Ubiquitin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-like protein

Species:

Leishmania mexicana

UniProt:

E9AP97_LEIMU

TriTrypDb:

LmxM.13.0730

Length:

827

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.596
CLV_C14_Caspase3-7	188	192	PF00656	0.644
CLV_C14_Caspase3-7	361	365	PF00656	0.504
CLV_C14_Caspase3-7	674	678	PF00656	0.522
CLV_C14_Caspase3-7	704	708	PF00656	0.701
CLV_MEL_PAP_1	524	530	PF00089	0.327
CLV_NRD_NRD_1	371	373	PF00675	0.496
CLV_NRD_NRD_1	470	472	PF00675	0.512
CLV_NRD_NRD_1	641	643	PF00675	0.652
CLV_PCSK_FUR_1	369	373	PF00082	0.492
CLV_PCSK_KEX2_1	371	373	PF00082	0.496
CLV_PCSK_KEX2_1	470	472	PF00082	0.510
CLV_PCSK_KEX2_1	641	643	PF00082	0.557
CLV_PCSK_KEX2_1	682	684	PF00082	0.544
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.544
CLV_PCSK_SKI1_1	682	686	PF00082	0.594
CLV_PCSK_SKI1_1	716	720	PF00082	0.716
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SPOP_SBC_1	433	437	PF00917	0.322
DOC_CKS1_1	789	794	PF01111	0.539
DOC_MAPK_gen_1	369	379	PF00069	0.598
DOC_MAPK_gen_1	641	649	PF00069	0.639
DOC_PP2B_LxvP_1	441	444	PF13499	0.487
DOC_PP2B_LxvP_1	460	463	PF13499	0.299
DOC_PP2B_LxvP_1	725	728	PF13499	0.541
DOC_PP4_FxxP_1	100	103	PF00568	0.701
DOC_PP4_MxPP_1	339	342	PF00568	0.568
DOC_SPAK_OSR1_1	34	38	PF12202	0.528
DOC_USP7_MATH_1	10	14	PF00917	0.485
DOC_USP7_MATH_1	127	131	PF00917	0.544
DOC_USP7_MATH_1	148	152	PF00917	0.700
DOC_USP7_MATH_1	185	189	PF00917	0.677
DOC_USP7_MATH_1	207	211	PF00917	0.603
DOC_USP7_MATH_1	335	339	PF00917	0.662
DOC_USP7_MATH_1	513	517	PF00917	0.512
DOC_USP7_MATH_1	616	620	PF00917	0.437
DOC_USP7_MATH_1	734	738	PF00917	0.592
DOC_USP7_MATH_1	800	804	PF00917	0.591
DOC_USP7_MATH_2	724	730	PF00917	0.653
DOC_WW_Pin1_4	161	166	PF00397	0.644
DOC_WW_Pin1_4	249	254	PF00397	0.707
DOC_WW_Pin1_4	287	292	PF00397	0.694
DOC_WW_Pin1_4	321	326	PF00397	0.681
DOC_WW_Pin1_4	337	342	PF00397	0.527
DOC_WW_Pin1_4	356	361	PF00397	0.432
DOC_WW_Pin1_4	424	429	PF00397	0.522
DOC_WW_Pin1_4	475	480	PF00397	0.509
DOC_WW_Pin1_4	619	624	PF00397	0.472
DOC_WW_Pin1_4	716	721	PF00397	0.718
DOC_WW_Pin1_4	788	793	PF00397	0.619
LIG_14-3-3_CanoR_1	371	379	PF00244	0.561
LIG_14-3-3_CanoR_1	391	397	PF00244	0.537
LIG_14-3-3_CanoR_1	491	500	PF00244	0.458
LIG_14-3-3_CanoR_1	552	560	PF00244	0.455
LIG_14-3-3_CanoR_1	641	649	PF00244	0.549
LIG_14-3-3_CanoR_1	740	748	PF00244	0.504
LIG_14-3-3_CanoR_1	806	815	PF00244	0.602
LIG_BIR_III_2	364	368	PF00653	0.492
LIG_BIR_III_4	184	188	PF00653	0.546
LIG_BRCT_BRCA1_1	136	140	PF00533	0.780
LIG_BRCT_BRCA1_1	586	590	PF00533	0.408
LIG_BRCT_BRCA1_1	645	649	PF00533	0.551
LIG_deltaCOP1_diTrp_1	810	815	PF00928	0.833
LIG_FHA_1	162	168	PF00498	0.538
LIG_FHA_1	207	213	PF00498	0.635
LIG_FHA_1	39	45	PF00498	0.528
LIG_FHA_1	425	431	PF00498	0.554
LIG_FHA_1	656	662	PF00498	0.711
LIG_FHA_1	67	73	PF00498	0.528
LIG_FHA_1	671	677	PF00498	0.559
LIG_FHA_2	21	27	PF00498	0.528
LIG_FHA_2	250	256	PF00498	0.664
LIG_FHA_2	357	363	PF00498	0.559
LIG_FHA_2	518	524	PF00498	0.509
LIG_FHA_2	683	689	PF00498	0.547
LIG_HCF-1_HBM_1	540	543	PF13415	0.427
LIG_IBAR_NPY_1	818	820	PF08397	0.633
LIG_Integrin_RGD_1	689	691	PF01839	0.559
LIG_LIR_Apic_2	393	397	PF02991	0.674
LIG_LIR_Gen_1	540	550	PF02991	0.427
LIG_LIR_Gen_1	692	703	PF02991	0.798
LIG_LIR_Nem_3	124	128	PF02991	0.670
LIG_LIR_Nem_3	540	546	PF02991	0.428
LIG_LIR_Nem_3	692	698	PF02991	0.749
LIG_LYPXL_yS_3	611	614	PF13949	0.510
LIG_NRBOX	624	630	PF00104	0.460
LIG_Pex14_1	632	636	PF04695	0.473
LIG_PTAP_UEV_1	656	661	PF05743	0.513
LIG_SH2_CRK	115	119	PF00017	0.617
LIG_SH2_CRK	394	398	PF00017	0.737
LIG_SH2_CRK	454	458	PF00017	0.400
LIG_SH2_NCK_1	394	398	PF00017	0.559
LIG_SH2_PTP2	543	546	PF00017	0.423
LIG_SH2_SRC	538	541	PF00017	0.423
LIG_SH2_SRC	769	772	PF00017	0.418
LIG_SH2_STAP1	636	640	PF00017	0.503
LIG_SH2_STAT3	344	347	PF00017	0.618
LIG_SH2_STAT5	117	120	PF00017	0.611
LIG_SH2_STAT5	394	397	PF00017	0.559
LIG_SH2_STAT5	538	541	PF00017	0.423
LIG_SH2_STAT5	543	546	PF00017	0.378
LIG_SH2_STAT5	571	574	PF00017	0.408
LIG_SH3_3	261	267	PF00018	0.592
LIG_SH3_3	290	296	PF00018	0.749
LIG_SH3_3	339	345	PF00018	0.713
LIG_SH3_3	654	660	PF00018	0.637
LIG_SH3_3	665	671	PF00018	0.550
LIG_SH3_3	70	76	PF00018	0.528
LIG_SH3_3	786	792	PF00018	0.668
LIG_SUMO_SIM_anti_2	15	20	PF11976	0.513
LIG_SUMO_SIM_par_1	15	20	PF11976	0.513
LIG_TRAF2_1	359	362	PF00917	0.567
LIG_TRAF2_1	398	401	PF00917	0.672
LIG_TRAF2_1	520	523	PF00917	0.401
LIG_TRAF2_1	744	747	PF00917	0.496
LIG_WRC_WIRS_1	528	533	PF05994	0.308
LIG_WW_1	341	344	PF00397	0.567
LIG_WW_3	324	328	PF00397	0.638
MOD_CDC14_SPxK_1	324	327	PF00782	0.676
MOD_CDK_SPK_2	716	721	PF00069	0.675
MOD_CDK_SPxK_1	321	327	PF00069	0.684
MOD_CDK_SPxxK_3	716	723	PF00069	0.601
MOD_CK1_1	106	112	PF00069	0.669
MOD_CK1_1	134	140	PF00069	0.626
MOD_CK1_1	152	158	PF00069	0.546
MOD_CK1_1	161	167	PF00069	0.618
MOD_CK1_1	180	186	PF00069	0.525
MOD_CK1_1	218	224	PF00069	0.661
MOD_CK1_1	289	295	PF00069	0.600
MOD_CK1_1	380	386	PF00069	0.483
MOD_CK1_1	418	424	PF00069	0.648
MOD_CK1_1	499	505	PF00069	0.323
MOD_CK1_1	551	557	PF00069	0.641
MOD_CK1_1	577	583	PF00069	0.283
MOD_CK1_1	58	64	PF00069	0.380
MOD_CK1_1	619	625	PF00069	0.425
MOD_CK1_1	643	649	PF00069	0.571
MOD_CK2_1	20	26	PF00069	0.380
MOD_CK2_1	249	255	PF00069	0.674
MOD_CK2_1	356	362	PF00069	0.560
MOD_CK2_1	517	523	PF00069	0.519
MOD_CK2_1	740	746	PF00069	0.546
MOD_CK2_1	754	760	PF00069	0.413
MOD_CMANNOS	812	815	PF00535	0.694
MOD_Cter_Amidation	680	683	PF01082	0.540
MOD_GlcNHglycan	118	121	PF01048	0.602
MOD_GlcNHglycan	12	15	PF01048	0.220
MOD_GlcNHglycan	187	190	PF01048	0.696
MOD_GlcNHglycan	333	336	PF01048	0.543
MOD_GlcNHglycan	373	376	PF01048	0.493
MOD_GlcNHglycan	417	420	PF01048	0.674
MOD_GlcNHglycan	515	518	PF01048	0.444
MOD_GlcNHglycan	553	556	PF01048	0.474
MOD_GlcNHglycan	586	589	PF01048	0.373
MOD_GlcNHglycan	604	607	PF01048	0.359
MOD_GlcNHglycan	668	671	PF01048	0.595
MOD_GlcNHglycan	677	680	PF01048	0.585
MOD_GlcNHglycan	728	731	PF01048	0.612
MOD_GlcNHglycan	732	735	PF01048	0.549
MOD_GlcNHglycan	742	745	PF01048	0.532
MOD_GlcNHglycan	784	787	PF01048	0.678
MOD_GlcNHglycan	822	825	PF01048	0.592
MOD_GlcNHglycan	88	93	PF01048	0.692
MOD_GSK3_1	127	134	PF00069	0.632
MOD_GSK3_1	148	155	PF00069	0.628
MOD_GSK3_1	161	168	PF00069	0.625
MOD_GSK3_1	214	221	PF00069	0.645
MOD_GSK3_1	226	233	PF00069	0.580
MOD_GSK3_1	245	252	PF00069	0.692
MOD_GSK3_1	285	292	PF00069	0.574
MOD_GSK3_1	313	320	PF00069	0.662
MOD_GSK3_1	331	338	PF00069	0.526
MOD_GSK3_1	386	393	PF00069	0.687
MOD_GSK3_1	414	421	PF00069	0.672
MOD_GSK3_1	433	440	PF00069	0.309
MOD_GSK3_1	498	505	PF00069	0.398
MOD_GSK3_1	508	515	PF00069	0.494
MOD_GSK3_1	597	604	PF00069	0.436
MOD_GSK3_1	615	622	PF00069	0.374
MOD_GSK3_1	636	643	PF00069	0.511
MOD_GSK3_1	651	658	PF00069	0.622
MOD_GSK3_1	666	673	PF00069	0.546
MOD_GSK3_1	726	733	PF00069	0.636
MOD_GSK3_1	736	743	PF00069	0.464
MOD_GSK3_1	780	787	PF00069	0.594
MOD_GSK3_1	802	809	PF00069	0.702
MOD_N-GLC_1	20	25	PF02516	0.327
MOD_N-GLC_1	226	231	PF02516	0.531
MOD_N-GLC_1	414	419	PF02516	0.697
MOD_N-GLC_1	472	477	PF02516	0.455
MOD_N-GLC_1	779	784	PF02516	0.601
MOD_NEK2_1	128	133	PF00069	0.603
MOD_NEK2_1	215	220	PF00069	0.610
MOD_NEK2_1	317	322	PF00069	0.708
MOD_NEK2_1	331	336	PF00069	0.572
MOD_NEK2_1	434	439	PF00069	0.498
MOD_NEK2_1	498	503	PF00069	0.427
MOD_NEK2_1	542	547	PF00069	0.394
MOD_NEK2_1	550	555	PF00069	0.473
MOD_NEK2_1	574	579	PF00069	0.450
MOD_NEK2_1	601	606	PF00069	0.480
MOD_NEK2_1	624	629	PF00069	0.461
MOD_NEK2_2	636	641	PF00069	0.467
MOD_PIKK_1	207	213	PF00454	0.635
MOD_PIKK_1	227	233	PF00454	0.509
MOD_PIKK_1	392	398	PF00454	0.601
MOD_PIKK_1	422	428	PF00454	0.579
MOD_PIKK_1	505	511	PF00454	0.492
MOD_PIKK_1	522	528	PF00454	0.345
MOD_PIKK_1	651	657	PF00454	0.566
MOD_PIKK_1	734	740	PF00454	0.589
MOD_PIKK_1	772	778	PF00454	0.483
MOD_PKA_1	371	377	PF00069	0.455
MOD_PKA_1	682	688	PF00069	0.539
MOD_PKA_2	285	291	PF00069	0.553
MOD_PKA_2	371	377	PF00069	0.511
MOD_PKA_2	390	396	PF00069	0.583
MOD_PKA_2	406	412	PF00069	0.703
MOD_PKA_2	5	11	PF00069	0.450
MOD_PKA_2	551	557	PF00069	0.463
MOD_PKA_2	577	583	PF00069	0.293
MOD_PKA_2	640	646	PF00069	0.617
MOD_PKA_2	682	688	PF00069	0.539
MOD_PKB_1	369	377	PF00069	0.453
MOD_Plk_1	20	26	PF00069	0.327
MOD_Plk_1	636	642	PF00069	0.474
MOD_Plk_1	643	649	PF00069	0.459
MOD_Plk_1	730	736	PF00069	0.589
MOD_Plk_2-3	20	26	PF00069	0.380
MOD_Plk_4	215	221	PF00069	0.643
MOD_Plk_4	347	353	PF00069	0.623
MOD_Plk_4	502	508	PF00069	0.319
MOD_Plk_4	542	548	PF00069	0.526
MOD_Plk_4	597	603	PF00069	0.428
MOD_Plk_4	616	622	PF00069	0.344
MOD_Plk_4	624	630	PF00069	0.404
MOD_ProDKin_1	161	167	PF00069	0.644
MOD_ProDKin_1	249	255	PF00069	0.708
MOD_ProDKin_1	287	293	PF00069	0.691
MOD_ProDKin_1	321	327	PF00069	0.684
MOD_ProDKin_1	337	343	PF00069	0.530
MOD_ProDKin_1	356	362	PF00069	0.428
MOD_ProDKin_1	424	430	PF00069	0.512
MOD_ProDKin_1	475	481	PF00069	0.503
MOD_ProDKin_1	619	625	PF00069	0.468
MOD_ProDKin_1	716	722	PF00069	0.717
MOD_ProDKin_1	788	794	PF00069	0.615
TRG_DiLeu_BaEn_4	361	367	PF01217	0.391
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.380
TRG_DiLeu_BaLyEn_6	657	662	PF01217	0.583
TRG_ENDOCYTIC_2	115	118	PF00928	0.714
TRG_ENDOCYTIC_2	454	457	PF00928	0.397
TRG_ENDOCYTIC_2	543	546	PF00928	0.423
TRG_ENDOCYTIC_2	571	574	PF00928	0.408
TRG_ENDOCYTIC_2	611	614	PF00928	0.510
TRG_ER_diArg_1	369	372	PF00400	0.496
TRG_ER_diArg_1	470	472	PF00400	0.507
TRG_ER_diArg_1	48	51	PF00400	0.380
TRG_ER_diArg_1	640	642	PF00400	0.528
TRG_NES_CRM1_1	26	38	PF08389	0.380
TRG_NES_CRM1_1	432	445	PF08389	0.487
TRG_NES_CRM1_1	534	548	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	371	376	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSG5	Leishmania donovani	83%	98%
A4H762	Leishmania braziliensis	66%	97%
A4HVK1	Leishmania infantum	84%	98%
Q4QG81	Leishmania major	83%	99%