Peptidase_M24 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metallopeptidase family M24, putative

Species:

Leishmania mexicana

UniProt:

E9AP92_LEIMU

TriTrypDb:

LmxM.13.0680

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AP92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP92

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004177	aminopeptidase activity	5	6
GO:0008233	peptidase activity	3	6
GO:0008238	exopeptidase activity	4	6
GO:0016787	hydrolase activity	2	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	477	483	PF00089	0.326
CLV_NRD_NRD_1	120	122	PF00675	0.634
CLV_NRD_NRD_1	281	283	PF00675	0.262
CLV_NRD_NRD_1	362	364	PF00675	0.417
CLV_NRD_NRD_1	409	411	PF00675	0.371
CLV_NRD_NRD_1	459	461	PF00675	0.324
CLV_NRD_NRD_1	528	530	PF00675	0.509
CLV_NRD_NRD_1	68	70	PF00675	0.712
CLV_NRD_NRD_1	78	80	PF00675	0.721
CLV_PCSK_FUR_1	18	22	PF00082	0.474
CLV_PCSK_FUR_1	347	351	PF00082	0.342
CLV_PCSK_FUR_1	76	80	PF00082	0.714
CLV_PCSK_KEX2_1	120	122	PF00082	0.650
CLV_PCSK_KEX2_1	20	22	PF00082	0.430
CLV_PCSK_KEX2_1	205	207	PF00082	0.387
CLV_PCSK_KEX2_1	283	285	PF00082	0.264
CLV_PCSK_KEX2_1	349	351	PF00082	0.370
CLV_PCSK_KEX2_1	362	364	PF00082	0.403
CLV_PCSK_KEX2_1	409	411	PF00082	0.371
CLV_PCSK_KEX2_1	490	492	PF00082	0.374
CLV_PCSK_KEX2_1	528	530	PF00082	0.584
CLV_PCSK_KEX2_1	554	556	PF00082	0.630
CLV_PCSK_KEX2_1	78	80	PF00082	0.713
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.430
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.374
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.216
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.370
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.417
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.628
CLV_PCSK_SKI1_1	193	197	PF00082	0.367
CLV_PCSK_SKI1_1	305	309	PF00082	0.345
CLV_PCSK_SKI1_1	362	366	PF00082	0.427
CLV_PCSK_SKI1_1	403	407	PF00082	0.538
CLV_PCSK_SKI1_1	41	45	PF00082	0.375
CLV_PCSK_SKI1_1	490	494	PF00082	0.427
CLV_PCSK_SKI1_1	543	547	PF00082	0.552
CLV_PCSK_SKI1_1	69	73	PF00082	0.721
CLV_Separin_Metazoa	66	70	PF03568	0.558
DEG_APCC_DBOX_1	119	127	PF00400	0.519
DEG_APCC_DBOX_1	304	312	PF00400	0.285
DEG_APCC_DBOX_1	68	76	PF00400	0.602
DEG_SCF_FBW7_1	499	506	PF00400	0.322
DEG_SPOP_SBC_1	85	89	PF00917	0.472
DOC_ANK_TNKS_1	349	356	PF00023	0.304
DOC_CKS1_1	500	505	PF01111	0.490
DOC_CYCLIN_RxL_1	190	199	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	527	533	PF00134	0.388
DOC_MAPK_FxFP_2	436	439	PF00069	0.452
DOC_MAPK_gen_1	18	27	PF00069	0.470
DOC_MAPK_gen_1	450	457	PF00069	0.456
DOC_MAPK_MEF2A_6	11	19	PF00069	0.494
DOC_MAPK_MEF2A_6	238	247	PF00069	0.275
DOC_MAPK_MEF2A_6	450	457	PF00069	0.389
DOC_PP4_FxxP_1	436	439	PF00568	0.452
DOC_USP7_MATH_1	106	110	PF00917	0.643
DOC_USP7_MATH_1	187	191	PF00917	0.175
DOC_USP7_MATH_1	422	426	PF00917	0.295
DOC_USP7_MATH_1	48	52	PF00917	0.664
DOC_USP7_MATH_1	512	516	PF00917	0.482
DOC_USP7_MATH_1	54	58	PF00917	0.775
DOC_USP7_MATH_1	7	11	PF00917	0.665
DOC_WW_Pin1_4	108	113	PF00397	0.553
DOC_WW_Pin1_4	224	229	PF00397	0.387
DOC_WW_Pin1_4	408	413	PF00397	0.488
DOC_WW_Pin1_4	499	504	PF00397	0.510
DOC_WW_Pin1_4	547	552	PF00397	0.672
LIG_14-3-3_CanoR_1	209	214	PF00244	0.303
LIG_14-3-3_CanoR_1	21	26	PF00244	0.497
LIG_14-3-3_CanoR_1	282	291	PF00244	0.406
LIG_14-3-3_CanoR_1	362	369	PF00244	0.431
LIG_14-3-3_CanoR_1	397	407	PF00244	0.473
LIG_14-3-3_CanoR_1	480	486	PF00244	0.317
LIG_14-3-3_CanoR_1	491	495	PF00244	0.357
LIG_14-3-3_CanoR_1	511	519	PF00244	0.334
LIG_14-3-3_CanoR_1	79	85	PF00244	0.556
LIG_Actin_WH2_2	302	318	PF00022	0.417
LIG_BRCT_BRCA1_1	115	119	PF00533	0.623
LIG_BRCT_BRCA1_1	56	60	PF00533	0.464
LIG_DLG_GKlike_1	23	30	PF00625	0.468
LIG_FHA_1	175	181	PF00498	0.302
LIG_FHA_1	259	265	PF00498	0.315
LIG_FHA_1	323	329	PF00498	0.331
LIG_FHA_1	482	488	PF00498	0.357
LIG_FHA_1	499	505	PF00498	0.480
LIG_FHA_2	177	183	PF00498	0.370
LIG_FHA_2	271	277	PF00498	0.388
LIG_FHA_2	363	369	PF00498	0.463
LIG_FHA_2	397	403	PF00498	0.457
LIG_FHA_2	409	415	PF00498	0.355
LIG_FHA_2	425	431	PF00498	0.494
LIG_FHA_2	511	517	PF00498	0.564
LIG_GSK3_LRP6_1	499	504	PF00069	0.316
LIG_LIR_Apic_2	433	439	PF02991	0.449
LIG_LIR_Gen_1	532	540	PF02991	0.477
LIG_LIR_Nem_3	532	536	PF02991	0.440
LIG_MAD2	73	81	PF02301	0.572
LIG_PCNA_yPIPBox_3	209	223	PF02747	0.340
LIG_PCNA_yPIPBox_3	316	328	PF02747	0.353
LIG_Pex14_2	436	440	PF04695	0.449
LIG_RPA_C_Fungi	18	30	PF08784	0.586
LIG_SH2_STAT3	335	338	PF00017	0.417
LIG_SH2_STAT5	476	479	PF00017	0.440
LIG_SH3_3	497	503	PF00018	0.413
LIG_SUMO_SIM_anti_2	522	528	PF11976	0.378
LIG_SUMO_SIM_par_1	260	266	PF11976	0.300
LIG_SUMO_SIM_par_1	482	488	PF11976	0.352
LIG_TRAF2_1	427	430	PF00917	0.402
MOD_CDC14_SPxK_1	227	230	PF00782	0.417
MOD_CDK_SPK_2	108	113	PF00069	0.448
MOD_CDK_SPxK_1	224	230	PF00069	0.417
MOD_CDK_SPxxK_3	547	554	PF00069	0.671
MOD_CK1_1	111	117	PF00069	0.466
MOD_CK1_1	212	218	PF00069	0.309
MOD_CK1_1	270	276	PF00069	0.354
MOD_CK1_1	292	298	PF00069	0.422
MOD_CK1_1	515	521	PF00069	0.543
MOD_CK1_1	550	556	PF00069	0.672
MOD_CK1_1	58	64	PF00069	0.754
MOD_CK1_1	83	89	PF00069	0.676
MOD_CK2_1	134	140	PF00069	0.573
MOD_CK2_1	180	186	PF00069	0.266
MOD_CK2_1	215	221	PF00069	0.395
MOD_CK2_1	396	402	PF00069	0.454
MOD_CK2_1	424	430	PF00069	0.394
MOD_CK2_1	510	516	PF00069	0.440
MOD_Cter_Amidation	203	206	PF01082	0.363
MOD_Cter_Amidation	347	350	PF01082	0.389
MOD_GlcNHglycan	108	111	PF01048	0.535
MOD_GlcNHglycan	11	14	PF01048	0.511
MOD_GlcNHglycan	115	118	PF01048	0.516
MOD_GlcNHglycan	167	170	PF01048	0.226
MOD_GlcNHglycan	256	259	PF01048	0.329
MOD_GlcNHglycan	269	272	PF01048	0.290
MOD_GlcNHglycan	294	297	PF01048	0.398
MOD_GlcNHglycan	481	484	PF01048	0.339
MOD_GlcNHglycan	5	8	PF01048	0.560
MOD_GlcNHglycan	50	53	PF01048	0.653
MOD_GlcNHglycan	60	63	PF01048	0.769
MOD_GlcNHglycan	88	91	PF01048	0.667
MOD_GlcNHglycan	97	100	PF01048	0.667
MOD_GSK3_1	102	109	PF00069	0.589
MOD_GSK3_1	140	147	PF00069	0.470
MOD_GSK3_1	176	183	PF00069	0.175
MOD_GSK3_1	19	26	PF00069	0.436
MOD_GSK3_1	254	261	PF00069	0.311
MOD_GSK3_1	263	270	PF00069	0.321
MOD_GSK3_1	283	290	PF00069	0.345
MOD_GSK3_1	3	10	PF00069	0.530
MOD_GSK3_1	475	482	PF00069	0.394
MOD_GSK3_1	499	506	PF00069	0.621
MOD_GSK3_1	50	57	PF00069	0.731
MOD_GSK3_1	58	65	PF00069	0.533
MOD_GSK3_1	79	86	PF00069	0.679
MOD_GSK3_1	91	98	PF00069	0.637
MOD_N-GLC_1	145	150	PF02516	0.511
MOD_N-GLC_1	215	220	PF02516	0.285
MOD_N-GLC_1	224	229	PF02516	0.285
MOD_NEK2_1	145	150	PF00069	0.540
MOD_NEK2_1	19	24	PF00069	0.499
MOD_NEK2_1	196	201	PF00069	0.500
MOD_NEK2_1	481	486	PF00069	0.344
MOD_NEK2_1	84	89	PF00069	0.595
MOD_PIKK_1	111	117	PF00454	0.702
MOD_PKA_1	282	288	PF00069	0.266
MOD_PKA_1	362	368	PF00069	0.425
MOD_PKA_1	490	496	PF00069	0.363
MOD_PKA_2	13	19	PF00069	0.482
MOD_PKA_2	283	289	PF00069	0.475
MOD_PKA_2	362	368	PF00069	0.445
MOD_PKA_2	396	402	PF00069	0.447
MOD_PKA_2	479	485	PF00069	0.316
MOD_PKA_2	490	496	PF00069	0.336
MOD_PKA_2	510	516	PF00069	0.595
MOD_PKB_1	21	29	PF00069	0.451
MOD_PKB_1	282	290	PF00069	0.233
MOD_Plk_1	140	146	PF00069	0.528
MOD_Plk_1	215	221	PF00069	0.285
MOD_Plk_1	515	521	PF00069	0.420
MOD_Plk_4	140	146	PF00069	0.425
MOD_Plk_4	403	409	PF00069	0.348
MOD_Plk_4	490	496	PF00069	0.355
MOD_Plk_4	80	86	PF00069	0.561
MOD_ProDKin_1	108	114	PF00069	0.548
MOD_ProDKin_1	224	230	PF00069	0.387
MOD_ProDKin_1	408	414	PF00069	0.502
MOD_ProDKin_1	499	505	PF00069	0.517
MOD_ProDKin_1	547	553	PF00069	0.669
TRG_ER_diArg_1	119	121	PF00400	0.567
TRG_ER_diArg_1	362	364	PF00400	0.432
TRG_ER_diArg_1	408	410	PF00400	0.346
TRG_ER_diArg_1	527	529	PF00400	0.385
TRG_ER_diArg_1	555	558	PF00400	0.695
TRG_ER_diArg_1	75	78	PF00400	0.719
TRG_NLS_MonoExtC_3	553	559	PF00514	0.628
TRG_NLS_MonoExtN_4	18	24	PF00514	0.464
TRG_NLS_MonoExtN_4	551	558	PF00514	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIM1	Leptomonas seymouri	28%	100%
A0A0N1IM06	Leptomonas seymouri	68%	98%
A0A0S4J160	Bodo saltans	30%	100%
A0A1X0NPS8	Trypanosomatidae	46%	100%
A0A3Q8IBA7	Leishmania donovani	29%	100%
A0A3Q8IBP5	Leishmania donovani	89%	98%
A0A3R7KN75	Trypanosoma rangeli	45%	100%
A4H757	Leishmania braziliensis	80%	100%
A4H9X3	Leishmania braziliensis	30%	100%
A4HVJ6	Leishmania infantum	89%	98%
D0A6Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AGR8	Leishmania infantum	29%	100%
E9ARW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4QDK5	Leishmania major	30%	100%
Q4QG86	Leishmania major	85%	99%
V5BFG1	Trypanosoma cruzi	47%	100%