UPF0301 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0301 protein

Gene product:

Uncharacterized ACR, COG1678, putative

Species:

Leishmania mexicana

UniProt:

E9AP79_LEIMU

TriTrypDb:

LmxM.13.0550

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.386
CLV_NRD_NRD_1	17	19	PF00675	0.387
CLV_NRD_NRD_1	252	254	PF00675	0.593
CLV_NRD_NRD_1	324	326	PF00675	0.692
CLV_NRD_NRD_1	370	372	PF00675	0.369
CLV_NRD_NRD_1	417	419	PF00675	0.369
CLV_NRD_NRD_1	619	621	PF00675	0.558
CLV_NRD_NRD_1	66	68	PF00675	0.368
CLV_NRD_NRD_1	9	11	PF00675	0.387
CLV_PCSK_FUR_1	616	620	PF00082	0.560
CLV_PCSK_KEX2_1	17	19	PF00082	0.377
CLV_PCSK_KEX2_1	324	326	PF00082	0.692
CLV_PCSK_KEX2_1	370	372	PF00082	0.369
CLV_PCSK_KEX2_1	417	419	PF00082	0.369
CLV_PCSK_KEX2_1	615	617	PF00082	0.560
CLV_PCSK_KEX2_1	618	620	PF00082	0.550
CLV_PCSK_KEX2_1	66	68	PF00082	0.385
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.616
CLV_PCSK_PC7_1	366	372	PF00082	0.369
CLV_PCSK_SKI1_1	201	205	PF00082	0.615
CLV_PCSK_SKI1_1	3	7	PF00082	0.404
CLV_PCSK_SKI1_1	366	370	PF00082	0.304
CLV_PCSK_SKI1_1	371	375	PF00082	0.304
CLV_PCSK_SKI1_1	378	382	PF00082	0.304
CLV_PCSK_SKI1_1	58	62	PF00082	0.449
DEG_APCC_DBOX_1	370	378	PF00400	0.369
DEG_APCC_DBOX_1	57	65	PF00400	0.381
DEG_Nend_UBRbox_2	1	3	PF02207	0.436
DEG_SPOP_SBC_1	549	553	PF00917	0.572
DOC_MAPK_gen_1	199	207	PF00069	0.446
DOC_MAPK_gen_1	260	269	PF00069	0.512
DOC_MAPK_gen_1	351	360	PF00069	0.454
DOC_MAPK_gen_1	370	377	PF00069	0.234
DOC_MAPK_MEF2A_6	146	154	PF00069	0.434
DOC_MAPK_MEF2A_6	260	269	PF00069	0.633
DOC_MAPK_MEF2A_6	351	360	PF00069	0.622
DOC_MAPK_MEF2A_6	370	377	PF00069	0.227
DOC_USP7_MATH_1	109	113	PF00917	0.639
DOC_USP7_MATH_1	118	122	PF00917	0.587
DOC_USP7_MATH_1	132	136	PF00917	0.528
DOC_USP7_MATH_1	275	279	PF00917	0.665
DOC_USP7_MATH_1	286	290	PF00917	0.574
DOC_USP7_MATH_1	316	320	PF00917	0.706
DOC_USP7_MATH_1	328	332	PF00917	0.627
DOC_USP7_MATH_1	430	434	PF00917	0.304
DOC_USP7_MATH_1	455	459	PF00917	0.304
DOC_USP7_MATH_1	515	519	PF00917	0.421
DOC_USP7_MATH_1	548	552	PF00917	0.719
DOC_USP7_MATH_1	580	584	PF00917	0.627
DOC_USP7_MATH_1	640	644	PF00917	0.368
DOC_WW_Pin1_4	168	173	PF00397	0.437
DOC_WW_Pin1_4	280	285	PF00397	0.614
DOC_WW_Pin1_4	323	328	PF00397	0.604
DOC_WW_Pin1_4	531	536	PF00397	0.500
DOC_WW_Pin1_4	605	610	PF00397	0.538
DOC_WW_Pin1_4	69	74	PF00397	0.395
LIG_14-3-3_CanoR_1	146	151	PF00244	0.450
LIG_14-3-3_CanoR_1	242	246	PF00244	0.631
LIG_14-3-3_CanoR_1	370	374	PF00244	0.304
LIG_14-3-3_CanoR_1	378	387	PF00244	0.304
LIG_14-3-3_CanoR_1	639	645	PF00244	0.376
LIG_BIR_III_4	125	129	PF00653	0.510
LIG_BRCT_BRCA1_1	56	60	PF00533	0.469
LIG_deltaCOP1_diTrp_1	43	47	PF00928	0.424
LIG_deltaCOP1_diTrp_1	51	60	PF00928	0.436
LIG_FAT_LD_1	466	474	PF03623	0.304
LIG_FHA_1	137	143	PF00498	0.653
LIG_FHA_1	147	153	PF00498	0.449
LIG_FHA_1	157	163	PF00498	0.237
LIG_FHA_1	198	204	PF00498	0.699
LIG_FHA_1	212	218	PF00498	0.428
LIG_FHA_1	370	376	PF00498	0.304
LIG_FHA_1	404	410	PF00498	0.304
LIG_FHA_1	422	428	PF00498	0.304
LIG_FHA_1	82	88	PF00498	0.424
LIG_FHA_2	286	292	PF00498	0.633
LIG_FHA_2	57	63	PF00498	0.438
LIG_LIR_Apic_2	72	78	PF02991	0.395
LIG_LIR_Gen_1	179	190	PF02991	0.451
LIG_LIR_Nem_3	179	185	PF02991	0.446
LIG_LIR_Nem_3	43	47	PF02991	0.424
LIG_LIR_Nem_3	7	12	PF02991	0.371
LIG_Pex14_1	637	641	PF04695	0.377
LIG_REV1ctd_RIR_1	366	375	PF16727	0.304
LIG_SH2_CRK	157	161	PF00017	0.421
LIG_SH2_CRK	641	645	PF00017	0.375
LIG_SH2_CRK	9	13	PF00017	0.366
LIG_SH2_NCK_1	641	645	PF00017	0.439
LIG_SH2_PTP2	75	78	PF00017	0.399
LIG_SH2_SRC	75	78	PF00017	0.532
LIG_SH2_STAP1	37	41	PF00017	0.426
LIG_SH2_STAP1	648	652	PF00017	0.385
LIG_SH2_STAT3	90	93	PF00017	0.403
LIG_SH2_STAT5	190	193	PF00017	0.386
LIG_SH2_STAT5	75	78	PF00017	0.539
LIG_SH3_3	445	451	PF00018	0.369
LIG_SH3_3	641	647	PF00018	0.451
LIG_SH3_3	74	80	PF00018	0.413
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.304
LIG_SUMO_SIM_anti_2	465	470	PF11976	0.477
LIG_SUMO_SIM_anti_2	481	488	PF11976	0.220
LIG_TRAF2_1	327	330	PF00917	0.719
LIG_TRAF2_1	335	338	PF00917	0.618
LIG_TRAF2_1	479	482	PF00917	0.369
LIG_TRAF2_1	575	578	PF00917	0.657
LIG_TRAF2_2	33	38	PF00917	0.405
LIG_TYR_ITIM	155	160	PF00017	0.423
LIG_UBA3_1	97	103	PF00899	0.358
LIG_WW_2	77	80	PF00397	0.425
MOD_CDK_SPK_2	531	536	PF00069	0.500
MOD_CK1_1	135	141	PF00069	0.586
MOD_CK1_1	158	164	PF00069	0.358
MOD_CK1_1	176	182	PF00069	0.396
MOD_CK1_1	211	217	PF00069	0.572
MOD_CK1_1	256	262	PF00069	0.648
MOD_CK1_1	293	299	PF00069	0.520
MOD_CK1_1	361	367	PF00069	0.586
MOD_CK1_1	433	439	PF00069	0.304
MOD_CK1_1	511	517	PF00069	0.304
MOD_CK2_1	118	124	PF00069	0.728
MOD_CK2_1	207	213	PF00069	0.594
MOD_CK2_1	285	291	PF00069	0.637
MOD_CK2_1	323	329	PF00069	0.845
MOD_CK2_1	332	338	PF00069	0.658
MOD_CK2_1	476	482	PF00069	0.369
MOD_CK2_1	550	556	PF00069	0.610
MOD_GlcNHglycan	111	114	PF01048	0.587
MOD_GlcNHglycan	120	123	PF01048	0.610
MOD_GlcNHglycan	134	137	PF01048	0.733
MOD_GlcNHglycan	210	213	PF01048	0.591
MOD_GlcNHglycan	256	259	PF01048	0.621
MOD_GlcNHglycan	288	291	PF01048	0.652
MOD_GlcNHglycan	295	298	PF01048	0.584
MOD_GlcNHglycan	329	333	PF01048	0.634
MOD_GlcNHglycan	334	337	PF01048	0.642
MOD_GlcNHglycan	383	386	PF01048	0.304
MOD_GlcNHglycan	432	435	PF01048	0.304
MOD_GlcNHglycan	476	481	PF01048	0.502
MOD_GlcNHglycan	510	513	PF01048	0.304
MOD_GlcNHglycan	552	555	PF01048	0.630
MOD_GlcNHglycan	566	569	PF01048	0.622
MOD_GlcNHglycan	571	574	PF01048	0.601
MOD_GlcNHglycan	582	585	PF01048	0.665
MOD_GlcNHglycan	628	631	PF01048	0.518
MOD_GSK3_1	132	139	PF00069	0.588
MOD_GSK3_1	197	204	PF00069	0.594
MOD_GSK3_1	207	214	PF00069	0.570
MOD_GSK3_1	286	293	PF00069	0.523
MOD_GSK3_1	328	335	PF00069	0.654
MOD_GSK3_1	399	406	PF00069	0.304
MOD_GSK3_1	433	440	PF00069	0.304
MOD_GSK3_1	511	518	PF00069	0.391
MOD_GSK3_1	522	529	PF00069	0.396
MOD_GSK3_1	605	612	PF00069	0.491
MOD_LATS_1	251	257	PF00433	0.500
MOD_N-GLC_1	176	181	PF02516	0.458
MOD_N-GLC_1	47	52	PF02516	0.468
MOD_N-GLC_1	69	74	PF02516	0.395
MOD_NEK2_1	173	178	PF00069	0.479
MOD_NEK2_1	229	234	PF00069	0.487
MOD_NEK2_1	358	363	PF00069	0.567
MOD_NEK2_1	369	374	PF00069	0.304
MOD_NEK2_1	432	437	PF00069	0.304
MOD_NEK2_1	522	527	PF00069	0.376
MOD_NEK2_1	96	101	PF00069	0.437
MOD_PIKK_1	24	30	PF00454	0.353
MOD_PKA_1	253	259	PF00069	0.628
MOD_PKA_2	145	151	PF00069	0.466
MOD_PKA_2	241	247	PF00069	0.538
MOD_PKA_2	369	375	PF00069	0.304
MOD_PKA_2	527	533	PF00069	0.568
MOD_Plk_1	19	25	PF00069	0.361
MOD_Plk_1	290	296	PF00069	0.525
MOD_Plk_1	399	405	PF00069	0.304
MOD_Plk_1	437	443	PF00069	0.304
MOD_Plk_1	515	521	PF00069	0.461
MOD_Plk_1	591	597	PF00069	0.469
MOD_Plk_2-3	56	62	PF00069	0.483
MOD_Plk_4	229	235	PF00069	0.459
MOD_Plk_4	421	427	PF00069	0.437
MOD_Plk_4	437	443	PF00069	0.216
MOD_Plk_4	633	639	PF00069	0.400
MOD_ProDKin_1	168	174	PF00069	0.433
MOD_ProDKin_1	280	286	PF00069	0.613
MOD_ProDKin_1	323	329	PF00069	0.605
MOD_ProDKin_1	531	537	PF00069	0.502
MOD_ProDKin_1	605	611	PF00069	0.540
MOD_ProDKin_1	69	75	PF00069	0.395
MOD_SUMO_for_1	498	501	PF00179	0.325
MOD_SUMO_for_1	589	592	PF00179	0.507
MOD_SUMO_rev_2	348	356	PF00179	0.566
MOD_SUMO_rev_2	50	55	PF00179	0.531
TRG_DiLeu_BaEn_1	355	360	PF01217	0.456
TRG_DiLeu_BaEn_1	383	388	PF01217	0.369
TRG_DiLeu_BaEn_2	55	61	PF01217	0.470
TRG_DiLeu_BaEn_2	91	97	PF01217	0.315
TRG_DiLeu_BaEn_3	337	343	PF01217	0.637
TRG_ENDOCYTIC_2	157	160	PF00928	0.422
TRG_ENDOCYTIC_2	506	509	PF00928	0.304
TRG_ENDOCYTIC_2	641	644	PF00928	0.371
TRG_ENDOCYTIC_2	648	651	PF00928	0.381
TRG_ENDOCYTIC_2	9	12	PF00928	0.386
TRG_ER_diArg_1	17	19	PF00400	0.380
TRG_ER_diArg_1	369	371	PF00400	0.369
TRG_ER_diArg_1	416	418	PF00400	0.369
TRG_ER_diArg_1	616	619	PF00400	0.558
TRG_ER_diArg_1	65	67	PF00400	0.370
TRG_NLS_MonoCore_2	614	619	PF00514	0.616
TRG_NLS_MonoExtC_3	614	619	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM6	Leptomonas seymouri	59%	100%
A0A3S7WSH5	Leishmania donovani	90%	100%
A4H744	Leishmania braziliensis	79%	98%
A4HVI4	Leishmania infantum	90%	100%
Q4QG99	Leishmania major	90%	100%