RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP90_LEIMU

TriTrypDb:

LmxM.13.0660

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP90

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.435
CLV_C14_Caspase3-7	599	603	PF00656	0.624
CLV_NRD_NRD_1	596	598	PF00675	0.740
CLV_PCSK_FUR_1	694	698	PF00082	0.480
CLV_PCSK_KEX2_1	595	597	PF00082	0.743
CLV_PCSK_KEX2_1	616	618	PF00082	0.756
CLV_PCSK_KEX2_1	696	698	PF00082	0.609
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.732
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.642
CLV_PCSK_SKI1_1	123	127	PF00082	0.537
CLV_PCSK_SKI1_1	142	146	PF00082	0.526
CLV_PCSK_SKI1_1	319	323	PF00082	0.581
CLV_PCSK_SKI1_1	398	402	PF00082	0.346
CLV_PCSK_SKI1_1	466	470	PF00082	0.457
DEG_APCC_DBOX_1	141	149	PF00400	0.573
DEG_APCC_DBOX_1	465	473	PF00400	0.337
DEG_SCF_TRCP1_1	525	530	PF00400	0.512
DOC_CYCLIN_yClb1_LxF_4	566	572	PF00134	0.347
DOC_MAPK_gen_1	639	647	PF00069	0.339
DOC_MAPK_MEF2A_6	425	432	PF00069	0.517
DOC_PP1_RVXF_1	247	253	PF00149	0.513
DOC_PP1_RVXF_1	393	400	PF00149	0.340
DOC_PP2B_LxvP_1	186	189	PF13499	0.515
DOC_USP7_MATH_1	179	183	PF00917	0.516
DOC_USP7_MATH_1	201	205	PF00917	0.732
DOC_USP7_MATH_1	211	215	PF00917	0.708
DOC_USP7_MATH_1	25	29	PF00917	0.557
DOC_USP7_MATH_1	502	506	PF00917	0.468
DOC_USP7_MATH_1	557	561	PF00917	0.637
DOC_USP7_MATH_1	6	10	PF00917	0.515
DOC_USP7_MATH_1	608	612	PF00917	0.822
DOC_USP7_MATH_1	96	100	PF00917	0.268
DOC_USP7_UBL2_3	619	623	PF12436	0.620
DOC_WW_Pin1_4	115	120	PF00397	0.514
DOC_WW_Pin1_4	257	262	PF00397	0.586
DOC_WW_Pin1_4	362	367	PF00397	0.681
DOC_WW_Pin1_4	454	459	PF00397	0.543
DOC_WW_Pin1_4	516	521	PF00397	0.562
LIG_14-3-3_CanoR_1	249	253	PF00244	0.512
LIG_14-3-3_CanoR_1	330	335	PF00244	0.468
LIG_14-3-3_CanoR_1	478	482	PF00244	0.623
LIG_14-3-3_CanoR_1	588	594	PF00244	0.759
LIG_Actin_WH2_2	384	400	PF00022	0.447
LIG_Actin_WH2_2	633	650	PF00022	0.378
LIG_BRCT_BRCA1_1	203	207	PF00533	0.474
LIG_Clathr_ClatBox_1	441	445	PF01394	0.457
LIG_Clathr_ClatBox_1	555	559	PF01394	0.558
LIG_CtBP_PxDLS_1	261	265	PF00389	0.707
LIG_CtBP_PxDLS_1	458	462	PF00389	0.515
LIG_FAT_LD_1	241	249	PF03623	0.535
LIG_FHA_1	125	131	PF00498	0.375
LIG_FHA_1	15	21	PF00498	0.460
LIG_FHA_1	35	41	PF00498	0.474
LIG_FHA_1	377	383	PF00498	0.604
LIG_FHA_1	386	392	PF00498	0.375
LIG_FHA_1	407	413	PF00498	0.480
LIG_FHA_1	454	460	PF00498	0.486
LIG_FHA_1	573	579	PF00498	0.628
LIG_FHA_1	635	641	PF00498	0.335
LIG_FHA_1	88	94	PF00498	0.418
LIG_FHA_2	132	138	PF00498	0.465
LIG_FHA_2	192	198	PF00498	0.619
LIG_FHA_2	33	39	PF00498	0.520
LIG_FHA_2	366	372	PF00498	0.507
LIG_FHA_2	571	577	PF00498	0.605
LIG_GBD_Chelix_1	140	148	PF00786	0.479
LIG_GBD_Chelix_1	349	357	PF00786	0.329
LIG_LIR_Gen_1	124	133	PF02991	0.488
LIG_LIR_Gen_1	302	311	PF02991	0.425
LIG_LIR_Gen_1	518	529	PF02991	0.415
LIG_LIR_Gen_1	654	663	PF02991	0.447
LIG_LIR_Nem_3	124	129	PF02991	0.491
LIG_LIR_Nem_3	170	176	PF02991	0.401
LIG_LIR_Nem_3	302	307	PF02991	0.424
LIG_LIR_Nem_3	462	468	PF02991	0.412
LIG_LIR_Nem_3	654	658	PF02991	0.447
LIG_NRBOX	240	246	PF00104	0.532
LIG_NRBOX	392	398	PF00104	0.393
LIG_NRBOX	48	54	PF00104	0.474
LIG_NRBOX	573	579	PF00104	0.611
LIG_PCNA_PIPBox_1	177	186	PF02747	0.523
LIG_PCNA_yPIPBox_3	101	110	PF02747	0.595
LIG_Pex14_1	300	304	PF04695	0.509
LIG_SH2_CRK	434	438	PF00017	0.248
LIG_SH2_CRK	465	469	PF00017	0.489
LIG_SH2_SRC	268	271	PF00017	0.603
LIG_SH2_STAP1	136	140	PF00017	0.521
LIG_SH2_STAP1	184	188	PF00017	0.505
LIG_SH2_STAP1	268	272	PF00017	0.640
LIG_SH2_STAT5	193	196	PF00017	0.494
LIG_SH2_STAT5	632	635	PF00017	0.355
LIG_SH2_STAT5	78	81	PF00017	0.422
LIG_SH3_3	452	458	PF00018	0.572
LIG_SH3_3	679	685	PF00018	0.363
LIG_SH3_3	80	86	PF00018	0.491
LIG_SH3_4	619	626	PF00018	0.511
LIG_Sin3_3	141	148	PF02671	0.497
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.476
LIG_SUMO_SIM_anti_2	530	536	PF11976	0.444
LIG_SUMO_SIM_par_1	440	445	PF11976	0.343
LIG_SUMO_SIM_par_1	554	560	PF11976	0.605
LIG_TRAF2_1	103	106	PF00917	0.476
LIG_TRAF2_1	43	46	PF00917	0.608
LIG_TRAF2_1	539	542	PF00917	0.500
LIG_TYR_ITIM	432	437	PF00017	0.272
LIG_UBA3_1	468	476	PF00899	0.445
LIG_WRC_WIRS_1	216	221	PF05994	0.615
MOD_CK1_1	118	124	PF00069	0.566
MOD_CK1_1	215	221	PF00069	0.499
MOD_CK1_1	260	266	PF00069	0.649
MOD_CK1_1	302	308	PF00069	0.494
MOD_CK1_1	34	40	PF00069	0.491
MOD_CK1_1	385	391	PF00069	0.468
MOD_CK1_1	482	488	PF00069	0.687
MOD_CK1_1	610	616	PF00069	0.799
MOD_CK1_1	672	678	PF00069	0.480
MOD_CK1_1	99	105	PF00069	0.565
MOD_CK2_1	111	117	PF00069	0.570
MOD_CK2_1	118	124	PF00069	0.505
MOD_CK2_1	179	185	PF00069	0.464
MOD_CK2_1	191	197	PF00069	0.570
MOD_CK2_1	248	254	PF00069	0.484
MOD_CK2_1	570	576	PF00069	0.645
MOD_CK2_1	6	12	PF00069	0.581
MOD_CK2_1	672	678	PF00069	0.480
MOD_CK2_1	99	105	PF00069	0.467
MOD_GlcNHglycan	113	116	PF01048	0.707
MOD_GlcNHglycan	120	123	PF01048	0.492
MOD_GlcNHglycan	23	26	PF01048	0.452
MOD_GlcNHglycan	27	30	PF01048	0.445
MOD_GlcNHglycan	287	290	PF01048	0.622
MOD_GlcNHglycan	301	304	PF01048	0.368
MOD_GlcNHglycan	342	345	PF01048	0.512
MOD_GlcNHglycan	362	365	PF01048	0.706
MOD_GlcNHglycan	371	375	PF01048	0.560
MOD_GlcNHglycan	489	492	PF01048	0.771
MOD_GlcNHglycan	525	528	PF01048	0.583
MOD_GlcNHglycan	578	581	PF01048	0.690
MOD_GlcNHglycan	610	613	PF01048	0.730
MOD_GlcNHglycan	671	674	PF01048	0.447
MOD_GSK3_1	111	118	PF00069	0.483
MOD_GSK3_1	131	138	PF00069	0.474
MOD_GSK3_1	14	21	PF00069	0.460
MOD_GSK3_1	152	159	PF00069	0.497
MOD_GSK3_1	184	191	PF00069	0.418
MOD_GSK3_1	211	218	PF00069	0.575
MOD_GSK3_1	244	251	PF00069	0.489
MOD_GSK3_1	253	260	PF00069	0.597
MOD_GSK3_1	385	392	PF00069	0.507
MOD_GSK3_1	482	489	PF00069	0.677
MOD_GSK3_1	523	530	PF00069	0.523
MOD_GSK3_1	572	579	PF00069	0.594
MOD_GSK3_1	607	614	PF00069	0.735
MOD_GSK3_1	95	102	PF00069	0.567
MOD_N-GLC_1	100	105	PF02516	0.444
MOD_N-GLC_1	257	262	PF02516	0.638
MOD_N-GLC_1	459	464	PF02516	0.465
MOD_N-GLC_1	482	487	PF02516	0.640
MOD_N-GLC_1	527	532	PF02516	0.491
MOD_N-GLC_1	608	613	PF02516	0.738
MOD_NEK2_1	108	113	PF00069	0.484
MOD_NEK2_1	131	136	PF00069	0.403
MOD_NEK2_1	156	161	PF00069	0.409
MOD_NEK2_1	244	249	PF00069	0.530
MOD_NEK2_1	412	417	PF00069	0.405
MOD_NEK2_1	461	466	PF00069	0.432
MOD_NEK2_1	468	473	PF00069	0.391
MOD_NEK2_1	570	575	PF00069	0.534
MOD_NEK2_2	179	184	PF00069	0.486
MOD_PIKK_1	557	563	PF00454	0.627
MOD_PIKK_1	587	593	PF00454	0.750
MOD_PIKK_1	78	84	PF00454	0.487
MOD_PK_1	55	61	PF00069	0.477
MOD_PKA_1	623	629	PF00069	0.570
MOD_PKA_1	696	702	PF00069	0.671
MOD_PKA_2	131	137	PF00069	0.395
MOD_PKA_2	248	254	PF00069	0.536
MOD_PKA_2	477	483	PF00069	0.646
MOD_PKA_2	587	593	PF00069	0.756
MOD_PKA_2	696	702	PF00069	0.675
MOD_PKB_1	328	336	PF00069	0.512
MOD_Plk_1	100	106	PF00069	0.434
MOD_Plk_1	184	190	PF00069	0.515
MOD_Plk_1	527	533	PF00069	0.402
MOD_Plk_4	152	158	PF00069	0.527
MOD_Plk_4	179	185	PF00069	0.415
MOD_Plk_4	188	194	PF00069	0.427
MOD_Plk_4	382	388	PF00069	0.510
MOD_Plk_4	389	395	PF00069	0.482
MOD_Plk_4	55	61	PF00069	0.453
MOD_ProDKin_1	115	121	PF00069	0.501
MOD_ProDKin_1	257	263	PF00069	0.586
MOD_ProDKin_1	362	368	PF00069	0.679
MOD_ProDKin_1	454	460	PF00069	0.541
MOD_ProDKin_1	516	522	PF00069	0.558
MOD_SUMO_rev_2	316	324	PF00179	0.535
MOD_SUMO_rev_2	58	67	PF00179	0.379
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.546
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.518
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.567
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.516
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.305
TRG_ENDOCYTIC_2	434	437	PF00928	0.397
TRG_ENDOCYTIC_2	465	468	PF00928	0.493
TRG_ER_diArg_1	327	330	PF00400	0.526
TRG_ER_diArg_1	594	597	PF00400	0.737
TRG_NES_CRM1_1	501	516	PF08389	0.575
TRG_NES_CRM1_1	554	566	PF08389	0.567
TRG_NLS_MonoExtC_3	615	620	PF00514	0.667
TRG_NLS_MonoExtN_4	619	626	PF00514	0.651
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP8	Leptomonas seymouri	61%	100%
A0A1X0NN36	Trypanosomatidae	29%	100%
A0A3S7WSF2	Leishmania donovani	92%	100%
A0A422NQL1	Trypanosoma rangeli	30%	100%
A4H755	Leishmania braziliensis	81%	100%
A4HVJ4	Leishmania infantum	92%	100%
D0A6R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QG88	Leishmania major	92%	100%
V5BAU6	Trypanosoma cruzi	32%	100%