Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APA3_LEIMU

TriTrypDb:

LmxM.13.0790

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APA3

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	7
GO:0002098	tRNA wobble uridine modification	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034227	tRNA thio-modification	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0002143	tRNA wobble position uridine thiolation	8	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	7
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.654
CLV_NRD_NRD_1	322	324	PF00675	0.487
CLV_NRD_NRD_1	523	525	PF00675	0.689
CLV_NRD_NRD_1	82	84	PF00675	0.551
CLV_PCSK_FUR_1	80	84	PF00082	0.391
CLV_PCSK_KEX2_1	82	84	PF00082	0.551
CLV_PCSK_SKI1_1	199	203	PF00082	0.566
CLV_PCSK_SKI1_1	284	288	PF00082	0.503
CLV_PCSK_SKI1_1	297	301	PF00082	0.373
CLV_PCSK_SKI1_1	381	385	PF00082	0.383
CLV_PCSK_SKI1_1	406	410	PF00082	0.464
CLV_PCSK_SKI1_1	419	423	PF00082	0.368
CLV_PCSK_SKI1_1	524	528	PF00082	0.750
CLV_Separin_Metazoa	490	494	PF03568	0.598
DEG_SCF_FBW7_1	217	223	PF00400	0.837
DEG_SCF_FBW7_1	604	609	PF00400	0.746
DEG_SPOP_SBC_1	135	139	PF00917	0.775
DEG_SPOP_SBC_1	597	601	PF00917	0.627
DEG_SPOP_SBC_1	611	615	PF00917	0.494
DOC_CKS1_1	217	222	PF01111	0.838
DOC_CYCLIN_yCln2_LP_2	541	547	PF00134	0.777
DOC_MAPK_gen_1	368	375	PF00069	0.539
DOC_PP2B_LxvP_1	130	133	PF13499	0.508
DOC_PP2B_LxvP_1	541	544	PF13499	0.784
DOC_USP7_MATH_1	108	112	PF00917	0.717
DOC_USP7_MATH_1	113	117	PF00917	0.639
DOC_USP7_MATH_1	135	139	PF00917	0.691
DOC_USP7_MATH_1	141	145	PF00917	0.694
DOC_USP7_MATH_1	220	224	PF00917	0.690
DOC_USP7_MATH_1	247	251	PF00917	0.787
DOC_USP7_MATH_1	348	352	PF00917	0.764
DOC_USP7_MATH_1	448	452	PF00917	0.650
DOC_USP7_MATH_1	606	610	PF00917	0.819
DOC_USP7_MATH_1	611	615	PF00917	0.695
DOC_USP7_MATH_1	664	668	PF00917	0.641
DOC_USP7_UBL2_3	192	196	PF12436	0.815
DOC_USP7_UBL2_3	521	525	PF12436	0.822
DOC_WW_Pin1_4	103	108	PF00397	0.555
DOC_WW_Pin1_4	109	114	PF00397	0.792
DOC_WW_Pin1_4	137	142	PF00397	0.706
DOC_WW_Pin1_4	216	221	PF00397	0.843
DOC_WW_Pin1_4	235	240	PF00397	0.541
DOC_WW_Pin1_4	437	442	PF00397	0.501
DOC_WW_Pin1_4	48	53	PF00397	0.514
DOC_WW_Pin1_4	602	607	PF00397	0.820
LIG_14-3-3_CanoR_1	100	108	PF00244	0.748
LIG_14-3-3_CanoR_1	160	164	PF00244	0.553
LIG_14-3-3_CanoR_1	270	278	PF00244	0.370
LIG_14-3-3_CanoR_1	291	301	PF00244	0.501
LIG_14-3-3_CanoR_1	305	310	PF00244	0.506
LIG_14-3-3_CanoR_1	381	390	PF00244	0.396
LIG_14-3-3_CanoR_1	406	415	PF00244	0.520
LIG_14-3-3_CanoR_1	416	422	PF00244	0.391
LIG_14-3-3_CanoR_1	673	678	PF00244	0.327
LIG_14-3-3_CanoR_1	74	81	PF00244	0.347
LIG_APCC_ABBA_1	545	550	PF00400	0.660
LIG_BIR_III_2	630	634	PF00653	0.567
LIG_CSL_BTD_1	631	634	PF09270	0.574
LIG_deltaCOP1_diTrp_1	630	637	PF00928	0.656
LIG_EVH1_2	633	637	PF00568	0.596
LIG_FHA_1	200	206	PF00498	0.647
LIG_FHA_1	255	261	PF00498	0.553
LIG_FHA_1	382	388	PF00498	0.350
LIG_FHA_1	407	413	PF00498	0.556
LIG_FHA_1	438	444	PF00498	0.505
LIG_FHA_1	447	453	PF00498	0.448
LIG_FHA_1	572	578	PF00498	0.311
LIG_FHA_1	666	672	PF00498	0.646
LIG_FHA_2	160	166	PF00498	0.558
LIG_FHA_2	555	561	PF00498	0.452
LIG_FHA_2	641	647	PF00498	0.741
LIG_LIR_Gen_1	164	174	PF02991	0.551
LIG_LIR_Gen_1	298	309	PF02991	0.590
LIG_LIR_Gen_1	426	436	PF02991	0.465
LIG_LIR_Gen_1	469	478	PF02991	0.482
LIG_LIR_Nem_3	164	170	PF02991	0.551
LIG_LIR_Nem_3	27	32	PF02991	0.460
LIG_LIR_Nem_3	298	304	PF02991	0.497
LIG_LIR_Nem_3	426	432	PF02991	0.462
LIG_LIR_Nem_3	469	475	PF02991	0.426
LIG_SH2_CRK	301	305	PF00017	0.499
LIG_SH2_CRK	429	433	PF00017	0.575
LIG_SH2_STAP1	271	275	PF00017	0.599
LIG_SH2_STAP1	285	289	PF00017	0.393
LIG_SH2_STAT3	173	176	PF00017	0.563
LIG_SH2_STAT3	581	584	PF00017	0.545
LIG_SH2_STAT3	623	626	PF00017	0.541
LIG_SH2_STAT3	75	78	PF00017	0.344
LIG_SH2_STAT5	173	176	PF00017	0.641
LIG_SH2_STAT5	24	27	PF00017	0.457
LIG_SH2_STAT5	279	282	PF00017	0.504
LIG_SH2_STAT5	32	35	PF00017	0.451
LIG_SH2_STAT5	429	432	PF00017	0.443
LIG_SH2_STAT5	439	442	PF00017	0.416
LIG_SH3_3	128	134	PF00018	0.490
LIG_SH3_3	214	220	PF00018	0.626
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.508
LIG_SUMO_SIM_par_1	594	602	PF11976	0.721
LIG_TRAF2_1	162	165	PF00917	0.513
LIG_TRAF2_1	338	341	PF00917	0.730
LIG_TRAF2_1	351	354	PF00917	0.556
LIG_TRAF2_1	487	490	PF00917	0.525
LIG_TRAF2_2	241	246	PF00917	0.567
LIG_TYR_ITIM	427	432	PF00017	0.585
LIG_WW_3	177	181	PF00397	0.671
MOD_CDK_SPK_2	602	607	PF00069	0.820
MOD_CDK_SPxxK_3	103	110	PF00069	0.735
MOD_CK1_1	137	143	PF00069	0.780
MOD_CK1_1	231	237	PF00069	0.737
MOD_CK1_1	254	260	PF00069	0.521
MOD_CK1_1	290	296	PF00069	0.528
MOD_CK1_1	466	472	PF00069	0.495
MOD_CK1_1	515	521	PF00069	0.704
MOD_CK1_1	576	582	PF00069	0.594
MOD_CK1_1	599	605	PF00069	0.791
MOD_CK1_1	609	615	PF00069	0.648
MOD_CK1_1	649	655	PF00069	0.668
MOD_CK1_1	99	105	PF00069	0.796
MOD_CK2_1	158	164	PF00069	0.549
MOD_CK2_1	292	298	PF00069	0.511
MOD_CK2_1	348	354	PF00069	0.507
MOD_CK2_1	552	558	PF00069	0.679
MOD_CK2_1	638	644	PF00069	0.791
MOD_GlcNHglycan	102	105	PF01048	0.703
MOD_GlcNHglycan	149	152	PF01048	0.719
MOD_GlcNHglycan	230	233	PF01048	0.696
MOD_GlcNHglycan	248	252	PF01048	0.530
MOD_GlcNHglycan	253	256	PF01048	0.532
MOD_GlcNHglycan	275	278	PF01048	0.549
MOD_GlcNHglycan	508	512	PF01048	0.713
MOD_GlcNHglycan	514	517	PF01048	0.648
MOD_GlcNHglycan	562	565	PF01048	0.490
MOD_GlcNHglycan	57	60	PF01048	0.491
MOD_GlcNHglycan	601	604	PF01048	0.740
MOD_GlcNHglycan	608	611	PF01048	0.650
MOD_GSK3_1	109	116	PF00069	0.655
MOD_GSK3_1	135	142	PF00069	0.691
MOD_GSK3_1	216	223	PF00069	0.762
MOD_GSK3_1	231	238	PF00069	0.695
MOD_GSK3_1	247	254	PF00069	0.503
MOD_GSK3_1	269	276	PF00069	0.498
MOD_GSK3_1	364	371	PF00069	0.623
MOD_GSK3_1	423	430	PF00069	0.432
MOD_GSK3_1	442	449	PF00069	0.648
MOD_GSK3_1	459	466	PF00069	0.439
MOD_GSK3_1	515	522	PF00069	0.755
MOD_GSK3_1	598	605	PF00069	0.739
MOD_GSK3_1	606	613	PF00069	0.678
MOD_GSK3_1	646	653	PF00069	0.643
MOD_GSK3_1	96	103	PF00069	0.744
MOD_N-GLC_1	649	654	PF02516	0.731
MOD_NEK2_1	114	119	PF00069	0.539
MOD_NEK2_1	136	141	PF00069	0.730
MOD_NEK2_1	287	292	PF00069	0.493
MOD_NEK2_1	374	379	PF00069	0.383
MOD_NEK2_1	459	464	PF00069	0.428
MOD_NEK2_1	598	603	PF00069	0.718
MOD_NEK2_2	448	453	PF00069	0.644
MOD_NEK2_2	657	662	PF00069	0.474
MOD_OFUCOSY	573	580	PF10250	0.550
MOD_PIKK_1	498	504	PF00454	0.606
MOD_PIKK_1	74	80	PF00454	0.369
MOD_PKA_2	159	165	PF00069	0.530
MOD_PKA_2	269	275	PF00069	0.517
MOD_PKA_2	290	296	PF00069	0.506
MOD_PKA_2	492	498	PF00069	0.649
MOD_PKA_2	606	612	PF00069	0.814
MOD_PKA_2	99	105	PF00069	0.811
MOD_PKB_1	303	311	PF00069	0.583
MOD_Plk_2-3	358	364	PF00069	0.684
MOD_Plk_2-3	640	646	PF00069	0.732
MOD_Plk_4	10	16	PF00069	0.485
MOD_Plk_4	114	120	PF00069	0.548
MOD_Plk_4	423	429	PF00069	0.433
MOD_Plk_4	459	465	PF00069	0.403
MOD_Plk_4	60	66	PF00069	0.476
MOD_Plk_4	612	618	PF00069	0.587
MOD_Plk_4	632	638	PF00069	0.667
MOD_Plk_4	673	679	PF00069	0.336
MOD_ProDKin_1	103	109	PF00069	0.552
MOD_ProDKin_1	137	143	PF00069	0.705
MOD_ProDKin_1	216	222	PF00069	0.838
MOD_ProDKin_1	235	241	PF00069	0.541
MOD_ProDKin_1	437	443	PF00069	0.499
MOD_ProDKin_1	48	54	PF00069	0.507
MOD_ProDKin_1	602	608	PF00069	0.822
TRG_ENDOCYTIC_2	271	274	PF00928	0.524
TRG_ENDOCYTIC_2	301	304	PF00928	0.499
TRG_ENDOCYTIC_2	429	432	PF00928	0.579
TRG_ENDOCYTIC_2	467	470	PF00928	0.522
TRG_ER_diArg_1	80	83	PF00400	0.534
TRG_NLS_MonoExtC_3	191	196	PF00514	0.734
TRG_NLS_MonoExtN_4	192	199	PF00514	0.720
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC5	Leptomonas seymouri	44%	100%
A0A3Q8I9K2	Leishmania donovani	84%	98%
A4H768	Leishmania braziliensis	68%	97%
A4HVK7	Leishmania infantum	84%	98%
Q4QG75	Leishmania major	82%	100%