Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania mexicana

UniProt:

E9AP95_LEIMU

TriTrypDb:

LmxM.13.0710

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP95

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048200	Golgi transport vesicle coating	7	1
GO:0048205	COPI coating of Golgi vesicle	8	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	8
GO:0008047	enzyme activator activity	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0030695	GTPase regulator activity	4	8
GO:0060589	nucleoside-triphosphatase regulator activity	3	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.576
CLV_C14_Caspase3-7	403	407	PF00656	0.567
CLV_NRD_NRD_1	253	255	PF00675	0.538
CLV_PCSK_KEX2_1	118	120	PF00082	0.381
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.373
CLV_PCSK_SKI1_1	350	354	PF00082	0.570
CLV_PCSK_SKI1_1	434	438	PF00082	0.440
CLV_PCSK_SKI1_1	84	88	PF00082	0.297
CLV_PCSK_SKI1_1	94	98	PF00082	0.242
DOC_MAPK_DCC_7	350	359	PF00069	0.476
DOC_MAPK_gen_1	58	66	PF00069	0.273
DOC_MAPK_MEF2A_6	58	66	PF00069	0.273
DOC_MAPK_MEF2A_6	78	87	PF00069	0.349
DOC_MAPK_RevD_3	191	207	PF00069	0.564
DOC_PP1_RVXF_1	28	34	PF00149	0.273
DOC_PP2B_LxvP_1	7	10	PF13499	0.480
DOC_PP4_FxxP_1	33	36	PF00568	0.273
DOC_USP7_MATH_1	166	170	PF00917	0.660
DOC_USP7_MATH_1	173	177	PF00917	0.606
DOC_USP7_MATH_1	195	199	PF00917	0.583
DOC_USP7_MATH_1	391	395	PF00917	0.617
DOC_USP7_MATH_1	414	418	PF00917	0.498
DOC_USP7_UBL2_3	218	222	PF12436	0.762
DOC_USP7_UBL2_3	94	98	PF12436	0.333
DOC_WW_Pin1_4	108	113	PF00397	0.416
DOC_WW_Pin1_4	135	140	PF00397	0.572
DOC_WW_Pin1_4	145	150	PF00397	0.513
DOC_WW_Pin1_4	153	158	PF00397	0.516
DOC_WW_Pin1_4	169	174	PF00397	0.543
DOC_WW_Pin1_4	175	180	PF00397	0.612
DOC_WW_Pin1_4	183	188	PF00397	0.667
DOC_WW_Pin1_4	320	325	PF00397	0.678
DOC_WW_Pin1_4	350	355	PF00397	0.716
LIG_14-3-3_CanoR_1	392	398	PF00244	0.553
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BRCT_BRCA1_1	155	159	PF00533	0.562
LIG_CtBP_PxDLS_1	356	360	PF00389	0.474
LIG_FHA_1	2	8	PF00498	0.571
LIG_FHA_1	236	242	PF00498	0.602
LIG_FHA_1	297	303	PF00498	0.675
LIG_FHA_1	44	50	PF00498	0.252
LIG_FHA_2	10	16	PF00498	0.444
LIG_FHA_2	180	186	PF00498	0.602
LIG_FHA_2	231	237	PF00498	0.530
LIG_FHA_2	401	407	PF00498	0.580
LIG_LIR_Apic_2	107	112	PF02991	0.426
LIG_LIR_Gen_1	41	50	PF02991	0.273
LIG_LIR_Nem_3	370	374	PF02991	0.545
LIG_LIR_Nem_3	41	45	PF02991	0.309
LIG_LIR_Nem_3	46	50	PF02991	0.308
LIG_PDZ_Class_3	435	440	PF00595	0.454
LIG_PTB_Apo_2	373	380	PF02174	0.584
LIG_PTB_Phospho_1	373	379	PF10480	0.586
LIG_SH2_CRK	109	113	PF00017	0.364
LIG_SH2_NCK_1	109	113	PF00017	0.404
LIG_SH2_STAP1	247	251	PF00017	0.540
LIG_SH2_STAT5	109	112	PF00017	0.401
LIG_SH2_STAT5	379	382	PF00017	0.604
LIG_SH2_STAT5	385	388	PF00017	0.626
LIG_SH3_1	284	290	PF00018	0.657
LIG_SH3_3	133	139	PF00018	0.468
LIG_SH3_3	284	290	PF00018	0.657
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.301
LIG_SUMO_SIM_par_1	192	198	PF11976	0.534
LIG_TRAF2_1	12	15	PF00917	0.455
LIG_TRAF2_1	233	236	PF00917	0.537
MOD_CK1_1	107	113	PF00069	0.394
MOD_CK1_1	148	154	PF00069	0.611
MOD_CK1_1	169	175	PF00069	0.563
MOD_CK1_1	186	192	PF00069	0.638
MOD_CK1_1	198	204	PF00069	0.559
MOD_CK1_1	345	351	PF00069	0.564
MOD_CK1_1	41	47	PF00069	0.280
MOD_CK2_1	230	236	PF00069	0.534
MOD_CK2_1	9	15	PF00069	0.447
MOD_Cter_Amidation	218	221	PF01082	0.645
MOD_DYRK1A_RPxSP_1	350	354	PF00069	0.612
MOD_GlcNHglycan	150	153	PF01048	0.511
MOD_GlcNHglycan	175	178	PF01048	0.659
MOD_GlcNHglycan	210	213	PF01048	0.649
MOD_GlcNHglycan	304	307	PF01048	0.612
MOD_GlcNHglycan	342	345	PF01048	0.621
MOD_GlcNHglycan	350	353	PF01048	0.664
MOD_GlcNHglycan	359	362	PF01048	0.754
MOD_GlcNHglycan	387	390	PF01048	0.601
MOD_GlcNHglycan	394	397	PF01048	0.722
MOD_GlcNHglycan	420	423	PF01048	0.532
MOD_GlcNHglycan	70	73	PF01048	0.333
MOD_GSK3_1	104	111	PF00069	0.446
MOD_GSK3_1	167	174	PF00069	0.599
MOD_GSK3_1	175	182	PF00069	0.623
MOD_GSK3_1	194	201	PF00069	0.430
MOD_GSK3_1	230	237	PF00069	0.588
MOD_GSK3_1	348	355	PF00069	0.719
MOD_GSK3_1	381	388	PF00069	0.622
MOD_GSK3_1	414	421	PF00069	0.505
MOD_GSK3_1	64	71	PF00069	0.293
MOD_N-GLC_1	340	345	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	208	213	PF00069	0.614
MOD_NEK2_1	314	319	PF00069	0.640
MOD_NEK2_1	357	362	PF00069	0.508
MOD_NEK2_1	418	423	PF00069	0.534
MOD_PIKK_1	126	132	PF00454	0.448
MOD_PKA_2	296	302	PF00069	0.759
MOD_PKA_2	391	397	PF00069	0.651
MOD_Plk_1	381	387	PF00069	0.589
MOD_Plk_4	104	110	PF00069	0.333
MOD_Plk_4	155	161	PF00069	0.561
MOD_Plk_4	277	283	PF00069	0.557
MOD_ProDKin_1	108	114	PF00069	0.411
MOD_ProDKin_1	135	141	PF00069	0.571
MOD_ProDKin_1	145	151	PF00069	0.513
MOD_ProDKin_1	153	159	PF00069	0.516
MOD_ProDKin_1	169	175	PF00069	0.545
MOD_ProDKin_1	183	189	PF00069	0.669
MOD_ProDKin_1	320	326	PF00069	0.674
MOD_ProDKin_1	350	356	PF00069	0.708
MOD_SUMO_rev_2	11	19	PF00179	0.387
TRG_DiLeu_BaEn_1	15	20	PF01217	0.424
TRG_ENDOCYTIC_2	117	120	PF00928	0.378
TRG_ENDOCYTIC_2	47	50	PF00928	0.313
TRG_NLS_Bipartite_1	206	224	PF00514	0.576
TRG_NLS_MonoExtN_4	218	224	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I148	Leptomonas seymouri	60%	98%
A0A0S4JHE6	Bodo saltans	38%	100%
A0A3Q8IHZ4	Leishmania donovani	91%	100%
A1L520	Bos taurus	28%	85%
A4H760	Leishmania braziliensis	77%	100%
A4HVJ9	Leishmania infantum	91%	100%
Q28CM8	Xenopus tropicalis	29%	84%
Q4QG83	Leishmania major	90%	98%
Q5RAT7	Pongo abelii	28%	84%
Q8N6H7	Homo sapiens	28%	84%
Q99K28	Mus musculus	27%	85%