Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP99_LEIMU

TriTrypDb:

LmxM.13.0750

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.493
CLV_NRD_NRD_1	71	73	PF00675	0.513
CLV_PCSK_KEX2_1	136	138	PF00082	0.528
CLV_PCSK_KEX2_1	156	158	PF00082	0.356
CLV_PCSK_KEX2_1	71	73	PF00082	0.538
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_MAPK_gen_1	136	144	PF00069	0.596
DOC_MAPK_gen_1	156	164	PF00069	0.361
DOC_MAPK_MEF2A_6	136	144	PF00069	0.596
DOC_PP1_RVXF_1	208	214	PF00149	0.499
DOC_PP2B_LxvP_1	168	171	PF13499	0.436
DOC_USP7_MATH_1	113	117	PF00917	0.551
DOC_USP7_MATH_1	206	210	PF00917	0.468
DOC_USP7_MATH_1	33	37	PF00917	0.781
DOC_USP7_MATH_1	99	103	PF00917	0.644
LIG_14-3-3_CanoR_1	150	158	PF00244	0.495
LIG_14-3-3_CanoR_1	4	8	PF00244	0.600
LIG_BIR_III_4	31	35	PF00653	0.545
LIG_FHA_1	95	101	PF00498	0.449
LIG_LIR_Nem_3	134	138	PF02991	0.399
LIG_LIR_Nem_3	163	167	PF02991	0.531
LIG_LIR_Nem_3	81	86	PF02991	0.674
LIG_PCNA_yPIPBox_3	172	181	PF02747	0.570
LIG_Pex14_1	78	82	PF04695	0.509
LIG_REV1ctd_RIR_1	80	89	PF16727	0.525
LIG_SH2_SRC	88	91	PF00017	0.561
LIG_SH2_STAP1	160	164	PF00017	0.528
LIG_SH2_STAT5	146	149	PF00017	0.488
LIG_SH3_3	119	125	PF00018	0.591
MOD_CK1_1	41	47	PF00069	0.626
MOD_CK2_1	149	155	PF00069	0.526
MOD_CK2_1	3	9	PF00069	0.599
MOD_CK2_1	99	105	PF00069	0.565
MOD_GlcNHglycan	12	15	PF01048	0.663
MOD_GlcNHglycan	152	155	PF01048	0.535
MOD_GlcNHglycan	64	67	PF01048	0.614
MOD_GSK3_1	38	45	PF00069	0.696
MOD_N-GLC_1	38	43	PF02516	0.565
MOD_NEK2_1	108	113	PF00069	0.710
MOD_NEK2_2	78	83	PF00069	0.643
MOD_PIKK_1	47	53	PF00454	0.638
MOD_PKA_2	108	114	PF00069	0.613
MOD_PKA_2	138	144	PF00069	0.538
MOD_PKA_2	149	155	PF00069	0.468
MOD_PKA_2	3	9	PF00069	0.610
MOD_PKA_2	94	100	PF00069	0.680
MOD_Plk_1	78	84	PF00069	0.627
MOD_Plk_4	182	188	PF00069	0.609
MOD_Plk_4	3	9	PF00069	0.686
MOD_Plk_4	78	84	PF00069	0.644
MOD_SUMO_for_1	100	103	PF00179	0.576
MOD_SUMO_for_1	199	202	PF00179	0.349
MOD_SUMO_rev_2	128	138	PF00179	0.632
TRG_DiLeu_BaEn_1	182	187	PF01217	0.462
TRG_DiLeu_BaEn_4	202	208	PF01217	0.489
TRG_ER_diArg_1	137	140	PF00400	0.526
TRG_ER_diArg_1	156	159	PF00400	0.371
TRG_NES_CRM1_1	205	218	PF08389	0.504
TRG_NLS_MonoExtC_3	135	140	PF00514	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D0	Leptomonas seymouri	66%	87%
A0A0S4JSG2	Bodo saltans	25%	78%
A0A1X0NNP5	Trypanosomatidae	48%	100%
A0A3S7WSJ5	Leishmania donovani	92%	100%
A4H764	Leishmania braziliensis	83%	100%
A4HVK3	Leishmania infantum	93%	100%
D0A6Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QG79	Leishmania major	93%	100%
V5DBN2	Trypanosoma cruzi	60%	77%