Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP89_LEIMU

TriTrypDb:

LmxM.13.0650

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AP89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP89

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016409	palmitoyltransferase activity	5	9
GO:0016417	S-acyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	9
GO:0019707	protein-cysteine S-acyltransferase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.546
CLV_MEL_PAP_1	80	86	PF00089	0.448
CLV_NRD_NRD_1	127	129	PF00675	0.398
CLV_NRD_NRD_1	167	169	PF00675	0.481
CLV_NRD_NRD_1	244	246	PF00675	0.480
CLV_NRD_NRD_1	250	252	PF00675	0.460
CLV_NRD_NRD_1	262	264	PF00675	0.409
CLV_NRD_NRD_1	275	277	PF00675	0.435
CLV_PCSK_KEX2_1	167	169	PF00082	0.481
CLV_PCSK_KEX2_1	244	246	PF00082	0.480
CLV_PCSK_KEX2_1	250	252	PF00082	0.460
CLV_PCSK_SKI1_1	20	24	PF00082	0.293
CLV_PCSK_SKI1_1	263	267	PF00082	0.374
DEG_APCC_DBOX_1	249	257	PF00400	0.619
DEG_APCC_DBOX_1	262	270	PF00400	0.588
DEG_APCC_DBOX_1	313	321	PF00400	0.509
DEG_APCC_DBOX_1	500	508	PF00400	0.604
DEG_SCF_FBW7_1	476	481	PF00400	0.503
DEG_SIAH_1	593	601	PF03145	0.698
DOC_AGCK_PIF_1	357	362	PF00069	0.179
DOC_CKS1_1	475	480	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.526
DOC_MAPK_gen_1	244	255	PF00069	0.637
DOC_MAPK_gen_1	276	283	PF00069	0.585
DOC_MAPK_gen_1	411	419	PF00069	0.497
DOC_MAPK_MEF2A_6	248	257	PF00069	0.611
DOC_MAPK_MEF2A_6	497	504	PF00069	0.588
DOC_MAPK_NFAT4_5	497	505	PF00069	0.591
DOC_PP2B_LxvP_1	468	471	PF13499	0.531
DOC_PP4_FxxP_1	283	286	PF00568	0.577
DOC_USP7_MATH_1	5	9	PF00917	0.694
DOC_USP7_MATH_2	77	83	PF00917	0.610
DOC_WW_Pin1_4	167	172	PF00397	0.672
DOC_WW_Pin1_4	3	8	PF00397	0.652
DOC_WW_Pin1_4	444	449	PF00397	0.715
DOC_WW_Pin1_4	474	479	PF00397	0.643
DOC_WW_Pin1_4	541	546	PF00397	0.709
DOC_WW_Pin1_4	581	586	PF00397	0.728
LIG_14-3-3_CanoR_1	128	134	PF00244	0.684
LIG_14-3-3_CanoR_1	167	171	PF00244	0.678
LIG_14-3-3_CanoR_1	503	508	PF00244	0.595
LIG_14-3-3_CanoR_1	83	89	PF00244	0.589
LIG_APCC_ABBA_1	187	192	PF00400	0.738
LIG_APCC_ABBAyCdc20_2	186	192	PF00400	0.737
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BRCT_BRCA1_1	380	384	PF00533	0.385
LIG_deltaCOP1_diTrp_1	491	496	PF00928	0.488
LIG_eIF4E_1	333	339	PF01652	0.447
LIG_eIF4E_1	340	346	PF01652	0.306
LIG_eIF4E_1	41	47	PF01652	0.534
LIG_FHA_1	195	201	PF00498	0.746
LIG_FHA_1	405	411	PF00498	0.623
LIG_FHA_1	475	481	PF00498	0.682
LIG_FHA_2	170	176	PF00498	0.699
LIG_FHA_2	179	185	PF00498	0.677
LIG_FHA_2	270	276	PF00498	0.610
LIG_FHA_2	461	467	PF00498	0.607
LIG_FHA_2	480	486	PF00498	0.559
LIG_FHA_2	568	574	PF00498	0.589
LIG_LIR_Apic_2	280	286	PF02991	0.576
LIG_LIR_Apic_2	584	590	PF02991	0.598
LIG_LIR_Gen_1	331	341	PF02991	0.559
LIG_LIR_Gen_1	352	362	PF02991	0.322
LIG_LIR_Gen_1	372	382	PF02991	0.232
LIG_LIR_Gen_1	383	392	PF02991	0.291
LIG_LIR_Gen_1	491	500	PF02991	0.484
LIG_LIR_Gen_1	57	66	PF02991	0.281
LIG_LIR_LC3C_4	48	51	PF02991	0.179
LIG_LIR_Nem_3	331	337	PF02991	0.559
LIG_LIR_Nem_3	352	357	PF02991	0.322
LIG_LIR_Nem_3	372	378	PF02991	0.232
LIG_LIR_Nem_3	381	387	PF02991	0.296
LIG_LIR_Nem_3	427	432	PF02991	0.653
LIG_LIR_Nem_3	491	496	PF02991	0.496
LIG_LIR_Nem_3	57	61	PF02991	0.423
LIG_NRBOX	388	394	PF00104	0.261
LIG_NRBOX	405	411	PF00104	0.705
LIG_NRBOX	48	54	PF00104	0.250
LIG_PCNA_PIPBox_1	347	356	PF02747	0.367
LIG_Pex14_1	358	362	PF04695	0.265
LIG_Pex14_2	374	378	PF04695	0.367
LIG_Pex14_2	492	496	PF04695	0.611
LIG_Pex14_2	58	62	PF04695	0.307
LIG_PTAP_UEV_1	589	594	PF05743	0.645
LIG_PTB_Apo_2	327	334	PF02174	0.509
LIG_PTB_Phospho_1	327	333	PF10480	0.509
LIG_REV1ctd_RIR_1	360	369	PF16727	0.307
LIG_SH2_CRK	429	433	PF00017	0.622
LIG_SH2_GRB2like	328	331	PF00017	0.592
LIG_SH2_GRB2like	587	590	PF00017	0.676
LIG_SH2_NCK_1	41	45	PF00017	0.504
LIG_SH2_PTP2	587	590	PF00017	0.633
LIG_SH2_SRC	328	331	PF00017	0.576
LIG_SH2_SRC	395	398	PF00017	0.521
LIG_SH2_SRC	429	432	PF00017	0.733
LIG_SH2_SRC	587	590	PF00017	0.633
LIG_SH2_STAP1	360	364	PF00017	0.321
LIG_SH2_STAP1	380	384	PF00017	0.162
LIG_SH2_STAP1	41	45	PF00017	0.522
LIG_SH2_STAT5	190	193	PF00017	0.674
LIG_SH2_STAT5	334	337	PF00017	0.370
LIG_SH2_STAT5	340	343	PF00017	0.281
LIG_SH2_STAT5	354	357	PF00017	0.291
LIG_SH2_STAT5	360	363	PF00017	0.166
LIG_SH2_STAT5	375	378	PF00017	0.385
LIG_SH2_STAT5	395	398	PF00017	0.362
LIG_SH2_STAT5	587	590	PF00017	0.676
LIG_SH3_1	587	593	PF00018	0.630
LIG_SH3_3	137	143	PF00018	0.818
LIG_SH3_3	568	574	PF00018	0.726
LIG_SH3_3	587	593	PF00018	0.720
LIG_SH3_3	71	77	PF00018	0.502
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.579
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.284
LIG_SUMO_SIM_anti_2	566	573	PF11976	0.684
LIG_SUMO_SIM_par_1	254	259	PF11976	0.579
LIG_SUMO_SIM_par_1	51	57	PF11976	0.196
LIG_SUMO_SIM_par_1	573	578	PF11976	0.639
LIG_TRAF2_1	172	175	PF00917	0.700
LIG_TRAF2_1	440	443	PF00917	0.688
LIG_TRAF2_1	448	451	PF00917	0.647
LIG_TYR_ITIM	338	343	PF00017	0.385
LIG_WRC_WIRS_1	55	60	PF05994	0.471
LIG_WRC_WIRS_1	89	94	PF05994	0.385
MOD_CK1_1	169	175	PF00069	0.633
MOD_CK1_1	198	204	PF00069	0.703
MOD_CK1_1	434	440	PF00069	0.643
MOD_CK1_1	548	554	PF00069	0.721
MOD_CK1_1	57	63	PF00069	0.295
MOD_CK1_1	581	587	PF00069	0.692
MOD_CK1_1	6	12	PF00069	0.597
MOD_CK1_1	65	71	PF00069	0.483
MOD_CK1_1	82	88	PF00069	0.375
MOD_CK2_1	169	175	PF00069	0.635
MOD_CK2_1	178	184	PF00069	0.608
MOD_CK2_1	460	466	PF00069	0.477
MOD_CK2_1	479	485	PF00069	0.414
MOD_GlcNHglycan	107	110	PF01048	0.479
MOD_GlcNHglycan	131	134	PF01048	0.529
MOD_GlcNHglycan	160	163	PF01048	0.450
MOD_GlcNHglycan	3	6	PF01048	0.699
MOD_GlcNHglycan	366	369	PF01048	0.461
MOD_GlcNHglycan	380	383	PF01048	0.283
MOD_GlcNHglycan	42	45	PF01048	0.506
MOD_GlcNHglycan	442	447	PF01048	0.664
MOD_GlcNHglycan	580	583	PF01048	0.659
MOD_GlcNHglycan	590	593	PF01048	0.664
MOD_GlcNHglycan	71	74	PF01048	0.528
MOD_GlcNHglycan	84	87	PF01048	0.462
MOD_GSK3_1	1	8	PF00069	0.650
MOD_GSK3_1	123	130	PF00069	0.688
MOD_GSK3_1	194	201	PF00069	0.720
MOD_GSK3_1	474	481	PF00069	0.430
MOD_GSK3_1	541	548	PF00069	0.665
MOD_GSK3_1	563	570	PF00069	0.568
MOD_GSK3_1	65	72	PF00069	0.350
MOD_N-GLC_1	299	304	PF02516	0.367
MOD_N-GLC_2	289	291	PF02516	0.367
MOD_N-GLC_2	309	311	PF02516	0.319
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	166	171	PF00069	0.669
MOD_NEK2_1	178	183	PF00069	0.563
MOD_NEK2_1	299	304	PF00069	0.325
MOD_NEK2_1	341	346	PF00069	0.340
MOD_NEK2_1	378	383	PF00069	0.360
MOD_NEK2_1	62	67	PF00069	0.290
MOD_NEK2_1	69	74	PF00069	0.420
MOD_NEK2_2	358	363	PF00069	0.325
MOD_PIKK_1	150	156	PF00454	0.643
MOD_PK_1	503	509	PF00069	0.498
MOD_PKA_2	127	133	PF00069	0.610
MOD_PKA_2	166	172	PF00069	0.648
MOD_PKA_2	82	88	PF00069	0.525
MOD_PKB_1	501	509	PF00069	0.495
MOD_Plk_1	178	184	PF00069	0.431
MOD_Plk_1	434	440	PF00069	0.597
MOD_Plk_1	567	573	PF00069	0.553
MOD_Plk_2-3	512	518	PF00069	0.633
MOD_Plk_4	341	347	PF00069	0.337
MOD_Plk_4	358	364	PF00069	0.209
MOD_Plk_4	369	375	PF00069	0.321
MOD_Plk_4	549	555	PF00069	0.491
MOD_Plk_4	567	573	PF00069	0.531
MOD_Plk_4	57	63	PF00069	0.456
MOD_Plk_4	583	589	PF00069	0.666
MOD_Plk_4	65	71	PF00069	0.350
MOD_Plk_4	88	94	PF00069	0.491
MOD_ProDKin_1	167	173	PF00069	0.593
MOD_ProDKin_1	3	9	PF00069	0.564
MOD_ProDKin_1	444	450	PF00069	0.652
MOD_ProDKin_1	474	480	PF00069	0.566
MOD_ProDKin_1	541	547	PF00069	0.649
MOD_ProDKin_1	581	587	PF00069	0.677
MOD_SUMO_for_1	602	605	PF00179	0.637
MOD_SUMO_rev_2	122	130	PF00179	0.493
TRG_DiLeu_BaEn_1	280	285	PF01217	0.414
TRG_DiLeu_BaEn_2	278	284	PF01217	0.469
TRG_ENDOCYTIC_2	333	336	PF00928	0.361
TRG_ENDOCYTIC_2	340	343	PF00928	0.245
TRG_ENDOCYTIC_2	354	357	PF00928	0.303
TRG_ENDOCYTIC_2	360	363	PF00928	0.167
TRG_ENDOCYTIC_2	375	378	PF00928	0.385
TRG_ENDOCYTIC_2	429	432	PF00928	0.545
TRG_ER_diArg_1	166	168	PF00400	0.613
TRG_ER_diArg_1	243	245	PF00400	0.615
TRG_ER_diArg_1	249	251	PF00400	0.596
TRG_ER_diArg_1	500	503	PF00400	0.475
TRG_NES_CRM1_1	232	246	PF08389	0.576
TRG_NLS_MonoExtC_3	246	251	PF00514	0.558
TRG_NLS_MonoExtN_4	244	251	PF00514	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C7	Leptomonas seymouri	49%	96%
A0A3Q8ICU7	Leishmania donovani	89%	100%
A0A3S5IRN1	Trypanosoma rangeli	27%	100%
A4H754	Leishmania braziliensis	72%	100%
A4HVJ3	Leishmania infantum	89%	100%
Q4QG89	Leishmania major	86%	100%
V5AVF5	Trypanosoma cruzi	26%	100%