LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AP83_LEIMU
TriTrypDb:
LmxM.13.0590
Length:
325

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AP83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP83

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 134 138 PF00082 0.483
CLV_PCSK_SKI1_1 70 74 PF00082 0.481
DEG_Nend_UBRbox_2 1 3 PF02207 0.404
DEG_SPOP_SBC_1 214 218 PF00917 0.551
DEG_SPOP_SBC_1 239 243 PF00917 0.468
DOC_CKS1_1 85 90 PF01111 0.347
DOC_MAPK_MEF2A_6 24 33 PF00069 0.424
DOC_MAPK_MEF2A_6 298 307 PF00069 0.425
DOC_MAPK_NFAT4_5 298 306 PF00069 0.424
DOC_PP1_RVXF_1 147 154 PF00149 0.566
DOC_PP1_RVXF_1 62 68 PF00149 0.449
DOC_PP2B_LxvP_1 180 183 PF13499 0.491
DOC_PP4_FxxP_1 247 250 PF00568 0.415
DOC_USP7_MATH_1 142 146 PF00917 0.496
DOC_USP7_MATH_1 234 238 PF00917 0.683
DOC_USP7_MATH_1 254 258 PF00917 0.342
DOC_USP7_MATH_1 68 72 PF00917 0.527
DOC_USP7_UBL2_3 137 141 PF12436 0.487
DOC_WW_Pin1_4 104 109 PF00397 0.499
DOC_WW_Pin1_4 228 233 PF00397 0.707
DOC_WW_Pin1_4 262 267 PF00397 0.420
DOC_WW_Pin1_4 84 89 PF00397 0.361
LIG_14-3-3_CanoR_1 221 225 PF00244 0.641
LIG_14-3-3_CanoR_1 24 31 PF00244 0.384
LIG_14-3-3_CanoR_1 270 280 PF00244 0.301
LIG_14-3-3_CanoR_1 43 47 PF00244 0.272
LIG_14-3-3_CanoR_1 62 68 PF00244 0.386
LIG_Actin_WH2_2 248 265 PF00022 0.391
LIG_BRCT_BRCA1_1 293 297 PF00533 0.382
LIG_FHA_1 177 183 PF00498 0.564
LIG_FHA_1 43 49 PF00498 0.429
LIG_FHA_2 214 220 PF00498 0.673
LIG_FHA_2 262 268 PF00498 0.491
LIG_FHA_2 314 320 PF00498 0.497
LIG_LIR_Apic_2 82 88 PF02991 0.374
LIG_LIR_Gen_1 174 183 PF02991 0.429
LIG_LIR_Gen_1 319 325 PF02991 0.588
LIG_LIR_Nem_3 15 19 PF02991 0.365
LIG_LIR_Nem_3 174 180 PF02991 0.435
LIG_LIR_Nem_3 26 31 PF02991 0.352
LIG_LIR_Nem_3 319 325 PF02991 0.548
LIG_LIR_Nem_3 53 59 PF02991 0.351
LIG_LYPXL_yS_3 28 31 PF13949 0.418
LIG_SH2_CRK 44 48 PF00017 0.506
LIG_SH2_CRK 60 64 PF00017 0.295
LIG_SH2_CRK 85 89 PF00017 0.378
LIG_SH2_SRC 58 61 PF00017 0.468
LIG_SH2_STAP1 19 23 PF00017 0.401
LIG_SH2_STAP1 50 54 PF00017 0.438
LIG_SH2_STAT5 16 19 PF00017 0.233
LIG_SH2_STAT5 186 189 PF00017 0.413
LIG_SH2_STAT5 246 249 PF00017 0.426
LIG_SH2_STAT5 44 47 PF00017 0.399
LIG_SH2_STAT5 56 59 PF00017 0.326
LIG_SH2_STAT5 78 81 PF00017 0.429
LIG_SH3_1 204 210 PF00018 0.412
LIG_SH3_3 192 198 PF00018 0.493
LIG_SH3_3 204 210 PF00018 0.645
LIG_SUMO_SIM_par_1 8 15 PF11976 0.391
LIG_TYR_ITIM 54 59 PF00017 0.317
MOD_CK1_1 145 151 PF00069 0.623
MOD_CK1_1 223 229 PF00069 0.667
MOD_CK1_1 311 317 PF00069 0.503
MOD_CK1_1 37 43 PF00069 0.359
MOD_CK2_1 214 220 PF00069 0.625
MOD_CK2_1 261 267 PF00069 0.401
MOD_GlcNHglycan 225 228 PF01048 0.725
MOD_GlcNHglycan 236 239 PF01048 0.501
MOD_GlcNHglycan 273 276 PF01048 0.456
MOD_GlcNHglycan 291 294 PF01048 0.494
MOD_GlcNHglycan 313 316 PF01048 0.473
MOD_GlcNHglycan 35 39 PF01048 0.378
MOD_GlcNHglycan 81 84 PF01048 0.388
MOD_GSK3_1 14 21 PF00069 0.300
MOD_GSK3_1 186 193 PF00069 0.462
MOD_GSK3_1 226 233 PF00069 0.655
MOD_GSK3_1 234 241 PF00069 0.721
MOD_GSK3_1 254 261 PF00069 0.499
MOD_GSK3_1 79 86 PF00069 0.390
MOD_NEK2_1 111 116 PF00069 0.554
MOD_NEK2_1 240 245 PF00069 0.529
MOD_NEK2_1 286 291 PF00069 0.533
MOD_NEK2_1 305 310 PF00069 0.497
MOD_NEK2_1 42 47 PF00069 0.424
MOD_PIKK_1 127 133 PF00454 0.568
MOD_PIKK_1 186 192 PF00454 0.567
MOD_PIKK_1 220 226 PF00454 0.641
MOD_PKA_2 220 226 PF00069 0.641
MOD_PKA_2 23 29 PF00069 0.393
MOD_PKA_2 42 48 PF00069 0.273
MOD_PKA_2 63 69 PF00069 0.469
MOD_Plk_1 111 117 PF00069 0.478
MOD_Plk_1 142 148 PF00069 0.546
MOD_Plk_1 157 163 PF00069 0.305
MOD_Plk_1 171 177 PF00069 0.538
MOD_Plk_1 34 40 PF00069 0.310
MOD_Plk_1 68 74 PF00069 0.521
MOD_Plk_4 176 182 PF00069 0.499
MOD_Plk_4 190 196 PF00069 0.342
MOD_Plk_4 50 56 PF00069 0.315
MOD_ProDKin_1 104 110 PF00069 0.495
MOD_ProDKin_1 228 234 PF00069 0.706
MOD_ProDKin_1 262 268 PF00069 0.419
MOD_ProDKin_1 84 90 PF00069 0.352
MOD_SUMO_for_1 140 143 PF00179 0.492
TRG_ENDOCYTIC_2 28 31 PF00928 0.512
TRG_ENDOCYTIC_2 281 284 PF00928 0.415
TRG_ENDOCYTIC_2 56 59 PF00928 0.397
TRG_ER_diArg_1 62 65 PF00400 0.436
TRG_NES_CRM1_1 2 15 PF08389 0.431
TRG_PTS1 322 325 PF00515 0.609

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I141 Leptomonas seymouri 59% 100%
A0A1X0NNS3 Trypanosomatidae 39% 100%
A0A3Q8I9L5 Leishmania donovani 94% 100%
A4H748 Leishmania braziliensis 83% 100%
A4HVI8 Leishmania infantum 94% 100%
D0A6R7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
Q4QG95 Leishmania major 92% 100%
V5BJY4 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS