Glucosamine 6-phosphate N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AP85_LEIMU

TriTrypDb:

LmxM.13.0610

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AP85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP85

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	7
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	7
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009225	nucleotide-sugar metabolic process	4	7
GO:0009226	nucleotide-sugar biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046349	amino sugar biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	7	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.353
CLV_PCSK_FUR_1	175	179	PF00082	0.335
CLV_PCSK_KEX2_1	177	179	PF00082	0.353
CLV_PCSK_SKI1_1	116	120	PF00082	0.451
CLV_PCSK_SKI1_1	216	220	PF00082	0.366
CLV_PCSK_SKI1_1	222	226	PF00082	0.306
CLV_PCSK_SKI1_1	33	37	PF00082	0.327
CLV_PCSK_SKI1_1	42	46	PF00082	0.425
CLV_PCSK_SKI1_1	59	63	PF00082	0.426
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.278
DOC_MAPK_gen_1	244	252	PF00069	0.389
DOC_MAPK_MEF2A_6	247	254	PF00069	0.282
DOC_MAPK_NFAT4_5	247	255	PF00069	0.294
DOC_PP1_RVXF_1	218	224	PF00149	0.214
DOC_PP2B_LxvP_1	252	255	PF13499	0.358
DOC_USP7_MATH_1	20	24	PF00917	0.373
DOC_USP7_MATH_1	228	232	PF00917	0.214
DOC_USP7_UBL2_3	38	42	PF12436	0.417
DOC_WW_Pin1_4	239	244	PF00397	0.415
LIG_14-3-3_CanoR_1	181	189	PF00244	0.241
LIG_14-3-3_CanoR_1	222	230	PF00244	0.389
LIG_Actin_WH2_2	104	121	PF00022	0.424
LIG_APCC_ABBA_1	70	75	PF00400	0.497
LIG_APCC_ABBAyCdc20_2	69	75	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BRCT_BRCA1_1	231	235	PF00533	0.453
LIG_EH_1	150	154	PF12763	0.481
LIG_eIF4E_1	163	169	PF01652	0.451
LIG_eIF4E_1	98	104	PF01652	0.373
LIG_FHA_1	171	177	PF00498	0.294
LIG_FHA_1	61	67	PF00498	0.366
LIG_FHA_2	24	30	PF00498	0.403
LIG_FHA_2	240	246	PF00498	0.430
LIG_GBD_Chelix_1	95	103	PF00786	0.420
LIG_HP1_1	255	259	PF01393	0.278
LIG_LIR_Gen_1	22	31	PF02991	0.484
LIG_LIR_Gen_1	46	55	PF02991	0.601
LIG_LIR_Nem_3	22	28	PF02991	0.508
LIG_LIR_Nem_3	43	48	PF02991	0.583
LIG_LIR_Nem_3	49	54	PF02991	0.513
LIG_Pex14_2	219	223	PF04695	0.453
LIG_SH2_GRB2like	98	101	PF00017	0.340
LIG_SH2_NCK_1	236	240	PF00017	0.453
LIG_SH2_STAP1	101	105	PF00017	0.358
LIG_SH2_STAT5	236	239	PF00017	0.364
LIG_SH2_STAT5	241	244	PF00017	0.399
LIG_SH2_STAT5	256	259	PF00017	0.246
LIG_SH2_STAT5	48	51	PF00017	0.407
LIG_SH2_STAT5	98	101	PF00017	0.364
LIG_SH3_4	38	45	PF00018	0.406
LIG_SxIP_EBH_1	162	175	PF03271	0.488
LIG_TRAF2_1	81	84	PF00917	0.511
LIG_WRC_WIRS_1	48	53	PF05994	0.293
MOD_CDK_SPK_2	239	244	PF00069	0.389
MOD_CK1_1	180	186	PF00069	0.453
MOD_CK1_1	23	29	PF00069	0.339
MOD_CK1_1	65	71	PF00069	0.513
MOD_GlcNHglycan	124	128	PF01048	0.485
MOD_GlcNHglycan	196	199	PF01048	0.310
MOD_GSK3_1	43	50	PF00069	0.422
MOD_N-GLC_1	9	14	PF02516	0.498
MOD_N-GLC_1	99	104	PF02516	0.317
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	117	122	PF00069	0.595
MOD_NEK2_1	123	128	PF00069	0.497
MOD_NEK2_1	62	67	PF00069	0.509
MOD_NEK2_1	99	104	PF00069	0.326
MOD_NEK2_2	170	175	PF00069	0.275
MOD_PKA_1	177	183	PF00069	0.453
MOD_PKA_2	177	183	PF00069	0.453
MOD_PKB_1	175	183	PF00069	0.453
MOD_Plk_1	99	105	PF00069	0.318
MOD_Plk_4	164	170	PF00069	0.514
MOD_Plk_4	20	26	PF00069	0.336
MOD_Plk_4	99	105	PF00069	0.329
MOD_ProDKin_1	239	245	PF00069	0.415
MOD_SUMO_rev_2	106	111	PF00179	0.434
MOD_SUMO_rev_2	53	61	PF00179	0.404
TRG_DiLeu_BaEn_1	107	112	PF01217	0.410
TRG_DiLeu_BaEn_1	30	35	PF01217	0.405
TRG_DiLeu_BaEn_4	83	89	PF01217	0.380
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.440
TRG_ENDOCYTIC_2	101	104	PF00928	0.388
TRG_ENDOCYTIC_2	256	259	PF00928	0.214
TRG_ENDOCYTIC_2	48	51	PF00928	0.426
TRG_ER_diArg_1	174	177	PF00400	0.350
TRG_ER_diArg_1	219	222	PF00400	0.214
TRG_ER_diArg_1	66	69	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B9	Leptomonas seymouri	52%	99%
A0A3S7WSF7	Leishmania donovani	81%	98%
A4H750	Leishmania braziliensis	66%	100%
A4HVJ0	Leishmania infantum	81%	98%
Q4QG93	Leishmania major	82%	100%