WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APA9_LEIMU

TriTrypDb:

LmxM.13.0850

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.625
CLV_C14_Caspase3-7	472	476	PF00656	0.615
CLV_NRD_NRD_1	295	297	PF00675	0.645
CLV_NRD_NRD_1	366	368	PF00675	0.548
CLV_NRD_NRD_1	440	442	PF00675	0.774
CLV_NRD_NRD_1	456	458	PF00675	0.580
CLV_NRD_NRD_1	488	490	PF00675	0.592
CLV_NRD_NRD_1	510	512	PF00675	0.612
CLV_NRD_NRD_1	586	588	PF00675	0.581
CLV_NRD_NRD_1	622	624	PF00675	0.719
CLV_NRD_NRD_1	672	674	PF00675	0.465
CLV_NRD_NRD_1	737	739	PF00675	0.592
CLV_NRD_NRD_1	834	836	PF00675	0.684
CLV_PCSK_KEX2_1	172	174	PF00082	0.540
CLV_PCSK_KEX2_1	295	297	PF00082	0.664
CLV_PCSK_KEX2_1	366	368	PF00082	0.548
CLV_PCSK_KEX2_1	417	419	PF00082	0.508
CLV_PCSK_KEX2_1	456	458	PF00082	0.752
CLV_PCSK_KEX2_1	488	490	PF00082	0.517
CLV_PCSK_KEX2_1	509	511	PF00082	0.600
CLV_PCSK_KEX2_1	586	588	PF00082	0.581
CLV_PCSK_KEX2_1	622	624	PF00082	0.721
CLV_PCSK_KEX2_1	674	676	PF00082	0.425
CLV_PCSK_KEX2_1	834	836	PF00082	0.679
CLV_PCSK_KEX2_1	861	863	PF00082	0.658
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.540
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.508
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.425
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.658
CLV_PCSK_PC7_1	506	512	PF00082	0.544
CLV_PCSK_SKI1_1	384	388	PF00082	0.465
CLV_PCSK_SKI1_1	656	660	PF00082	0.584
CLV_PCSK_SKI1_1	696	700	PF00082	0.505
DEG_SCF_FBW7_1	324	329	PF00400	0.582
DEG_SPOP_SBC_1	632	636	PF00917	0.740
DEG_SPOP_SBC_1	829	833	PF00917	0.665
DOC_CYCLIN_RxL_1	381	390	PF00134	0.478
DOC_MAPK_HePTP_8	735	747	PF00069	0.459
DOC_MAPK_MEF2A_6	312	319	PF00069	0.539
DOC_MAPK_MEF2A_6	738	747	PF00069	0.575
DOC_PP1_RVXF_1	709	715	PF00149	0.540
DOC_PP4_FxxP_1	535	538	PF00568	0.503
DOC_USP7_MATH_1	139	143	PF00917	0.604
DOC_USP7_MATH_1	166	170	PF00917	0.540
DOC_USP7_MATH_1	190	194	PF00917	0.699
DOC_USP7_MATH_1	239	243	PF00917	0.683
DOC_USP7_MATH_1	350	354	PF00917	0.658
DOC_USP7_MATH_1	447	451	PF00917	0.615
DOC_USP7_MATH_1	455	459	PF00917	0.620
DOC_USP7_MATH_1	632	636	PF00917	0.655
DOC_USP7_MATH_1	724	728	PF00917	0.520
DOC_USP7_MATH_1	743	747	PF00917	0.700
DOC_USP7_MATH_1	748	752	PF00917	0.751
DOC_USP7_MATH_1	837	841	PF00917	0.626
DOC_USP7_MATH_1	843	847	PF00917	0.579
DOC_USP7_UBL2_3	147	151	PF12436	0.548
DOC_WW_Pin1_4	123	128	PF00397	0.800
DOC_WW_Pin1_4	135	140	PF00397	0.589
DOC_WW_Pin1_4	162	167	PF00397	0.720
DOC_WW_Pin1_4	188	193	PF00397	0.608
DOC_WW_Pin1_4	273	278	PF00397	0.636
DOC_WW_Pin1_4	284	289	PF00397	0.621
DOC_WW_Pin1_4	322	327	PF00397	0.633
DOC_WW_Pin1_4	354	359	PF00397	0.541
DOC_WW_Pin1_4	390	395	PF00397	0.549
DOC_WW_Pin1_4	441	446	PF00397	0.675
DOC_WW_Pin1_4	633	638	PF00397	0.552
DOC_WW_Pin1_4	808	813	PF00397	0.808
DOC_WW_Pin1_4	818	823	PF00397	0.677
LIG_14-3-3_CanoR_1	140	144	PF00244	0.553
LIG_14-3-3_CanoR_1	273	277	PF00244	0.643
LIG_14-3-3_CanoR_1	304	313	PF00244	0.571
LIG_14-3-3_CanoR_1	384	394	PF00244	0.504
LIG_14-3-3_CanoR_1	436	445	PF00244	0.674
LIG_14-3-3_CanoR_1	456	460	PF00244	0.605
LIG_14-3-3_CanoR_1	463	473	PF00244	0.698
LIG_14-3-3_CanoR_1	623	633	PF00244	0.695
LIG_14-3-3_CanoR_1	738	743	PF00244	0.485
LIG_14-3-3_CanoR_1	818	822	PF00244	0.707
LIG_BRCT_BRCA1_1	473	477	PF00533	0.674
LIG_BRCT_BRCA1_1	531	535	PF00533	0.545
LIG_EVH1_2	593	597	PF00568	0.595
LIG_FHA_1	189	195	PF00498	0.533
LIG_FHA_1	332	338	PF00498	0.588
LIG_FHA_1	543	549	PF00498	0.591
LIG_FHA_2	194	200	PF00498	0.614
LIG_FHA_2	264	270	PF00498	0.626
LIG_FHA_2	470	476	PF00498	0.673
LIG_FHA_2	594	600	PF00498	0.691
LIG_FHA_2	674	680	PF00498	0.497
LIG_FHA_2	818	824	PF00498	0.599
LIG_LIR_Apic_2	338	344	PF02991	0.725
LIG_LIR_Apic_2	458	462	PF02991	0.670
LIG_LIR_Apic_2	532	538	PF02991	0.528
LIG_LIR_Nem_3	381	385	PF02991	0.501
LIG_LIR_Nem_3	524	528	PF02991	0.490
LIG_LIR_Nem_3	560	565	PF02991	0.595
LIG_SH2_CRK	459	463	PF00017	0.675
LIG_SH2_GRB2like	527	530	PF00017	0.512
LIG_SH2_NCK_1	341	345	PF00017	0.546
LIG_SH2_SRC	536	539	PF00017	0.479
LIG_SH2_STAP1	382	386	PF00017	0.495
LIG_SH2_STAT3	855	858	PF00017	0.630
LIG_SH2_STAT5	331	334	PF00017	0.639
LIG_SH2_STAT5	385	388	PF00017	0.458
LIG_SH2_STAT5	525	528	PF00017	0.510
LIG_SH2_STAT5	536	539	PF00017	0.497
LIG_SH2_STAT5	688	691	PF00017	0.525
LIG_SH2_STAT5	855	858	PF00017	0.688
LIG_SH3_1	561	567	PF00018	0.605
LIG_SH3_3	133	139	PF00018	0.599
LIG_SH3_3	244	250	PF00018	0.750
LIG_SH3_3	256	262	PF00018	0.698
LIG_SH3_3	283	289	PF00018	0.651
LIG_SH3_3	299	305	PF00018	0.636
LIG_SH3_3	535	541	PF00018	0.549
LIG_SH3_3	561	567	PF00018	0.692
LIG_SH3_3	640	646	PF00018	0.685
LIG_SH3_3	742	748	PF00018	0.653
LIG_SH3_3	806	812	PF00018	0.808
LIG_SUMO_SIM_par_1	393	400	PF11976	0.476
LIG_TRAF2_1	29	32	PF00917	0.561
LIG_TRAF2_1	518	521	PF00917	0.507
LIG_TRAF2_1	64	67	PF00917	0.557
LIG_TRAF2_1	676	679	PF00917	0.485
LIG_TRAF2_1	99	102	PF00917	0.614
LIG_TYR_ITIM	548	553	PF00017	0.649
LIG_WW_3	592	596	PF00397	0.597
MOD_CDC14_SPxK_1	636	639	PF00782	0.550
MOD_CDK_SPK_2	135	140	PF00069	0.549
MOD_CDK_SPK_2	441	446	PF00069	0.531
MOD_CDK_SPxK_1	633	639	PF00069	0.553
MOD_CK1_1	193	199	PF00069	0.613
MOD_CK1_1	420	426	PF00069	0.564
MOD_CK1_1	432	438	PF00069	0.632
MOD_CK1_1	450	456	PF00069	0.744
MOD_CK1_1	464	470	PF00069	0.557
MOD_CK1_1	570	576	PF00069	0.648
MOD_CK1_1	624	630	PF00069	0.709
MOD_CK1_1	654	660	PF00069	0.625
MOD_CK1_1	727	733	PF00069	0.626
MOD_CK1_1	751	757	PF00069	0.773
MOD_CK1_1	828	834	PF00069	0.656
MOD_CK1_1	857	863	PF00069	0.633
MOD_CK2_1	162	168	PF00069	0.635
MOD_CK2_1	263	269	PF00069	0.640
MOD_CK2_1	272	278	PF00069	0.608
MOD_CK2_1	515	521	PF00069	0.627
MOD_CK2_1	593	599	PF00069	0.604
MOD_CK2_1	673	679	PF00069	0.507
MOD_CK2_1	768	774	PF00069	0.593
MOD_CK2_1	787	793	PF00069	0.511
MOD_CK2_1	817	823	PF00069	0.648
MOD_DYRK1A_RPxSP_1	273	277	PF00069	0.643
MOD_DYRK1A_RPxSP_1	818	822	PF00069	0.649
MOD_GlcNHglycan	141	144	PF01048	0.571
MOD_GlcNHglycan	224	227	PF01048	0.620
MOD_GlcNHglycan	235	239	PF01048	0.714
MOD_GlcNHglycan	241	244	PF01048	0.688
MOD_GlcNHglycan	352	355	PF01048	0.604
MOD_GlcNHglycan	422	425	PF01048	0.588
MOD_GlcNHglycan	453	456	PF01048	0.610
MOD_GlcNHglycan	466	469	PF01048	0.549
MOD_GlcNHglycan	572	575	PF01048	0.605
MOD_GlcNHglycan	726	729	PF01048	0.609
MOD_GlcNHglycan	740	743	PF01048	0.640
MOD_GlcNHglycan	750	753	PF01048	0.612
MOD_GlcNHglycan	755	758	PF01048	0.625
MOD_GlcNHglycan	770	773	PF01048	0.592
MOD_GlcNHglycan	789	792	PF01048	0.571
MOD_GlcNHglycan	827	830	PF01048	0.659
MOD_GlcNHglycan	865	868	PF01048	0.696
MOD_GSK3_1	135	142	PF00069	0.550
MOD_GSK3_1	162	169	PF00069	0.602
MOD_GSK3_1	234	241	PF00069	0.719
MOD_GSK3_1	300	307	PF00069	0.763
MOD_GSK3_1	320	327	PF00069	0.768
MOD_GSK3_1	350	357	PF00069	0.500
MOD_GSK3_1	386	393	PF00069	0.639
MOD_GSK3_1	397	404	PF00069	0.515
MOD_GSK3_1	432	439	PF00069	0.677
MOD_GSK3_1	447	454	PF00069	0.650
MOD_GSK3_1	469	476	PF00069	0.808
MOD_GSK3_1	477	484	PF00069	0.572
MOD_GSK3_1	593	600	PF00069	0.626
MOD_GSK3_1	621	628	PF00069	0.589
MOD_GSK3_1	645	652	PF00069	0.687
MOD_GSK3_1	669	676	PF00069	0.556
MOD_GSK3_1	743	750	PF00069	0.735
MOD_GSK3_1	804	811	PF00069	0.788
MOD_GSK3_1	825	832	PF00069	0.653
MOD_GSK3_1	853	860	PF00069	0.784
MOD_N-GLC_1	208	213	PF02516	0.687
MOD_N-GLC_1	853	858	PF02516	0.686
MOD_N-GLC_2	426	428	PF02516	0.497
MOD_NEK2_1	319	324	PF00069	0.582
MOD_NEK2_1	397	402	PF00069	0.511
MOD_NEK2_1	473	478	PF00069	0.798
MOD_NEK2_1	597	602	PF00069	0.567
MOD_NEK2_1	607	612	PF00069	0.565
MOD_NEK2_1	626	631	PF00069	0.601
MOD_NEK2_1	666	671	PF00069	0.571
MOD_NEK2_1	853	858	PF00069	0.523
MOD_NEK2_2	412	417	PF00069	0.495
MOD_NEK2_2	580	585	PF00069	0.595
MOD_NEK2_2	651	656	PF00069	0.599
MOD_PIKK_1	304	310	PF00454	0.734
MOD_PIKK_1	607	613	PF00454	0.593
MOD_PIKK_1	645	651	PF00454	0.657
MOD_PIKK_1	666	672	PF00454	0.572
MOD_PIKK_1	854	860	PF00454	0.572
MOD_PKA_1	417	423	PF00069	0.512
MOD_PKA_1	673	679	PF00069	0.413
MOD_PKA_1	738	744	PF00069	0.491
MOD_PKA_2	139	145	PF00069	0.551
MOD_PKA_2	272	278	PF00069	0.648
MOD_PKA_2	417	423	PF00069	0.591
MOD_PKA_2	435	441	PF00069	0.497
MOD_PKA_2	455	461	PF00069	0.650
MOD_PKA_2	469	475	PF00069	0.653
MOD_PKA_2	570	576	PF00069	0.629
MOD_PKA_2	621	627	PF00069	0.657
MOD_PKA_2	817	823	PF00069	0.708
MOD_PKB_1	623	631	PF00069	0.564
MOD_PKB_1	671	679	PF00069	0.529
MOD_Plk_1	320	326	PF00069	0.512
MOD_Plk_1	369	375	PF00069	0.640
MOD_Plk_1	397	403	PF00069	0.508
MOD_Plk_1	429	435	PF00069	0.609
MOD_Plk_2-3	176	182	PF00069	0.617
MOD_Plk_2-3	251	257	PF00069	0.618
MOD_Plk_4	190	196	PF00069	0.534
MOD_Plk_4	542	548	PF00069	0.573
MOD_ProDKin_1	123	129	PF00069	0.795
MOD_ProDKin_1	135	141	PF00069	0.589
MOD_ProDKin_1	162	168	PF00069	0.721
MOD_ProDKin_1	188	194	PF00069	0.609
MOD_ProDKin_1	273	279	PF00069	0.638
MOD_ProDKin_1	284	290	PF00069	0.619
MOD_ProDKin_1	322	328	PF00069	0.632
MOD_ProDKin_1	354	360	PF00069	0.535
MOD_ProDKin_1	390	396	PF00069	0.548
MOD_ProDKin_1	441	447	PF00069	0.675
MOD_ProDKin_1	633	639	PF00069	0.553
MOD_ProDKin_1	808	814	PF00069	0.812
MOD_ProDKin_1	818	824	PF00069	0.672
MOD_SUMO_for_1	205	208	PF00179	0.642
MOD_SUMO_rev_2	198	207	PF00179	0.642
MOD_SUMO_rev_2	251	260	PF00179	0.548
MOD_SUMO_rev_2	435	444	PF00179	0.614
MOD_SUMO_rev_2	704	712	PF00179	0.608
TRG_ENDOCYTIC_2	550	553	PF00928	0.580
TRG_ER_diArg_1	294	296	PF00400	0.661
TRG_ER_diArg_1	365	367	PF00400	0.569
TRG_ER_diArg_1	487	489	PF00400	0.670
TRG_ER_diArg_1	509	511	PF00400	0.555
TRG_ER_diArg_1	621	623	PF00400	0.771
TRG_ER_diArg_1	834	836	PF00400	0.676
TRG_NLS_MonoExtC_3	672	678	PF00514	0.431
TRG_NLS_MonoExtN_4	671	677	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	675	679	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	834	839	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T9	Leptomonas seymouri	41%	100%
A0A3S7WSK5	Leishmania donovani	79%	80%
A4H773	Leishmania braziliensis	61%	98%
A4HVL3	Leishmania infantum	80%	83%
Q4QG69	Leishmania major	83%	100%