TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9APA1_LEIMU

TriTrypDb:

LmxM.13.0770

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APA1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.687
CLV_NRD_NRD_1	359	361	PF00675	0.476
CLV_NRD_NRD_1	537	539	PF00675	0.437
CLV_NRD_NRD_1	66	68	PF00675	0.455
CLV_PCSK_FUR_1	357	361	PF00082	0.472
CLV_PCSK_KEX2_1	359	361	PF00082	0.476
CLV_PCSK_KEX2_1	537	539	PF00082	0.437
CLV_PCSK_KEX2_1	65	67	PF00082	0.458
CLV_PCSK_PC7_1	62	68	PF00082	0.530
CLV_PCSK_SKI1_1	111	115	PF00082	0.534
CLV_PCSK_SKI1_1	123	127	PF00082	0.608
CLV_PCSK_SKI1_1	203	207	PF00082	0.506
CLV_PCSK_SKI1_1	296	300	PF00082	0.541
CLV_PCSK_SKI1_1	359	363	PF00082	0.477
CLV_PCSK_SKI1_1	417	421	PF00082	0.615
CLV_PCSK_SKI1_1	67	71	PF00082	0.474
DEG_APCC_DBOX_1	110	118	PF00400	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SPOP_SBC_1	399	403	PF00917	0.534
DOC_CKS1_1	361	366	PF01111	0.408
DOC_CKS1_1	542	547	PF01111	0.555
DOC_CYCLIN_RxL_1	62	73	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.558
DOC_MAPK_gen_1	62	71	PF00069	0.477
DOC_MAPK_HePTP_8	516	528	PF00069	0.399
DOC_MAPK_MEF2A_6	207	214	PF00069	0.318
DOC_MAPK_MEF2A_6	519	528	PF00069	0.401
DOC_MAPK_RevD_3	52	67	PF00069	0.406
DOC_PP2B_LxvP_1	462	465	PF13499	0.455
DOC_USP7_MATH_1	149	153	PF00917	0.695
DOC_USP7_MATH_1	217	221	PF00917	0.516
DOC_USP7_MATH_1	313	317	PF00917	0.627
DOC_USP7_MATH_1	400	404	PF00917	0.659
DOC_USP7_MATH_1	407	411	PF00917	0.598
DOC_USP7_MATH_1	496	500	PF00917	0.529
DOC_USP7_MATH_1	81	85	PF00917	0.639
DOC_USP7_MATH_2	304	310	PF00917	0.493
DOC_USP7_UBL2_3	123	127	PF12436	0.503
DOC_WW_Pin1_4	136	141	PF00397	0.557
DOC_WW_Pin1_4	189	194	PF00397	0.603
DOC_WW_Pin1_4	212	217	PF00397	0.575
DOC_WW_Pin1_4	24	29	PF00397	0.560
DOC_WW_Pin1_4	326	331	PF00397	0.594
DOC_WW_Pin1_4	360	365	PF00397	0.423
DOC_WW_Pin1_4	403	408	PF00397	0.642
DOC_WW_Pin1_4	410	415	PF00397	0.686
DOC_WW_Pin1_4	475	480	PF00397	0.376
DOC_WW_Pin1_4	541	546	PF00397	0.585
DOC_WW_Pin1_4	8	13	PF00397	0.379
LIG_14-3-3_CanoR_1	111	117	PF00244	0.537
LIG_14-3-3_CanoR_1	229	233	PF00244	0.563
LIG_14-3-3_CanoR_1	359	364	PF00244	0.502
LIG_14-3-3_CanoR_1	421	431	PF00244	0.573
LIG_14-3-3_CanoR_1	495	505	PF00244	0.506
LIG_14-3-3_CanoR_1	82	89	PF00244	0.649
LIG_Actin_WH2_2	265	283	PF00022	0.486
LIG_Actin_WH2_2	480	497	PF00022	0.442
LIG_BIR_III_4	374	378	PF00653	0.394
LIG_Clathr_ClatBox_1	484	488	PF01394	0.346
LIG_Clathr_ClatBox_1	539	543	PF01394	0.397
LIG_FHA_1	105	111	PF00498	0.633
LIG_FHA_1	333	339	PF00498	0.454
LIG_FHA_1	360	366	PF00498	0.451
LIG_FHA_1	382	388	PF00498	0.402
LIG_FHA_1	411	417	PF00498	0.649
LIG_FHA_1	53	59	PF00498	0.418
LIG_FHA_1	9	15	PF00498	0.379
LIG_FHA_2	351	357	PF00498	0.475
LIG_FHA_2	4	10	PF00498	0.419
LIG_GBD_Chelix_1	286	294	PF00786	0.435
LIG_LIR_Gen_1	106	117	PF02991	0.610
LIG_LIR_Nem_3	106	112	PF02991	0.609
LIG_LIR_Nem_3	506	511	PF02991	0.384
LIG_LIR_Nem_3	534	539	PF02991	0.342
LIG_NRBOX	289	295	PF00104	0.511
LIG_NRBOX	53	59	PF00104	0.454
LIG_SH2_CRK	341	345	PF00017	0.520
LIG_SH2_STAT3	163	166	PF00017	0.564
LIG_SH3_2	545	550	PF14604	0.591
LIG_SH3_3	298	304	PF00018	0.561
LIG_SH3_3	333	339	PF00018	0.314
LIG_SH3_3	376	382	PF00018	0.436
LIG_SH3_3	445	451	PF00018	0.635
LIG_SH3_3	542	548	PF00018	0.715
LIG_SUMO_SIM_par_1	208	215	PF11976	0.402
LIG_WW_3	79	83	PF00397	0.755
MOD_CDC14_SPxK_1	547	550	PF00782	0.599
MOD_CDK_SPxK_1	544	550	PF00069	0.585
MOD_CDK_SPxxK_3	410	417	PF00069	0.514
MOD_CK1_1	152	158	PF00069	0.665
MOD_CK1_1	22	28	PF00069	0.674
MOD_CK1_1	231	237	PF00069	0.609
MOD_CK1_1	401	407	PF00069	0.646
MOD_CK1_1	410	416	PF00069	0.496
MOD_CK2_1	350	356	PF00069	0.481
MOD_CK2_1	496	502	PF00069	0.471
MOD_GlcNHglycan	151	154	PF01048	0.602
MOD_GlcNHglycan	21	24	PF01048	0.502
MOD_GlcNHglycan	315	318	PF01048	0.737
MOD_GlcNHglycan	403	406	PF01048	0.541
MOD_GlcNHglycan	409	412	PF01048	0.506
MOD_GlcNHglycan	498	501	PF01048	0.536
MOD_GlcNHglycan	528	531	PF01048	0.507
MOD_GlcNHglycan	76	79	PF01048	0.683
MOD_GlcNHglycan	83	86	PF01048	0.666
MOD_GlcNHglycan	97	100	PF01048	0.787
MOD_GSK3_1	148	155	PF00069	0.727
MOD_GSK3_1	22	29	PF00069	0.570
MOD_GSK3_1	3	10	PF00069	0.431
MOD_GSK3_1	307	314	PF00069	0.691
MOD_GSK3_1	381	388	PF00069	0.489
MOD_GSK3_1	394	401	PF00069	0.457
MOD_GSK3_1	403	410	PF00069	0.581
MOD_GSK3_1	473	480	PF00069	0.368
MOD_GSK3_1	70	77	PF00069	0.689
MOD_GSK3_1	81	88	PF00069	0.662
MOD_N-GLC_1	136	141	PF02516	0.598
MOD_N-GLC_2	236	238	PF02516	0.487
MOD_N-GLC_2	525	527	PF02516	0.465
MOD_NEK2_1	112	117	PF00069	0.556
MOD_NEK2_1	307	312	PF00069	0.742
MOD_NEK2_1	435	440	PF00069	0.362
MOD_NEK2_1	473	478	PF00069	0.379
MOD_NEK2_1	53	58	PF00069	0.355
MOD_NEK2_1	7	12	PF00069	0.507
MOD_NEK2_1	70	75	PF00069	0.572
MOD_NEK2_2	104	109	PF00069	0.581
MOD_PIKK_1	381	387	PF00454	0.476
MOD_PIKK_1	435	441	PF00454	0.501
MOD_PIKK_1	456	462	PF00454	0.546
MOD_PK_1	477	483	PF00069	0.349
MOD_PKA_1	359	365	PF00069	0.454
MOD_PKA_2	228	234	PF00069	0.568
MOD_PKA_2	3	9	PF00069	0.470
MOD_PKA_2	359	365	PF00069	0.502
MOD_PKA_2	81	87	PF00069	0.647
MOD_PKB_1	357	365	PF00069	0.457
MOD_Plk_1	90	96	PF00069	0.515
MOD_Plk_4	104	110	PF00069	0.665
MOD_Plk_4	112	118	PF00069	0.449
MOD_Plk_4	477	483	PF00069	0.349
MOD_Plk_4	53	59	PF00069	0.394
MOD_Plk_4	531	537	PF00069	0.410
MOD_ProDKin_1	136	142	PF00069	0.549
MOD_ProDKin_1	189	195	PF00069	0.599
MOD_ProDKin_1	212	218	PF00069	0.573
MOD_ProDKin_1	24	30	PF00069	0.568
MOD_ProDKin_1	326	332	PF00069	0.582
MOD_ProDKin_1	360	366	PF00069	0.419
MOD_ProDKin_1	403	409	PF00069	0.643
MOD_ProDKin_1	410	416	PF00069	0.672
MOD_ProDKin_1	475	481	PF00069	0.375
MOD_ProDKin_1	541	547	PF00069	0.594
MOD_ProDKin_1	8	14	PF00069	0.376
MOD_SUMO_rev_2	295	304	PF00179	0.416
TRG_DiLeu_BaEn_1	426	431	PF01217	0.439
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.443
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.408
TRG_ENDOCYTIC_2	341	344	PF00928	0.519
TRG_ENDOCYTIC_2	486	489	PF00928	0.354
TRG_ER_diArg_1	357	360	PF00400	0.479
TRG_ER_diArg_1	536	538	PF00400	0.371
TRG_ER_diArg_1	65	67	PF00400	0.354
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI5	Leptomonas seymouri	30%	93%
A0A3S7WSG2	Leishmania donovani	85%	100%
A4H766	Leishmania braziliensis	67%	100%
A4HVK5	Leishmania infantum	84%	100%
Q4QG77	Leishmania major	83%	100%