Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP86_LEIMU

TriTrypDb:

LmxM.13.0620

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	114	120	PF00089	0.573
CLV_NRD_NRD_1	112	114	PF00675	0.758
CLV_NRD_NRD_1	116	118	PF00675	0.711
CLV_NRD_NRD_1	179	181	PF00675	0.643
CLV_NRD_NRD_1	274	276	PF00675	0.489
CLV_NRD_NRD_1	303	305	PF00675	0.439
CLV_NRD_NRD_1	310	312	PF00675	0.428
CLV_NRD_NRD_1	73	75	PF00675	0.620
CLV_PCSK_KEX2_1	112	114	PF00082	0.758
CLV_PCSK_KEX2_1	116	118	PF00082	0.711
CLV_PCSK_KEX2_1	274	276	PF00082	0.489
CLV_PCSK_KEX2_1	303	305	PF00082	0.439
CLV_PCSK_KEX2_1	310	312	PF00082	0.428
CLV_PCSK_PC7_1	112	118	PF00082	0.504
CLV_PCSK_SKI1_1	310	314	PF00082	0.466
CLV_PCSK_SKI1_1	340	344	PF00082	0.411
CLV_PCSK_SKI1_1	380	384	PF00082	0.501
CLV_PCSK_SKI1_1	407	411	PF00082	0.426
DEG_APCC_DBOX_1	406	414	PF00400	0.408
DEG_SCF_FBW7_1	210	215	PF00400	0.682
DEG_SPOP_SBC_1	150	154	PF00917	0.669
DEG_SPOP_SBC_1	250	254	PF00917	0.630
DEG_SPOP_SBC_1	282	286	PF00917	0.434
DEG_SPOP_SBC_1	59	63	PF00917	0.599
DEG_SPOP_SBC_1	92	96	PF00917	0.606
DOC_CKS1_1	20	25	PF01111	0.574
DOC_CKS1_1	209	214	PF01111	0.683
DOC_MAPK_DCC_7	411	419	PF00069	0.495
DOC_MAPK_MEF2A_6	411	419	PF00069	0.495
DOC_USP7_MATH_1	106	110	PF00917	0.492
DOC_USP7_MATH_1	129	133	PF00917	0.660
DOC_USP7_MATH_1	144	148	PF00917	0.552
DOC_USP7_MATH_1	151	155	PF00917	0.637
DOC_USP7_MATH_1	156	160	PF00917	0.583
DOC_USP7_MATH_1	250	254	PF00917	0.621
DOC_USP7_MATH_1	282	286	PF00917	0.453
DOC_USP7_MATH_1	59	63	PF00917	0.599
DOC_USP7_MATH_1	92	96	PF00917	0.620
DOC_USP7_MATH_1	99	103	PF00917	0.520
DOC_WW_Pin1_4	125	130	PF00397	0.752
DOC_WW_Pin1_4	152	157	PF00397	0.665
DOC_WW_Pin1_4	169	174	PF00397	0.516
DOC_WW_Pin1_4	19	24	PF00397	0.537
DOC_WW_Pin1_4	208	213	PF00397	0.666
DOC_WW_Pin1_4	214	219	PF00397	0.680
DOC_WW_Pin1_4	28	33	PF00397	0.528
DOC_WW_Pin1_4	95	100	PF00397	0.569
LIG_14-3-3_CanoR_1	303	312	PF00244	0.433
LIG_14-3-3_CanoR_1	380	389	PF00244	0.556
LIG_APCC_ABBA_1	312	317	PF00400	0.429
LIG_APCC_ABBAyCdc20_2	311	317	PF00400	0.429
LIG_BRCT_BRCA1_1	23	27	PF00533	0.606
LIG_EH_1	47	51	PF12763	0.631
LIG_FHA_1	133	139	PF00498	0.600
LIG_FHA_1	218	224	PF00498	0.611
LIG_FHA_1	329	335	PF00498	0.326
LIG_FHA_1	40	46	PF00498	0.656
LIG_FHA_1	79	85	PF00498	0.674
LIG_LIR_Apic_2	206	212	PF02991	0.622
LIG_LIR_Gen_1	9	19	PF02991	0.604
LIG_LIR_Nem_3	16	21	PF02991	0.569
LIG_LIR_Nem_3	9	14	PF02991	0.705
LIG_LYPXL_yS_3	18	21	PF13949	0.595
LIG_PCNA_yPIPBox_3	351	361	PF02747	0.399
LIG_SH2_CRK	11	15	PF00017	0.655
LIG_SH2_CRK	187	191	PF00017	0.497
LIG_SH2_CRK	225	229	PF00017	0.679
LIG_SH3_3	213	219	PF00018	0.716
LIG_SH3_3	262	268	PF00018	0.557
LIG_SH3_3	46	52	PF00018	0.567
LIG_SUMO_SIM_anti_2	387	393	PF11976	0.417
LIG_TRAF2_1	321	324	PF00917	0.435
LIG_TYR_ITIM	185	190	PF00017	0.461
LIG_TYR_ITIM	223	228	PF00017	0.646
MOD_CDK_SPxxK_3	169	176	PF00069	0.511
MOD_CK1_1	102	108	PF00069	0.625
MOD_CK1_1	127	133	PF00069	0.603
MOD_CK1_1	152	158	PF00069	0.720
MOD_CK1_1	203	209	PF00069	0.578
MOD_CK1_1	217	223	PF00069	0.648
MOD_CK1_1	253	259	PF00069	0.610
MOD_CK1_1	280	286	PF00069	0.545
MOD_CK1_1	31	37	PF00069	0.537
MOD_CK1_1	58	64	PF00069	0.775
MOD_CK1_1	73	79	PF00069	0.560
MOD_CK1_1	82	88	PF00069	0.591
MOD_CK1_1	94	100	PF00069	0.684
MOD_CK2_1	359	365	PF00069	0.310
MOD_Cter_Amidation	308	311	PF01082	0.433
MOD_GlcNHglycan	104	107	PF01048	0.594
MOD_GlcNHglycan	108	111	PF01048	0.696
MOD_GlcNHglycan	164	167	PF01048	0.551
MOD_GlcNHglycan	203	206	PF01048	0.692
MOD_GlcNHglycan	230	233	PF01048	0.667
MOD_GlcNHglycan	240	243	PF01048	0.536
MOD_GlcNHglycan	258	261	PF01048	0.633
MOD_GlcNHglycan	286	289	PF01048	0.589
MOD_GlcNHglycan	401	406	PF01048	0.569
MOD_GlcNHglycan	57	60	PF01048	0.648
MOD_GlcNHglycan	81	84	PF01048	0.655
MOD_GlcNHglycan	87	90	PF01048	0.633
MOD_GSK3_1	123	130	PF00069	0.803
MOD_GSK3_1	152	159	PF00069	0.660
MOD_GSK3_1	208	215	PF00069	0.663
MOD_GSK3_1	234	241	PF00069	0.800
MOD_GSK3_1	245	252	PF00069	0.636
MOD_GSK3_1	277	284	PF00069	0.574
MOD_GSK3_1	31	38	PF00069	0.609
MOD_GSK3_1	338	345	PF00069	0.391
MOD_GSK3_1	55	62	PF00069	0.483
MOD_GSK3_1	75	82	PF00069	0.528
MOD_GSK3_1	87	94	PF00069	0.597
MOD_GSK3_1	95	102	PF00069	0.472
MOD_N-GLC_1	55	60	PF02516	0.586
MOD_NEK2_1	123	128	PF00069	0.662
MOD_NEK2_1	162	167	PF00069	0.510
MOD_NEK2_1	251	256	PF00069	0.646
MOD_NEK2_1	305	310	PF00069	0.433
MOD_NEK2_1	338	343	PF00069	0.415
MOD_NEK2_1	93	98	PF00069	0.601
MOD_PIKK_1	142	148	PF00454	0.567
MOD_PIKK_1	22	28	PF00454	0.526
MOD_PKA_1	116	122	PF00069	0.711
MOD_PKA_2	116	122	PF00069	0.735
MOD_PKA_2	387	393	PF00069	0.587
MOD_PKA_2	73	79	PF00069	0.734
MOD_PKB_1	77	85	PF00069	0.563
MOD_Plk_1	359	365	PF00069	0.374
MOD_Plk_4	31	37	PF00069	0.500
MOD_Plk_4	387	393	PF00069	0.478
MOD_ProDKin_1	125	131	PF00069	0.753
MOD_ProDKin_1	152	158	PF00069	0.665
MOD_ProDKin_1	169	175	PF00069	0.517
MOD_ProDKin_1	19	25	PF00069	0.540
MOD_ProDKin_1	208	214	PF00069	0.662
MOD_ProDKin_1	28	34	PF00069	0.525
MOD_ProDKin_1	95	101	PF00069	0.571
MOD_SUMO_rev_2	323	329	PF00179	0.410
TRG_DiLeu_BaEn_4	324	330	PF01217	0.507
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.433
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.573
TRG_ENDOCYTIC_2	11	14	PF00928	0.616
TRG_ENDOCYTIC_2	18	21	PF00928	0.545
TRG_ENDOCYTIC_2	187	190	PF00928	0.531
TRG_ENDOCYTIC_2	225	228	PF00928	0.687
TRG_ER_diArg_1	112	114	PF00400	0.591
TRG_ER_diArg_1	116	118	PF00400	0.627
TRG_ER_diArg_1	273	275	PF00400	0.483
TRG_ER_diArg_1	303	305	PF00400	0.439
TRG_ER_diArg_1	310	312	PF00400	0.428
TRG_ER_diArg_1	77	80	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE7	Leptomonas seymouri	47%	100%
A0A3Q8I9J2	Leishmania donovani	85%	100%
A4H751	Leishmania braziliensis	69%	98%
A4HVJ1	Leishmania infantum	85%	100%
Q4QG92	Leishmania major	86%	99%