Mitochondrial processing peptidase alpha subunit,putative (Metallo-peptidase, clan me, family m16)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase alpha subunit, putative

Species:

Leishmania mexicana

UniProt:

E9APB1_LEIMU

TriTrypDb:

LmxM.13.0870

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9APB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APB1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	22
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.406
CLV_C14_Caspase3-7	434	438	PF00656	0.574
CLV_C14_Caspase3-7	484	488	PF00656	0.442
CLV_NRD_NRD_1	165	167	PF00675	0.651
CLV_NRD_NRD_1	3	5	PF00675	0.556
CLV_NRD_NRD_1	354	356	PF00675	0.507
CLV_PCSK_KEX2_1	165	167	PF00082	0.642
CLV_PCSK_KEX2_1	3	5	PF00082	0.556
CLV_PCSK_KEX2_1	498	500	PF00082	0.420
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.420
CLV_PCSK_SKI1_1	225	229	PF00082	0.436
CLV_PCSK_SKI1_1	356	360	PF00082	0.409
CLV_PCSK_SKI1_1	419	423	PF00082	0.448
CLV_PCSK_SKI1_1	445	449	PF00082	0.487
CLV_PCSK_SKI1_1	70	74	PF00082	0.398
DEG_Nend_Nbox_1	1	3	PF02207	0.574
DEG_SPOP_SBC_1	108	112	PF00917	0.352
DEG_SPOP_SBC_1	156	160	PF00917	0.451
DEG_SPOP_SBC_1	251	255	PF00917	0.336
DOC_MAPK_gen_1	137	146	PF00069	0.325
DOC_MAPK_gen_1	498	505	PF00069	0.313
DOC_MAPK_MEF2A_6	137	146	PF00069	0.338
DOC_PP4_FxxP_1	196	199	PF00568	0.380
DOC_PP4_FxxP_1	396	399	PF00568	0.339
DOC_USP7_MATH_1	130	134	PF00917	0.441
DOC_USP7_MATH_1	245	249	PF00917	0.446
DOC_USP7_MATH_1	251	255	PF00917	0.380
DOC_USP7_MATH_1	46	50	PF00917	0.603
DOC_USP7_MATH_1	488	492	PF00917	0.322
DOC_USP7_MATH_1	79	83	PF00917	0.376
DOC_USP7_UBL2_3	444	448	PF12436	0.289
DOC_WW_Pin1_4	157	162	PF00397	0.375
DOC_WW_Pin1_4	286	291	PF00397	0.436
DOC_WW_Pin1_4	29	34	PF00397	0.531
DOC_WW_Pin1_4	395	400	PF00397	0.368
LIG_14-3-3_CanoR_1	123	129	PF00244	0.420
LIG_14-3-3_CanoR_1	419	428	PF00244	0.507
LIG_14-3-3_CanoR_1	70	79	PF00244	0.493
LIG_Clathr_ClatBox_1	118	122	PF01394	0.387
LIG_eIF4E_1	400	406	PF01652	0.330
LIG_FHA_1	157	163	PF00498	0.430
LIG_FHA_1	400	406	PF00498	0.414
LIG_FHA_1	420	426	PF00498	0.215
LIG_FHA_1	447	453	PF00498	0.345
LIG_FHA_1	71	77	PF00498	0.486
LIG_FHA_2	316	322	PF00498	0.442
LIG_FHA_2	332	338	PF00498	0.508
LIG_FHA_2	456	462	PF00498	0.383
LIG_FHA_2	478	484	PF00498	0.438
LIG_LIR_Apic_2	214	220	PF02991	0.401
LIG_LIR_Apic_2	262	267	PF02991	0.348
LIG_LIR_Gen_1	185	196	PF02991	0.347
LIG_LIR_Nem_3	185	191	PF02991	0.333
LIG_LIR_Nem_3	259	264	PF02991	0.319
LIG_LIR_Nem_3	461	465	PF02991	0.342
LIG_PTB_Apo_2	113	120	PF02174	0.370
LIG_PTB_Apo_2	237	244	PF02174	0.487
LIG_PTB_Apo_2	285	292	PF02174	0.417
LIG_SH2_CRK	93	97	PF00017	0.409
LIG_SH2_GRB2like	286	289	PF00017	0.408
LIG_SH2_NCK_1	93	97	PF00017	0.421
LIG_SH2_PTP2	141	144	PF00017	0.400
LIG_SH2_PTP2	264	267	PF00017	0.323
LIG_SH2_SRC	93	96	PF00017	0.381
LIG_SH2_STAP1	223	227	PF00017	0.460
LIG_SH2_STAP1	25	29	PF00017	0.658
LIG_SH2_STAP1	261	265	PF00017	0.319
LIG_SH2_STAP1	501	505	PF00017	0.332
LIG_SH2_STAT3	223	226	PF00017	0.342
LIG_SH2_STAT5	141	144	PF00017	0.380
LIG_SH2_STAT5	264	267	PF00017	0.299
LIG_SH2_STAT5	317	320	PF00017	0.418
LIG_SH2_STAT5	462	465	PF00017	0.334
LIG_SH2_STAT5	86	89	PF00017	0.298
LIG_SH3_1	93	99	PF00018	0.516
LIG_SH3_3	2	8	PF00018	0.494
LIG_SH3_3	42	48	PF00018	0.627
LIG_SH3_3	93	99	PF00018	0.399
LIG_SUMO_SIM_par_1	306	313	PF11976	0.301
LIG_TRAF2_1	481	484	PF00917	0.528
MOD_CK1_1	155	161	PF00069	0.512
MOD_CK1_1	438	444	PF00069	0.412
MOD_CK1_1	471	477	PF00069	0.510
MOD_CK1_1	49	55	PF00069	0.646
MOD_CK1_1	506	512	PF00069	0.373
MOD_CK2_1	130	136	PF00069	0.387
MOD_CK2_1	20	26	PF00069	0.589
MOD_CK2_1	315	321	PF00069	0.400
MOD_CK2_1	477	483	PF00069	0.457
MOD_GlcNHglycan	154	157	PF01048	0.525
MOD_GlcNHglycan	293	296	PF01048	0.495
MOD_GlcNHglycan	492	495	PF01048	0.393
MOD_GlcNHglycan	51	54	PF01048	0.565
MOD_GSK3_1	152	159	PF00069	0.471
MOD_GSK3_1	395	402	PF00069	0.409
MOD_GSK3_1	431	438	PF00069	0.472
MOD_GSK3_1	47	54	PF00069	0.573
MOD_GSK3_1	473	480	PF00069	0.461
MOD_GSK3_1	503	510	PF00069	0.351
MOD_N-GLC_1	114	119	PF02516	0.425
MOD_N-GLC_1	474	479	PF02516	0.312
MOD_N-GLC_1	506	511	PF02516	0.510
MOD_NEK2_1	107	112	PF00069	0.372
MOD_NEK2_1	227	232	PF00069	0.461
MOD_NEK2_1	446	451	PF00069	0.408
MOD_NEK2_1	503	508	PF00069	0.331
MOD_NEK2_2	114	119	PF00069	0.401
MOD_NEK2_2	306	311	PF00069	0.313
MOD_OFUCOSY	463	469	PF10250	0.304
MOD_PIKK_1	32	38	PF00454	0.536
MOD_PIKK_1	446	452	PF00454	0.432
MOD_PK_1	51	57	PF00069	0.396
MOD_PKA_2	204	210	PF00069	0.403
MOD_Plk_1	114	120	PF00069	0.407
MOD_Plk_1	474	480	PF00069	0.459
MOD_Plk_1	506	512	PF00069	0.301
MOD_Plk_4	114	120	PF00069	0.408
MOD_Plk_4	252	258	PF00069	0.442
MOD_Plk_4	339	345	PF00069	0.405
MOD_Plk_4	361	367	PF00069	0.325
MOD_Plk_4	435	441	PF00069	0.514
MOD_Plk_4	507	513	PF00069	0.319
MOD_ProDKin_1	157	163	PF00069	0.378
MOD_ProDKin_1	286	292	PF00069	0.444
MOD_ProDKin_1	29	35	PF00069	0.531
MOD_ProDKin_1	395	401	PF00069	0.368
MOD_SUMO_for_1	310	313	PF00179	0.280
MOD_SUMO_for_1	410	413	PF00179	0.349
MOD_SUMO_rev_2	23	29	PF00179	0.548
MOD_SUMO_rev_2	491	500	PF00179	0.332
TRG_ENDOCYTIC_2	141	144	PF00928	0.400
TRG_ENDOCYTIC_2	501	504	PF00928	0.330
TRG_ER_diArg_1	2	4	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM61	Leptomonas seymouri	40%	100%
A0A0N1PFG1	Leptomonas seymouri	78%	100%
A0A0S4IY11	Bodo saltans	42%	100%
A0A0S4JST8	Bodo saltans	46%	100%
A0A1X0NPP7	Trypanosomatidae	55%	100%
A0A1X0NXN6	Trypanosomatidae	38%	100%
A0A3Q8IBQ6	Leishmania donovani	94%	100%
A0A3R7JXS6	Trypanosoma rangeli	37%	100%
A0A3R7MEV0	Trypanosoma rangeli	53%	100%
A0A3S7WWC3	Leishmania donovani	40%	100%
A4H775	Leishmania braziliensis	81%	100%
A4HBN2	Leishmania braziliensis	40%	93%
A4HVL5	Leishmania infantum	94%	100%
A4HZ33	Leishmania infantum	40%	100%
D0A6P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AV01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
P43265	Euglena gracilis	24%	100%
Q4QCI1	Leishmania major	41%	93%
Q4QG67	Leishmania major	93%	100%
Q54F93	Dictyostelium discoideum	24%	100%
Q5R513	Pongo abelii	21%	100%
Q9DC61	Mus musculus	22%	100%
Q9ZU25	Arabidopsis thaliana	21%	100%
V5BB16	Trypanosoma cruzi	54%	95%
V5BQ54	Trypanosoma cruzi	38%	100%