Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APA4_LEIMU

TriTrypDb:

LmxM.13.0800

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.671
CLV_C14_Caspase3-7	29	33	PF00656	0.642
CLV_NRD_NRD_1	107	109	PF00675	0.684
CLV_NRD_NRD_1	204	206	PF00675	0.665
CLV_NRD_NRD_1	211	213	PF00675	0.600
CLV_NRD_NRD_1	3	5	PF00675	0.606
CLV_PCSK_FUR_1	21	25	PF00082	0.699
CLV_PCSK_KEX2_1	107	109	PF00082	0.569
CLV_PCSK_KEX2_1	208	210	PF00082	0.620
CLV_PCSK_KEX2_1	23	25	PF00082	0.758
CLV_PCSK_KEX2_1	3	5	PF00082	0.606
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.620
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.692
CLV_PCSK_SKI1_1	115	119	PF00082	0.608
CLV_PCSK_SKI1_1	213	217	PF00082	0.595
CLV_PCSK_SKI1_1	93	97	PF00082	0.591
DEG_APCC_DBOX_1	92	100	PF00400	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.626
DEG_SPOP_SBC_1	189	193	PF00917	0.548
DEG_SPOP_SBC_1	25	29	PF00917	0.644
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.571
DOC_MAPK_gen_1	3	11	PF00069	0.609
DOC_USP7_MATH_1	149	153	PF00917	0.721
DOC_USP7_MATH_1	15	19	PF00917	0.583
DOC_USP7_MATH_1	154	158	PF00917	0.743
DOC_USP7_MATH_1	167	171	PF00917	0.570
DOC_USP7_MATH_1	25	29	PF00917	0.684
DOC_USP7_MATH_1	33	37	PF00917	0.666
DOC_USP7_MATH_1	40	44	PF00917	0.631
DOC_USP7_UBL2_3	118	122	PF12436	0.722
DOC_USP7_UBL2_3	202	206	PF12436	0.667
DOC_WW_Pin1_4	128	133	PF00397	0.651
DOC_WW_Pin1_4	147	152	PF00397	0.669
DOC_WW_Pin1_4	76	81	PF00397	0.618
LIG_14-3-3_CanoR_1	212	222	PF00244	0.594
LIG_14-3-3_CanoR_1	59	68	PF00244	0.527
LIG_FHA_1	183	189	PF00498	0.531
LIG_FHA_1	191	197	PF00498	0.539
LIG_FHA_1	214	220	PF00498	0.698
LIG_FHA_1	55	61	PF00498	0.558
LIG_FHA_1	77	83	PF00498	0.502
LIG_FHA_2	192	198	PF00498	0.643
LIG_HP1_1	102	106	PF01393	0.556
LIG_LIR_Gen_1	69	80	PF02991	0.530
LIG_LIR_Nem_3	63	68	PF02991	0.513
LIG_LIR_Nem_3	69	75	PF02991	0.455
LIG_PDZ_Class_2	219	224	PF00595	0.629
LIG_Pex14_1	54	58	PF04695	0.564
LIG_RPA_C_Fungi	103	115	PF08784	0.567
LIG_SH2_STAT5	46	49	PF00017	0.560
LIG_SH3_3	42	48	PF00018	0.606
LIG_SUMO_SIM_par_1	190	199	PF11976	0.488
MOD_CK1_1	124	130	PF00069	0.638
MOD_CK1_1	175	181	PF00069	0.561
MOD_CK1_1	191	197	PF00069	0.624
MOD_CK1_1	204	210	PF00069	0.518
MOD_CK1_1	211	217	PF00069	0.659
MOD_CK1_1	28	34	PF00069	0.636
MOD_GlcNHglycan	123	126	PF01048	0.595
MOD_GlcNHglycan	13	16	PF01048	0.628
MOD_GlcNHglycan	151	154	PF01048	0.588
MOD_GlcNHglycan	156	159	PF01048	0.684
MOD_GlcNHglycan	17	20	PF01048	0.700
MOD_GlcNHglycan	177	180	PF01048	0.628
MOD_GlcNHglycan	213	216	PF01048	0.591
MOD_GlcNHglycan	32	36	PF01048	0.663
MOD_GlcNHglycan	42	45	PF01048	0.509
MOD_GSK3_1	11	18	PF00069	0.638
MOD_GSK3_1	124	131	PF00069	0.666
MOD_GSK3_1	136	143	PF00069	0.605
MOD_GSK3_1	204	211	PF00069	0.588
MOD_GSK3_1	24	31	PF00069	0.666
MOD_NEK2_1	11	16	PF00069	0.539
MOD_NEK2_1	136	141	PF00069	0.649
MOD_NEK2_1	196	201	PF00069	0.761
MOD_NEK2_1	2	7	PF00069	0.608
MOD_NEK2_1	67	72	PF00069	0.584
MOD_PIKK_1	130	136	PF00454	0.649
MOD_PIKK_1	60	66	PF00454	0.523
MOD_PKA_1	208	214	PF00069	0.558
MOD_PKA_2	2	8	PF00069	0.609
MOD_PKA_2	204	210	PF00069	0.667
MOD_PKA_2	211	217	PF00069	0.599
MOD_Plk_4	191	197	PF00069	0.549
MOD_Plk_4	67	73	PF00069	0.513
MOD_ProDKin_1	128	134	PF00069	0.654
MOD_ProDKin_1	147	153	PF00069	0.670
MOD_ProDKin_1	76	82	PF00069	0.618
TRG_ER_diArg_1	106	108	PF00400	0.565
TRG_ER_diArg_1	2	4	PF00400	0.616
TRG_NLS_MonoExtC_3	204	209	PF00514	0.668
TRG_NLS_MonoExtN_4	202	209	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	115	120	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9H5	Leishmania donovani	88%	100%
A4H769	Leishmania braziliensis	68%	100%
A4HVK8	Leishmania infantum	88%	100%
Q4QG74	Leishmania major	90%	100%