Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AP75_LEIMU

TriTrypDb:

LmxM.13.0510

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AP75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AP75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.670
CLV_NRD_NRD_1	175	177	PF00675	0.536
CLV_NRD_NRD_1	32	34	PF00675	0.531
CLV_NRD_NRD_1	41	43	PF00675	0.595
CLV_PCSK_KEX2_1	16	18	PF00082	0.551
CLV_PCSK_KEX2_1	175	177	PF00082	0.520
CLV_PCSK_KEX2_1	247	249	PF00082	0.655
CLV_PCSK_KEX2_1	32	34	PF00082	0.507
CLV_PCSK_KEX2_1	41	43	PF00082	0.577
CLV_PCSK_KEX2_1	75	77	PF00082	0.555
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.670
DEG_APCC_DBOX_1	61	69	PF00400	0.425
DEG_Nend_UBRbox_2	1	3	PF02207	0.606
DEG_SCF_FBW7_1	4	11	PF00400	0.622
DOC_CYCLIN_RxL_1	172	182	PF00134	0.648
DOC_MAPK_MEF2A_6	162	171	PF00069	0.542
DOC_MAPK_MEF2A_6	55	63	PF00069	0.541
DOC_MAPK_RevD_3	61	76	PF00069	0.551
DOC_PP1_RVXF_1	173	180	PF00149	0.644
DOC_PP2B_LxvP_1	236	239	PF13499	0.638
DOC_USP7_MATH_1	215	219	PF00917	0.479
DOC_USP7_MATH_1	25	29	PF00917	0.604
DOC_USP7_MATH_1	8	12	PF00917	0.699
DOC_WW_Pin1_4	134	139	PF00397	0.643
DOC_WW_Pin1_4	4	9	PF00397	0.706
LIG_14-3-3_CanoR_1	175	180	PF00244	0.560
LIG_14-3-3_CanoR_1	62	72	PF00244	0.603
LIG_Actin_WH2_2	209	225	PF00022	0.602
LIG_FHA_1	105	111	PF00498	0.652
LIG_FHA_1	186	192	PF00498	0.603
LIG_FHA_2	179	185	PF00498	0.428
LIG_FHA_2	46	52	PF00498	0.454
LIG_FHA_2	5	11	PF00498	0.703
LIG_FHA_2	98	104	PF00498	0.647
LIG_Integrin_RGD_1	121	123	PF01839	0.656
LIG_LIR_Gen_1	85	92	PF02991	0.598
LIG_LIR_Nem_3	85	90	PF02991	0.605
LIG_NRP_CendR_1	247	249	PF00754	0.655
LIG_SH2_PTP2	135	138	PF00017	0.531
LIG_SH2_STAP1	30	34	PF00017	0.484
LIG_SH2_STAT3	34	37	PF00017	0.552
LIG_SH2_STAT5	135	138	PF00017	0.605
LIG_SH3_3	218	224	PF00018	0.654
LIG_SUMO_SIM_par_1	76	81	PF11976	0.528
LIG_TRAF2_1	100	103	PF00917	0.643
LIG_WRC_WIRS_1	192	197	PF05994	0.516
LIG_WW_3	237	241	PF00397	0.534
MOD_CK1_1	141	147	PF00069	0.596
MOD_CK1_1	178	184	PF00069	0.567
MOD_CK1_1	194	200	PF00069	0.481
MOD_CK1_1	35	41	PF00069	0.569
MOD_CK1_1	9	15	PF00069	0.515
MOD_CK2_1	178	184	PF00069	0.524
MOD_CK2_1	4	10	PF00069	0.729
MOD_CK2_1	97	103	PF00069	0.662
MOD_GlcNHglycan	143	146	PF01048	0.729
MOD_GlcNHglycan	158	161	PF01048	0.558
MOD_GlcNHglycan	201	204	PF01048	0.582
MOD_GlcNHglycan	217	220	PF01048	0.566
MOD_GlcNHglycan	37	40	PF01048	0.599
MOD_GlcNHglycan	65	68	PF01048	0.463
MOD_GSK3_1	134	141	PF00069	0.543
MOD_GSK3_1	33	40	PF00069	0.537
MOD_GSK3_1	4	11	PF00069	0.632
MOD_GSK3_1	41	48	PF00069	0.625
MOD_GSK3_1	78	85	PF00069	0.552
MOD_GSK3_1	88	95	PF00069	0.539
MOD_NEK2_1	140	145	PF00069	0.566
MOD_NEK2_1	199	204	PF00069	0.520
MOD_NEK2_1	63	68	PF00069	0.607
MOD_NEK2_1	83	88	PF00069	0.546
MOD_NEK2_2	104	109	PF00069	0.572
MOD_PIKK_1	33	39	PF00454	0.668
MOD_PKA_1	175	181	PF00069	0.534
MOD_PKA_1	32	38	PF00069	0.658
MOD_PKA_1	41	47	PF00069	0.659
MOD_PKA_2	175	181	PF00069	0.560
MOD_PKA_2	199	205	PF00069	0.427
MOD_PKA_2	239	245	PF00069	0.555
MOD_PKA_2	32	38	PF00069	0.605
MOD_PKA_2	41	47	PF00069	0.594
MOD_PKA_2	92	98	PF00069	0.669
MOD_Plk_1	9	15	PF00069	0.466
MOD_Plk_4	191	197	PF00069	0.560
MOD_Plk_4	25	31	PF00069	0.529
MOD_ProDKin_1	134	140	PF00069	0.648
MOD_ProDKin_1	4	10	PF00069	0.707
TRG_ER_diArg_1	175	177	PF00400	0.646
TRG_ER_diArg_1	246	249	PF00400	0.647
TRG_ER_diArg_1	32	34	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q3	Leptomonas seymouri	59%	85%
A0A1X0NN61	Trypanosomatidae	34%	100%
A0A3S5H6N4	Leishmania donovani	88%	100%
A0A422NQK2	Trypanosoma rangeli	33%	100%
A4H740	Leishmania braziliensis	79%	100%
A4HVI0	Leishmania infantum	88%	100%
D0A6T1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QGA3	Leishmania major	87%	100%
V5AVG9	Trypanosoma cruzi	36%	86%