t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP87_LEIMU

TriTrypDb:

LmxM.13.0630

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.578
CLV_NRD_NRD_1	150	152	PF00675	0.693
CLV_PCSK_KEX2_1	150	152	PF00082	0.693
CLV_PCSK_KEX2_1	41	43	PF00082	0.460
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.546
CLV_PCSK_SKI1_1	67	71	PF00082	0.477
DEG_Nend_UBRbox_3	1	3	PF02207	0.574
DEG_SPOP_SBC_1	87	91	PF00917	0.728
DOC_PP4_FxxP_1	280	283	PF00568	0.625
DOC_USP7_MATH_1	103	107	PF00917	0.764
DOC_USP7_MATH_1	138	142	PF00917	0.719
DOC_USP7_MATH_1	146	150	PF00917	0.760
DOC_USP7_MATH_1	254	258	PF00917	0.777
DOC_USP7_MATH_1	26	30	PF00917	0.611
DOC_WW_Pin1_4	142	147	PF00397	0.581
DOC_WW_Pin1_4	88	93	PF00397	0.769
LIG_Actin_WH2_2	43	61	PF00022	0.546
LIG_BRCT_BRCA1_1	209	213	PF00533	0.540
LIG_deltaCOP1_diTrp_1	186	193	PF00928	0.668
LIG_EH_1	163	167	PF12763	0.476
LIG_eIF4E_1	52	58	PF01652	0.445
LIG_FHA_1	260	266	PF00498	0.721
LIG_FHA_1	52	58	PF00498	0.445
LIG_LIR_Apic_2	111	116	PF02991	0.561
LIG_LIR_Apic_2	279	283	PF02991	0.628
LIG_LIR_Gen_1	195	205	PF02991	0.470
LIG_LIR_Gen_1	3	12	PF02991	0.476
LIG_LIR_Nem_3	195	201	PF02991	0.486
LIG_LIR_Nem_3	209	215	PF02991	0.424
LIG_LIR_Nem_3	3	8	PF02991	0.485
LIG_MLH1_MIPbox_1	209	213	PF16413	0.546
LIG_PTB_Apo_2	107	114	PF02174	0.484
LIG_PTB_Phospho_1	107	113	PF10480	0.484
LIG_SH2_CRK	113	117	PF00017	0.573
LIG_SH2_NCK_1	73	77	PF00017	0.605
LIG_SH2_STAT5	218	221	PF00017	0.531
MOD_CK1_1	121	127	PF00069	0.697
MOD_CK1_1	29	35	PF00069	0.580
MOD_CK1_1	3	9	PF00069	0.420
MOD_CK1_1	60	66	PF00069	0.523
MOD_CK1_1	82	88	PF00069	0.728
MOD_CK1_1	91	97	PF00069	0.672
MOD_CK2_1	103	109	PF00069	0.647
MOD_CK2_1	3	9	PF00069	0.420
MOD_GlcNHglycan	105	108	PF01048	0.698
MOD_GlcNHglycan	126	129	PF01048	0.690
MOD_GlcNHglycan	133	136	PF01048	0.677
MOD_GlcNHglycan	161	164	PF01048	0.670
MOD_GlcNHglycan	166	169	PF01048	0.680
MOD_GlcNHglycan	175	178	PF01048	0.685
MOD_GlcNHglycan	28	31	PF01048	0.528
MOD_GlcNHglycan	74	77	PF01048	0.626
MOD_GlcNHglycan	84	87	PF01048	0.800
MOD_GSK3_1	136	143	PF00069	0.677
MOD_GSK3_1	146	153	PF00069	0.628
MOD_GSK3_1	207	214	PF00069	0.546
MOD_GSK3_1	255	262	PF00069	0.746
MOD_GSK3_1	82	89	PF00069	0.788
MOD_N-GLC_1	103	108	PF02516	0.725
MOD_N-GLC_1	158	163	PF02516	0.761
MOD_N-GLC_1	254	259	PF02516	0.656
MOD_N-GLC_2	142	144	PF02516	0.502
MOD_N-GLC_2	237	239	PF02516	0.376
MOD_NEK2_1	108	113	PF00069	0.726
MOD_NEK2_1	264	269	PF00069	0.659
MOD_NEK2_1	51	56	PF00069	0.460
MOD_NEK2_1	57	62	PF00069	0.482
MOD_NEK2_1	72	77	PF00069	0.494
MOD_NEK2_2	97	102	PF00069	0.688
MOD_PIKK_1	118	124	PF00454	0.699
MOD_PIKK_1	207	213	PF00454	0.535
MOD_PIKK_1	29	35	PF00454	0.546
MOD_PIKK_1	45	51	PF00454	0.336
MOD_PIKK_1	79	85	PF00454	0.717
MOD_PKA_1	150	156	PF00069	0.688
MOD_PKA_2	150	156	PF00069	0.747
MOD_Plk_1	108	114	PF00069	0.709
MOD_Plk_1	15	21	PF00069	0.611
MOD_Plk_4	108	114	PF00069	0.701
MOD_Plk_4	276	282	PF00069	0.631
MOD_ProDKin_1	142	148	PF00069	0.581
MOD_ProDKin_1	88	94	PF00069	0.765
MOD_SUMO_rev_2	34	43	PF00179	0.556
MOD_SUMO_rev_2	60	69	PF00179	0.539
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C2	Leptomonas seymouri	65%	100%
A0A3Q8I9G5	Leishmania donovani	90%	99%
A0A422NQM7	Trypanosoma rangeli	36%	100%
A4H752	Leishmania braziliensis	74%	100%
D0A6R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGJ9	Leishmania infantum	90%	100%
Q4QG91	Leishmania major	89%	100%
V5AVG0	Trypanosoma cruzi	40%	100%