Succinate dehydrogenase assembly factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex1_LYR-like, putative

Species:

Leishmania mexicana

UniProt:

E9APA6_LEIMU

TriTrypDb:

LmxM.13.0820

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005758	mitochondrial intermembrane space	6	1
GO:0031970	organelle envelope lumen	5	1

Expansion

Sequence features

E9APA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APA6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0033108	mitochondrial respiratory chain complex assembly	6	7
GO:0034552	respiratory chain complex II assembly	6	7
GO:0034553	mitochondrial respiratory chain complex II assembly	7	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0006082	organic acid metabolic process	3	1
GO:0006105	succinate metabolic process	7	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043648	dicarboxylic acid metabolic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.517
CLV_PCSK_KEX2_1	217	219	PF00082	0.274
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.274
CLV_PCSK_SKI1_1	159	163	PF00082	0.274
CLV_PCSK_SKI1_1	210	214	PF00082	0.303
CLV_PCSK_SKI1_1	217	221	PF00082	0.430
CLV_PCSK_SKI1_1	232	236	PF00082	0.468
CLV_PCSK_SKI1_1	87	91	PF00082	0.388
CLV_PCSK_SKI1_1	95	99	PF00082	0.287
DEG_APCC_DBOX_1	63	71	PF00400	0.448
DEG_MDM2_SWIB_1	192	200	PF02201	0.474
DOC_CKS1_1	161	166	PF01111	0.462
DOC_CYCLIN_RxL_1	153	165	PF00134	0.483
DOC_CYCLIN_RxL_1	214	223	PF00134	0.583
DOC_MAPK_gen_1	92	100	PF00069	0.474
DOC_PP1_RVXF_1	85	91	PF00149	0.388
DOC_USP7_MATH_1	43	47	PF00917	0.583
DOC_USP7_MATH_1	5	9	PF00917	0.619
DOC_USP7_MATH_1	71	75	PF00917	0.437
DOC_WW_Pin1_4	160	165	PF00397	0.608
DOC_WW_Pin1_4	80	85	PF00397	0.562
LIG_14-3-3_CanoR_1	239	247	PF00244	0.504
LIG_14-3-3_CanoR_1	64	68	PF00244	0.550
LIG_Actin_WH2_2	224	241	PF00022	0.467
LIG_Actin_WH2_2	48	66	PF00022	0.501
LIG_deltaCOP1_diTrp_1	85	90	PF00928	0.394
LIG_eIF4E_1	156	162	PF01652	0.462
LIG_FHA_1	131	137	PF00498	0.436
LIG_FHA_2	141	147	PF00498	0.567
LIG_FHA_2	206	212	PF00498	0.474
LIG_FHA_2	80	86	PF00498	0.440
LIG_LIR_Apic_2	78	84	PF02991	0.503
LIG_LIR_Gen_1	195	204	PF02991	0.474
LIG_LIR_Gen_1	59	70	PF02991	0.495
LIG_LIR_Nem_3	154	160	PF02991	0.570
LIG_LIR_Nem_3	195	200	PF02991	0.474
LIG_LIR_Nem_3	59	65	PF02991	0.509
LIG_NRBOX	157	163	PF00104	0.474
LIG_Pex14_1	86	90	PF04695	0.379
LIG_Pex14_2	169	173	PF04695	0.474
LIG_Pex14_2	192	196	PF04695	0.474
LIG_REV1ctd_RIR_1	233	243	PF16727	0.492
LIG_SH2_CRK	94	98	PF00017	0.474
LIG_SH2_NCK_1	81	85	PF00017	0.413
LIG_SH2_SRC	197	200	PF00017	0.474
LIG_SH2_STAP1	193	197	PF00017	0.474
LIG_SH2_STAT3	199	202	PF00017	0.503
LIG_SH2_STAT5	156	159	PF00017	0.471
LIG_SH2_STAT5	160	163	PF00017	0.476
LIG_SH2_STAT5	199	202	PF00017	0.474
LIG_SH2_STAT5	62	65	PF00017	0.512
LIG_SH2_STAT5	81	84	PF00017	0.373
LIG_SH3_3	12	18	PF00018	0.534
LIG_TRFH_1	160	164	PF08558	0.462
LIG_UBA3_1	97	103	PF00899	0.474
MOD_CDK_SPxxK_3	80	87	PF00069	0.484
MOD_CK1_1	108	114	PF00069	0.474
MOD_CK1_1	122	128	PF00069	0.474
MOD_CK1_1	131	137	PF00069	0.474
MOD_CK1_1	205	211	PF00069	0.474
MOD_CK1_1	46	52	PF00069	0.523
MOD_CK1_1	56	62	PF00069	0.508
MOD_CK2_1	192	198	PF00069	0.539
MOD_CK2_1	205	211	PF00069	0.432
MOD_CK2_1	79	85	PF00069	0.452
MOD_GlcNHglycan	121	124	PF01048	0.288
MOD_GlcNHglycan	204	207	PF01048	0.396
MOD_GlcNHglycan	24	27	PF01048	0.533
MOD_GlcNHglycan	45	48	PF01048	0.680
MOD_GlcNHglycan	7	10	PF01048	0.679
MOD_GSK3_1	127	134	PF00069	0.526
MOD_GSK3_1	43	50	PF00069	0.518
MOD_N-GLC_1	53	58	PF02516	0.569
MOD_NEK2_1	192	197	PF00069	0.474
MOD_NEK2_1	238	243	PF00069	0.526
MOD_NEK2_1	63	68	PF00069	0.470
MOD_NEK2_1	79	84	PF00069	0.460
MOD_NEK2_1	93	98	PF00069	0.516
MOD_NMyristoyl	1	7	PF02799	0.568
MOD_PIKK_1	128	134	PF00454	0.526
MOD_PIKK_1	238	244	PF00454	0.531
MOD_PKA_2	238	244	PF00069	0.496
MOD_PKA_2	30	36	PF00069	0.472
MOD_PKA_2	63	69	PF00069	0.485
MOD_Plk_1	53	59	PF00069	0.564
MOD_Plk_4	131	137	PF00069	0.399
MOD_Plk_4	187	193	PF00069	0.468
MOD_Plk_4	47	53	PF00069	0.564
MOD_ProDKin_1	160	166	PF00069	0.608
MOD_ProDKin_1	80	86	PF00069	0.551
MOD_SUMO_rev_2	222	227	PF00179	0.541
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.453
TRG_ENDOCYTIC_2	197	200	PF00928	0.474
TRG_ENDOCYTIC_2	21	24	PF00928	0.560
TRG_ENDOCYTIC_2	62	65	PF00928	0.512
TRG_ENDOCYTIC_2	94	97	PF00928	0.474
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R0	Leptomonas seymouri	65%	79%
A0A3S5H6N9	Leishmania donovani	89%	98%
A4H770	Leishmania braziliensis	83%	100%
A4HVL0	Leishmania infantum	89%	98%
Q4QG72	Leishmania major	88%	100%