PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9AP93_LEIMU

TriTrypDb:

LmxM.13.0690

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.635
CLV_C14_Caspase3-7	813	817	PF00656	0.454
CLV_NRD_NRD_1	175	177	PF00675	0.692
CLV_NRD_NRD_1	265	267	PF00675	0.515
CLV_NRD_NRD_1	288	290	PF00675	0.575
CLV_NRD_NRD_1	383	385	PF00675	0.631
CLV_NRD_NRD_1	446	448	PF00675	0.609
CLV_NRD_NRD_1	461	463	PF00675	0.627
CLV_NRD_NRD_1	739	741	PF00675	0.628
CLV_NRD_NRD_1	780	782	PF00675	0.410
CLV_NRD_NRD_1	835	837	PF00675	0.526
CLV_PCSK_KEX2_1	288	290	PF00082	0.575
CLV_PCSK_KEX2_1	382	384	PF00082	0.644
CLV_PCSK_KEX2_1	417	419	PF00082	0.661
CLV_PCSK_KEX2_1	446	448	PF00082	0.609
CLV_PCSK_KEX2_1	461	463	PF00082	0.627
CLV_PCSK_KEX2_1	739	741	PF00082	0.628
CLV_PCSK_KEX2_1	780	782	PF00082	0.444
CLV_PCSK_KEX2_1	791	793	PF00082	0.483
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.704
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.661
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.547
CLV_PCSK_SKI1_1	172	176	PF00082	0.656
CLV_PCSK_SKI1_1	328	332	PF00082	0.523
CLV_PCSK_SKI1_1	620	624	PF00082	0.604
CLV_PCSK_SKI1_1	761	765	PF00082	0.670
CLV_PCSK_SKI1_1	780	784	PF00082	0.383
CLV_PCSK_SKI1_1	845	849	PF00082	0.349
CLV_PCSK_SKI1_1	908	912	PF00082	0.304
DEG_APCC_DBOX_1	907	915	PF00400	0.304
DEG_COP1_1	600	609	PF00400	0.620
DEG_SCF_FBW7_1	466	471	PF00400	0.613
DEG_SCF_FBW7_1	573	578	PF00400	0.648
DEG_SCF_FBW7_1	927	933	PF00400	0.465
DEG_SPOP_SBC_1	181	185	PF00917	0.616
DEG_SPOP_SBC_1	716	720	PF00917	0.590
DOC_CKS1_1	598	603	PF01111	0.621
DOC_CKS1_1	626	631	PF01111	0.616
DOC_CKS1_1	927	932	PF01111	0.480
DOC_CYCLIN_yCln2_LP_2	319	325	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	877	883	PF00134	0.304
DOC_MAPK_gen_1	791	798	PF00069	0.447
DOC_MAPK_MEF2A_6	187	196	PF00069	0.593
DOC_MAPK_MEF2A_6	791	798	PF00069	0.447
DOC_MAPK_MEF2A_6	876	883	PF00069	0.304
DOC_PP1_RVXF_1	892	898	PF00149	0.304
DOC_PP1_RVXF_1	902	908	PF00149	0.304
DOC_PP2B_LxvP_1	877	880	PF13499	0.304
DOC_PP4_FxxP_1	598	601	PF00568	0.622
DOC_USP7_MATH_1	105	109	PF00917	0.626
DOC_USP7_MATH_1	129	133	PF00917	0.649
DOC_USP7_MATH_1	142	146	PF00917	0.615
DOC_USP7_MATH_1	181	185	PF00917	0.550
DOC_USP7_MATH_1	277	281	PF00917	0.657
DOC_USP7_MATH_1	306	310	PF00917	0.568
DOC_USP7_MATH_1	33	37	PF00917	0.582
DOC_USP7_MATH_1	368	372	PF00917	0.633
DOC_USP7_MATH_1	401	405	PF00917	0.581
DOC_USP7_MATH_1	42	46	PF00917	0.514
DOC_USP7_MATH_1	477	481	PF00917	0.653
DOC_USP7_MATH_1	487	491	PF00917	0.572
DOC_USP7_MATH_1	563	567	PF00917	0.672
DOC_USP7_MATH_1	575	579	PF00917	0.649
DOC_USP7_MATH_1	609	613	PF00917	0.620
DOC_USP7_MATH_1	65	69	PF00917	0.633
DOC_USP7_MATH_1	659	663	PF00917	0.773
DOC_USP7_MATH_1	665	669	PF00917	0.669
DOC_USP7_MATH_1	676	680	PF00917	0.573
DOC_USP7_MATH_1	695	699	PF00917	0.798
DOC_USP7_MATH_1	714	718	PF00917	0.586
DOC_USP7_MATH_1	757	761	PF00917	0.648
DOC_USP7_MATH_1	784	788	PF00917	0.463
DOC_USP7_MATH_1	934	938	PF00917	0.722
DOC_USP7_MATH_1	96	100	PF00917	0.543
DOC_USP7_UBL2_3	353	357	PF12436	0.644
DOC_WW_Pin1_4	175	180	PF00397	0.611
DOC_WW_Pin1_4	209	214	PF00397	0.582
DOC_WW_Pin1_4	255	260	PF00397	0.653
DOC_WW_Pin1_4	377	382	PF00397	0.635
DOC_WW_Pin1_4	403	408	PF00397	0.628
DOC_WW_Pin1_4	464	469	PF00397	0.616
DOC_WW_Pin1_4	478	483	PF00397	0.588
DOC_WW_Pin1_4	5	10	PF00397	0.554
DOC_WW_Pin1_4	57	62	PF00397	0.643
DOC_WW_Pin1_4	571	576	PF00397	0.640
DOC_WW_Pin1_4	591	596	PF00397	0.662
DOC_WW_Pin1_4	597	602	PF00397	0.601
DOC_WW_Pin1_4	625	630	PF00397	0.616
DOC_WW_Pin1_4	685	690	PF00397	0.819
DOC_WW_Pin1_4	75	80	PF00397	0.589
DOC_WW_Pin1_4	829	834	PF00397	0.511
DOC_WW_Pin1_4	898	903	PF00397	0.369
DOC_WW_Pin1_4	926	931	PF00397	0.461
LIG_14-3-3_CanoR_1	288	297	PF00244	0.527
LIG_14-3-3_CanoR_1	402	406	PF00244	0.597
LIG_14-3-3_CanoR_1	461	468	PF00244	0.627
LIG_14-3-3_CanoR_1	620	629	PF00244	0.608
LIG_14-3-3_CanoR_1	653	663	PF00244	0.581
LIG_14-3-3_CanoR_1	678	687	PF00244	0.611
LIG_14-3-3_CanoR_1	761	770	PF00244	0.614
LIG_14-3-3_CanoR_1	780	789	PF00244	0.381
LIG_14-3-3_CanoR_1	845	853	PF00244	0.334
LIG_Actin_WH2_2	775	793	PF00022	0.408
LIG_BRCT_BRCA1_1	479	483	PF00533	0.608
LIG_BRCT_BRCA1_1	7	11	PF00533	0.551
LIG_BRCT_BRCA1_1	719	723	PF00533	0.626
LIG_CSL_BTD_1	256	259	PF09270	0.490
LIG_FHA_1	269	275	PF00498	0.599
LIG_FHA_1	292	298	PF00498	0.502
LIG_FHA_1	32	38	PF00498	0.623
LIG_FHA_1	388	394	PF00498	0.643
LIG_FHA_1	404	410	PF00498	0.683
LIG_FHA_1	41	47	PF00498	0.515
LIG_FHA_1	433	439	PF00498	0.628
LIG_FHA_1	522	528	PF00498	0.690
LIG_FHA_1	598	604	PF00498	0.641
LIG_FHA_1	621	627	PF00498	0.657
LIG_FHA_1	72	78	PF00498	0.591
LIG_FHA_1	829	835	PF00498	0.508
LIG_FHA_2	163	169	PF00498	0.680
LIG_FHA_2	240	246	PF00498	0.622
LIG_FHA_2	367	373	PF00498	0.721
LIG_FHA_2	374	380	PF00498	0.541
LIG_FHA_2	428	434	PF00498	0.639
LIG_FHA_2	846	852	PF00498	0.291
LIG_FHA_2	901	907	PF00498	0.369
LIG_LIR_Apic_2	896	902	PF02991	0.369
LIG_LIR_Gen_1	140	150	PF02991	0.613
LIG_LIR_Gen_1	199	205	PF02991	0.628
LIG_LIR_Gen_1	768	778	PF02991	0.409
LIG_LIR_Gen_1	913	922	PF02991	0.304
LIG_LIR_Nem_3	140	146	PF02991	0.615
LIG_LIR_Nem_3	199	204	PF02991	0.629
LIG_LIR_Nem_3	768	773	PF02991	0.438
LIG_LIR_Nem_3	8	14	PF02991	0.619
LIG_LIR_Nem_3	850	856	PF02991	0.310
LIG_LIR_Nem_3	906	910	PF02991	0.304
LIG_LIR_Nem_3	913	918	PF02991	0.304
LIG_MAD2	474	482	PF02301	0.592
LIG_MYND_1	842	846	PF01753	0.325
LIG_Pex14_2	197	201	PF04695	0.571
LIG_SH2_CRK	143	147	PF00017	0.627
LIG_SH2_CRK	770	774	PF00017	0.392
LIG_SH2_NCK_1	122	126	PF00017	0.586
LIG_SH2_NCK_1	143	147	PF00017	0.627
LIG_SH2_NCK_1	312	316	PF00017	0.537
LIG_SH2_NCK_1	320	324	PF00017	0.529
LIG_SH2_NCK_1	899	903	PF00017	0.369
LIG_SH2_SRC	312	315	PF00017	0.495
LIG_SH2_SRC	320	323	PF00017	0.564
LIG_SH2_SRC	857	860	PF00017	0.369
LIG_SH2_STAP1	122	126	PF00017	0.485
LIG_SH2_STAP1	143	147	PF00017	0.627
LIG_SH2_STAP1	770	774	PF00017	0.380
LIG_SH2_STAT3	16	19	PF00017	0.637
LIG_SH2_STAT5	16	19	PF00017	0.637
LIG_SH3_3	186	192	PF00018	0.575
LIG_SH3_3	253	259	PF00018	0.637
LIG_SH3_3	55	61	PF00018	0.542
LIG_SH3_3	626	632	PF00018	0.560
LIG_SH3_3	76	82	PF00018	0.587
LIG_SH3_3	840	846	PF00018	0.284
LIG_SH3_3	906	912	PF00018	0.304
LIG_SH3_4	353	360	PF00018	0.588
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.514
LIG_TRAF2_1	848	851	PF00917	0.304
LIG_TYR_ITIM	12	17	PF00017	0.628
LIG_TYR_ITIM	318	323	PF00017	0.480
LIG_TYR_ITSM	766	773	PF00017	0.442
LIG_WRC_WIRS_1	37	42	PF05994	0.617
MOD_CDC14_SPxK_1	688	691	PF00782	0.676
MOD_CDC14_SPxK_1	901	904	PF00782	0.369
MOD_CDK_SPK_2	377	382	PF00069	0.700
MOD_CDK_SPxK_1	377	383	PF00069	0.635
MOD_CDK_SPxK_1	468	474	PF00069	0.605
MOD_CDK_SPxK_1	571	577	PF00069	0.658
MOD_CDK_SPxK_1	685	691	PF00069	0.680
MOD_CDK_SPxK_1	898	904	PF00069	0.369
MOD_CDK_SPxxK_3	377	384	PF00069	0.635
MOD_CDK_SPxxK_3	829	836	PF00069	0.509
MOD_CK1_1	108	114	PF00069	0.532
MOD_CK1_1	258	264	PF00069	0.659
MOD_CK1_1	291	297	PF00069	0.570
MOD_CK1_1	324	330	PF00069	0.740
MOD_CK1_1	36	42	PF00069	0.564
MOD_CK1_1	363	369	PF00069	0.562
MOD_CK1_1	389	395	PF00069	0.696
MOD_CK1_1	532	538	PF00069	0.531
MOD_CK1_1	56	62	PF00069	0.728
MOD_CK1_1	640	646	PF00069	0.633
MOD_CK1_1	649	655	PF00069	0.626
MOD_CK1_1	679	685	PF00069	0.628
MOD_CK1_1	717	723	PF00069	0.656
MOD_CK1_1	725	731	PF00069	0.605
MOD_CK1_1	747	753	PF00069	0.731
MOD_CK1_1	78	84	PF00069	0.575
MOD_CK1_1	829	835	PF00069	0.508
MOD_CK1_1	90	96	PF00069	0.611
MOD_CK1_1	913	919	PF00069	0.369
MOD_CK1_1	99	105	PF00069	0.654
MOD_CK2_1	162	168	PF00069	0.678
MOD_CK2_1	239	245	PF00069	0.632
MOD_CK2_1	366	372	PF00069	0.710
MOD_CK2_1	373	379	PF00069	0.548
MOD_CK2_1	654	660	PF00069	0.678
MOD_CK2_1	679	685	PF00069	0.627
MOD_CK2_1	845	851	PF00069	0.328
MOD_Cter_Amidation	459	462	PF01082	0.630
MOD_GlcNHglycan	105	108	PF01048	0.575
MOD_GlcNHglycan	132	135	PF01048	0.644
MOD_GlcNHglycan	151	154	PF01048	0.651
MOD_GlcNHglycan	279	282	PF01048	0.699
MOD_GlcNHglycan	29	32	PF01048	0.493
MOD_GlcNHglycan	290	293	PF01048	0.484
MOD_GlcNHglycan	323	326	PF01048	0.659
MOD_GlcNHglycan	331	334	PF01048	0.620
MOD_GlcNHglycan	362	365	PF01048	0.667
MOD_GlcNHglycan	489	492	PF01048	0.753
MOD_GlcNHglycan	514	517	PF01048	0.653
MOD_GlcNHglycan	532	535	PF01048	0.517
MOD_GlcNHglycan	565	568	PF01048	0.561
MOD_GlcNHglycan	607	610	PF01048	0.628
MOD_GlcNHglycan	611	614	PF01048	0.612
MOD_GlcNHglycan	639	642	PF01048	0.650
MOD_GlcNHglycan	656	659	PF01048	0.543
MOD_GlcNHglycan	693	696	PF01048	0.676
MOD_GlcNHglycan	719	722	PF01048	0.664
MOD_GlcNHglycan	725	728	PF01048	0.604
MOD_GlcNHglycan	746	749	PF01048	0.670
MOD_GlcNHglycan	750	753	PF01048	0.657
MOD_GlcNHglycan	786	789	PF01048	0.315
MOD_GlcNHglycan	828	831	PF01048	0.545
MOD_GlcNHglycan	93	96	PF01048	0.598
MOD_GlcNHglycan	936	939	PF01048	0.595
MOD_GSK3_1	105	112	PF00069	0.525
MOD_GSK3_1	203	210	PF00069	0.555
MOD_GSK3_1	27	34	PF00069	0.578
MOD_GSK3_1	275	282	PF00069	0.673
MOD_GSK3_1	335	342	PF00069	0.763
MOD_GSK3_1	359	366	PF00069	0.566
MOD_GSK3_1	36	43	PF00069	0.703
MOD_GSK3_1	368	375	PF00069	0.615
MOD_GSK3_1	382	389	PF00069	0.669
MOD_GSK3_1	401	408	PF00069	0.817
MOD_GSK3_1	423	430	PF00069	0.787
MOD_GSK3_1	460	467	PF00069	0.666
MOD_GSK3_1	487	494	PF00069	0.705
MOD_GSK3_1	49	56	PF00069	0.495
MOD_GSK3_1	501	508	PF00069	0.530
MOD_GSK3_1	517	524	PF00069	0.622
MOD_GSK3_1	529	536	PF00069	0.709
MOD_GSK3_1	552	559	PF00069	0.744
MOD_GSK3_1	571	578	PF00069	0.522
MOD_GSK3_1	605	612	PF00069	0.675
MOD_GSK3_1	621	628	PF00069	0.612
MOD_GSK3_1	636	643	PF00069	0.613
MOD_GSK3_1	645	652	PF00069	0.723
MOD_GSK3_1	654	661	PF00069	0.635
MOD_GSK3_1	691	698	PF00069	0.759
MOD_GSK3_1	71	78	PF00069	0.640
MOD_GSK3_1	715	722	PF00069	0.641
MOD_GSK3_1	739	746	PF00069	0.682
MOD_GSK3_1	747	754	PF00069	0.595
MOD_GSK3_1	757	764	PF00069	0.516
MOD_GSK3_1	780	787	PF00069	0.395
MOD_GSK3_1	828	835	PF00069	0.491
MOD_GSK3_1	87	94	PF00069	0.520
MOD_GSK3_1	926	933	PF00069	0.516
MOD_GSK3_1	943	950	PF00069	0.608
MOD_GSK3_1	96	103	PF00069	0.690
MOD_LATS_1	499	505	PF00433	0.675
MOD_N-GLC_1	207	212	PF02516	0.530
MOD_N-GLC_1	27	32	PF02516	0.482
MOD_N-GLC_1	4	9	PF02516	0.617
MOD_N-GLC_1	555	560	PF02516	0.595
MOD_N-GLC_1	575	580	PF02516	0.496
MOD_N-GLC_1	620	625	PF02516	0.704
MOD_N-GLC_1	696	701	PF02516	0.644
MOD_NEK2_1	38	43	PF00069	0.554
MOD_NEK2_1	387	392	PF00069	0.528
MOD_NEK2_1	4	9	PF00069	0.600
MOD_NEK2_1	439	444	PF00069	0.618
MOD_NEK2_1	49	54	PF00069	0.569
MOD_NEK2_1	517	522	PF00069	0.623
MOD_NEK2_1	585	590	PF00069	0.662
MOD_NEK2_1	64	69	PF00069	0.564
MOD_NEK2_1	723	728	PF00069	0.510
MOD_NEK2_1	91	96	PF00069	0.587
MOD_NEK2_2	33	38	PF00069	0.583
MOD_NEK2_2	412	417	PF00069	0.556
MOD_NEK2_2	893	898	PF00069	0.369
MOD_PIKK_1	109	115	PF00454	0.604
MOD_PIKK_1	162	168	PF00454	0.601
MOD_PIKK_1	196	202	PF00454	0.632
MOD_PIKK_1	268	274	PF00454	0.620
MOD_PIKK_1	279	285	PF00454	0.646
MOD_PIKK_1	297	303	PF00454	0.383
MOD_PIKK_1	306	312	PF00454	0.524
MOD_PIKK_1	31	37	PF00454	0.586
MOD_PIKK_1	335	341	PF00454	0.654
MOD_PIKK_1	708	714	PF00454	0.708
MOD_PIKK_1	734	740	PF00454	0.621
MOD_PK_1	434	440	PF00069	0.622
MOD_PKA_1	288	294	PF00069	0.604
MOD_PKA_1	739	745	PF00069	0.653
MOD_PKA_1	780	786	PF00069	0.368
MOD_PKA_2	227	233	PF00069	0.693
MOD_PKA_2	288	294	PF00069	0.593
MOD_PKA_2	339	345	PF00069	0.656
MOD_PKA_2	359	365	PF00069	0.645
MOD_PKA_2	401	407	PF00069	0.590
MOD_PKA_2	460	466	PF00069	0.630
MOD_PKA_2	521	527	PF00069	0.687
MOD_PKA_2	609	615	PF00069	0.615
MOD_PKA_2	695	701	PF00069	0.621
MOD_PKA_2	739	745	PF00069	0.653
MOD_PKA_2	765	771	PF00069	0.473
MOD_PKA_2	780	786	PF00069	0.360
MOD_Plk_1	207	213	PF00069	0.532
MOD_Plk_1	505	511	PF00069	0.614
MOD_Plk_1	575	581	PF00069	0.499
MOD_Plk_1	620	626	PF00069	0.705
MOD_Plk_1	659	665	PF00069	0.774
MOD_Plk_1	863	869	PF00069	0.326
MOD_Plk_2-3	427	433	PF00069	0.584
MOD_Plk_4	33	39	PF00069	0.625
MOD_Plk_4	42	48	PF00069	0.542
MOD_Plk_4	434	440	PF00069	0.622
MOD_Plk_4	621	627	PF00069	0.611
MOD_Plk_4	719	725	PF00069	0.504
MOD_Plk_4	87	93	PF00069	0.531
MOD_Plk_4	893	899	PF00069	0.304
MOD_Plk_4	910	916	PF00069	0.183
MOD_ProDKin_1	175	181	PF00069	0.608
MOD_ProDKin_1	209	215	PF00069	0.587
MOD_ProDKin_1	255	261	PF00069	0.656
MOD_ProDKin_1	377	383	PF00069	0.635
MOD_ProDKin_1	403	409	PF00069	0.628
MOD_ProDKin_1	464	470	PF00069	0.616
MOD_ProDKin_1	478	484	PF00069	0.587
MOD_ProDKin_1	5	11	PF00069	0.553
MOD_ProDKin_1	57	63	PF00069	0.644
MOD_ProDKin_1	571	577	PF00069	0.643
MOD_ProDKin_1	591	597	PF00069	0.661
MOD_ProDKin_1	625	631	PF00069	0.617
MOD_ProDKin_1	685	691	PF00069	0.822
MOD_ProDKin_1	75	81	PF00069	0.588
MOD_ProDKin_1	829	835	PF00069	0.508
MOD_ProDKin_1	898	904	PF00069	0.369
MOD_ProDKin_1	926	932	PF00069	0.468
TRG_DiLeu_BaEn_1	314	319	PF01217	0.496
TRG_DiLeu_BaEn_2	478	484	PF01217	0.567
TRG_DiLeu_BaEn_4	851	857	PF01217	0.304
TRG_DiLeu_BaLyEn_6	906	911	PF01217	0.304
TRG_ENDOCYTIC_2	14	17	PF00928	0.633
TRG_ENDOCYTIC_2	143	146	PF00928	0.628
TRG_ENDOCYTIC_2	320	323	PF00928	0.486
TRG_ENDOCYTIC_2	770	773	PF00928	0.394
TRG_ENDOCYTIC_2	853	856	PF00928	0.310
TRG_ENDOCYTIC_2	857	860	PF00928	0.325
TRG_ER_diArg_1	288	290	PF00400	0.579
TRG_ER_diArg_1	780	782	PF00400	0.410
TRG_NLS_MonoExtC_3	381	386	PF00514	0.648
TRG_NLS_MonoExtN_4	381	386	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	854	859	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9G3	Leptomonas seymouri	44%	88%
A0A3S5H6N7	Leishmania donovani	90%	100%
A4H758	Leishmania braziliensis	71%	100%
A4HVJ7	Leishmania infantum	90%	100%
Q4QG85	Leishmania major	89%	100%