Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AP96_LEIMU

TriTrypDb:

LmxM.13.0720

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP96

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0003960	NADPH:quinone reductase activity	5	7
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	7
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	7
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.455
CLV_NRD_NRD_1	267	269	PF00675	0.386
CLV_PCSK_KEX2_1	114	116	PF00082	0.471
CLV_PCSK_SKI1_1	115	119	PF00082	0.382
CLV_PCSK_SKI1_1	187	191	PF00082	0.374
CLV_PCSK_SKI1_1	41	45	PF00082	0.322
CLV_PCSK_SKI1_1	90	94	PF00082	0.351
DEG_Nend_UBRbox_3	1	3	PF02207	0.644
DOC_MAPK_gen_1	122	132	PF00069	0.388
DOC_MAPK_gen_1	268	275	PF00069	0.336
DOC_MAPK_MEF2A_6	125	132	PF00069	0.389
DOC_MAPK_MEF2A_6	268	275	PF00069	0.386
DOC_MAPK_MEF2A_6	336	345	PF00069	0.347
DOC_MAPK_NFAT4_5	125	133	PF00069	0.357
DOC_PP4_FxxP_1	285	288	PF00568	0.329
DOC_USP7_MATH_1	225	229	PF00917	0.290
DOC_USP7_MATH_1	25	29	PF00917	0.541
DOC_USP7_UBL2_3	336	340	PF12436	0.379
DOC_WW_Pin1_4	181	186	PF00397	0.414
LIG_14-3-3_CanoR_1	208	215	PF00244	0.162
LIG_14-3-3_CanoR_1	246	251	PF00244	0.400
LIG_Actin_WH2_2	78	95	PF00022	0.403
LIG_BRCT_BRCA1_1	19	23	PF00533	0.409
LIG_BRCT_BRCA1_1	282	286	PF00533	0.379
LIG_CSL_BTD_1	68	71	PF09270	0.162
LIG_CtBP_PxDLS_1	129	133	PF00389	0.299
LIG_deltaCOP1_diTrp_1	330	333	PF00928	0.445
LIG_deltaCOP1_diTrp_1	67	76	PF00928	0.162
LIG_FHA_1	134	140	PF00498	0.372
LIG_FHA_1	190	196	PF00498	0.408
LIG_FHA_1	282	288	PF00498	0.346
LIG_FHA_1	58	64	PF00498	0.403
LIG_LIR_Apic_2	283	288	PF02991	0.294
LIG_LIR_Gen_1	108	117	PF02991	0.336
LIG_LIR_Gen_1	323	333	PF02991	0.412
LIG_LIR_Nem_3	10	14	PF02991	0.467
LIG_LIR_Nem_3	100	106	PF02991	0.314
LIG_LIR_Nem_3	108	112	PF02991	0.319
LIG_LIR_Nem_3	126	130	PF02991	0.483
LIG_LIR_Nem_3	20	26	PF02991	0.430
LIG_LIR_Nem_3	318	322	PF02991	0.405
LIG_LIR_Nem_3	323	329	PF02991	0.384
LIG_LIR_Nem_3	67	72	PF02991	0.219
LIG_LYPXL_SIV_4	225	233	PF13949	0.403
LIG_MLH1_MIPbox_1	282	286	PF16413	0.403
LIG_PDZ_Class_2	340	345	PF00595	0.322
LIG_Pex14_2	286	290	PF04695	0.436
LIG_Pex14_2	72	76	PF04695	0.329
LIG_SH2_CRK	109	113	PF00017	0.319
LIG_SH2_CRK	293	297	PF00017	0.454
LIG_SH2_NCK_1	226	230	PF00017	0.329
LIG_SH2_NCK_1	326	330	PF00017	0.439
LIG_SH2_STAT5	127	130	PF00017	0.428
LIG_SH2_STAT5	49	52	PF00017	0.403
LIG_SH3_3	141	147	PF00018	0.383
LIG_SH3_3	27	33	PF00018	0.466
LIG_SH3_3	65	71	PF00018	0.320
LIG_SUMO_SIM_par_1	128	133	PF11976	0.294
LIG_SUMO_SIM_par_1	81	87	PF11976	0.316
LIG_TYR_ITIM	224	229	PF00017	0.348
LIG_WRC_WIRS_1	282	287	PF05994	0.290
MOD_CDC14_SPxK_1	184	187	PF00782	0.313
MOD_CDK_SPxK_1	181	187	PF00069	0.313
MOD_CK1_1	133	139	PF00069	0.372
MOD_CK1_1	183	189	PF00069	0.394
MOD_CK1_1	281	287	PF00069	0.331
MOD_CK2_1	25	31	PF00069	0.508
MOD_GlcNHglycan	131	135	PF01048	0.388
MOD_GlcNHglycan	278	281	PF01048	0.296
MOD_GlcNHglycan	86	89	PF01048	0.385
MOD_GSK3_1	174	181	PF00069	0.369
MOD_GSK3_1	276	283	PF00069	0.331
MOD_N-GLC_1	52	57	PF02516	0.329
MOD_NEK2_1	130	135	PF00069	0.295
MOD_NEK2_1	191	196	PF00069	0.447
MOD_NEK2_1	276	281	PF00069	0.342
MOD_OFUCOSY	176	182	PF10250	0.402
MOD_PIKK_1	97	103	PF00454	0.346
MOD_PKA_2	207	213	PF00069	0.182
MOD_PKA_2	257	263	PF00069	0.397
MOD_PKB_1	244	252	PF00069	0.272
MOD_Plk_4	174	180	PF00069	0.362
MOD_Plk_4	25	31	PF00069	0.501
MOD_Plk_4	281	287	PF00069	0.319
MOD_ProDKin_1	181	187	PF00069	0.414
MOD_SUMO_rev_2	87	94	PF00179	0.403
TRG_ENDOCYTIC_2	103	106	PF00928	0.375
TRG_ENDOCYTIC_2	109	112	PF00928	0.358
TRG_ENDOCYTIC_2	11	14	PF00928	0.444
TRG_ENDOCYTIC_2	127	130	PF00928	0.474
TRG_ENDOCYTIC_2	226	229	PF00928	0.329
TRG_ENDOCYTIC_2	293	296	PF00928	0.463
TRG_ENDOCYTIC_2	326	329	PF00928	0.434
TRG_ENDOCYTIC_2	49	52	PF00928	0.441
TRG_ER_diArg_1	243	246	PF00400	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	41%	100%
A0A0N0P5I8	Leptomonas seymouri	28%	93%
A0A0N0P6Q4	Leptomonas seymouri	26%	100%
A0A0N0P7C5	Leptomonas seymouri	75%	100%
A0A0N1I913	Leptomonas seymouri	38%	99%
A0A0N1PB21	Leptomonas seymouri	28%	100%
A0A0S4ILS9	Bodo saltans	29%	100%
A0A0S4IUY2	Bodo saltans	27%	100%
A0A0S4JMB1	Bodo saltans	52%	99%
A0A0S4KHW9	Bodo saltans	28%	100%
A0A1W5SKT4	Aspergillus terreus	29%	97%
A0A1X0NZZ5	Trypanosomatidae	27%	100%
A0A1X0P0B2	Trypanosomatidae	51%	100%
A0A1X0P8R2	Trypanosomatidae	28%	100%
A0A3Q8IRG0	Leishmania donovani	43%	100%
A0A3R7L374	Trypanosoma rangeli	32%	100%
A0A3S7WSH2	Leishmania donovani	94%	100%
A0A422NF38	Trypanosoma rangeli	25%	100%
A0A422NKE0	Trypanosoma rangeli	56%	100%
A0A451EJQ8	Leishmania donovani	29%	100%
A4H3L9	Leishmania braziliensis	31%	100%
A4H761	Leishmania braziliensis	91%	100%
A4HPT6	Leishmania braziliensis	42%	99%
A4HVK0	Leishmania infantum	94%	100%
A4IE56	Leishmania infantum	43%	100%
A6QQF5	Bos taurus	29%	99%
A7RK30	Nematostella vectensis	28%	95%
B0BNC9	Rattus norvegicus	30%	99%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ACK2	Leishmania major	29%	100%
E9AG46	Leishmania infantum	29%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
K4BW79	Solanum lycopersicum	25%	89%
O23939	Fragaria vesca	25%	100%
O34812	Bacillus subtilis (strain 168)	27%	100%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O97764	Bos taurus	26%	100%
P11415	Cavia porcellus	26%	100%
P19333	Tetronarce californica	25%	91%
P28304	Escherichia coli (strain K12)	31%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
P42865	Leishmania amazonensis	42%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	29%	100%
P47199	Mus musculus	25%	100%
P76113	Escherichia coli (strain K12)	27%	100%
P97584	Rattus norvegicus	28%	100%
Q08257	Homo sapiens	25%	100%
Q0CJC5	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	29%	97%
Q0MVN8	Sus scrofa	25%	100%
Q24K16	Bos taurus	41%	92%
Q28452	Lama guanicoe	26%	100%
Q28719	Oryctolagus cuniculus	25%	99%
Q39173	Arabidopsis thaliana	29%	100%
Q3MIE4	Rattus norvegicus	29%	85%
Q3UNZ8	Mus musculus	30%	99%
Q4Q0Z7	Leishmania major	44%	99%
Q4QG82	Leishmania major	94%	100%
Q53FA7	Homo sapiens	27%	100%
Q54YT4	Dictyostelium discoideum	26%	99%
Q5R4S7	Pongo abelii	25%	100%
Q62465	Mus musculus	30%	85%
Q6AYT0	Rattus norvegicus	25%	100%
Q6WAU0	Mentha piperita	28%	100%
Q7T3C7	Danio rerio	26%	89%
Q7YS70	Bos taurus	27%	92%
Q80TB8	Mus musculus	23%	83%
Q84V25	Fragaria ananassa	25%	100%
Q8BGC4	Mus musculus	42%	92%
Q8JFV8	Danio rerio	29%	71%
Q8LCU7	Arabidopsis thaliana	26%	92%
Q8N4Q0	Homo sapiens	40%	92%
Q91YR9	Mus musculus	30%	100%
Q941I0	Fragaria ananassa	24%	100%
Q99536	Homo sapiens	30%	88%
Q9C0Y6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	99%
Q9DCS3	Mus musculus	28%	92%
Q9EQZ5	Cavia porcellus	28%	100%
Q9HCJ6	Homo sapiens	24%	82%
Q9SLN8	Nicotiana tabacum	30%	100%
Q9SV68	Arabidopsis thaliana	28%	100%
Q9V6U9	Drosophila melanogaster	25%	97%
Q9Z311	Rattus norvegicus	28%	92%
V5B1P3	Trypanosoma cruzi	23%	100%
V5BXF0	Trypanosoma cruzi	32%	100%