Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP78_LEIMU

TriTrypDb:

LmxM.13.0540

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7
GO:0016020	membrane	2	6

Expansion

Sequence features

E9AP78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.507
CLV_NRD_NRD_1	54	56	PF00675	0.386
CLV_PCSK_FUR_1	45	49	PF00082	0.431
CLV_PCSK_KEX2_1	178	180	PF00082	0.446
CLV_PCSK_KEX2_1	47	49	PF00082	0.402
CLV_PCSK_KEX2_1	53	55	PF00082	0.391
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.458
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.430
CLV_PCSK_SKI1_1	128	132	PF00082	0.453
CLV_PCSK_SKI1_1	33	37	PF00082	0.392
CLV_PCSK_SKI1_1	86	90	PF00082	0.430
DEG_APCC_DBOX_1	127	135	PF00400	0.339
DEG_Nend_UBRbox_3	1	3	PF02207	0.663
DOC_CKS1_1	1	6	PF01111	0.759
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.417
DOC_MAPK_DCC_7	126	136	PF00069	0.340
DOC_MAPK_gen_1	126	133	PF00069	0.162
DOC_MAPK_gen_1	45	52	PF00069	0.654
DOC_MAPK_MEF2A_6	126	133	PF00069	0.340
DOC_MAPK_NFAT4_5	126	134	PF00069	0.162
DOC_PP2B_LxvP_1	129	132	PF13499	0.417
DOC_USP7_MATH_1	35	39	PF00917	0.625
DOC_USP7_MATH_1	67	71	PF00917	0.761
DOC_USP7_MATH_1	7	11	PF00917	0.697
DOC_USP7_MATH_1	82	86	PF00917	0.656
DOC_USP7_UBL2_3	178	182	PF12436	0.744
DOC_WW_Pin1_4	188	193	PF00397	0.692
DOC_WW_Pin1_4	9	14	PF00397	0.641
LIG_14-3-3_CanoR_1	24	29	PF00244	0.604
LIG_14-3-3_CanoR_1	81	88	PF00244	0.676
LIG_BRCT_BRCA1_1	96	100	PF00533	0.541
LIG_FHA_1	139	145	PF00498	0.308
LIG_FHA_1	82	88	PF00498	0.615
LIG_FHA_2	184	190	PF00498	0.696
LIG_LIR_Gen_1	25	35	PF02991	0.544
LIG_LIR_Gen_1	46	57	PF02991	0.655
LIG_LIR_Nem_3	25	31	PF02991	0.551
LIG_LIR_Nem_3	46	52	PF02991	0.647
LIG_Pex14_1	96	100	PF04695	0.527
LIG_SH2_NCK_1	28	32	PF00017	0.624
LIG_SH2_SRC	28	31	PF00017	0.551
LIG_SH2_STAP1	28	32	PF00017	0.605
LIG_SH2_STAT5	121	124	PF00017	0.423
LIG_SH2_STAT5	157	160	PF00017	0.598
LIG_SH2_STAT5	49	52	PF00017	0.578
LIG_SH3_3	129	135	PF00018	0.274
LIG_TRAF2_1	27	30	PF00917	0.534
LIG_TYR_ITIM	26	31	PF00017	0.541
MOD_CK1_1	112	118	PF00069	0.275
MOD_CK1_1	191	197	PF00069	0.564
MOD_CK2_1	183	189	PF00069	0.677
MOD_CK2_1	24	30	PF00069	0.551
MOD_CMANNOS	142	145	PF00535	0.289
MOD_GlcNHglycan	102	105	PF01048	0.353
MOD_GlcNHglycan	69	72	PF01048	0.476
MOD_GlcNHglycan	9	12	PF01048	0.461
MOD_GlcNHglycan	92	95	PF01048	0.388
MOD_GSK3_1	106	113	PF00069	0.226
MOD_GSK3_1	90	97	PF00069	0.590
MOD_N-GLC_1	7	12	PF02516	0.470
MOD_NEK2_1	100	105	PF00069	0.565
MOD_NEK2_1	183	188	PF00069	0.647
MOD_NEK2_2	96	101	PF00069	0.592
MOD_PKA_2	80	86	PF00069	0.679
MOD_Plk_4	35	41	PF00069	0.609
MOD_Plk_4	96	102	PF00069	0.650
MOD_ProDKin_1	188	194	PF00069	0.692
MOD_ProDKin_1	9	15	PF00069	0.641
TRG_DiLeu_BaEn_1	61	66	PF01217	0.619
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.607
TRG_ENDOCYTIC_2	121	124	PF00928	0.462
TRG_ENDOCYTIC_2	28	31	PF00928	0.540
TRG_ENDOCYTIC_2	49	52	PF00928	0.543
TRG_ER_diArg_1	125	128	PF00400	0.297
TRG_ER_diArg_1	179	181	PF00400	0.737
TRG_ER_diArg_1	52	55	PF00400	0.588
TRG_NLS_MonoCore_2	177	182	PF00514	0.734
TRG_NLS_MonoExtC_3	177	182	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE47	Leptomonas seymouri	75%	100%
A0A0S4J5J9	Bodo saltans	41%	100%
A0A1X0NNT8	Trypanosomatidae	42%	96%
A0A3Q8IHY4	Leishmania donovani	94%	100%
A0A3R7MTA4	Trypanosoma rangeli	49%	100%
A4H743	Leishmania braziliensis	83%	100%
A4HVI3	Leishmania infantum	94%	100%
D0A6S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4QGA0	Leishmania major	95%	100%
V5DBH6	Trypanosoma cruzi	48%	100%