787
CLV_PCSK_KEX2_1	694	696	PF00082	0.770
CLV_PCSK_KEX2_1	81	83	PF00082	0.586
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.662
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.787
CLV_PCSK_PC1ET2_1	694	696	PF00082	0.770
CLV_PCSK_SKI1_1	388	392	PF00082	0.509
CLV_PCSK_SKI1_1	457	461	PF00082	0.612
CLV_PCSK_SKI1_1	690	694	PF00082	0.860
DEG_SCF_FBW7_1	124	131	PF00400	0.785
DEG_SPOP_SBC_1	128	132	PF00917	0.791
DOC_AGCK_PIF_2	45	50	PF00069	0.612
DOC_CKS1_1	125	130	PF01111	0.807
DOC_CKS1_1	35	40	PF01111	0.629
DOC_MAPK_DCC_7	333	341	PF00069	0.659
DOC_MAPK_gen_1	393	400	PF00069	0.629
DOC_MAPK_MEF2A_6	393	400	PF00069	0.528
DOC_MAPK_NFAT4_5	393	401	PF00069	0.638
DOC_PP2B_LxvP_1	15	18	PF13499	0.632
DOC_USP7_MATH_1	128	132	PF00917	0.795
DOC_USP7_MATH_1	148	152	PF00917	0.543
DOC_USP7_MATH_1	528	532	PF00917	0.772
DOC_USP7_MATH_1	549	553	PF00917	0.907
DOC_USP7_MATH_1	558	562	PF00917	0.808
DOC_USP7_MATH_1	586	590	PF00917	0.861
DOC_USP7_MATH_1	592	596	PF00917	0.769
DOC_USP7_MATH_1	620	624	PF00917	0.757
DOC_USP7_MATH_1	670	674	PF00917	0.898
DOC_USP7_UBL2_3	457	461	PF12436	0.612
DOC_USP7_UBL2_3	672	676	PF12436	0.797
DOC_USP7_UBL2_3	677	681	PF12436	0.778
DOC_USP7_UBL2_3	690	694	PF12436	0.582
DOC_WW_Pin1_4	124	129	PF00397	0.881
DOC_WW_Pin1_4	20	25	PF00397	0.683
DOC_WW_Pin1_4	34	39	PF00397	0.672
DOC_WW_Pin1_4	566	571	PF00397	0.735
DOC_WW_Pin1_4	588	593	PF00397	0.796
DOC_WW_Pin1_4	66	71	PF00397	0.616
DOC_WW_Pin1_4	95	100	PF00397	0.774
LIG_14-3-3_CanoR_1	327	333	PF00244	0.764
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BRCT_BRCA1_1	41	45	PF00533	0.595
LIG_CSL_BTD_1	15	18	PF09270	0.632
LIG_CtBP_PxDLS_1	38	42	PF00389	0.598
LIG_EH1_1	265	273	PF00400	0.713
LIG_FHA_1	12	18	PF00498	0.633
LIG_FHA_1	171	177	PF00498	0.805
LIG_FHA_1	25	31	PF00498	0.687
LIG_FHA_1	370	376	PF00498	0.547
LIG_FHA_2	343	349	PF00498	0.721
LIG_FHA_2	35	41	PF00498	0.693
LIG_FHA_2	602	608	PF00498	0.733
LIG_FHA_2	67	73	PF00498	0.607
LIG_IBAR_NPY_1	123	125	PF08397	0.600
LIG_IBAR_NPY_1	264	266	PF08397	0.822
LIG_Integrin_isoDGR_2	11	13	PF01839	0.761
LIG_Integrin_RGD_1	222	224	PF01839	0.875
LIG_IRF3_LxIS_1	5	10	PF10401	0.712
LIG_LIR_Apic_2	293	299	PF02991	0.794
LIG_LIR_Apic_2	352	357	PF02991	0.513
LIG_LIR_Gen_1	403	412	PF02991	0.658
LIG_LIR_Nem_3	403	407	PF02991	0.665
LIG_LIR_Nem_3	42	48	PF02991	0.601
LIG_LIR_Nem_3	422	427	PF02991	0.333
LIG_LIR_Nem_3	79	83	PF02991	0.611
LIG_NRBOX	171	177	PF00104	0.703
LIG_SH2_CRK	354	358	PF00017	0.587
LIG_SH2_CRK	96	100	PF00017	0.784
LIG_SH2_GRB2like	354	357	PF00017	0.578
LIG_SH2_NCK_1	96	100	PF00017	0.784
LIG_SH2_PTP2	35	38	PF00017	0.631
LIG_SH2_STAP1	238	242	PF00017	0.837
LIG_SH2_STAP1	50	54	PF00017	0.706
LIG_SH2_STAT3	50	53	PF00017	0.614
LIG_SH2_STAT5	35	38	PF00017	0.631
LIG_SH2_STAT5	429	432	PF00017	0.528
LIG_SH2_STAT5	46	49	PF00017	0.614
LIG_SH2_STAT5	518	521	PF00017	0.795
LIG_SH2_STAT5	8	11	PF00017	0.644
LIG_SH3_3	301	307	PF00018	0.548
LIG_SH3_3	341	347	PF00018	0.634
LIG_SH3_3	564	570	PF00018	0.605
LIG_SH3_4	677	684	PF00018	0.877
LIG_TRAF2_1	403	406	PF00917	0.665
LIG_TRAF2_1	647	650	PF00917	0.903
LIG_UBA3_1	467	476	PF00899	0.598
MOD_CK1_1	131	137	PF00069	0.768
MOD_CK1_1	146	152	PF00069	0.852
MOD_CK1_1	616	622	PF00069	0.745
MOD_CK1_1	623	629	PF00069	0.721
MOD_CK2_1	20	26	PF00069	0.671
MOD_CK2_1	34	40	PF00069	0.644
MOD_CK2_1	342	348	PF00069	0.728
MOD_CK2_1	400	406	PF00069	0.660
MOD_CK2_1	533	539	PF00069	0.786
MOD_CK2_1	636	642	PF00069	0.701
MOD_CK2_1	66	72	PF00069	0.617
MOD_Cter_Amidation	289	292	PF01082	0.766
MOD_Cter_Amidation	391	394	PF01082	0.665
MOD_GlcNHglycan	1	4	PF01048	0.684
MOD_GlcNHglycan	146	149	PF01048	0.852
MOD_GlcNHglycan	150	153	PF01048	0.830
MOD_GlcNHglycan	167	170	PF01048	0.536
MOD_GlcNHglycan	186	189	PF01048	0.654
MOD_GlcNHglycan	216	219	PF01048	0.724
MOD_GlcNHglycan	288	291	PF01048	0.783
MOD_GlcNHglycan	521	524	PF01048	0.875
MOD_GlcNHglycan	556	559	PF01048	0.888
MOD_GlcNHglycan	577	580	PF01048	0.788
MOD_GlcNHglycan	618	621	PF01048	0.763
MOD_GlcNHglycan	637	641	PF01048	0.864
MOD_GSK3_1	124	131	PF00069	0.825
MOD_GSK3_1	143	150	PF00069	0.799
MOD_GSK3_1	18	25	PF00069	0.613
MOD_GSK3_1	286	293	PF00069	0.808
MOD_GSK3_1	315	322	PF00069	0.867
MOD_GSK3_1	519	526	PF00069	0.775
MOD_GSK3_1	554	561	PF00069	0.831
MOD_GSK3_1	582	589	PF00069	0.879
MOD_GSK3_1	614	621	PF00069	0.734
MOD_GSK3_1	622	629	PF00069	0.730
MOD_GSK3_1	7	14	PF00069	0.687
MOD_N-GLC_1	189	194	PF02516	0.855
MOD_N-GLC_1	198	203	PF02516	0.767
MOD_NEK2_1	143	148	PF00069	0.791
MOD_NEK2_1	236	241	PF00069	0.835
MOD_NEK2_1	309	314	PF00069	0.761
MOD_NEK2_1	328	333	PF00069	0.516
MOD_NEK2_1	39	44	PF00069	0.604
MOD_NEK2_1	517	522	PF00069	0.795
MOD_NEK2_1	636	641	PF00069	0.605
MOD_NEK2_1	7	12	PF00069	0.641
MOD_PIKK_1	131	137	PF00454	0.765
MOD_PIKK_1	170	176	PF00454	0.803
MOD_PIKK_1	190	196	PF00454	0.558
MOD_PIKK_1	236	242	PF00454	0.838
MOD_PIKK_1	317	323	PF00454	0.878
MOD_PIKK_1	355	361	PF00454	0.396
MOD_PIKK_1	509	515	PF00454	0.726
MOD_PIKK_1	523	529	PF00454	0.593
MOD_PIKK_1	542	548	PF00454	0.799
MOD_PIKK_1	549	555	PF00454	0.793
MOD_PIKK_1	568	574	PF00454	0.568
MOD_PKA_1	690	696	PF00069	0.877
MOD_PKA_2	18	24	PF00069	0.704
MOD_PKA_2	290	296	PF00069	0.879
MOD_Plk_2-3	342	348	PF00069	0.648
MOD_Plk_2-3	533	539	PF00069	0.786
MOD_Plk_4	349	355	PF00069	0.559
MOD_Plk_4	369	375	PF00069	0.397
MOD_ProDKin_1	124	130	PF00069	0.883
MOD_ProDKin_1	20	26	PF00069	0.677
MOD_ProDKin_1	34	40	PF00069	0.668
MOD_ProDKin_1	566	572	PF00069	0.737
MOD_ProDKin_1	588	594	PF00069	0.797
MOD_ProDKin_1	66	72	PF00069	0.617
MOD_ProDKin_1	95	101	PF00069	0.779
MOD_SUMO_rev_2	23	30	PF00179	0.788
MOD_SUMO_rev_2	348	353	PF00179	0.622
MOD_SUMO_rev_2	383	390	PF00179	0.591
MOD_SUMO_rev_2	403	410	PF00179	0.572
MOD_SUMO_rev_2	487	494	PF00179	0.756
MOD_SUMO_rev_2	661	670	PF00179	0.802
TRG_DiLeu_BaEn_2	85	91	PF01217	0.621
TRG_ENDOCYTIC_2	260	263	PF00928	0.841
TRG_ER_diArg_1	225	227	PF00400	0.867
TRG_ER_diArg_1	80	82	PF00400	0.579
TRG_NLS_Bipartite_1	671	686	PF00514	0.831
TRG_NLS_MonoExtC_3	680	685	PF00514	0.780
TRG_NLS_MonoExtC_3	693	698	PF00514	0.769
TRG_NLS_MonoExtN_4	669	675	PF00514	0.794
TRG_NLS_MonoExtN_4	678	685	PF00514	0.769
TRG_NLS_MonoExtN_4	691	698	PF00514	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX4	Leptomonas seymouri	57%	100%
A0A3S5H6P0	Leishmania donovani	94%	100%
A4H776	Leishmania braziliensis	86%	98%
A4HVL6	Leishmania infantum	93%	100%
Q4QG66	Leishmania major	88%	99%