Putative lectin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lectin

Gene product:

mannose-specific lectin, putative

Species:

Leishmania mexicana

UniProt:

E9AP91_LEIMU

TriTrypDb:

LmxM.13.0670

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AP91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP91

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0030246	carbohydrate binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.519
CLV_NRD_NRD_1	138	140	PF00675	0.535
CLV_NRD_NRD_1	390	392	PF00675	0.589
CLV_NRD_NRD_1	405	407	PF00675	0.575
CLV_NRD_NRD_1	430	432	PF00675	0.638
CLV_NRD_NRD_1	433	435	PF00675	0.637
CLV_PCSK_FUR_1	428	432	PF00082	0.783
CLV_PCSK_KEX2_1	138	140	PF00082	0.534
CLV_PCSK_KEX2_1	390	392	PF00082	0.573
CLV_PCSK_KEX2_1	405	407	PF00082	0.596
CLV_PCSK_KEX2_1	430	432	PF00082	0.776
CLV_PCSK_KEX2_1	433	435	PF00082	0.800
CLV_PCSK_SKI1_1	17	21	PF00082	0.465
DEG_SCF_FBW7_2	8	15	PF00400	0.454
DOC_MAPK_gen_1	138	146	PF00069	0.334
DOC_MAPK_MEF2A_6	138	146	PF00069	0.448
DOC_MAPK_MEF2A_6	192	199	PF00069	0.335
DOC_MAPK_NFAT4_5	192	200	PF00069	0.280
DOC_MIT_MIM_1	386	396	PF04212	0.530
DOC_PP1_RVXF_1	185	192	PF00149	0.298
DOC_PP2B_LxvP_1	216	219	PF13499	0.335
DOC_PP4_FxxP_1	112	115	PF00568	0.326
DOC_PP4_FxxP_1	117	120	PF00568	0.317
DOC_PP4_FxxP_1	28	31	PF00568	0.335
DOC_USP7_MATH_1	142	146	PF00917	0.335
DOC_WW_Pin1_4	243	248	PF00397	0.390
DOC_WW_Pin1_4	434	439	PF00397	0.705
DOC_WW_Pin1_4	8	13	PF00397	0.462
LIG_14-3-3_CanoR_1	119	124	PF00244	0.298
LIG_14-3-3_CanoR_1	258	263	PF00244	0.749
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BIR_III_3	1	5	PF00653	0.570
LIG_BRCT_BRCA1_1	169	173	PF00533	0.335
LIG_FHA_1	18	24	PF00498	0.456
LIG_FHA_1	206	212	PF00498	0.335
LIG_FHA_1	229	235	PF00498	0.359
LIG_FHA_1	262	268	PF00498	0.648
LIG_FHA_1	372	378	PF00498	0.771
LIG_FHA_1	402	408	PF00498	0.654
LIG_FHA_1	66	72	PF00498	0.393
LIG_FHA_2	204	210	PF00498	0.335
LIG_HP1_1	142	146	PF01393	0.335
LIG_LIR_Apic_2	27	31	PF02991	0.335
LIG_LIR_Gen_1	239	249	PF02991	0.335
LIG_LIR_Gen_1	54	62	PF02991	0.335
LIG_LIR_Gen_1	80	90	PF02991	0.335
LIG_LIR_Nem_3	121	126	PF02991	0.334
LIG_LIR_Nem_3	174	178	PF02991	0.369
LIG_LIR_Nem_3	239	245	PF02991	0.335
LIG_LIR_Nem_3	54	60	PF02991	0.335
LIG_LIR_Nem_3	80	85	PF02991	0.335
LIG_MYND_1	8	12	PF01753	0.458
LIG_Pex14_2	126	130	PF04695	0.335
LIG_SH2_GRB2like	133	136	PF00017	0.335
LIG_SH2_PTP2	57	60	PF00017	0.335
LIG_SH2_STAP1	253	257	PF00017	0.611
LIG_SH2_STAT5	190	193	PF00017	0.308
LIG_SH2_STAT5	198	201	PF00017	0.298
LIG_SH2_STAT5	224	227	PF00017	0.298
LIG_SH2_STAT5	418	421	PF00017	0.527
LIG_SH2_STAT5	57	60	PF00017	0.335
LIG_SH3_3	103	109	PF00018	0.246
LIG_SH3_3	87	93	PF00018	0.335
LIG_TRAF2_1	12	15	PF00917	0.507
LIG_TRAF2_1	296	299	PF00917	0.605
LIG_WW_3	108	112	PF00397	0.335
MOD_CK1_1	200	206	PF00069	0.359
MOD_CK1_1	228	234	PF00069	0.341
MOD_CK1_1	48	54	PF00069	0.348
MOD_CK2_1	203	209	PF00069	0.335
MOD_DYRK1A_RPxSP_1	434	438	PF00069	0.702
MOD_GlcNHglycan	227	230	PF01048	0.535
MOD_GlcNHglycan	369	372	PF01048	0.664
MOD_GlcNHglycan	47	50	PF01048	0.619
MOD_GSK3_1	228	235	PF00069	0.359
MOD_GSK3_1	257	264	PF00069	0.673
MOD_GSK3_1	281	288	PF00069	0.665
MOD_GSK3_1	367	374	PF00069	0.707
MOD_GSK3_1	47	54	PF00069	0.328
MOD_NEK2_1	164	169	PF00069	0.335
MOD_NEK2_1	197	202	PF00069	0.285
MOD_NEK2_1	211	216	PF00069	0.285
MOD_NEK2_1	225	230	PF00069	0.270
MOD_PIKK_1	63	69	PF00454	0.298
MOD_PKA_2	118	124	PF00069	0.298
MOD_PKA_2	200	206	PF00069	0.308
MOD_PKA_2	211	217	PF00069	0.280
MOD_PKA_2	257	263	PF00069	0.745
MOD_PKA_2	401	407	PF00069	0.658
MOD_PKA_2	58	64	PF00069	0.335
MOD_Plk_4	142	148	PF00069	0.335
MOD_Plk_4	48	54	PF00069	0.335
MOD_ProDKin_1	243	249	PF00069	0.405
MOD_ProDKin_1	434	440	PF00069	0.706
MOD_ProDKin_1	8	14	PF00069	0.452
MOD_SUMO_for_1	191	194	PF00179	0.335
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.335
TRG_ENDOCYTIC_2	224	227	PF00928	0.298
TRG_ENDOCYTIC_2	57	60	PF00928	0.335
TRG_ENDOCYTIC_2	91	94	PF00928	0.326
TRG_ER_diArg_1	382	385	PF00400	0.601
TRG_ER_diArg_1	390	392	PF00400	0.529
TRG_ER_diArg_1	395	398	PF00400	0.537
TRG_ER_diArg_1	405	407	PF00400	0.570
TRG_ER_diArg_1	428	431	PF00400	0.653
TRG_ER_diArg_1	432	434	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8H3	Leishmania donovani	83%	100%
A4H756	Leishmania braziliensis	66%	100%
A4HVJ5	Leishmania infantum	83%	100%
Q5FB95	Rattus norvegicus	26%	89%
Q8VCD3	Mus musculus	25%	89%