Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9APA2_LEIMU

TriTrypDb:

LmxM.13.0780

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9APA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APA2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0007165	signal transduction	2	2
GO:0035556	intracellular signal transduction	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004707	MAP kinase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.456
CLV_C14_Caspase3-7	253	257	PF00656	0.557
CLV_C14_Caspase3-7	268	272	PF00656	0.468
CLV_C14_Caspase3-7	351	355	PF00656	0.284
CLV_C14_Caspase3-7	57	61	PF00656	0.454
CLV_NRD_NRD_1	195	197	PF00675	0.485
CLV_NRD_NRD_1	291	293	PF00675	0.361
CLV_PCSK_KEX2_1	18	20	PF00082	0.429
CLV_PCSK_KEX2_1	195	197	PF00082	0.535
CLV_PCSK_KEX2_1	524	526	PF00082	0.572
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.447
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.584
CLV_PCSK_SKI1_1	101	105	PF00082	0.391
CLV_PCSK_SKI1_1	173	177	PF00082	0.415
CLV_PCSK_SKI1_1	195	199	PF00082	0.520
CLV_PCSK_SKI1_1	293	297	PF00082	0.391
CLV_PCSK_SKI1_1	314	318	PF00082	0.302
CLV_PCSK_SKI1_1	401	405	PF00082	0.312
CLV_PCSK_SKI1_1	442	446	PF00082	0.345
CLV_PCSK_SKI1_1	451	455	PF00082	0.312
CLV_PCSK_SKI1_1	541	545	PF00082	0.350
CLV_Separin_Metazoa	468	472	PF03568	0.331
DEG_APCC_DBOX_1	540	548	PF00400	0.341
DEG_COP1_1	520	529	PF00400	0.539
DEG_ODPH_VHL_1	186	199	PF01847	0.454
DEG_SPOP_SBC_1	251	255	PF00917	0.556
DEG_SPOP_SBC_1	457	461	PF00917	0.186
DOC_CYCLIN_RxL_1	398	408	PF00134	0.361
DOC_CYCLIN_RxL_1	98	105	PF00134	0.328
DOC_MAPK_gen_1	18	24	PF00069	0.434
DOC_MAPK_gen_1	314	323	PF00069	0.270
DOC_PP4_FxxP_1	136	139	PF00568	0.305
DOC_USP7_MATH_1	14	18	PF00917	0.424
DOC_USP7_MATH_1	209	213	PF00917	0.550
DOC_USP7_MATH_1	251	255	PF00917	0.658
DOC_USP7_MATH_1	425	429	PF00917	0.332
DOC_USP7_UBL2_3	450	454	PF12436	0.320
DOC_WW_Pin1_4	211	216	PF00397	0.571
DOC_WW_Pin1_4	369	374	PF00397	0.385
DOC_WW_Pin1_4	460	465	PF00397	0.335
DOC_WW_Pin1_4	469	474	PF00397	0.240
LIG_Actin_WH2_2	157	175	PF00022	0.324
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BIR_III_1	1	5	PF00653	0.531
LIG_BIR_III_3	1	5	PF00653	0.531
LIG_BIR_III_4	269	273	PF00653	0.460
LIG_EH_1	504	508	PF12763	0.278
LIG_eIF4E_1	89	95	PF01652	0.435
LIG_FHA_1	114	120	PF00498	0.337
LIG_FHA_1	279	285	PF00498	0.532
LIG_FHA_1	29	35	PF00498	0.397
LIG_FHA_1	344	350	PF00498	0.500
LIG_FHA_1	363	369	PF00498	0.211
LIG_FHA_1	439	445	PF00498	0.301
LIG_FHA_1	461	467	PF00498	0.322
LIG_FHA_1	89	95	PF00498	0.426
LIG_FHA_2	169	175	PF00498	0.333
LIG_FHA_2	180	186	PF00498	0.466
LIG_FHA_2	251	257	PF00498	0.651
LIG_FHA_2	349	355	PF00498	0.299
LIG_FHA_2	463	469	PF00498	0.331
LIG_FHA_2	574	580	PF00498	0.396
LIG_LIR_Apic_2	134	139	PF02991	0.317
LIG_LIR_Apic_2	357	363	PF02991	0.312
LIG_LIR_Gen_1	147	154	PF02991	0.371
LIG_LIR_Gen_1	159	170	PF02991	0.374
LIG_LIR_Gen_1	33	43	PF02991	0.418
LIG_LIR_Gen_1	557	564	PF02991	0.458
LIG_LIR_Nem_3	134	140	PF02991	0.316
LIG_LIR_Nem_3	147	151	PF02991	0.408
LIG_LIR_Nem_3	157	161	PF02991	0.392
LIG_LIR_Nem_3	288	294	PF02991	0.273
LIG_LIR_Nem_3	33	38	PF02991	0.392
LIG_LIR_Nem_3	380	385	PF02991	0.364
LIG_LIR_Nem_3	39	44	PF02991	0.429
LIG_LIR_Nem_3	417	422	PF02991	0.361
LIG_LIR_Nem_3	51	55	PF02991	0.528
LIG_LIR_Nem_3	511	516	PF02991	0.454
LIG_LIR_Nem_3	557	562	PF02991	0.497
LIG_NRBOX	33	39	PF00104	0.374
LIG_NRBOX	465	471	PF00104	0.247
LIG_PTB_Apo_2	502	509	PF02174	0.313
LIG_REV1ctd_RIR_1	505	514	PF16727	0.409
LIG_SH2_CRK	148	152	PF00017	0.434
LIG_SH2_CRK	513	517	PF00017	0.469
LIG_SH2_CRK	52	56	PF00017	0.375
LIG_SH2_NCK_1	360	364	PF00017	0.270
LIG_SH2_NCK_1	41	45	PF00017	0.431
LIG_SH2_NCK_1	75	79	PF00017	0.447
LIG_SH2_SRC	513	516	PF00017	0.427
LIG_SH2_SRC	75	78	PF00017	0.483
LIG_SH2_STAP1	148	152	PF00017	0.411
LIG_SH2_STAP1	190	194	PF00017	0.524
LIG_SH2_STAP1	405	409	PF00017	0.361
LIG_SH2_STAT5	162	165	PF00017	0.372
LIG_SH2_STAT5	170	173	PF00017	0.423
LIG_SH2_STAT5	305	308	PF00017	0.398
LIG_SH2_STAT5	348	351	PF00017	0.411
LIG_SH2_STAT5	405	408	PF00017	0.270
LIG_SH2_STAT5	54	57	PF00017	0.360
LIG_SH3_3	272	278	PF00018	0.571
LIG_SH3_3	513	519	PF00018	0.443
LIG_SUMO_SIM_anti_2	476	487	PF11976	0.186
LIG_SUMO_SIM_par_1	280	286	PF11976	0.494
LIG_SUMO_SIM_par_1	364	372	PF11976	0.311
LIG_TRAF2_1	71	74	PF00917	0.441
MOD_CK1_1	213	219	PF00069	0.614
MOD_CK1_1	283	289	PF00069	0.186
MOD_CK1_1	326	332	PF00069	0.361
MOD_CK1_1	460	466	PF00069	0.186
MOD_CK2_1	168	174	PF00069	0.330
MOD_CK2_1	179	185	PF00069	0.461
MOD_CK2_1	36	42	PF00069	0.460
MOD_CK2_1	429	435	PF00069	0.366
MOD_CK2_1	462	468	PF00069	0.331
MOD_GlcNHglycan	131	134	PF01048	0.325
MOD_GlcNHglycan	202	205	PF01048	0.425
MOD_GlcNHglycan	424	428	PF01048	0.360
MOD_GlcNHglycan	538	541	PF01048	0.497
MOD_GlcNHglycan	56	59	PF01048	0.402
MOD_GSK3_1	175	182	PF00069	0.430
MOD_GSK3_1	209	216	PF00069	0.563
MOD_GSK3_1	410	417	PF00069	0.288
MOD_GSK3_1	425	432	PF00069	0.230
MOD_GSK3_1	452	459	PF00069	0.319
MOD_GSK3_1	532	539	PF00069	0.506
MOD_GSK3_1	573	580	PF00069	0.461
MOD_N-GLC_1	342	347	PF02516	0.370
MOD_N-GLC_1	354	359	PF02516	0.207
MOD_NEK2_1	168	173	PF00069	0.322
MOD_NEK2_1	176	181	PF00069	0.398
MOD_NEK2_1	200	205	PF00069	0.375
MOD_NEK2_1	323	328	PF00069	0.380
MOD_NEK2_1	403	408	PF00069	0.361
MOD_NEK2_1	444	449	PF00069	0.340
MOD_NEK2_1	452	457	PF00069	0.343
MOD_NEK2_1	558	563	PF00069	0.410
MOD_PIKK_1	354	360	PF00454	0.288
MOD_PIKK_1	410	416	PF00454	0.278
MOD_PK_1	525	531	PF00069	0.567
MOD_PKA_2	329	335	PF00069	0.394
MOD_PKA_2	495	501	PF00069	0.312
MOD_Plk_1	168	174	PF00069	0.330
MOD_Plk_1	176	182	PF00069	0.411
MOD_Plk_1	28	34	PF00069	0.430
MOD_Plk_1	323	329	PF00069	0.361
MOD_Plk_1	354	360	PF00069	0.278
MOD_Plk_1	480	486	PF00069	0.186
MOD_Plk_1	76	82	PF00069	0.542
MOD_Plk_2-3	144	150	PF00069	0.397
MOD_Plk_4	176	182	PF00069	0.611
MOD_Plk_4	348	354	PF00069	0.270
MOD_Plk_4	414	420	PF00069	0.332
MOD_Plk_4	480	486	PF00069	0.343
MOD_Plk_4	558	564	PF00069	0.504
MOD_Plk_4	6	12	PF00069	0.554
MOD_Plk_4	90	96	PF00069	0.368
MOD_ProDKin_1	211	217	PF00069	0.571
MOD_ProDKin_1	369	375	PF00069	0.385
MOD_ProDKin_1	460	466	PF00069	0.335
MOD_ProDKin_1	469	475	PF00069	0.240
MOD_SUMO_for_1	316	319	PF00179	0.301
MOD_SUMO_for_1	564	567	PF00179	0.432
MOD_SUMO_rev_2	550	558	PF00179	0.563
MOD_SUMO_rev_2	567	576	PF00179	0.437
TRG_DiLeu_BaEn_1	33	38	PF01217	0.423
TRG_ENDOCYTIC_2	148	151	PF00928	0.371
TRG_ENDOCYTIC_2	162	165	PF00928	0.375
TRG_ENDOCYTIC_2	291	294	PF00928	0.326
TRG_ENDOCYTIC_2	297	300	PF00928	0.353
TRG_ENDOCYTIC_2	305	308	PF00928	0.369
TRG_ENDOCYTIC_2	41	44	PF00928	0.422
TRG_ENDOCYTIC_2	513	516	PF00928	0.446
TRG_ENDOCYTIC_2	52	55	PF00928	0.384
TRG_ER_diArg_1	194	196	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ0	Leptomonas seymouri	73%	100%
A0A3Q8I9M4	Leishmania donovani	88%	95%
A0A3S5IR55	Trypanosoma rangeli	51%	100%
A4H641	Leishmania braziliensis	30%	100%
A4H767	Leishmania braziliensis	78%	100%
A4HVK6	Leishmania infantum	88%	81%
Q4QG76	Leishmania major	89%	98%
Q4QHG6	Leishmania major	30%	100%
V5AVM7	Trypanosoma cruzi	48%	100%